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Items: 1 to 50 of 337

1.

Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin.

Quek LE, Krycer JR, Ohno S, Yugi K, Fazakerley DJ, Scalzo R, Elkington SD, Dai Z, Hirayama A, Ikeda S, Shoji F, Suzuki K, Locasale JW, Soga T, James DE, Kuroda S.

iScience. 2020 Feb 21;23(2):100855. doi: 10.1016/j.isci.2020.100855. Epub 2020 Jan 21.

2.

Effects of lake water level fluctuation due to drought and extreme winter precipitation on mixing and water quality of an alpine lake, Case Study: Lake Arrowhead, California.

Saber A, James DE, Hannoun IA.

Sci Total Environ. 2020 Jan 18;714:136762. doi: 10.1016/j.scitotenv.2020.136762. [Epub ahead of print]

PMID:
32023782
3.

Clinically Negligible Pharmacokinetic and Pharmacodynamic Interactions Between Lanabecestat and Dabigatran Etexilate, a Prototypical P-gp Substrate.

Monk SA, Kugler AR, Andersen SW, Ayan-Oshodi MA, James DE, Mullen J, Zimmer JA, Willis BA.

J Clin Pharmacol. 2019 Dec 18. doi: 10.1002/jcph.1558. [Epub ahead of print]

PMID:
31853995
4.

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt.

Su Z, Burchfield JG, Yang P, Humphrey SJ, Yang G, Francis D, Yasmin S, Shin SY, Norris DM, Kearney AL, Astore MA, Scavuzzo J, Fisher-Wellman KH, Wang QP, Parker BL, Neely GG, Vafaee F, Chiu J, Yeo R, Hogg PJ, Fazakerley DJ, Nguyen LK, Kuyucak S, James DE.

Nat Commun. 2019 Dec 2;10(1):5486. doi: 10.1038/s41467-019-13114-4.

5.

Estimation of water quality profiles in deep lakes based on easily measurable constituents at the water surface using artificial neural networks coupled with stationary wavelet transform.

Saber A, James DE, Hayes DF.

Sci Total Environ. 2019 Dec 1;694:133690. doi: 10.1016/j.scitotenv.2019.133690. Epub 2019 Aug 1.

PMID:
31756801
6.

Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes.

Krycer JR, Elkington SD, Diaz-Vegas A, Cooke KC, Burchfield JG, Fisher-Wellman KH, Cooney GJ, Fazakerley DJ, James DE.

J Biol Chem. 2020 Jan 3;295(1):99-110. doi: 10.1074/jbc.RA119.011695. Epub 2019 Nov 19.

PMID:
31744882
7.

Growth Factor-Dependent and -Independent Activation of mTORC2.

Knudsen JR, Fritzen AM, James DE, Jensen TE, Kleinert M, Richter EA.

Trends Endocrinol Metab. 2020 Jan;31(1):13-24. doi: 10.1016/j.tem.2019.09.005. Epub 2019 Nov 4. Review.

PMID:
31699566
8.

Phosphoproteomics of Acute Cell Stressors Targeting Exercise Signaling Networks Reveal Drug Interactions Regulating Protein Secretion.

Needham EJ, Humphrey SJ, Cooke KC, Fazakerley DJ, Duan X, Parker BL, James DE.

Cell Rep. 2019 Nov 5;29(6):1524-1538.e6. doi: 10.1016/j.celrep.2019.10.001.

9.

Lactate production is a prioritized feature of adipocyte metabolism.

Krycer JR, Quek LE, Francis D, Fazakerley DJ, Elkington SD, Diaz-Vegas A, Cooke KC, Weiss FC, Duan X, Kurdyukov S, Zhou PX, Tambar UK, Hirayama A, Ikeda S, Kamei Y, Soga T, Cooney GJ, James DE.

J Biol Chem. 2020 Jan 3;295(1):83-98. doi: 10.1074/jbc.RA119.011178. Epub 2019 Nov 5.

PMID:
31690627
10.

Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes.

Kearney AL, Cooke KC, Norris DM, Zadoorian A, Krycer JR, Fazakerley DJ, Burchfield JG, James DE.

