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Items: 1 to 50 of 332

1.

68Ga-DOTA-E[c(RGDfK)]2 Positron Emission Tomography Imaging of SHARPIN-Regulated Integrin Activity in Mice.

Siitonen R, Peuhu E, Autio AK, Liljenbäck H, Mattila E, Metsälä O, Käkelä M, Saanijoki T, Dijkgraaf I, Jalkanen S, Ivaska J, Roivainen A.

J Nucl Med. 2019 Mar 8. pii: jnumed.118.222026. doi: 10.2967/jnumed.118.222026. [Epub ahead of print]

PMID:
30850498
2.

Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8+ T Cell Response Against Immunosuppressive Tumors.

Viitala MK, Virtakoivu R, Tadayon S, Rannikko J, Jalkanen S, Hollmén M.

Clin Cancer Res. 2019 Feb 12. pii: clincanres.3016.2018. doi: 10.1158/1078-0432.CCR-18-3016. [Epub ahead of print]

PMID:
30755440
3.

Safety Study of Single-Dose Intravenously Administered DOTA-Siglec-9 Peptide in Sprague Dawley Rats.

Chrusciel P, Yatkin E, Li XG, Jaakkola UM, Knuuti J, Jalkanen S, Roivainen A.

Int J Toxicol. 2019 Jan/Feb;38(1):4-11. doi: 10.1177/1091581818821606. Epub 2019 Jan 20.

4.

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage.

Zeiner J, Loukovaara S, Losenkova K, Zuccarini M, Korhonen AM, Lehti K, Kauppinen A, Kaarniranta K, Müller CE, Jalkanen S, Yegutkin GG.

J Mol Med (Berl). 2019 Mar;97(3):341-354. doi: 10.1007/s00109-018-01734-0. Epub 2019 Jan 7.

5.

Serum cytokine levels differ according to major cardiovascular risk factors in patients with lower limb atherosclerosis.

Jalkanen J, Hollmén M, Maksimow M, Jalkanen S, Hakovirta H.

Cytokine. 2019 Feb;114:74-80. doi: 10.1016/j.cyto.2018.11.001. Epub 2018 Nov 13.

PMID:
30442459
6.

Cell-type-specific CD73 expression is an independent prognostic factor in bladder cancer.

Koivisto MK, Tervahartiala M, Kenessey I, Jalkanen S, Boström PJ, Salmi M.

Carcinogenesis. 2019 Mar 12;40(1):84-92. doi: 10.1093/carcin/bgy154.

PMID:
30395172
7.

Enhanced Antibody Production in Clever-1/Stabilin-1-Deficient Mice.

Dunkel J, Viitala M, Karikoski M, Rantakari P, Virtakoivu R, Elima K, Hollmén M, Jalkanen S, Salmi M.

Front Immunol. 2018 Oct 8;9:2257. doi: 10.3389/fimmu.2018.02257. eCollection 2018.

8.

Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women.

Munukka E, Ahtiainen JP, Puigbó P, Jalkanen S, Pahkala K, Keskitalo A, Kujala UM, Pietilä S, Hollmén M, Elo L, Huovinen P, D'Auria G, Pekkala S.

Front Microbiol. 2018 Oct 3;9:2323. doi: 10.3389/fmicb.2018.02323. eCollection 2018.

9.

Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.

Keskitalo A, Munukka E, Toivonen R, Hollmén M, Kainulainen H, Huovinen P, Jalkanen S, Pekkala S.

PLoS One. 2018 May 30;13(5):e0198262. doi: 10.1371/journal.pone.0198262. eCollection 2018.

10.

Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosis.

Elo P, Tadayon S, Liljenbäck H, Teuho J, Käkelä M, Koskensalo K, Saunavaara V, Virta J, Veres TZ, Kiviniemi A, Saraste A, Marjamäki P, Airas L, Jalkanen S, Roivainen A.

J Neuroinflammation. 2018 May 1;15(1):128. doi: 10.1186/s12974-018-1152-2.

