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Items: 27

1.

Oxidative stress response plays a role in antibiotic tolerance of Streptococcus mutans biofilms.

Nilsson M, Jakobsen TH, Givskov M, Twetman S, Tolker-Nielsen T.

Microbiology. 2019 Mar;165(3):334-342. doi: 10.1099/mic.0.000773. Epub 2019 Jan 21.

PMID:
30663959
2.

Implants induce a new niche for microbiomes.

Jakobsen TH, Eickhardt SR, Gheorghe AG, Stenqvist C, Sønderholm M, Stavnsberg C, Jensen PØ, Odgaard A, Whiteley M, Moser C, Hvolris J, Hougen HP, Bjarnsholt T.

APMIS. 2018 Aug;126(8):685-692. doi: 10.1111/apm.12862. Epub 2018 Jul 2.

PMID:
29962006
3.

Qualitative and Quantitative Determination of Quorum Sensing Inhibition In Vitro.

Jakobsen TH, Alhede M, Hultqvist LD, Bjarnsholt T, Givskov M.

Methods Mol Biol. 2018;1673:275-285. doi: 10.1007/978-1-4939-7309-5_21.

PMID:
29130180
4.

Imaging N-Acyl Homoserine Lactone Quorum Sensing In Vivo.

Hultqvist LD, Alhede M, Jakobsen TH, Givskov M, Bjarnsholt T.

Methods Mol Biol. 2018;1673:203-212. doi: 10.1007/978-1-4939-7309-5_16.

PMID:
29130175
5.

Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries.

Belstrøm D, Constancias F, Liu Y, Yang L, Drautz-Moses DI, Schuster SC, Kohli GS, Jakobsen TH, Holmstrup P, Givskov M.

NPJ Biofilms Microbiomes. 2017 Oct 2;3:23. doi: 10.1038/s41522-017-0031-4. eCollection 2017.

6.

Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes.

Jakobsen TH, Tolker-Nielsen T, Givskov M.

Int J Mol Sci. 2017 Sep 13;18(9). pii: E1970. doi: 10.3390/ijms18091970. Review.

7.

A broad range quorum sensing inhibitor working through sRNA inhibition.

Jakobsen TH, Warming AN, Vejborg RM, Moscoso JA, Stegger M, Lorenzen F, Rybtke M, Andersen JB, Petersen R, Andersen PS, Nielsen TE, Tolker-Nielsen T, Filloux A, Ingmer H, Givskov M.

Sci Rep. 2017 Aug 29;7(1):9857. doi: 10.1038/s41598-017-09886-8.

8.

Pseudomonas aeruginosa Aggregate Formation in an Alginate Bead Model System Exhibits In Vivo-Like Characteristics.

Sønderholm M, Kragh KN, Koren K, Jakobsen TH, Darch SE, Alhede M, Jensen PØ, Whiteley M, Kühl M, Bjarnsholt T.

Appl Environ Microbiol. 2017 Apr 17;83(9). pii: e00113-17. doi: 10.1128/AEM.00113-17. Print 2017 May 1.

9.

Fusaric acid and analogues as Gram-negative bacterial quorum sensing inhibitors.

Tung TT, Jakobsen TH, Dao TT, Fuglsang AT, Givskov M, Christensen SB, Nielsen J.

Eur J Med Chem. 2017 Jan 27;126:1011-1020. doi: 10.1016/j.ejmech.2016.11.044. Epub 2016 Nov 24.

PMID:
28033578
10.

Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa.

Fong J, Yuan M, Jakobsen TH, Mortensen KT, Delos Santos MM, Chua SL, Yang L, Tan CH, Nielsen TE, Givskov M.

J Med Chem. 2017 Jan 12;60(1):215-227. doi: 10.1021/acs.jmedchem.6b01025. Epub 2016 Dec 28.

PMID:
27977197
11.

Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa.

Hansen MR, Jakobsen TH, Bang CG, Cohrt AE, Hansen CL, Clausen JW, Le Quement ST, Tolker-Nielsen T, Givskov M, Nielsen TE.

Bioorg Med Chem. 2015 Apr 1;23(7):1638-50. doi: 10.1016/j.bmc.2015.01.038. Epub 2015 Jan 31.

PMID:
25716005
12.

Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa.

Tan SY, Liu Y, Chua SL, Vejborg RM, Jakobsen TH, Chew SC, Li Y, Nielsen TE, Tolker-Nielsen T, Yang L, Givskov M.

Antimicrob Agents Chemother. 2014 Nov;58(11):6648-59. doi: 10.1128/AAC.02620-13. Epub 2014 Aug 25.

13.

Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators.

Hansen MR, Le Quement ST, Jakobsen TH, Skovstrup S, Taboureau O, Tolker-Nielsen T, Givskov M, Nielsen TE.

Chembiochem. 2014 Feb 10;15(3):460-5. doi: 10.1002/cbic.201300533. Epub 2014 Jan 16.

PMID:
24436223
14.

Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes.

