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Building Complexity: Making and Breaking Synthetic Subunits of the HIV Capsid.

James LC, Böcking T.

Cell Host Microbe. 2019 Aug 14;26(2):151-153. doi: 10.1016/j.chom.2019.07.011.


The HIV-1 Capsid: More than Just a Delivery Package.

James LC.

Adv Exp Med Biol. 2019;1140:69-83. doi: 10.1007/978-3-030-14741-9_4.


Complement C4 Prevents Viral Infection through Capsid Inactivation.

Bottermann M, Foss S, Caddy SL, Clift D, van Tienen LM, Vaysburd M, Cruickshank J, O'Connell K, Clark J, Mayes K, Higginson K, Lode HE, McAdam MB, Sandlie I, Andersen JT, James LC.

Cell Host Microbe. 2019 Apr 10;25(4):617-629.e7. doi: 10.1016/j.chom.2019.02.016. Epub 2019 Mar 26.


Publisher Correction: Acute and rapid degradation of endogenous proteins by Trim-Away.

Clift D, So C, McEwan WA, James LC, Schuh M.

Nat Protoc. 2019 Aug;14(8):2596. doi: 10.1038/s41596-018-0092-8.


Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling.

Fletcher AJ, Vaysburd M, Maslen S, Zeng J, Skehel JM, Towers GJ, James LC.

Cell Host Microbe. 2018 Dec 12;24(6):761-775.e6. doi: 10.1016/j.chom.2018.10.007. Epub 2018 Nov 29.


IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating.

Dick RA, Mallery DL, Vogt VM, James LC.

Viruses. 2018 Nov 15;10(11). pii: E640. doi: 10.3390/v10110640. Review.


Acute and rapid degradation of endogenous proteins by Trim-Away.

Clift D, So C, McEwan WA, James LC, Schuh M.

Nat Protoc. 2018 Oct;13(10):2149-2175. doi: 10.1038/s41596-018-0028-3. Erratum in: Nat Protoc. 2018 Nov 30;:.


TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination.

Bottermann M, Foss S, van Tienen LM, Vaysburd M, Cruickshank J, O'Connell K, Clark J, Mayes K, Higginson K, Hirst JC, McAdam MB, Slodkowicz G, Hutchinson E, Kozik P, Andersen JT, James LC.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10440-10445. doi: 10.1073/pnas.1806314115. Epub 2018 Sep 12.


The Human Immunodeficiency Virus Capsid Is More Than Just a Genome Package.

James LC, Jacques DA.

Annu Rev Virol. 2018 Sep 29;5(1):209-225. doi: 10.1146/annurev-virology-092917-043430. Epub 2018 Jul 27. Review.


IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis.

Mallery DL, Márquez CL, McEwan WA, Dickson CF, Jacques DA, Anandapadamanaban M, Bichel K, Towers GJ, Saiardi A, Böcking T, James LC.

Elife. 2018 May 31;7. pii: e35335. doi: 10.7554/eLife.35335.


Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.

Dickson C, Fletcher AJ, Vaysburd M, Yang JC, Mallery DL, Zeng J, Johnson CM, McLaughlin SH, Skehel M, Maslen S, Cruickshank J, Huguenin-Dezot N, Chin JW, Neuhaus D, James LC.

Elife. 2018 Apr 18;7. pii: e32660. doi: 10.7554/eLife.32660.


Intracellular Antiviral Immunity.

Bottermann M, James LC.

Adv Virus Res. 2018;100:309-354. doi: 10.1016/bs.aivir.2018.01.002. Epub 2018 Feb 16. Review.


Characterization of innate immune viral sensors in patients following allogeneic hematopoietic stem cell transplantation.

Caddy SL, Wang M, Krishnamurthy P, Uttenthal B, Chandra A, Crawley C, James LC.

Innate Immun. 2018 Feb;24(2):112-121. doi: 10.1177/1753425918757898. Epub 2018 Feb 12.


Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein.

Khamina K, Lercher A, Caldera M, Schliehe C, Vilagos B, Sahin M, Kosack L, Bhattacharya A, Májek P, Stukalov A, Sacco R, James LC, Pinschewer DD, Bennett KL, Menche J, Bergthaler A.

PLoS Pathog. 2017 Dec 20;13(12):e1006758. doi: 10.1371/journal.ppat.1006758. eCollection 2017 Dec.


A Method for the Acute and Rapid Degradation of Endogenous Proteins.

Clift D, McEwan WA, Labzin LI, Konieczny V, Mogessie B, James LC, Schuh M.

Cell. 2017 Dec 14;171(7):1692-1706.e18. doi: 10.1016/j.cell.2017.10.033. Epub 2017 Nov 16.


Corrigendum: Antibody-antigen kinetics constrain intracellular humoral immunity.

Bottermann M, Lode HE, Watkinson RE, Foss S, Sandlie I, Andersen JT, James LC.

Sci Rep. 2017 Apr 6;7:45418. doi: 10.1038/srep45418. No abstract available.


Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.