11.

Correlation between increasing tissue ischemia and circulating levels of angiogenic growth factors in peripheral artery disease.

Jalkanen J, Hautero O, Maksimow M, Jalkanen S, Hakovirta H.

Cytokine. 2018 Oct;110:24-28. doi: 10.1016/j.cyto.2018.04.012. Epub 2018 Apr 23.

PMID:
29689451
12.

Endothelial cells cope with hypoxia-induced depletion of ATP via activation of cellular purine turnover and phosphotransfer networks.

Losenkova K, Zuccarini M, Helenius M, Jacquemet G, Gerasimovskaya E, Tallgren C, Jalkanen S, Yegutkin GG.

Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1804-1815. doi: 10.1016/j.bbadis.2018.03.001. Epub 2018 Mar 4.

PMID:
29514048
13.

Chronic Active Arthritis Driven by Macrophages Without Involvement of T Cells: A Novel Experimental Model of Rheumatoid Arthritis.

Hagert C, Sareila O, Kelkka T, Nandakumar KS, Collin M, Xu B, Guérard S, Bäcklund J, Jalkanen S, Holmdahl R.

Arthritis Rheumatol. 2018 Aug;70(8):1343-1353. doi: 10.1002/art.40482. Epub 2018 Jun 20.

PMID:
29513929
14.

The Macrophage Mannose Receptor Regulate Mannan-Induced Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis-Like Disease Models.

Hagert C, Sareila O, Kelkka T, Jalkanen S, Holmdahl R.

Front Immunol. 2018 Feb 6;9:114. doi: 10.3389/fimmu.2018.00114. eCollection 2018.

15.

Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry.

Virtanen H, Silvola JMU, Autio A, Li XG, Liljenbäck H, Hellberg S, Siitonen R, Ståhle M, Käkelä M, Airaksinen AJ, Helariutta K, Tolvanen T, Veres TZ, Saraste A, Knuuti J, Jalkanen S, Roivainen A.

Contrast Media Mol Imaging. 2017 Dec 31;2017:7645070. doi: 10.1155/2017/7645070. eCollection 2017.

16.

Mapping the interaction site and effect of the Siglec-9 inflammatory biomarker on human primary amine oxidase.

Lopes de Carvalho L, Elovaara H, de Ruyck J, Vergoten G, Jalkanen S, Guédez G, Salminen TA.

Sci Rep. 2018 Feb 1;8(1):2086. doi: 10.1038/s41598-018-20618-4.

17.

Exploring Alternative Radiolabeling Strategies for Sialic Acid-Binding Immunoglobulin-Like Lectin 9 Peptide: [68Ga]Ga- and [18F]AlF-NOTA-Siglec-9.

Moisio O, Siitonen R, Liljenbäck H, Suomela E, Jalkanen S, Li XG, Roivainen A.

Molecules. 2018 Jan 31;23(2). pii: E305. doi: 10.3390/molecules23020305.

18.

Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice.

Siitonen R, Pietikäinen A, Liljenbäck H, Käkelä M, Söderström M, Jalkanen S, Hytönen J, Roivainen A.

Arthritis Res Ther. 2017 Nov 22;19(1):254. doi: 10.1186/s13075-017-1460-4.

19.

Vascular Adhesion Protein-1: A Cell Surface Amine Oxidase in Translation.

Salmi M, Jalkanen S.

Antioxid Redox Signal. 2017 Dec 7. doi: 10.1089/ars.2017.7418. [Epub ahead of print]

20.

Immunological tumor status may predict response to neoadjuvant chemotherapy and outcome after radical cystectomy in bladder cancer.

Tervahartiala M, Taimen P, Mirtti T, Koskinen I, Ecke T, Jalkanen S, Boström PJ.

Sci Rep. 2017 Oct 4;7(1):12682. doi: 10.1038/s41598-017-12892-5.

21.

