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Items: 1 to 50 of 160

1.

Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach.

Kaur H, Hartmann JB, Jakob RP, Zahn M, Zimmermann I, Maier T, Seeger MA, Hiller S.

J Biomol NMR. 2019 Jul;73(6-7):375-384. doi: 10.1007/s10858-019-00250-8. Epub 2019 May 9.

PMID:
31073665
2.

Improvement of Aglycone π-Stacking Yields Nanomolar to Sub-nanomolar FimH Antagonists.

Schönemann W, Cramer J, Mühlethaler T, Fiege B, Silbermann M, Rabbani S, Dätwyler P, Zihlmann P, Jakob RP, Sager CP, Smieško M, Schwardt O, Maier T, Ernst B.

ChemMedChem. 2019 Apr 3;14(7):749-757. doi: 10.1002/cmdc.201900051. Epub 2019 Feb 22.

PMID:
30710416
3.

Correction: DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations (doi:10.1242/bio.036749).

Vigano MA, Bieli D, Schaefer JV, Jakob RP, Matsuda S, Maier T, Plückthun A, Affolter M.

Biol Open. 2018 Dec 13;7(12). pii: bio040832. doi: 10.1242/bio.040832. No abstract available.

4.

Binding of the Bacterial Adhesin FimH to Its Natural, Multivalent High-Mannose Type Glycan Targets.

Sauer MM, Jakob RP, Luber T, Canonica F, Navarra G, Ernst B, Unverzagt C, Maier T, Glockshuber R.

J Am Chem Soc. 2019 Jan 16;141(2):936-944. doi: 10.1021/jacs.8b10736. Epub 2018 Dec 28.

PMID:
30543411
5.

DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations.

Vigano MA, Bieli D, Schaefer JV, Jakob RP, Matsuda S, Maier T, Plückthun A, Affolter M.

Biol Open. 2018 Oct 29;7(11). pii: bio036749. doi: 10.1242/bio.036749. Erratum in: Biol Open. 2018 Dec 13;7(12):.

6.

KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists.

Zihlmann P, Silbermann M, Sharpe T, Jiang X, Mühlethaler T, Jakob RP, Rabbani S, Sager CP, Frei P, Pang L, Maier T, Ernst B.

Chemistry. 2018 Sep 3;24(49):13049-13057. doi: 10.1002/chem.201802599. Epub 2018 Jul 27.

PMID:
29939458
7.

A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy.

Bauer D, Meinhold S, Jakob RP, Stigler J, Merkel U, Maier T, Rief M, Žoldák G.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4666-4671. doi: 10.1073/pnas.1716899115. Epub 2018 Apr 18.

8.

The price of flexibility - a case study on septanoses as pyranose mimetics.

Sager CP, Fiege B, Zihlmann P, Vannam R, Rabbani S, Jakob RP, Preston RC, Zalewski A, Maier T, Peczuh MW, Ernst B.

Chem Sci. 2017 Nov 8;9(3):646-654. doi: 10.1039/c7sc04289b. eCollection 2018 Jan 21.

9.

The structural organization of substrate loading in iterative polyketide synthases.

Herbst DA, Huitt-Roehl CR, Jakob RP, Kravetz JM, Storm PA, Alley JR, Townsend CA, Maier T.

Nat Chem Biol. 2018 May;14(5):474-479. doi: 10.1038/s41589-018-0026-3. Epub 2018 Apr 2.

10.

Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain: Engineering a minimalistic allosteric system.

Rabbani S, Fiege B, Eris D, Silbermann M, Jakob RP, Navarra G, Maier T, Ernst B.

J Biol Chem. 2018 Feb 2;293(5):1835-1849. doi: 10.1074/jbc.M117.802942. Epub 2017 Nov 27.

11.

Carbohydrate-Lectin Interactions: An Unexpected Contribution to Affinity.

Navarra G, Zihlmann P, Jakob RP, Stangier K, Preston RC, Rabbani S, Smiesko M, Wagner B, Maier T, Ernst B.

Chembiochem. 2017 Mar 16;18(6):539-544. doi: 10.1002/cbic.201600615. Epub 2017 Feb 7.

PMID:
28076665
12.

Healing of the Acutely Injured Anterior Cruciate Ligament: Functional Treatment with the ACL-Jack, a Dynamic Posterior Drawer Brace.