J Biol Chem. 2019 Nov 8;294(45):16729-16739. doi: 10.1074/jbc.RA119.010036. Epub 2019 Sep 22.

PMID:
31548312
11.

A modified gas-trapping method for high-throughput metabolic experiments in Drosophila melanogaster.

Francis D, Krycer JR, Cooney GJ, James DE.

Biotechniques. 2019 Sep;67(3):123-125. doi: 10.2144/btn-2019-0062. Epub 2019 Aug 6.

12.

Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry.

Nelson ME, Parker BL, Burchfield JG, Hoffman NJ, Needham EJ, Cooke KC, Naim T, Sylow L, Ling NX, Francis D, Norris DM, Chaudhuri R, Oakhill JS, Richter EA, Lynch GS, Stöckli J, James DE.

EMBO J. 2019 Dec 16;38(24):e102578. doi: 10.15252/embj.2019102578. Epub 2019 Aug 5.

PMID:
31381180
13.

Assessment of Transporter Polymorphisms as a Factor in a BCRP Drug Interaction Study With Lanabecestat.

Willis BA, Andersen SW, Ayan-Oshodi M, James DE, Liffick E, Hillgren K, Guo Y, Monk SA.

J Clin Pharmacol. 2020 Jan;60(1):107-116. doi: 10.1002/jcph.1500. Epub 2019 Aug 5.

PMID:
31378968
14.

Small-protein Enrichment Assay Enables the Rapid, Unbiased Analysis of Over 100 Low Abundance Factors from Human Plasma.

Harney DJ, Hutchison AT, Su Z, Hatchwell L, Heilbronn LK, Hocking S, James DE, Larance M.

Mol Cell Proteomics. 2019 Sep;18(9):1899-1915. doi: 10.1074/mcp.TIR119.001562. Epub 2019 Jul 15.

PMID:
31308252
15.

Thirty sweet years of GLUT4.

Klip A, McGraw TE, James DE.

J Biol Chem. 2019 Jul 26;294(30):11369-11381. doi: 10.1074/jbc.REV119.008351. Epub 2019 Jun 7. Review.

16.

ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation.

Stöckli J, Zadoorian A, Cooke KC, Deshpande V, Yau B, Herrmann G, Kebede MA, Humphrey SJ, James DE.

Mol Metab. 2019 Jul;25:83-94. doi: 10.1016/j.molmet.2019.05.002. Epub 2019 May 6.

17.

Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency.

Yang P, Humphrey SJ, Cinghu S, Pathania R, Oldfield AJ, Kumar D, Perera D, Yang JYH, James DE, Mann M, Jothi R.

Cell Syst. 2019 May 22;8(5):427-445.e10. doi: 10.1016/j.cels.2019.03.012. Epub 2019 May 8.

18.

Reduced insulin action in muscle of high fat diet rats over the diurnal cycle is not associated with defective insulin signaling.

Small L, Brandon AE, Parker BL, Deshpande V, Samsudeen AF, Kowalski GM, Reznick J, Wilks DL, Preston E, Bruce CR, James DE, Turner N, Cooney GJ.

Mol Metab. 2019 Jul;25:107-118. doi: 10.1016/j.molmet.2019.04.006. Epub 2019 Apr 12.

19.

Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models.

Jiménez de Oya N, Esler WP, Huard K, El-Kattan AF, Karamanlidis G, Blázquez AB, Ramos-Ibeas P, Escribano-Romero E, Louloudes-Lázaro A, Casas J, Sobrino F, Hoehn K, James DE, Gutiérrez-Adán A, Saiz JC, Martín-Acebes MA.

Emerg Microbes Infect. 2019;8(1):624-636. doi: 10.1080/22221751.2019.1604084.

20.

Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway.

Mills RJ, Parker BL, Quaife-Ryan GA, Voges HK, Needham EJ, Bornot A, Ding M, Andersson H, Polla M, Elliott DA, Drowley L, Clausen M, Plowright AT, Barrett IP, Wang QD, James DE, Porrello ER, Hudson JE.

Cell Stem Cell. 2019 Jun 6;24(6):895-907.e6. doi: 10.1016/j.stem.2019.03.009. Epub 2019 Mar 28.

