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Items: 25

1.

Poly (ADP) ribose glycohydrolase can be effectively targeted in pancreatic cancer.

Jain A, Agostini LC, McCarthy GA, Chand SN, Ramirez A, Nevler A, Cozzitorto J, Schultz CW, Lowder CY, Smith KM, Waddell ID, Raitses-Gurevich M, Stossel C, Gorman YG, Atias D, Yeo CJ, Winter JM, Olive KP, Golan T, Pishvaian MJ, Ogilvie D, James DI, Jordan AM, Brody JR.

Cancer Res. 2019 Jul 4. pii: canres.3645.2018. doi: 10.1158/0008-5472.CAN-18-3645. [Epub ahead of print]

PMID:
31273064
2.

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

Gogola E, Duarte AA, de Ruiter JR, Wiegant WW, Schmid JA, de Bruijn R, James DI, Llobet SG, Vis DJ, Annunziato S, van den Broek B, Barazas M, Kersbergen A, van de Ven M, Tarsounas M, Ogilvie DJ, van Vugt M, Wessels LFA, Bartkova J, Gromova I, Andújar-Sánchez M, Bartek J, Lopes M, van Attikum H, Borst P, Jonkers J, Rottenberg S.

Cancer Cell. 2019 Jun 10;35(6):950-952. doi: 10.1016/j.ccell.2019.05.012. No abstract available.

3.

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors.

Pillay N, Tighe A, Nelson L, Littler S, Coulson-Gilmer C, Bah N, Golder A, Bakker B, Spierings DCJ, James DI, Smith KM, Jordan AM, Morgan RD, Ogilvie DJ, Foijer F, Jackson DA, Taylor SS.

Cancer Cell. 2019 Mar 18;35(3):519-533.e8. doi: 10.1016/j.ccell.2019.02.004.

4.

Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.

Acton B, Small HF, Smith KM, McGonagle A, Stowell AIJ, James DI, Hamilton NM, Hamilton N, Hitchin JR, Hutton CP, Waddell ID, Ogilvie DJ, Jordan AM.

Bioorg Med Chem Lett. 2019 Feb 15;29(4):560-562. doi: 10.1016/j.bmcl.2018.12.066. Epub 2019 Jan 2.

5.

Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.

Waszkowycz B, Smith KM, McGonagle AE, Jordan AM, Acton B, Fairweather EE, Griffiths LA, Hamilton NM, Hamilton NS, Hitchin JR, Hutton CP, James DI, Jones CD, Jones S, Mould DP, Small HF, Stowell AIJ, Tucker JA, Waddell ID, Ogilvie DJ.

J Med Chem. 2018 Dec 13;61(23):10767-10792. doi: 10.1021/acs.jmedchem.8b01407. Epub 2018 Nov 19.

PMID:
30403352
6.

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

Gogola E, Duarte AA, de Ruiter JR, Wiegant WW, Schmid JA, de Bruijn R, James DI, Guerrero Llobet S, Vis DJ, Annunziato S, van den Broek B, Barazas M, Kersbergen A, van de Ven M, Tarsounas M, Ogilvie DJ, van Vugt M, Wessels LFA, Bartkova J, Gromova I, Andújar-Sánchez M, Bartek J, Lopes M, van Attikum H, Borst P, Jonkers J, Rottenberg S.

Cancer Cell. 2018 Jun 11;33(6):1078-1093.e12. doi: 10.1016/j.ccell.2018.05.008. Erratum in: Cancer Cell. 2019 Jun 10;35(6):950-952.

7.

Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib.

Gravells P, Neale J, Grant E, Nathubhai A, Smith KM, James DI, Bryant HE.

DNA Repair (Amst). 2018 Jan;61:25-36. doi: 10.1016/j.dnarep.2017.11.004. Epub 2017 Nov 22.

8.

Studying Catabolism of Protein ADP-Ribosylation.

Palazzo L, James DI, Waddell ID, Ahel I.

Methods Mol Biol. 2017;1608:415-430. doi: 10.1007/978-1-4939-6993-7_26.

PMID:
28695524
9.

Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase.

Gravells P, Grant E, Smith KM, James DI, Bryant HE.

DNA Repair (Amst). 2017 Apr;52:81-91. doi: 10.1016/j.dnarep.2017.02.010. Epub 2017 Feb 17.

10.

An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells.

James DI, Durant S, Eckersley K, Fairweather E, Griffiths LA, Hamilton N, Kelly P, O'Connor M, Shea K, Waddell ID, Ogilvie DJ.

Version 2. F1000Res. 2016 Apr 25 [revised 2016 Jan 1];5:736. eCollection 2016.

11.

IncucyteDRC: An R package for the dose response analysis of live cell imaging data.