Jacobi M, Reischl N, Rönn K, Magnusson RA, Gautier E, Jakob RP.

Adv Orthop. 2016;2016:1609067. doi: 10.1155/2016/1609067. Epub 2016 Dec 7.

13.

Corrigendum: Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases.

Herbst DA, Jakob RP, Zähringer F, Maier T.

Nature. 2016 Aug 18;536(7616):360. doi: 10.1038/nature18281. Epub 2016 May 11. No abstract available.

PMID:
27281192
14.

Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps.

Jakob RP, Schmidpeter PA, Koch JR, Schmid FX, Maier T.

PLoS One. 2016 Jun 8;11(6):e0157070. doi: 10.1371/journal.pone.0157070. eCollection 2016.

15.

Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases.

Herbst DA, Jakob RP, Zähringer F, Maier T.

Nature. 2016 Mar 24;531(7595):533-7. doi: 10.1038/nature16993. Epub 2016 Mar 14. Erratum in: Nature. 2016 Aug 18;536(7616):360.

PMID:
26976449
16.

Catch-bond mechanism of the bacterial adhesin FimH.

Sauer MM, Jakob RP, Eras J, Baday S, Eriş D, Navarra G, Bernèche S, Ernst B, Maier T, Glockshuber R.

Nat Commun. 2016 Mar 7;7:10738. doi: 10.1038/ncomms10738.

17.

E-selectin ligand complexes adopt an extended high-affinity conformation.

Preston RC, Jakob RP, Binder FP, Sager CP, Ernst B, Maier T.

J Mol Cell Biol. 2016 Feb;8(1):62-72. doi: 10.1093/jmcb/mjv046. Epub 2015 Jun 27.

18.

The Role of Cells in Meniscal Guided Tissue Regeneration: A Proof of Concept Study in a Goat Model.

Jülke H, Mainil-Varlet P, Jakob RP, Brehm W, Schäfer B, Nesic D.

Cartilage. 2015 Jan;6(1):20-9. doi: 10.1177/1947603514548213.

19.

The tyrosine gate of the bacterial lectin FimH: a conformational analysis by NMR spectroscopy and X-ray crystallography.

Fiege B, Rabbani S, Preston RC, Jakob RP, Zihlmann P, Schwardt O, Jiang X, Maier T, Ernst B.

Chembiochem. 2015 May 26;16(8):1235-46. doi: 10.1002/cbic.201402714. Epub 2015 May 4.

PMID:
25940742
20.

High tibial osteotomy: indications, techniques, and postoperative management.

Prodromos CC, Amendola A, Jakob RP.

Instr Course Lect. 2015;64:555-65. Review.

PMID:
25745938
21.

FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile.

Kleeb S, Pang L, Mayer K, Eris D, Sigl A, Preston RC, Zihlmann P, Sharpe T, Jakob RP, Abgottspon D, Hutter AS, Scharenberg M, Jiang X, Navarra G, Rabbani S, Smiesko M, Lüdin N, Bezençon J, Schwardt O, Maier T, Ernst B.

J Med Chem. 2015 Mar 12;58(5):2221-39. doi: 10.1021/jm501524q. Epub 2015 Feb 20.

PMID:
25666045
22.

Dimeric Structure of the Bacterial Extracellular Foldase PrsA.

Jakob RP, Koch JR, Burmann BM, Schmidpeter PA, Hunkeler M, Hiller S, Schmid FX, Maier T.

J Biol Chem. 2015 Feb 6;290(6):3278-92. doi: 10.1074/jbc.M114.622910. Epub 2014 Dec 17.

23.

Evolutionary origins of the multienzyme architecture of giant fungal fatty acid synthase.

Bukhari HST, Jakob RP, Maier T.

Structure. 2014 Dec 2;22(12):1775-1785. doi: 10.1016/j.str.2014.09.016. Epub 2014 Nov 13.

24.

Energetic communication between functional sites of the gene-3-protein during infection by phage fd.

Hoffmann-Thoms S, Jakob RP, Schmid FX.

J Mol Biol. 2014 Apr 17;426(8):1711-22. doi: 10.1016/j.jmb.2014.01.002. Epub 2014 Jan 15.

PMID:
24440124
25.

The structural basis of autotransporter translocation by TamA.

Gruss F, Zähringer F, Jakob RP, Burmann BM, Hiller S, Maier T.

