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Items: 1 to 50 of 268

1.

Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study.

vom Dorp F, Sanders H, Boergermann C, Lümmen G, Rübben H, Jakobs KH, Schmidt M.

Urol Int. 2011;86(2):220-7. doi: 10.1159/000321271. Epub 2010 Nov 4.

PMID:
21051874
2.

8-pCPT-conjugated cyclic AMP analogs exert thromboxane receptor antagonistic properties.

Sand C, Grandoch M, Börgermann C, Oude Weernink PA, Mahlke Y, Schwindenhammer B, Weber AA, Fischer JW, Jakobs KH, Schmidt M.

Thromb Haemost. 2010 Mar;103(3):662-78. doi: 10.1160/TH09-06-0341. Epub 2010 Feb 2.

PMID:
20135060
3.

Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts.

Claas RF, ter Braak M, Hegen B, Hardel V, Angioni C, Schmidt H, Jakobs KH, Van Veldhoven PP, zu Heringdorf DM.

Cell Signal. 2010 Mar;22(3):476-83. doi: 10.1016/j.cellsig.2009.11.001.

PMID:
19913094
4.

Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors.

ter Braak M, Danneberg K, Lichte K, Liphardt K, Ktistakis NT, Pitson SM, Hla T, Jakobs KH, Meyer zu Heringdorf D.

Biochim Biophys Acta. 2009 May;1791(5):357-70.

PMID:
19830907
5.

B cell receptor-induced growth arrest and apoptosis in WEHI-231 immature B lymphoma cells involve cyclic AMP and Epac proteins.

Grandoch M, López de Jesús M, Oude Weernink PA, Weber AA, Jakobs KH, Schmidt M.

Cell Signal. 2009 Apr;21(4):609-21. doi: 10.1016/j.cellsig.2009.01.002. Epub 2009 Jan 7.

PMID:
19167486
6.

Lysophospholipid receptor-mediated calcium signaling in human keratinocytes.

Lichte K, Rossi R, Danneberg K, ter Braak M, Kürschner U, Jakobs KH, Kleuser B, Meyer zu Heringdorf D.

J Invest Dermatol. 2008 Jun;128(6):1487-98. doi: 10.1038/sj.jid.5701207. Epub 2008 Jan 3.

7.

Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin.

Han L, Stope MB, de Jesús ML, Oude Weernink PA, Urban M, Wieland T, Rosskopf D, Mizuno K, Jakobs KH, Schmidt M.

EMBO J. 2007 Oct 3;26(19):4189-202. Epub 2007 Sep 13.

8.

[WITHDRAWN Control of platelet function by Epac protein.]

Börgermann C, Schenck M, Jakobs KH, Schmidt M, Rübben H, Vom Dorp F.

Urologe A. 2007 Aug 4. [Epub ahead of print] German. No abstract available.

PMID:
17628777
9.

Regulator of G-protein signalling 3 redirects prototypical Gi-coupled receptors from Rac1 to RhoA activation.

Vogt A, Lutz S, Rümenapp U, Han L, Jakobs KH, Schmidt M, Wieland T.

Cell Signal. 2007 Jun;19(6):1229-37. Epub 2007 Jan 17.

PMID:
17300916
10.

Epac and the cardiovascular system.

Schmidt M, Sand C, Jakobs KH, Michel MC, Weernink PA.

Curr Opin Pharmacol. 2007 Apr;7(2):193-200. Epub 2007 Feb 2. Review.

PMID:
17276729
11.

Renal mesangial cells: moving on sphingosine kinase-1.

Meyer zu Heringdorf D, Jakobs KH.

Br J Pharmacol. 2007 Feb;150(3):255-7. Epub 2007 Jan 2.

12.

Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism.

Meyer zu Heringdorf D, Jakobs KH.

Biochim Biophys Acta. 2007 Apr;1768(4):923-40. Epub 2006 Oct 4. Review.

13.

Dynamic phospholipid signaling by G protein-coupled receptors.

Oude Weernink PA, Han L, Jakobs KH, Schmidt M.

Biochim Biophys Acta. 2007 Apr;1768(4):888-900. Epub 2006 Sep 23. Review.

14.

Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation.

López De Jesús M, Stope MB, Oude Weernink PA, Mahlke Y, Börgermann C, Ananaba VN, Rimmbach C, Rosskopf D, Michel MC, Jakobs KH, Schmidt M.