Chapman PJ, James DI, Watson AJ, Hopkins GV, Waddell ID, Ogilvie DJ.

F1000Res. 2016 May 23;5:962. eCollection 2016.

12.

First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.

James DI, Smith KM, Jordan AM, Fairweather EE, Griffiths LA, Hamilton NS, Hitchin JR, Hutton CP, Jones S, Kelly P, McGonagle AE, Small H, Stowell AI, Tucker J, Waddell ID, Waszkowycz B, Ogilvie DJ.

ACS Chem Biol. 2016 Nov 18;11(11):3179-3190. Epub 2016 Oct 12.

PMID:
27689388
13.

A high-throughput screening-compatible homogeneous time-resolved fluorescence assay measuring the glycohydrolase activity of human poly(ADP-ribose) glycohydrolase.

Stowell AI, James DI, Waddell ID, Bennett N, Truman C, Hardern IM, Ogilvie DJ.

Anal Biochem. 2016 Jun 15;503:58-64. doi: 10.1016/j.ab.2016.03.016. Epub 2016 Mar 29.

PMID:
27036617
14.

One-Step Synthesis of Precursor Oligomers for Organic Photovoltaics: A Comparative Study between Polymers and Small Molecules.

Li W, Wang D, Wang S, Ma W, Hedström S, James DI, Xu X, Persson P, Fabiano S, Berggren M, Inganäs O, Huang F, Wang E.

ACS Appl Mater Interfaces. 2015 Dec 16;7(49):27106-14. doi: 10.1021/acsami.5b09460. Epub 2015 Dec 7.

PMID:
26592898
15.

Compartmentalization of electrophoretically separated analytes in a multiphase microfluidic platform.

Draper MC, Niu X, Cho S, James DI, Edel JB.

Anal Chem. 2012 Jul 3;84(13):5801-8. doi: 10.1021/ac301141x. Epub 2012 Jun 13.

PMID:
22656086
16.

Novel steroid inhibitors of glucose 6-phosphate dehydrogenase.

Hamilton NM, Dawson M, Fairweather EE, Hamilton NS, Hitchin JR, James DI, Jones SD, Jordan AM, Lyons AJ, Small HF, Thomson GJ, Waddell ID, Ogilvie DJ.

J Med Chem. 2012 May 10;55(9):4431-45. doi: 10.1021/jm300317k. Epub 2012 Apr 27.

PMID:
22506561
17.

A new thiophene substituted isoindigo based copolymer for high performance ambipolar transistors.

Ashraf RS, Kronemeijer AJ, James DI, Sirringhaus H, McCulloch I.

Chem Commun (Camb). 2012 Apr 25;48(33):3939-41. doi: 10.1039/c2cc30169e. Epub 2012 Mar 16.

PMID:
22422164
18.

Design of semiconducting indacenodithiophene polymers for high performance transistors and solar cells.

McCulloch I, Ashraf RS, Biniek L, Bronstein H, Combe C, Donaghey JE, James DI, Nielsen CB, Schroeder BC, Zhang W.

Acc Chem Res. 2012 May 15;45(5):714-22. doi: 10.1021/ar200208g. Epub 2012 Jan 26.

PMID:
22280366
19.

Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA.

Parone PA, Da Cruz S, Tondera D, Mattenberger Y, James DI, Maechler P, Barja F, Martinou JC.

PLoS One. 2008 Sep 22;3(9):e3257. doi: 10.1371/journal.pone.0003257.

20.

Mitochondrial dynamics and apoptosis: a painful separation.

James DI, Martinou JC.

Dev Cell. 2008 Sep;15(3):341-3. doi: 10.1016/j.devcel.2008.08.011.

21.

Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.

Parone PA, James DI, Da Cruz S, Mattenberger Y, Donzé O, Barja F, Martinou JC.

Mol Cell Biol. 2006 Oct;26(20):7397-408.

22.

BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1.

Carpenter B, Hill KJ, Charalambous M, Wagner KJ, Lahiri D, James DI, Andersen JS, Schumacher V, Royer-Pokora B, Mann M, Ward A, Roberts SG.

Mol Cell Biol. 2004 Jan;24(2):537-49.

23.

hFis1, a novel component of the mammalian mitochondrial fission machinery.

James DI, Parone PA, Mattenberger Y, Martinou JC.

J Biol Chem. 2003 Sep 19;278(38):36373-9. Epub 2003 Jun 3. Erratum in: J Biol Chem. 2004 Aug 20;279(34):36166.

24.
25.

Intrauterine effect of phenothiazines.

O'Connor M, Johnson GH, James DI.

Med J Aust. 1981 Apr 18;1(8):416-7.

PMID:
7254089

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