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Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer.

Totiger TM, Srinivasan S, Jala VR, Lamichhane P, Dosch AR, Gaidarski AA, Joshi C, Rangappa S, Castellanos J, Vemula PK, Chen X, Kwon D, Kashikar N, VanSaun M, Merchant NB, Nagathihalli NS.

Mol Cancer Ther. 2018 Nov 7. pii: molcanther.0464.2018. doi: 10.1158/1535-7163.MCT-18-0464. [Epub ahead of print]


Enhanced gut barrier integrity sensitizes colon cancer to immune therapy.

Bhutiani N, Li Q, Anderson CD, Gallagher HC, De Jesus M, Singh R, Jala VR, Fraig M, Gu T, Egilmez NK.

Oncoimmunology. 2018 Aug 23;7(11):e1498438. doi: 10.1080/2162402X.2018.1498438. eCollection 2018.


Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction.

Shao T, Zhao C, Li F, Gu Z, Liu L, Zhang L, Wang Y, He L, Liu Y, Liu Q, Chen Y, Donde H, Wang R, Jala VR, Barve S, Chen SY, Zhang X, Chen Y, McClain CJ, Feng W.

J Hepatol. 2018 Oct;69(4):886-895. doi: 10.1016/j.jhep.2018.05.021. Epub 2018 May 25.


Inflammasome-Independent Leukotriene B4 Production Drives Crystalline Silica-Induced Sterile Inflammation.

Hegde B, Bodduluri SR, Satpathy SR, Alghsham RS, Jala VR, Uriarte SM, Chung DH, Lawrenz MB, Haribabu B.

J Immunol. 2018 May 15;200(10):3556-3567. doi: 10.4049/jimmunol.1701504. Epub 2018 Apr 2.


Mast Cell-Dependent CD8+ T-cell Recruitment Mediates Immune Surveillance of Intestinal Tumors in ApcMin/+ Mice.

Bodduluri SR, Mathis S, Maturu P, Krishnan E, Satpathy SR, Chilton PM, Mitchell TC, Lira S, Locati M, Mantovani A, Jala VR, Haribabu B.

Cancer Immunol Res. 2018 Jan 30. doi: 10.1158/2326-6066.CIR-17-0424. [Epub ahead of print]


Leukotriene B4-receptor-1 mediated host response shapes gut microbiota and controls colon tumor progression.

Jala VR, Maturu P, Bodduluri SR, Krishnan E, Mathis S, Subbarao K, Wang M, Jenson AB, Proctor ML, Rouchka EC, Knight R, Haribabu B.

Oncoimmunology. 2017 Aug 10;6(12):e1361593. doi: 10.1080/2162402X.2017.1361593. eCollection 2017.


The yin and yang of leukotriene B4 mediated inflammation in cancer.

Jala VR, Bodduluri SR, Satpathy SR, Chheda Z, Sharma RK, Haribabu B.

Semin Immunol. 2017 Oct;33:58-64. doi: 10.1016/j.smim.2017.09.005. Epub 2017 Oct 2. Review.


Microbiota-activated CD103+ DCs stemming from microbiota adaptation specifically drive γδT17 proliferation and activation.

Fleming C, Cai Y, Sun X, Jala VR, Xue F, Morrissey S, Wei YL, Chien YH, Zhang HG, Haribabu B, Huang J, Yan J.

Microbiome. 2017 Apr 24;5(1):46. doi: 10.1186/s40168-017-0263-9.


Oral administration of a recombinant cholera toxin B subunit promotes mucosal healing in the colon.

Baldauf KJ, Royal JM, Kouokam JC, Haribabu B, Jala VR, Yaddanapudi K, Hamorsky KT, Dryden GW, Matoba N.

Mucosal Immunol. 2017 Jul;10(4):887-900. doi: 10.1038/mi.2016.95. Epub 2016 Nov 2.


