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Items: 1 to 50 of 165

1.

Relating Ettringite Formation and Rheological Changes during the Initial Cement Hydration: A Comparative Study Applying XRD Analysis, Rheological Measurements and Modeling.

Jakob C, Jansen D, Ukrainczyk N, Koenders E, Pott U, Stephan D, Neubauer J.

Materials (Basel). 2019 Sep 12;12(18). pii: E2957. doi: 10.3390/ma12182957.

2.

Bei gebrechlichen Patienten darf der Blutdruck etwas höher sein.

Jakob C.

MMW Fortschr Med. 2019 Jun;161(11):14-16. doi: 10.1007/s15006-019-0598-1. German. No abstract available.

PMID:
31183720
3.

Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer.

Petros AM, Korepanova A, Jakob CG, Qiu W, Panchal SC, Wang J, Dietrich JD, Brewer JT, Pohlki F, Kling A, Wilcox K, Lakics V, Bahnassawy L, Reinhardt P, Partha SK, Bodelle PM, Lake M, Charych EI, Stoll VS, Sun C, Mohler EG.

J Med Chem. 2019 Apr 25;62(8):4120-4130. doi: 10.1021/acs.jmedchem.9b00178. Epub 2019 Apr 12.

PMID:
30933499
4.

[Infectious Diseases - Pioneer of Digital Medicine].

Vehreschild JJ, Claßen AY, Jakob C.

Dtsch Med Wochenschr. 2019 Apr;144(7):442-446. doi: 10.1055/a-0740-8510. Epub 2019 Mar 29. German.

PMID:
30925597
5.

Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors.

Geneste H, Drescher K, Jakob C, Laplanche L, Ochse M, Torrent M.

Bioorg Med Chem Lett. 2019 Feb 1;29(3):406-412. doi: 10.1016/j.bmcl.2018.12.029. Epub 2018 Dec 19.

PMID:
30587449
6.

Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.

Jakob CG, Upadhyay AK, Donner PL, Nicholl E, Addo SN, Qiu W, Ling C, Gopalakrishnan SM, Torrent M, Cepa SP, Shanley J, Shoemaker AR, Sun CC, Vasudevan A, Woller KR, Shotwell JB, Shaw B, Bian Z, Hutti JE.

J Med Chem. 2018 Aug 9;61(15):6647-6657. doi: 10.1021/acs.jmedchem.8b00305. Epub 2018 Jul 30.

PMID:
30004704
7.

Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, Faivre E, Ferguson D, Buchanan FG, Martin RL, Torrent M, Chiang GG, Karukurichi K, Langston JW, Weinert BT, Choudhary C, de Vries P, Kluge AF, Patane MA, Van Drie JH, Wang C, McElligott D, Kesicki EA, Marmorstein R, Sun C, Cole PA, Rosenberg SH, Michaelides MR, Lai A, Bromberg KD.

Nature. 2018 Jun;558(7710):E1. doi: 10.1038/s41586-018-0111-5.

PMID:
29769713
8.

Wenn Stress Tinnitus verstärkt.

Jakob C.

MMW Fortschr Med. 2018 Apr;160(7):65. doi: 10.1007/s15006-018-0440-1. German. No abstract available.

PMID:
29663199
9.

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, Faivre E, Ferguson D, Buchanan FG, Martin RL, Torrent M, Chiang GG, Karukurichi K, Langston JW, Weinert BT, Choudhary C, de Vries P, Van Drie JH, McElligott D, Kesicki E, Marmorstein R, Sun C, Cole PA, Rosenberg SH, Michaelides MR, Lai A, Bromberg KD.

Nature. 2017 Oct 5;550(7674):128-132. doi: 10.1038/nature24028. Epub 2017 Sep 27. Erratum in: Nature. 2018 May 16;:.

10.

Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM, Cheng D, Klinge KL, Li HQ, Pliushchev M, Algire MA, Maag D, Guo J, Dietrich J, Panchal SC, Petros AM, Sweis RF, Torrent M, Bigelow LJ, Senisterra G, Li F, Kennedy S, Wu Q, Osterling DJ, Lindley DJ, Gao W, Galasinski S, Barsyte-Lovejoy D, Vedadi M, Buchanan FG, Arrowsmith CH, Chiang GG, Sun C, Pappano WN.

Nat Chem Biol. 2017 Jul 18;13(8):922. doi: 10.1038/nchembio0817-922b. No abstract available.

PMID:
28853738
11.

Analysis of hematopoietic recovery after autologous transplantation as method of quality control for long-term progenitor cell cryopreservation.

Pavlů J, Auner HW, Szydlo RM, Sevillano B, Palani R, O'Boyle F, Chaidos A, Jakob C, Kanfer E, MacDonald D, Milojkovic D, Rahemtulla A, Bradshaw A, Olavarria E, Apperley JF, Pello OM.

Bone Marrow Transplant. 2017 Dec;52(12):1599-1601. doi: 10.1038/bmt.2017.113. Epub 2017 Jun 26.

12.

Verhindern Sie „Aufklärungsschäden“!

Jakob C.

MMW Fortschr Med. 2017 Jun;159(11):20. doi: 10.1007/s15006-017-9765-4. German. No abstract available.

PMID:
28608094
13.

Wann muss der obstipierte Patient unter’s Messer?

Jakob C.

MMW Fortschr Med. 2017 Apr;159(7):18. doi: 10.1007/s15006-017-9513-9. German. No abstract available.