Nat Struct Mol Biol. 2013 Nov;20(11):1318-20. doi: 10.1038/nsmb.2689. Epub 2013 Sep 22.

PMID:
24056943
26.

Initiation of phage infection by partial unfolding and prolyl isomerization.

Hoffmann-Thoms S, Weininger U, Eckert B, Jakob RP, Koch JR, Balbach J, Schmid FX.

J Biol Chem. 2013 May 3;288(18):12979-91. doi: 10.1074/jbc.M112.442525. Epub 2013 Mar 13.

27.

ACL reconstruction with physiological graft tension by intraoperative adjustment of the anteroposterior translation to the uninjured contralateral knee.

Bastian JD, Tomagra S, Schuster AJ, Werlen S, Jakob RP, Zumstein MA.

Knee Surg Sports Traumatol Arthrosc. 2014 May;22(5):1055-60. doi: 10.1007/s00167-013-2465-4. Epub 2013 Mar 8.

PMID:
23471531
28.

Structural and energetic basis of infection by the filamentous bacteriophage IKe.

Jakob RP, Geitner AJ, Weininger U, Balbach J, Dobbek H, Schmid FX.

Mol Microbiol. 2012 Jun;84(6):1124-38. doi: 10.1111/j.1365-2958.2012.08079.x. Epub 2012 May 17.

29.

Treatment of isolated chondral and osteochondral defects in the knee by autologous matrix-induced chondrogenesis (AMIC).

Kusano T, Jakob RP, Gautier E, Magnussen RA, Hoogewoud H, Jacobi M.

Knee Surg Sports Traumatol Arthrosc. 2012 Oct;20(10):2109-15. Epub 2011 Dec 25.

PMID:
22198419
30.

The filamentous phages fd and IF1 use different mechanisms to infect Escherichia coli.

Lorenz SH, Jakob RP, Weininger U, Balbach J, Dobbek H, Schmid FX.

J Mol Biol. 2011 Jan 28;405(4):989-1003. doi: 10.1016/j.jmb.2010.11.030. Epub 2010 Nov 24.

PMID:
21110981
31.

Distal femoral varus osteotomy: problems associated with the lateral open-wedge technique.

Jacobi M, Wahl P, Bouaicha S, Jakob RP, Gautier E.

Arch Orthop Trauma Surg. 2011 Jun;131(6):725-8. doi: 10.1007/s00402-010-1193-1. Epub 2010 Oct 14.

PMID:
20945150
32.

Acute isolated injury of the posterior cruciate ligament treated by a dynamic anterior drawer brace: a preliminary report.

Jacobi M, Reischl N, Wahl P, Gautier E, Jakob RP.

J Bone Joint Surg Br. 2010 Oct;92(10):1381-4. doi: 10.1302/0301-620X.92B10.24807.

PMID:
20884975
33.

High tibial valgus osteotomy in unicompartmental medial osteoarthritis of the knee: a retrospective follow-up study over 13-21 years.

Schallberger A, Jacobi M, Wahl P, Maestretti G, Jakob RP.

Knee Surg Sports Traumatol Arthrosc. 2011 Jan;19(1):122-7. doi: 10.1007/s00167-010-1256-4. Epub 2010 Sep 7.

PMID:
20821190
34.

Biomechanical investigation of an alternative concept to angular stable plating using conventional fixation hardware.

Windolf M, Klos K, Wähnert D, van der Pol B, Radtke R, Schwieger K, Jakob RP.

BMC Musculoskelet Disord. 2010 May 21;11:95. doi: 10.1186/1471-2474-11-95.

35.

Elimination of a cis-proline-containing loop and turn optimization stabilizes a protein and accelerates its folding.

Jakob RP, Zierer BK, Weininger U, Hofmann SD, Lorenz SH, Balbach J, Dobbek H, Schmid FX.

J Mol Biol. 2010 Jun 4;399(2):331-46. doi: 10.1016/j.jmb.2010.04.007. Epub 2010 Apr 13.

PMID:
20394751
36.

Association between mechanical axis of the leg and osteochondritis dissecans of the knee: radiographic study on 103 knees.

Jacobi M, Wahl P, Bouaicha S, Jakob RP, Gautier E.

Am J Sports Med. 2010 Jul;38(7):1425-8. doi: 10.1177/0363546509359070. Epub 2010 Mar 29.

PMID:
20351199
37.