Chemoattractant Receptors BLT1 and CXCR3 Regulate Antitumor Immunity by Facilitating CD8+ T Cell Migration into Tumors.

Chheda ZS, Sharma RK, Jala VR, Luster AD, Haribabu B.

J Immunol. 2016 Sep 1;197(5):2016-26. doi: 10.4049/jimmunol.1502376. Epub 2016 Jul 27.


Erratum to: Impact of Bi-Axial Shear on Atherogenic Gene Expression by Endothelial Cells.

Chakraborty A, Chakraborty S, Jala VR, Thomas JM, Sharp MK, Berson RE, Haribabu B.

Ann Biomed Eng. 2016 Oct;44(10):3046. doi: 10.1007/s10439-016-1665-8. No abstract available.


Gut Microbiota Conversion of Dietary Ellagic Acid into Bioactive Phytoceutical Urolithin A Inhibits Heme Peroxidases.

Saha P, Yeoh BS, Singh R, Chandrasekar B, Vemula PK, Haribabu B, Vijay-Kumar M, Jala VR.

PLoS One. 2016 Jun 2;11(6):e0156811. doi: 10.1371/journal.pone.0156811. eCollection 2016.


Impact of Bi-Axial Shear on Atherogenic Gene Expression by Endothelial Cells.

Chakraborty A, Chakraborty S, Jala VR, Thomas JM, Sharp MK, Berson RE, Haribabu B.

Ann Biomed Eng. 2016 Oct;44(10):3032-3045. doi: 10.1007/s10439-016-1626-2. Epub 2016 May 2. Erratum in: Ann Biomed Eng. 2016 Oct;44(10):3046.


Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice.

Zheng S, Coventry S, Cai L, Powell DW, Jala VR, Haribabu B, Epstein PN.

J Diabetes Res. 2016;2016:5362506. doi: 10.1155/2016/5362506. Epub 2015 Dec 20.


A spontaneous metastasis model reveals the significance of claudin-9 overexpression in lung cancer metastasis.

Sharma RK, Chheda ZS, Das Purkayastha BP, Gomez-Gutierrez JG, Jala VR, Haribabu B.

Clin Exp Metastasis. 2016 Mar;33(3):263-75. doi: 10.1007/s10585-015-9776-4. Epub 2015 Dec 15.


Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth.

Satpathy SR, Jala VR, Bodduluri SR, Krishnan E, Hegde B, Hoyle GW, Fraig M, Luster AD, Haribabu B.

Nat Commun. 2015 Apr 29;6:7064. doi: 10.1038/ncomms8064.


Evidence for a link between gut microbiota and hypertension in the Dahl rat.

Mell B, Jala VR, Mathew AV, Byun J, Waghulde H, Zhang Y, Haribabu B, Vijay-Kumar M, Pennathur S, Joe B.

Physiol Genomics. 2015 Jun;47(6):187-97. doi: 10.1152/physiolgenomics.00136.2014. Epub 2015 Mar 31.


Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups.

Hester CM, Jala VR, Langille MG, Umar S, Greiner KA, Haribabu B.

World J Gastroenterol. 2015 Mar 7;21(9):2759-69. doi: 10.3748/wjg.v21.i9.2759.


Role of bacterial infection in the epigenetic regulation of Wnt antagonist WIF1 by PRC2 protein EZH2.

Roy BC, Subramaniam D, Ahmed I, Jala VR, Hester CM, Greiner KA, Haribabu B, Anant S, Umar S.

Oncogene. 2015 Aug 20;34(34):4519-30. doi: 10.1038/onc.2014.386. Epub 2014 Dec 8.


Regulation of cytotoxic T-Lymphocyte trafficking to tumors by chemoattractants: implications for immunotherapy.

Sharma RK, Chheda ZS, Jala VR, Haribabu B.

Expert Rev Vaccines. 2015 Apr;14(4):537-49. doi: 10.1586/14760584.2015.982101. Epub 2014 Dec 8. Review.


Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis.