PMID:
30930147
21.

Proteomic Analysis of Human Plasma during Intermittent Fasting.

Harney DJ, Hutchison AT, Hatchwell L, Humphrey SJ, James DE, Hocking S, Heilbronn LK, Larance M.

J Proteome Res. 2019 May 3;18(5):2228-2240. doi: 10.1021/acs.jproteome.9b00090. Epub 2019 Apr 1.

22.

An integrative systems genetic analysis of mammalian lipid metabolism.

Parker BL, Calkin AC, Seldin MM, Keating MF, Tarling EJ, Yang P, Moody SC, Liu Y, Zerenturk EJ, Needham EJ, Miller ML, Clifford BL, Morand P, Watt MJ, Meex RCR, Peng KY, Lee R, Jayawardana K, Pan C, Mellett NA, Weir JM, Lazarus R, Lusis AJ, Meikle PJ, James DE, de Aguiar Vallim TQ, Drew BG.

Nature. 2019 Mar;567(7747):187-193. doi: 10.1038/s41586-019-0984-y. Epub 2019 Feb 27.

23.

Illuminating the dark phosphoproteome.

Needham EJ, Parker BL, Burykin T, James DE, Humphrey SJ.

Sci Signal. 2019 Jan 22;12(565). pii: eaau8645. doi: 10.1126/scisignal.aau8645. Review.

PMID:
30670635
24.

RagC phosphorylation autoregulates mTOR complex 1.

Yang G, Humphrey SJ, Murashige DS, Francis D, Wang QP, Cooke KC, Neely GG, James DE.

EMBO J. 2019 Feb 1;38(3). pii: e99548. doi: 10.15252/embj.201899548. Epub 2018 Dec 14.

25.

Development of a human skeletal micro muscle platform with pacing capabilities.

Mills RJ, Parker BL, Monnot P, Needham EJ, Vivien CJ, Ferguson C, Parton RG, James DE, Porrello ER, Hudson JE.

Biomaterials. 2019 Apr;198:217-227. doi: 10.1016/j.biomaterials.2018.11.030. Epub 2018 Nov 28.

PMID:
30527761
26.

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass.

Cantley J, Davenport A, Vetterli L, Nemes NJ, Whitworth PT, Boslem E, Thai LM, Mellett N, Meikle PJ, Hoehn KL, James DE, Biden TJ.

Diabetologia. 2019 Jan;62(1):99-111. doi: 10.1007/s00125-018-4743-7. Epub 2018 Oct 17.

27.

Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance.

Brandon AE, Liao BM, Diakanastasis B, Parker BL, Raddatz K, McManus SA, O'Reilly L, Kimber E, van der Kraan AG, Hancock D, Henstridge DC, Meikle PJ, Cooney GJ, James DE, Reibe S, Febbraio MA, Biden TJ, Schmitz-Peiffer C.

Cell Metab. 2019 Jan 8;29(1):183-191.e7. doi: 10.1016/j.cmet.2018.09.013. Epub 2018 Oct 11.

28.

High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform.

Humphrey SJ, Karayel O, James DE, Mann M.

Nat Protoc. 2018 Sep;13(9):1897-1916. doi: 10.1038/s41596-018-0014-9.

PMID:
30190555
29.

Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle.

Hingst JR, Bruhn L, Hansen MB, Rosschou MF, Birk JB, Fentz J, Foretz M, Viollet B, Sakamoto K, Færgeman NJ, Havelund JF, Parker BL, James DE, Kiens B, Richter EA, Jensen J, Wojtaszewski JFP.

Mol Metab. 2018 Oct;16:24-34. doi: 10.1016/j.molmet.2018.07.001. Epub 2018 Jul 25.

30.

Muscle and adipose tissue insulin resistance: malady without mechanism?

Fazakerley DJ, Krycer JR, Kearney AL, Hocking SL, James DE.

J Lipid Res. 2019 Oct;60(10):1720-1732. doi: 10.1194/jlr.R087510. Epub 2018 Jul 27. Review.

PMID:
30054342
31.

Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training.