J Biol Chem. 2006 Aug 4;281(31):21837-47. Epub 2006 Jun 5.

15.

Antihypertensive action of 2-hydroxyoleic acid in SHRs via modulation of the protein kinase A pathway and Rho kinase.

Alemany R, Vögler O, Terés S, Egea C, Baamonde C, Barceló F, Delgado C, Jakobs KH, Escribá PV.

J Lipid Res. 2006 Aug;47(8):1762-70. Epub 2006 May 10.

16.

Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats.

Hennenberg M, Biecker E, Trebicka J, Jochem K, Zhou Q, Schmidt M, Jakobs KH, Sauerbruch T, Heller J.

Gastroenterology. 2006 Mar;130(3):838-54.

PMID:
16530523
17.

The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA.

Lutz S, Freichel-Blomquist A, Yang Y, Rümenapp U, Jakobs KH, Schmidt M, Wieland T.

J Biol Chem. 2005 Mar 25;280(12):11134-9. Epub 2005 Jan 4.

18.

Regulation and cellular roles of phosphoinositide 5-kinases.

Oude Weernink PA, Schmidt M, Jakobs KH.

Eur J Pharmacol. 2004 Oct 1;500(1-3):87-99. Review.

PMID:
15464023
19.

Arrestin-independent internalization of G protein-coupled receptors.

van Koppen CJ, Jakobs KH.

Mol Pharmacol. 2004 Sep;66(3):365-7. No abstract available.

PMID:
15322226
20.

Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors.

Keiper M, Stope MB, Szatkowski D, Böhm A, Tysack K, Vom Dorp F, Saur O, Oude Weernink PA, Evellin S, Jakobs KH, Schmidt M.

J Biol Chem. 2004 Nov 5;279(45):46497-508. Epub 2004 Aug 19.

21.

Inhibition of phospholipase C-epsilon by Gi-coupled receptors.

vom Dorp F, Sari AY, Sanders H, Keiper M, Oude Weernink PA, Jakobs KH, Schmidt M.

Cell Signal. 2004 Aug;16(8):921-8.

PMID:
15157671
22.

Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3.

Stope MB, Vom Dorp F, Szatkowski D, Böhm A, Keiper M, Nolte J, Oude Weernink PA, Rosskopf D, Evellin S, Jakobs KH, Schmidt M.

Mol Cell Biol. 2004 Jun;24(11):4664-76.

23.

p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene.

Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T.

Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):540-6. Epub 2004 Apr 7.

PMID:
15069594
24.

More hints on Wnts: gene profiling by beta2-adrenergic receptor-frizzled chimeras.

Rosskopf D, Jakobs KH.

Mol Pharmacol. 2004 Jan;65(1):12-4. No abstract available.

PMID:
14722231
25.

Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.

Weernink PA, Meletiadis K, Hommeltenberg S, Hinz M, Ishihara H, Schmidt M, Jakobs KH.

J Biol Chem. 2004 Feb 27;279(9):7840-9. Epub 2003 Dec 17.

26.

Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors.

Meyer zu Heringdorf D, Liliom K, Schaefer M, Danneberg K, Jaggar JH, Tigyi G, Jakobs KH.

FEBS Lett. 2003 Nov 20;554(3):443-9.

27.

Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1).

zu Heringdorf DM, Vincent ME, Lipinski M, Danneberg K, Stropp U, Wang DA, Tigyi G, Jakobs KH.

Cell Signal. 2003 Jul;15(7):677-87.

PMID:
12742228
28.

Interaction of Gbeta3s, a splice variant of the G-protein Gbeta3, with Ggamma- and Galpha-proteins.

Rosskopf D, Koch K, Habich C, Geerdes J, Ludwig A, Wilhelms S, Jakobs KH, Siffert W.

Cell Signal. 2003 May;15(5):479-88.

PMID:
12639711
29.

Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function.

Altmann C, Meyer Zu Heringdorf D, Böyükbas D, Haude M, Jakobs KH, Michel MC.

Br J Pharmacol. 2003 Feb;138(3):435-44.

30.
31.
32.

Adhesiveness of human uterine epithelial RL95-2 cells to trophoblast: rho protein regulation.

Heneweer C, Kruse LH, Kindhäuser F, Schmidt M, Jakobs KH, Denker HW, Thie M.

Mol Hum Reprod. 2002 Nov;8(11):1014-22.

PMID:
12397214
33.