McEwan WA, Falcon B, Vaysburd M, Clift D, Oblak AL, Ghetti B, Goedert M, James LC.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):574-579. doi: 10.1073/pnas.1607215114. Epub 2017 Jan 3.


Antibody-antigen kinetics constrain intracellular humoral immunity.

Bottermann M, Lode HE, Watkinson RE, Foss S, Sandlie I, Andersen JT, James LC.

Sci Rep. 2016 Nov 24;6:37457. doi: 10.1038/srep37457. Erratum in: Sci Rep. 2017 Apr 06;7:45418.


HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.

Jacques DA, McEwan WA, Hilditch L, Price AJ, Towers GJ, James LC.

Nature. 2016 Aug 18;536(7616):349-53. Epub 2016 Aug 10.


Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy.

Diggle CP, Sukoff Rizzo SJ, Popiolek M, Hinttala R, Schülke JP, Kurian MA, Carr IM, Markham AF, Bonthron DT, Watson C, Sharif SM, Reinhart V, James LC, Vanase-Frawley MA, Charych E, Allen M, Harms J, Schmidt CJ, Ng J, Pysden K, Strick C, Vieira P, Mankinen K, Kokkonen H, Kallioinen M, Sormunen R, Rinne JO, Johansson J, Alakurtti K, Huilaja L, Hurskainen T, Tasanen K, Anttila E, Marques TR, Howes O, Politis M, Fahiminiya S, Nguyen KQ, Majewski J, Uusimaa J, Sheridan E, Brandon NJ.

Am J Hum Genet. 2016 Apr 7;98(4):735-43. doi: 10.1016/j.ajhg.2016.03.015.


TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity.

Foss S, Watkinson RE, Grevys A, McAdam MB, Bern M, Høydahl LS, Dalhus B, Michaelsen TE, Sandlie I, James LC, Andersen JT.

J Immunol. 2016 Apr 15;196(8):3452-3459. doi: 10.4049/jimmunol.1502601. Epub 2016 Mar 9.


Coordinated Neutralization and Immune Activation by the Cytosolic Antibody Receptor TRIM21.

Fletcher AJ, James LC.

J Virol. 2016 Apr 29;90(10):4856-4859. doi: 10.1128/JVI.00050-16. Print 2016 May 15. Review.


Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation.

Kuhlmann N, Wroblowski S, Knyphausen P, de Boor S, Brenig J, Zienert AY, Meyer-Teschendorf K, Praefcke GJ, Nolte H, Krüger M, Schacherl M, Baumann U, James LC, Chin JW, Lammers M.

J Biol Chem. 2016 Mar 11;291(11):5484-99. doi: 10.1074/jbc.M115.707091. Epub 2015 Dec 30.


TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus.

Watkinson RE, McEwan WA, Tam JC, Vaysburd M, James LC.

PLoS Pathog. 2015 Oct 27;11(10):e1005253. doi: 10.1371/journal.ppat.1005253. eCollection 2015 Oct.


TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity.

Foss S, Watkinson R, Sandlie I, James LC, Andersen JT.

Immunol Rev. 2015 Nov;268(1):328-39. doi: 10.1111/imr.12363. Review.


Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21.

Fletcher AJ, Mallery DL, Watkinson RE, Dickson CF, James LC.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):10014-9. doi: 10.1073/pnas.1507534112. Epub 2015 Jul 6.


HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.

Zhou J, Price AJ, Halambage UD, James LC, Aiken C.

J Virol. 2015 Sep;89(17):9068-79. doi: 10.1128/JVI.00340-15. Epub 2015 Jun 24.


Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin.

Rhodes DA, Chen HC, Price AJ, Keeble AH, Davey MS, James LC, Eberl M, Trowsdale J.

J Immunol. 2015 Mar 1;194(5):2390-8. doi: 10.4049/jimmunol.1401064. Epub 2015 Jan 30.


TRIM21-dependent intracellular antibody neutralization of virus infection.

McEwan WA, James LC.

Prog Mol Biol Transl Sci. 2015;129:167-87. doi: 10.1016/bs.pmbts.2014.10.006. Epub 2014 Dec 12. Review.


Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.

Price AJ, Jacques DA, McEwan WA, Fletcher AJ, Essig S, Chin JW, Halambage UD, Aiken C, James LC.

PLoS Pathog. 2014 Oct 30;10(10):e1004459. doi: 10.1371/journal.ppat.1004459. eCollection 2014 Oct.


Intracellular sensing of complement C3 activates cell autonomous immunity.

Tam JC, Bidgood SR, McEwan WA, James LC.

Science. 2014 Sep 5;345(6201):1256070. doi: 10.1126/science.1256070. Epub 2014 Sep 4.


Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells.

Bidgood SR, Tam JC, McEwan WA, Mallery DL, James LC.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13463-8. doi: 10.1073/pnas.1410980111. Epub 2014 Aug 28.


Intracellular antibody immunity and the cytosolic Fc receptor TRIM21.

James LC.