Plasma levels of hepatocyte growth factor and placental growth factor predict mortality in a general population: a prospective cohort study.

Santalahti K, Havulinna A, Maksimow M, Zeller T, Blankenberg S, Vehtari A, Joensuu H, Jalkanen S, Salomaa V, Salmi M.

J Intern Med. 2017 Oct;282(4):340-352. doi: 10.1111/joim.12648. Epub 2017 Jul 31.

PMID:
28682476
22.

Exploring the radiosynthesis and in vitro characteristics of [68 Ga]Ga-DOTA-Siglec-9.

Jensen SB, Käkelä M, Jødal L, Moisio O, Alstrup AKO, Jalkanen S, Roivainen A.

J Labelled Comp Radiopharm. 2017 Jul;60(9):439-449. doi: 10.1002/jlcr.3525. Epub 2017 Jun 21.

PMID:
28556976
23.

Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy.

Veres TZ, Kopcsányi T, Tirri M, Braun A, Miyasaka M, Germain RN, Jalkanen S, Salmi M.

Sci Rep. 2017 Apr 6;7(1):694. doi: 10.1038/s41598-017-00769-6.

24.

Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice.

Munukka E, Rintala A, Toivonen R, Nylund M, Yang B, Takanen A, Hänninen A, Vuopio J, Huovinen P, Jalkanen S, Pekkala S.

ISME J. 2017 Jul;11(7):1667-1679. doi: 10.1038/ismej.2017.24. Epub 2017 Apr 4.

25.

Amine oxidase activity regulates the development of pulmonary fibrosis.

Marttila-Ichihara F, Elima K, Auvinen K, Veres TZ, Rantakari P, Weston C, Miyasaka M, Adams D, Jalkanen S, Salmi M.

FASEB J. 2017 Jun;31(6):2477-2491. doi: 10.1096/fj.201600935R. Epub 2017 Mar 1.

PMID:
28251930
26.

Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.

Ahola-Olli AV, Würtz P, Havulinna AS, Aalto K, Pitkänen N, Lehtimäki T, Kähönen M, Lyytikäinen LP, Raitoharju E, Seppälä I, Sarin AP, Ripatti S, Palotie A, Perola M, Viikari JS, Jalkanen S, Maksimow M, Salomaa V, Salmi M, Kettunen J, Raitakari OT.

Am J Hum Genet. 2017 Jan 5;100(1):40-50. doi: 10.1016/j.ajhg.2016.11.007. Epub 2016 Dec 15.

27.

Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence.

Wang Q, Würtz P, Auro K, Mäkinen VP, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Jokelainen J, Santalahti K, Salmi M, Blankenberg S, Zeller T, Viikari J, Kähönen M, Lehtimäki T, Salomaa V, Perola M, Jalkanen S, Järvelin MR, Raitakari OT, Kettunen J, Lawlor DA, Ala-Korpela M.

BMC Med. 2016 Dec 13;14(1):205.

28.

Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells.

Veres TZ, Kopcsányi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN.

J Immunol. 2017 Jan 15;198(2):895-907. doi: 10.4049/jimmunol.1601448. Epub 2016 Nov 30.

29.

Multivalent Interactions of Human Primary Amine Oxidase with the V and C22 Domains of Sialic Acid-Binding Immunoglobulin-Like Lectin-9 Regulate Its Binding and Amine Oxidase Activity.

Elovaara H, Parkash V, Fair-Mäkelä R, Salo-Ahen OM, Guédez G, Bligt-Lindén E, Grönholm J, Jalkanen S, Salminen TA.

PLoS One. 2016 Nov 28;11(11):e0166935. doi: 10.1371/journal.pone.0166935. eCollection 2016.

30.

Thymocytes in Lyve1-CRE/S1pr1f/f Mice Accumulate in the Thymus due to Cell-Intrinsic Loss of Sphingosine-1-Phosphate Receptor Expression.