Jakobsen TH, Hansen MA, Jensen PØ, Hansen L, Riber L, Cockburn A, Kolpen M, Rønne Hansen C, Ridderberg W, Eickhardt S, Hansen M, Kerpedjiev P, Alhede M, Qvortrup K, Burmølle M, Moser C, Kühl M, Ciofu O, Givskov M, Sørensen SJ, Høiby N, Bjarnsholt T.

PLoS One. 2013 Jul 22;8(7):e68484. doi: 10.1371/journal.pone.0068484. Print 2013.

15.

Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors.

Jakobsen TH, Bjarnsholt T, Jensen PØ, Givskov M, Høiby N.

Future Microbiol. 2013 Jul;8(7):901-21. doi: 10.2217/fmb.13.57. Review.

PMID:
23841636
16.

Kinetic model for signal binding to the Quorum sensing regulator LasR.

Claussen A, Jakobsen TH, Bjarnsholt T, Givskov M, Welch M, Ferkinghoff-Borg J, Sams T.

Int J Mol Sci. 2013 Jun 27;14(7):13360-76. doi: 10.3390/ijms140713360.

17.

Identification of LasR ligands through a virtual screening approach.

Skovstrup S, Le Quement ST, Hansen T, Jakobsen TH, Harmsen M, Tolker-Nielsen T, Nielsen TE, Givskov M, Taboureau O.

ChemMedChem. 2013 Jan;8(1):157-63. doi: 10.1002/cmdc.201200434. Epub 2012 Nov 30.

PMID:
23203920
18.

Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing.

Jakobsen TH, van Gennip M, Phipps RK, Shanmugham MS, Christensen LD, Alhede M, Skindersoe ME, Rasmussen TB, Friedrich K, Uthe F, Jensen PØ, Moser C, Nielsen KF, Eberl L, Larsen TO, Tanner D, Høiby N, Bjarnsholt T, Givskov M.

Antimicrob Agents Chemother. 2012 May;56(5):2314-25. doi: 10.1128/AAC.05919-11. Epub 2012 Feb 6.

19.

Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.

Christensen LD, van Gennip M, Jakobsen TH, Alhede M, Hougen HP, Høiby N, Bjarnsholt T, Givskov M.

J Antimicrob Chemother. 2012 May;67(5):1198-206. doi: 10.1093/jac/dks002. Epub 2012 Feb 1.

PMID:
22302561
20.

Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa.

Jakobsen TH, Bragason SK, Phipps RK, Christensen LD, van Gennip M, Alhede M, Skindersoe M, Larsen TO, Høiby N, Bjarnsholt T, Givskov M.

Appl Environ Microbiol. 2012 Apr;78(7):2410-21. doi: 10.1128/AEM.05992-11. Epub 2012 Jan 27.

21.

Qualitative and quantitative determination of quorum sensing inhibition in vitro.

Jakobsen TH, van Gennip M, Christensen LD, Bjarnsholt T, Givskov M.

Methods Mol Biol. 2011;692:253-63. doi: 10.1007/978-1-60761-971-0_18.

PMID:
21031317
22.

Imaging N-acyl homoserine lactone quorum sensing in vivo.

Christensen LD, van Gennip M, Jakobsen TH, Givskov M, Bjarnsholt T.

Methods Mol Biol. 2011;692:147-57. doi: 10.1007/978-1-60761-971-0_11.

PMID:
21031310
23.

Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients.

Bjarnsholt T, Jensen PØ, Jakobsen TH, Phipps R, Nielsen AK, Rybtke MT, Tolker-Nielsen T, Givskov M, Høiby N, Ciofu O; Scandinavian Cystic Fibrosis Study Consortium.

PLoS One. 2010 Apr 12;5(4):e10115. doi: 10.1371/journal.pone.0010115.

24.

In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect.

Bjarnsholt T, van Gennip M, Jakobsen TH, Christensen LD, Jensen PØ, Givskov M.

Nat Protoc. 2010 Feb;5(2):282-93. doi: 10.1038/nprot.2009.205. Epub 2010 Jan 28.

PMID:
20134428
25.

Quorum sensing regulation in Aeromonas hydrophila.

Garde C, Bjarnsholt T, Givskov M, Jakobsen TH, Hentzer M, Claussen A, Sneppen K, Ferkinghoff-Borg J, Sams T.

J Mol Biol. 2010 Mar 5;396(4):849-57. doi: 10.1016/j.jmb.2010.01.002. Epub 2010 Jan 11.

PMID:
20064524
26.

Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors.

Yang L, Rybtke MT, Jakobsen TH, Hentzer M, Bjarnsholt T, Givskov M, Tolker-Nielsen T.

Antimicrob Agents Chemother. 2009 Jun;53(6):2432-43. doi: 10.1128/AAC.01283-08. Epub 2009 Apr 13.

27.

3-Methoxyflavones and a novel coumarin from Psiadia dentata.

Jakobsen TH, Marcussen HV, Adsersen A, Strasberg D, Smitt UW, Jaroszewski JW.

Biochem Syst Ecol. 2001 Oct;29(9):963-965. No abstract available.

PMID:
11445297

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