Gorla SK, McNair NN, Yang G, Gao S, Hu M, Jala VR, Haribabu B, Striepen B, Cuny GD, Mead JR, Hedstrom L.

Antimicrob Agents Chemother. 2014;58(3):1603-14. doi: 10.1128/AAC.02075-13. Epub 2013 Dec 23.


Expression of leukotriene B₄ receptor-1 on CD8⁺ T cells is required for their migration into tumors to elicit effective antitumor immunity.

Sharma RK, Chheda Z, Jala VR, Haribabu B.

J Immunol. 2013 Sep 15;191(6):3462-70. doi: 10.4049/jimmunol.1300967. Epub 2013 Aug 19.


Enhanced expression of G-protein coupled estrogen receptor (GPER/GPR30) in lung cancer.

Jala VR, Radde BN, Haribabu B, Klinge CM.

BMC Cancer. 2012 Dec 28;12:624. doi: 10.1186/1471-2407-12-624.


Synergistic cytotoxic action of cisplatin and withaferin A on ovarian cancer cell lines.

Kakar SS, Jala VR, Fong MY.

Biochem Biophys Res Commun. 2012 Jul 13;423(4):819-25. doi: 10.1016/j.bbrc.2012.06.047. Epub 2012 Jun 16.


Effects of biaxial oscillatory shear stress on endothelial cell proliferation and morphology.

Chakraborty A, Chakraborty S, Jala VR, Haribabu B, Sharp MK, Berson RE.

Biotechnol Bioeng. 2012 Mar;109(3):695-707. doi: 10.1002/bit.24352. Epub 2011 Nov 10.


Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation.

Cai Y, Shen X, Ding C, Qi C, Li K, Li X, Jala VR, Zhang HG, Wang T, Zheng J, Yan J.

Immunity. 2011 Oct 28;35(4):596-610. doi: 10.1016/j.immuni.2011.08.001. Epub 2011 Oct 6. Erratum in: Immunity. 2011 Oct 28;35(4):649.


Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity.

Spite M, Hellmann J, Tang Y, Mathis SP, Kosuri M, Bhatnagar A, Jala VR, Haribabu B.

J Immunol. 2011 Aug 15;187(4):1942-9. doi: 10.4049/jimmunol.1100196. Epub 2011 Jul 8.


Real-time imaging of leukotriene B₄ mediated cell migration and BLT1 interactions with β-arrestin.

Jala VR, Haribabu B.

J Vis Exp. 2010 Dec 23;(46). pii: 2315. doi: 10.3791/2315.


Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis.

Mathis SP, Jala VR, Lee DM, Haribabu B.

J Immunol. 2010 Sep 1;185(5):3049-56. doi: 10.4049/jimmunol.1001031. Epub 2010 Jul 23.


Differential activation and regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimer.

Nasser MW, Raghuwanshi SK, Grant DJ, Jala VR, Rajarathnam K, Richardson RM.

J Immunol. 2009 Sep 1;183(5):3425-32. doi: 10.4049/jimmunol.0900305. Epub 2009 Aug 10.


Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14.

Salogni L, Musso T, Bosisio D, Mirolo M, Jala VR, Haribabu B, Locati M, Sozzani S.

Blood. 2009 Jun 4;113(23):5848-56. doi: 10.1182/blood-2008-12-194597. Epub 2009 Apr 1.


Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells.

Estrada R, Wang L, Jala VR, Lee JF, Lin CY, Gray RD, Haribabu B, Lee MJ.

Histochem Cell Biol. 2009 Feb;131(2):239-49. doi: 10.1007/s00418-008-0521-9. Epub 2008 Oct 21.


Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation.

Bonecchi R, Borroni EM, Anselmo A, Doni A, Savino B, Mirolo M, Fabbri M, Jala VR, Haribabu B, Mantovani A, Locati M.

Blood. 2008 Aug 1;112(3):493-503. doi: 10.1182/blood-2007-08-108316. Epub 2008 May 14.