Takeda A, Hossain MS, Rantakari P, Simmons S, Sasaki N, Salmi M, Jalkanen S, Miyasaka M.

Front Immunol. 2016 Nov 8;7:489. eCollection 2016.

31.

Regulation of CD73 in the development of lower limb atherosclerosis.

Jalkanen J, Hollmén M, Jalkanen S, Hakovirta H.

Purinergic Signal. 2017 Mar;13(1):127-134. doi: 10.1007/s11302-016-9545-0. Epub 2016 Nov 10.

32.

Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment: A new step in migration.

Patten DA, Wilson GK, Bailey D, Shaw RK, Jalkanen S, Salmi M, Rot A, Weston CJ, Adams DH, Shetty S.

Hepatology. 2017 Jan;65(1):294-309. doi: 10.1002/hep.28879. Epub 2016 Nov 25.

33.

Soluble CD73 in Critically Ill Septic Patients - Data from the Prospective FINNAKI Study.

Vaara ST, Hollmén M, Korhonen AM, Maksimow M, Ala-Kokko T, Salmi M, Jalkanen S, Pettilä V; FINNAKI Study Group.

PLoS One. 2016 Oct 12;11(10):e0164420. doi: 10.1371/journal.pone.0164420. eCollection 2016.

34.

Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques.

Silvola JM, Virtanen H, Siitonen R, Hellberg S, Liljenbäck H, Metsälä O, Ståhle M, Saanijoki T, Käkelä M, Hakovirta H, Ylä-Herttuala S, Saukko P, Jauhiainen M, Veres TZ, Jalkanen S, Knuuti J, Saraste A, Roivainen A.

Sci Rep. 2016 Oct 12;6:35089. doi: 10.1038/srep35089.

35.

Deregulation of ocular nucleotide homeostasis in patients with diabetic retinopathy.

Loukovaara S, Sandholm J, Aalto K, Liukkonen J, Jalkanen S, Yegutkin GG.

J Mol Med (Berl). 2017 Feb;95(2):193-204. doi: 10.1007/s00109-016-1472-6. Epub 2016 Sep 16.

PMID:
27638339
36.

Compared to Intermittant Claudication Critical Limb Ischemia Is Associated with Elevated Levels of Cytokines.

Jalkanen J, Maksimow M, Hollmén M, Jalkanen S, Hakovirta H.

PLoS One. 2016 Sep 9;11(9):e0162353. doi: 10.1371/journal.pone.0162353. eCollection 2016.

37.

Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic.

Iftakhar-E-Khuda I, Fair-Mäkelä R, Kukkonen-Macchi A, Elima K, Karikoski M, Rantakari P, Miyasaka M, Salmi M, Jalkanen S.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10643-8. doi: 10.1073/pnas.1602357113. Epub 2016 Sep 6.

38.

Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence.

Wang Q, Würtz P, Auro K, Morin-Papunen L, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Joensuu A, Havulinna AS, Aalto K, Salmi M, Blankenberg S, Zeller T, Viikari J, Kähönen M, Lehtimäki T, Salomaa V, Jalkanen S, Järvelin MR, Perola M, Raitakari OT, Lawlor DA, Kettunen J, Ala-Korpela M.

Int J Epidemiol. 2016 Oct;45(5):1445-1457. Epub 2016 Aug 18.

39.

Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury.

Rantakari P, Patten DA, Valtonen J, Karikoski M, Gerke H, Dawes H, Laurila J, Ohlmeier S, Elima K, Hübscher SG, Weston CJ, Jalkanen S, Adams DH, Salmi M, Shetty S.

Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9298-303. doi: 10.1073/pnas.1604780113. Epub 2016 Jul 29.

40.

Leukocyte trafficking is not affected by multikinase inhibitors sunitinib or sorafenib in mice.

Laurila JP, Laukkanen MO, Joensuu H, Salmi M, Jalkanen S.

Int J Cancer. 2016 Nov 15;139(10):2270-6. doi: 10.1002/ijc.30285. Epub 2016 Aug 11.