Kleinert M, Parker BL, Jensen TE, Raun SH, Pham P, Han X, James DE, Richter EA, Sylow L.

Sci Rep. 2018 Jul 16;8(1):10723. doi: 10.1038/s41598-018-28540-5.

32.

Membrane Topology of Trafficking Regulator of GLUT4 1 (TRARG1).

Duan X, Krycer JR, Cooke KC, Yang G, James DE, Fazakerley DJ.

Biochemistry. 2018 Jul 3;57(26):3606-3615. doi: 10.1021/acs.biochem.8b00361. Epub 2018 Jun 7.

PMID:
29787242
33.

MASTL overexpression promotes chromosome instability and metastasis in breast cancer.

Rogers S, McCloy RA, Parker BL, Gallego-Ortega D, Law AMK, Chin VT, Conway JRW, Fey D, Millar EKA, O'Toole S, Deng N, Swarbrick A, Chastain PD, Cesare AJ, Timpson P, Caldon CE, Croucher DR, James DE, Watkins DN, Burgess A.

Oncogene. 2018 Aug;37(33):4518-4533. doi: 10.1038/s41388-018-0295-z. Epub 2018 May 10.

34.

Tankyrase modulates insulin sensitivity in skeletal muscle cells by regulating the stability of GLUT4 vesicle proteins.

Su Z, Deshpande V, James DE, Stöckli J.

J Biol Chem. 2018 Jun 1;293(22):8578-8587. doi: 10.1074/jbc.RA117.001058. Epub 2018 Apr 18.

35.

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation.

Fazakerley DJ, Minard AY, Krycer JR, Thomas KC, Stöckli J, Harney DJ, Burchfield JG, Maghzal GJ, Caldwell ST, Hartley RC, Stocker R, Murphy MP, James DE.

J Biol Chem. 2018 May 11;293(19):7315-7328. doi: 10.1074/jbc.RA117.001254. Epub 2018 Mar 29.

36.

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice.

Burchfield JG, Kebede MA, Meoli CC, Stöckli J, Whitworth PT, Wright AL, Hoffman NJ, Minard AY, Ma X, Krycer JR, Nelson ME, Tan SX, Yau B, Thomas KC, Wee NKY, Khor EC, Enriquez RF, Vissel B, Biden TJ, Baldock PA, Hoehn KL, Cantley J, Cooney GJ, James DE, Fazakerley DJ.

J Biol Chem. 2018 Apr 13;293(15):5731-5745. doi: 10.1074/jbc.RA117.000808. Epub 2018 Feb 13.

37.

Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake.

Small L, Brandon AE, Quek LE, Krycer JR, James DE, Turner N, Cooney GJ.

Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E258-E266. doi: 10.1152/ajpendo.00386.2017. Epub 2018 Feb 6.

38.

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.

Fazakerley DJ, Chaudhuri R, Yang P, Maghzal GJ, Thomas KC, Krycer JR, Humphrey SJ, Parker BL, Fisher-Wellman KH, Meoli CC, Hoffman NJ, Diskin C, Burchfield JG, Cowley MJ, Kaplan W, Modrusan Z, Kolumam G, Yang JY, Chen DL, Samocha-Bonet D, Greenfield JR, Hoehn KL, Stocker R, James DE.

Elife. 2018 Feb 6;7. pii: e32111. doi: 10.7554/eLife.32111.

39.

A gas trapping method for high-throughput metabolic experiments.

Krycer JR, Diskin C, Nelson ME, Zeng XY, Fazakerley DJ, James DE.

Biotechniques. 2018 Jan 1;64(1):27-29. doi: 10.2144/000114629.

40.

The transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes.

Chaudhuri R, Krycer JR, Fazakerley DJ, Fisher-Wellman KH, Su Z, Hoehn KL, Yang JYH, Kuncic Z, Vafaee F, James DE.

Sci Rep. 2018 Jan 29;8(1):1774. doi: 10.1038/s41598-018-20104-x.

41.

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise.

Whitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M, Hughes WE, Egan CL, Cron L, Watt KI, Kuchel RP, Jayasooriah N, Estevez E, Petzold T, Suter CM, Gregorevic P, Kiens B, Richter EA, James DE, Wojtaszewski JFP, Febbraio MA.