Curr Top Microbiol Immunol. 2014;382:51-66. doi: 10.1007/978-3-319-07911-0_3.


Antibody- and TRIM21-dependent intracellular restriction of Salmonella enterica.

Rakebrandt N, Lentes S, Neumann H, James LC, Neumann-Staubitz P.

Pathog Dis. 2014 Nov;72(2):131-7. doi: 10.1111/2049-632X.12192. Epub 2014 Jun 27.


Intracellular antibody immunity.

Watkinson RE, McEwan WA, James LC.

J Clin Immunol. 2014 Jul;34 Suppl 1:S30-4. doi: 10.1007/s10875-014-0017-4. Epub 2014 Apr 11. Review.


HIV-1 evades innate immune recognition through specific cofactor recruitment.

Rasaiyaah J, Tan CP, Fletcher AJ, Price AJ, Blondeau C, Hilditch L, Jacques DA, Selwood DL, James LC, Noursadeghi M, Towers GJ.

Nature. 2013 Nov 21;503(7476):402-405. doi: 10.1038/nature12769. Epub 2013 Nov 6.


HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358.

Bichel K, Price AJ, Schaller T, Towers GJ, Freund SM, James LC.

Retrovirology. 2013 Jul 31;10:81. doi: 10.1186/1742-4690-10-81.


Intracellular antibody receptor TRIM21 prevents fatal viral infection.

Vaysburd M, Watkinson RE, Cooper H, Reed M, O'Connell K, Smith J, Cruickshanks J, James LC.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12397-401. doi: 10.1073/pnas.1301918110. Epub 2013 Jul 9.


Cellular self-defense: how cell-autonomous immunity protects against pathogens.

Randow F, MacMicking JD, James LC.

Science. 2013 May 10;340(6133):701-6. doi: 10.1126/science.1233028. Review.


Simultaneous neutralization and innate immune detection of a replicating virus by TRIM21.

Watkinson RE, Tam JC, Vaysburd MJ, James LC.

J Virol. 2013 Jul;87(13):7309-13. doi: 10.1128/JVI.00647-13. Epub 2013 Apr 17.


Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21.

McEwan WA, Tam JC, Watkinson RE, Bidgood SR, Mallery DL, James LC.

Nat Immunol. 2013 Apr;14(4):327-36. doi: 10.1038/ni.2548. Epub 2013 Mar 3.


The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import.

Veillette M, Bichel K, Pawlica P, Freund SM, Plourde MB, Pham QT, Reyes-Moreno C, James LC, Berthoux L.

Retrovirology. 2013 Feb 28;10:25. doi: 10.1186/1742-4690-10-25.


Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.

Tuttle JB, Anderson M, Bechle BM, Campbell BM, Chang C, Dounay AB, Evrard E, Fonseca KR, Gan X, Ghosh S, Horner W, James LC, Kim JY, McAllister LA, Pandit J, Parikh VD, Rago BJ, Salafia MA, Strick CA, Zawadzke LE, Verhoest PR.

ACS Med Chem Lett. 2012 Oct 24;4(1):37-40. doi: 10.1021/ml300237v. eCollection 2013 Jan 10.


AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization.

Hauler F, Mallery DL, McEwan WA, Bidgood SR, James LC.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19733-8. doi: 10.1073/pnas.1210659109. Epub 2012 Oct 22.


CPSF6 defines a conserved capsid interface that modulates HIV-1 replication.

Price AJ, Fletcher AJ, Schaller T, Elliott T, Lee K, KewalRamani VN, Chin JW, Towers GJ, James LC.

PLoS Pathog. 2012;8(8):e1002896. doi: 10.1371/journal.ppat.1002896. Epub 2012 Aug 30.


Regulation of virus neutralization and the persistent fraction by TRIM21.

McEwan WA, Hauler F, Williams CR, Bidgood SR, Mallery DL, Crowther RA, James LC.

J Virol. 2012 Aug;86(16):8482-91. doi: 10.1128/JVI.00728-12. Epub 2012 May 30.


Diverse HIV viruses are targeted by a conformationally dynamic antiviral.

Caines ME, Bichel K, Price AJ, McEwan WA, Towers GJ, Willett BJ, Freund SM, James LC.

Nat Struct Mol Biol. 2012 Mar 11;19(4):411-6. doi: 10.1038/nsmb.2253.


HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency.

Schaller T, Ocwieja KE, Rasaiyaah J, Price AJ, Brady TL, Roth SL, Hué S, Fletcher AJ, Lee K, KewalRamani VN, Noursadeghi M, Jenner RG, James LC, Bushman FD, Towers GJ.

PLoS Pathog. 2011 Dec;7(12):e1002439. doi: 10.1371/journal.ppat.1002439. Epub 2011 Dec 8.


Intracellular antibody-mediated immunity and the role of TRIM21.

McEwan WA, Mallery DL, Rhodes DA, Trowsdale J, James LC.

Bioessays. 2011 Nov;33(11):803-9. doi: 10.1002/bies.201100093. Epub 2011 Aug 29.


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