41.

Circulating Cytokines Predict the Development of Insulin Resistance in a Prospective Finnish Population Cohort.

Santalahti K, Maksimow M, Airola A, Pahikkala T, Hutri-Kähönen N, Jalkanen S, Raitakari OT, Salmi M.

J Clin Endocrinol Metab. 2016 Sep;101(9):3361-9. doi: 10.1210/jc.2016-2081. Epub 2016 Jun 30.

PMID:
27362289
42.

Age-, sex- and glucose-dependent correlation of plasma soluble vascular adhesion protein-1 concentration with cardiovascular risk factors and subclinical atherosclerosis.

Chen DW, Jin Y, Zhao RM, Long LJ, Zhang J, Han CL, Roivainen A, Knuuti J, Jalkanen S, Wang JC.

Eur Rev Med Pharmacol Sci. 2016 Apr;20(8):1544-58.

43.

G-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer.

Hollmén M, Karaman S, Schwager S, Lisibach A, Christiansen AJ, Maksimow M, Varga Z, Jalkanen S, Detmar M.

Oncoimmunology. 2015 Nov 24;5(3):e1115177. eCollection 2016 Mar.

44.

The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection.

Ritchie SC, Würtz P, Nath AP, Abraham G, Havulinna AS, Fearnley LG, Sarin AP, Kangas AJ, Soininen P, Aalto K, Seppälä I, Raitoharju E, Salmi M, Maksimow M, Männistö S, Kähönen M, Juonala M, Ripatti S, Lehtimäki T, Jalkanen S, Perola M, Raitakari O, Salomaa V, Ala-Korpela M, Kettunen J, Inouye M.

Cell Syst. 2015 Oct 28;1(4):293-301. doi: 10.1016/j.cels.2015.09.007. Epub 2015 Oct 22.

45.

Simvastatin use associated with low intraocular ADP levels in patients with sight-threatening diabetic retinopathy.

Tuuminen R, Yegutkin GG, Jalkanen S, Loukovaara S.

Graefes Arch Clin Exp Ophthalmol. 2016 Aug;254(8):1643-4. doi: 10.1007/s00417-016-3349-3. Epub 2016 Apr 15. No abstract available.

PMID:
27084086
46.

Feasibility of (68)Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in a porcine model of acute respiratory distress syndrome.

Retamal J, Sörensen J, Lubberink M, Suarez-Sipmann F, Borges JB, Feinstein R, Jalkanen S, Antoni G, Hedenstierna G, Roivainen A, Larsson A, Velikyan I.

Am J Nucl Med Mol Imaging. 2016 Jan 28;6(1):18-31. eCollection 2016.

47.

Expression of the semicarbazide-sensitive amine oxidase in articular cartilage: its role in terminal differentiation of chondrocytes in rat and human.

Filip A, Pinzano A, Bianchi A, Fève B, Jalkanen S, Gillet P, Mainard D, Lacolley P, Magdalou J, Mercier N.

Osteoarthritis Cartilage. 2016 Jul;24(7):1223-34. doi: 10.1016/j.joca.2016.01.340. Epub 2016 Feb 4.

48.

Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility.

Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E.

Elife. 2016 Feb 2;5:e10561. doi: 10.7554/eLife.10561.

49.

Hypoxia-induced inflammation and purinergic signaling in cross clamping the human aorta.

Jalkanen J, Maksimow M, Jalkanen S, Hakovirta H.

Springerplus. 2016 Jan 4;5:2. doi: 10.1186/s40064-015-1651-x. eCollection 2016.

50.

Monocyte Stabilin-1 Suppresses the Activation of Th1 Lymphocytes.

Palani S, Elima K, Ekholm E, Jalkanen S, Salmi M.

J Immunol. 2016 Jan 1;196(1):115-23. doi: 10.4049/jimmunol.1500257. Epub 2015 Nov 25.

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