Problem- vs. lecture-based pharmacology teaching in a German medical school.

Michel MC, Bischoff A, Zu Heringdorf M, Neumann D, Jakobs KH.

Naunyn Schmiedebergs Arch Pharmacol. 2002 Jul;366(1):64-8. Epub 2002 May 22.

PMID:
12107635
34.

Novel teaching techniques in pharmacology.

Herzig S, Jakobs KH, Michel MC.

Naunyn Schmiedebergs Arch Pharmacol. 2002 Jul;366(1):1. Epub 2002 Apr 18. No abstract available.

PMID:
12107625
35.

A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain.

Rümenapp U, Freichel-Blomquist A, Wittinghofer B, Jakobs KH, Wieland T.

Biochem J. 2002 Sep 15;366(Pt 3):721-8.

36.

Sphingosylphosphorylcholine-biological functions and mechanisms of action.

Meyer zu Heringdorf D, Himmel HM, Jakobs KH.

Biochim Biophys Acta. 2002 May 23;1582(1-3):178-89. Review.

PMID:
12069827
37.

Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.

Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T.

J Mol Cell Cardiol. 2002 Apr;34(4):441-53.

PMID:
11991733
38.

Comparison of problem-and lecture-based pharmacology teaching.

Michel MC, Bischoff A, Jakobs KH.

Trends Pharmacol Sci. 2002 Apr;23(4):168-70. Review.

PMID:
11931991
39.

Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B.

Evellin S, Nolte J, Tysack K, vom Dorp F, Thiel M, Weernink PA, Jakobs KH, Webb EJ, Lomasney JW, Schmidt M.

J Biol Chem. 2002 May 10;277(19):16805-13. Epub 2002 Mar 4.

40.

Spontaneous release of GDP from Gi proteins and inhibition of adenylyl cyclase in cardiac sarcolemmal membranes.

Lutz S, Baltus D, Jakobs KH, Niroomand F.

Naunyn Schmiedebergs Arch Pharmacol. 2002 Jan;365(1):50-5. Epub 2001 Nov 13.

PMID:
11862333
41.

Transient relaxation of rat mesenteric microvessels by ceramides.

Czyborra P, Saxe M, Fetscher C, Meyer Zu Heringdorf D, Herzig S, Jakobs KH, Michel MC, Bischoff A.

Br J Pharmacol. 2002 Jan;135(2):417-26.

42.

Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate.

Alemany R, Kleuser B, Ruwisch L, Danneberg K, Lass H, Hashemi R, Spiegel S, Jakobs KH, Meyer zu Heringdorf D.

FEBS Lett. 2001 Dec 7;509(2):239-44.

43.

A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase.

Schmidt M, Evellin S, Weernink PA, von Dorp F, Rehmann H, Lomasney JW, Jakobs KH.

Nat Cell Biol. 2001 Nov;3(11):1020-4.

PMID:
11715024
44.

Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors.

van Koppen CJ, Meyer zu Heringdorf D, Alemany R, Jakobs KH.

Life Sci. 2001 Apr 27;68(22-23):2535-40.

PMID:
11392623
45.

Lysosphingolipid receptor-mediated diuresis and natriuresis in anaesthetized rats.

Bischoff A, Meyer Zu Heringdorf D, Jakobs KH, Michel MC.

Br J Pharmacol. 2001 Apr;132(8):1925-33.

46.

Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors.

Meyer zu Heringdorf D, Lass H, Kuchar I, Lipinski M, Alemany R, Rümenapp U, Jakobs KH.

Eur J Pharmacol. 2001 Mar 2;414(2-3):145-54.

PMID:
11239914
47.

Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor.

Blomquist A, Schwörer G, Schablowski H, Psoma A, Lehnen M, Jakobs KH, Rümenapp U.

Biochem J. 2000 Dec 1;352 Pt 2:319-25.

48.

The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins: regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling.

Rümenapp U, Asmus M, Schablowski H, Woznicki M, Han L, Jakobs KH, Fahimi-Vahid M, Michalek C, Wieland T, Schmidt M.

J Biol Chem. 2001 Jan 26;276(4):2474-9. Epub 2000 Oct 17.

49.
50.

Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner.

Bischoff A, Czyborra P, Meyer Zu Heringdorf D, Jakobs KH, Michel MC.

Br J Pharmacol. 2000 Aug;130(8):1878-83.

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