Chaperone domains convert prolyl isomerases into generic catalysts of protein folding.

Jakob RP, Zoldák G, Aumüller T, Schmid FX.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20282-7. doi: 10.1073/pnas.0909544106. Epub 2009 Nov 17.

38.

The prolyl isomerase domain of PpiD from Escherichia coli shows a parvulin fold but is devoid of catalytic activity.

Weininger U, Jakob RP, Kovermann M, Balbach J, Schmid FX.

Protein Sci. 2010 Jan;19(1):6-18. doi: 10.1002/pro.277.

39.

Avoiding intraoperative complications in open-wedge high tibial valgus osteotomy: technical advancement.

Jacobi M, Wahl P, Jakob RP.

Knee Surg Sports Traumatol Arthrosc. 2010 Feb;18(2):200-3. doi: 10.1007/s00167-009-0928-4. Epub 2009 Sep 26.

PMID:
19784624
40.

A remote prolyl isomerization controls domain assembly via a hydrogen bonding network.

Weininger U, Jakob RP, Eckert B, Schweimer K, Schmid FX, Balbach J.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12335-40. doi: 10.1073/pnas.0902102106. Epub 2009 Jul 15.

41.

Molecular determinants of a native-state prolyl isomerization.

Jakob RP, Schmid FX.

J Mol Biol. 2009 Apr 10;387(4):1017-31. doi: 10.1016/j.jmb.2009.02.021. Epub 2009 Feb 20.

PMID:
19232524
42.

Infections after high tibial open wedge osteotomy: a case control study.

Reischl N, Wahl P, Jacobi M, Clerc S, Gautier E, Jakob RP.

Arch Orthop Trauma Surg. 2009 Nov;129(11):1483-7. doi: 10.1007/s00402-008-0773-9. Epub 2008 Nov 13.

PMID:
19005658
43.

Quercetinase QueD of Streptomyces sp. FLA, a monocupin dioxygenase with a preference for nickel and cobalt.

Merkens H, Kappl R, Jakob RP, Schmid FX, Fetzner S.

Biochemistry. 2008 Nov 18;47(46):12185-96. doi: 10.1021/bi801398x. Epub 2008 Oct 25.

PMID:
18950192
44.

Increased folding stability of TEM-1 beta-lactamase by in vitro selection.

Kather I, Jakob RP, Dobbek H, Schmid FX.

J Mol Biol. 2008 Oct 31;383(1):238-51. doi: 10.1016/j.jmb.2008.07.082. Epub 2008 Aug 3.

PMID:
18706424
45.

Energetic coupling between native-state prolyl isomerization and conformational protein folding.

Jakob RP, Schmid FX.

J Mol Biol. 2008 Apr 11;377(5):1560-75. doi: 10.1016/j.jmb.2008.02.010. Epub 2008 Feb 13.

PMID:
18325533
46.

Prospective study of standalone balloon kyphoplasty with calcium phosphate cement augmentation in traumatic fractures.

Maestretti G, Cremer C, Otten P, Jakob RP.

Eur Spine J. 2007 May;16(5):601-10. Epub 2006 Nov 22.

47.

Repair of superficial osteochondral defects with an autologous scaffold-free cartilage construct in a caprine model: implantation method and short-term results.

Brehm W, Aklin B, Yamashita T, Rieser F, Trüb T, Jakob RP, Mainil-Varlet P.

Osteoarthritis Cartilage. 2006 Dec;14(12):1214-26. Epub 2006 Jul 3.

48.

Impact loading of articular cartilage during transplantation of osteochondral autograft.

Whiteside RA, Jakob RP, Wyss UP, Mainil-Varlet P.

J Bone Joint Surg Br. 2005 Sep;87(9):1285-91. Erratum in: J Bone Joint Surg Br. 2005 Nov;87(11):1583.

PMID:
16129760
49.

A new mechanical testing device for measuring anteroposterior knee laxity.

Schuster AJ, McNicholas MJ, Wachtl SW, McGurty DW, Jakob RP.

Am J Sports Med. 2004 Oct-Nov;32(7):1731-5.

PMID:
15494340
50.

Accuracy of frontal and sagittal plane correction in open-wedge high tibial osteotomy.

Marti CB, Gautier E, Wachtl SW, Jakob RP.

Arthroscopy. 2004 Apr;20(4):366-72. Review.

PMID:
15067275

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