Endogenous IL-10 leads to impaired bacterial clearance and reduced survival in a murine model of chronic peritonitis.

Lenz AM, Franklin GA, Fairweather M, McClintock ML, Jala VR, Peyton JC, Gardner SA, Cheadle WG.

Cytokine. 2007 Dec;40(3):207-15. Epub 2007 Nov 28.


Role of leukotriene B4 receptors in rheumatoid arthritis.

Mathis S, Jala VR, Haribabu B.

Autoimmun Rev. 2007 Nov;7(1):12-7. Epub 2007 Mar 30. Review.


Heat shock protein 27 regulates neutrophil chemotaxis and exocytosis through two independent mechanisms.

Jog NR, Jala VR, Ward RA, Rane MJ, Haribabu B, McLeish KR.

J Immunol. 2007 Feb 15;178(4):2421-8.


Critical role for polar residues in coupling leukotriene B4 binding to signal transduction in BLT1.

Basu S, Jala VR, Mathis S, Rajagopal ST, Del Prete A, Maturu P, Trent JO, Haribabu B.

J Biol Chem. 2007 Mar 30;282(13):10005-17. Epub 2007 Jan 21.


Real-time analysis of G protein-coupled receptor signaling in live cells.

Jala VR, Haribabu B.

Methods Mol Biol. 2006;332:159-65.


Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells.

Kucia M, Reca R, Jala VR, Dawn B, Ratajczak J, Ratajczak MZ.

Leukemia. 2005 Jul;19(7):1118-27. Review.


Role of Lys-226 in the catalytic mechanism of Bacillus stearothermophilus serine hydroxymethyltransferase--crystal structure and kinetic studies.

Bhavani S, Trivedi V, Jala VR, Subramanya HS, Kaul P, Prakash V, Appaji Rao N, Savithri HS.

Biochemistry. 2005 May 10;44(18):6929-37.


Akt inhibition upregulates FasL, downregulates c-FLIPs and induces caspase-8-dependent cell death in Jurkat T lymphocytes.

Uriarte SM, Joshi-Barve S, Song Z, Sahoo R, Gobejishvili L, Jala VR, Haribabu B, McClain C, Barve S.

Cell Death Differ. 2005 Mar;12(3):233-42.


Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors.

Jala VR, Shao WH, Haribabu B.

J Biol Chem. 2005 Feb 11;280(6):4880-7. Epub 2004 Nov 23.


Leukotrienes and atherosclerosis: new roles for old mediators.

Jala VR, Haribabu B.

Trends Immunol. 2004 Jun;25(6):315-22. Review.


beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.

Galliera E, Jala VR, Trent JO, Bonecchi R, Signorelli P, Lefkowitz RJ, Mantovani A, Locati M, Haribabu B.

J Biol Chem. 2004 Jun 11;279(24):25590-7. Epub 2004 Apr 13.


Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms.

Subbarao K, Jala VR, Mathis S, Suttles J, Zacharias W, Ahamed J, Ali H, Tseng MT, Haribabu B.

Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):369-75. Epub 2003 Dec 1.


Disruption of distal interactions of Arg 262 and of substrate binding to Ser 52 affect catalysis of sheep liver cytosolic serine hydroxymethyltransferase.

Jala VR, Ambili M, Prakash V, Rao NA, Savithri HS.

Indian J Biochem Biophys. 2003 Aug;40(4):226-37.


Characterization of recombinant diaminopropionate ammonia-lyase from Escherichia coli and Salmonella typhimurium.

Khan F, Jala VR, Rao NA, Savithri HS.

Biochem Biophys Res Commun. 2003 Jul 11;306(4):1083-8.


Structure-function relationship in serine hydroxymethyltransferase.

Appaji Rao N, Ambili M, Jala VR, Subramanya HS, Savithri HS.

Biochim Biophys Acta. 2003 Apr 11;1647(1-2):24-9. Review.


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