Cell Metab. 2018 Jan 9;27(1):237-251.e4. doi: 10.1016/j.cmet.2017.12.001.

42.

The Geometric Framework for Nutrition as a tool in precision medicine.

Simpson SJ, Le Couteur DG, James DE, George J, Gunton JE, Solon-Biet SM, Raubenheimer D.

Nutr Healthy Aging. 2017 Dec 7;4(3):217-226. doi: 10.3233/NHA-170027. Review.

43.

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism.

Krycer JR, Yugi K, Hirayama A, Fazakerley DJ, Quek LE, Scalzo R, Ohno S, Hodson MP, Ikeda S, Shoji F, Suzuki K, Domanova W, Parker BL, Nelson ME, Humphrey SJ, Turner N, Hoehn KL, Cooney GJ, Soga T, Kuroda S, James DE.

Cell Rep. 2017 Dec 19;21(12):3536-3547. doi: 10.1016/j.celrep.2017.11.085.

44.

Glucose Transport: Methods for Interrogating GLUT4 Trafficking in Adipocytes.

Norris DM, Geddes TA, James DE, Fazakerley DJ, Burchfield JG.

Methods Mol Biol. 2018;1713:193-215. doi: 10.1007/978-1-4939-7507-5_15.

PMID:
29218527
45.

Investigation of kinetics and absorption isotherm models for hydroponic phytoremediation of waters contaminated with sulfate.

Saber A, Tafazzoli M, Mortazavian S, James DE.

J Environ Manage. 2018 Feb 1;207:276-291. doi: 10.1016/j.jenvman.2017.11.039. Epub 2017 Dec 12.

PMID:
29179117
46.

Metabolomic analysis of insulin resistance across different mouse strains and diets.

Stöckli J, Fisher-Wellman KH, Chaudhuri R, Zeng XY, Fazakerley DJ, Meoli CC, Thomas KC, Hoffman NJ, Mangiafico SP, Xirouchaki CE, Yang CH, Ilkayeva O, Wong K, Cooney GJ, Andrikopoulos S, Muoio DM, James DE.

J Biol Chem. 2017 Nov 24;292(47):19135-19145. doi: 10.1074/jbc.M117.818351. Epub 2017 Oct 5.

47.

Multiplexed Temporal Quantification of the Exercise-regulated Plasma Peptidome.

Parker BL, Burchfield JG, Clayton D, Geddes TA, Payne RJ, Kiens B, Wojtaszewski JFP, Richter EA, James DE.

Mol Cell Proteomics. 2017 Dec;16(12):2055-2068. doi: 10.1074/mcp.RA117.000020. Epub 2017 Oct 5.

48.

Prairie strips improve biodiversity and the delivery of multiple ecosystem services from corn-soybean croplands.

Schulte LA, Niemi J, Helmers MJ, Liebman M, Arbuckle JG, James DE, Kolka RK, O'Neal ME, Tomer MD, Tyndall JC, Asbjornsen H, Drobney P, Neal J, Van Ryswyk G, Witte C.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11247-11252. doi: 10.1073/pnas.1620229114. Epub 2017 Oct 2. Erratum in: Proc Natl Acad Sci U S A. 2017 Nov 27;:.

49.

Correction: Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies.

Domanova W, Krycer JR, Chaudhuri R, Yang P, Vafaee F, Fazakerley DJ, Humphrey SJ, James DE, Kuncic Z.

PLoS One. 2017 Sep 28;12(9):e0185871. doi: 10.1371/journal.pone.0185871. eCollection 2017.

50.

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest.

Mills RJ, Titmarsh DM, Koenig X, Parker BL, Ryall JG, Quaife-Ryan GA, Voges HK, Hodson MP, Ferguson C, Drowley L, Plowright AT, Needham EJ, Wang QD, Gregorevic P, Xin M, Thomas WG, Parton RG, Nielsen LK, Launikonis BS, James DE, Elliott DA, Porrello ER, Hudson JE.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8372-E8381. doi: 10.1073/pnas.1707316114. Epub 2017 Sep 15.

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