PMID:
28417404
14.

Depressions-Therapie leicht gemacht.

Jakob C.

MMW Fortschr Med. 2017 Mar;159(4):16. doi: 10.1007/s15006-017-9308-z. German. No abstract available.

PMID:
28265945
15.

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.

Curtin ML, Pliushchev MA, Li HQ, Torrent M, Dietrich JD, Jakob CG, Zhu H, Zhao H, Wang Y, Ji Z, Clark RF, Sarris KA, Selvaraju S, Shaw B, Algire MA, He Y, Richardson PL, Sweis RF, Sun C, Chiang GG, Michaelides MR.

Bioorg Med Chem Lett. 2017 Apr 1;27(7):1576-1583. doi: 10.1016/j.bmcl.2017.02.030. Epub 2017 Feb 20.

PMID:
28254486
16.

Climate research must sharpen its view.

Marotzke J, Jakob C, Bony S, Dirmeyer PA, O'Gorman PA, Hawkins E, Perkins-Kirkpatrick S, Nowicki S, Paulavets K, Seneviratne SI, Stevens B, Tuma M.

Nat Clim Chang. 2017 Feb;7(2):89-91. doi: 10.1038/nclimate3206. Epub 2017 Jan 16.

17.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM, Cheng D, Klinge KL, Li HQ, Pliushchev M, Algire MA, Maag D, Guo J, Dietrich J, Panchal SC, Petros AM, Sweis RF, Torrent M, Bigelow LJ, Senisterra G, Li F, Kennedy S, Wu Q, Osterling DJ, Lindley DJ, Gao W, Galasinski S, Barsyte-Lovejoy D, Vedadi M, Buchanan FG, Arrowsmith CH, Chiang GG, Sun C, Pappano WN.

Nat Chem Biol. 2017 Apr;13(4):389-395. doi: 10.1038/nchembio.2306. Epub 2017 Jan 30. Erratum in: Nat Chem Biol. 2017 Jul 18;13(8):922.

PMID:
28135237
18.

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.

Bromberg KD, Mitchell TR, Upadhyay AK, Jakob CG, Jhala MA, Comess KM, Lasko LM, Li C, Tuzon CT, Dai Y, Li F, Eram MS, Nuber A, Soni NB, Manaves V, Algire MA, Sweis RF, Torrent M, Schotta G, Sun C, Michaelides MR, Shoemaker AR, Arrowsmith CH, Brown PJ, Santhakumar V, Martin A, Rice JC, Chiang GG, Vedadi M, Barsyte-Lovejoy D, Pappano WN.

Nat Chem Biol. 2017 Mar;13(3):317-324. doi: 10.1038/nchembio.2282. Epub 2017 Jan 23.

PMID:
28114273
19.

Mammalian-target of rapamycin inhibition with temsirolimus in myelodysplastic syndromes (MDS) patients is associated with considerable toxicity: results of the temsirolimus pilot trial by the German MDS Study Group (D-MDS).

Wermke M, Schuster C, Nolte F, Al-Ali HK, Kiewe P, Schönefeldt C, Jakob C, von Bonin M, Hentschel L, Klut IM, Ehninger G, Bornhäuser M, Baretton G, Germing U, Herbst R, Haase D, Hofmann WK, Platzbecker U.

Br J Haematol. 2016 Dec;175(5):917-924. doi: 10.1111/bjh.14345. Epub 2016 Oct 7.

PMID:
27714772
20.

SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.

Schlicher L, Wissler M, Preiss F, Brauns-Schubert P, Jakob C, Dumit V, Borner C, Dengjel J, Maurer U.

EMBO Rep. 2016 Oct;17(10):1485-1497. Epub 2016 Jul 25.

21.

A novel four-dimensional analytical approach for analysis of complex samples.

Stephan S, Jakob C, Hippler J, Schmitz OJ.

Anal Bioanal Chem. 2016 May;408(14):3751-9. doi: 10.1007/s00216-016-9460-9. Epub 2016 Apr 1.

PMID:
27038056
22.

[The man without brain. Biopathological studies about dysgenesis of central nervous system in the man].

Jakob C.

Vertex. 2015 Jan;XXVI(119):68-71. Spanish. No abstract available.

PMID:
26480278
23.

[The man without a brain. Pathobiological dysgenesis studies of the human central nervous system].

Jakob C.

Vertex. 2015 Jan-Feb;26(119):68-71. Spanish. No abstract available.

PMID:
26323117
24.

[Specific Self-Efficacy for Modifying Sexual Interest in Children (SSIC): Construction and Validation of a Measuring Instrument].

Tozdan S, Jakob C, Schuhmann P, Budde M, Briken P.

Psychother Psychosom Med Psychol. 2015 Sep;65(9-10):345-52. doi: 10.1055/s-0035-1548842. Epub 2015 Jun 25. German.

PMID:
26110457
25.

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.

Sweis RF, Wang Z, Algire M, Arrowsmith CH, Brown PJ, Chiang GG, Guo J, Jakob CG, Kennedy S, Li F, Maag D, Shaw B, Soni NB, Vedadi M, Pappano WN.

ACS Med Chem Lett. 2015 Apr 29;6(6):695-700. doi: 10.1021/acsmedchemlett.5b00124. eCollection 2015 Jun 11.

26.

Increases in tropical rainfall driven by changes in frequency of organized deep convection.

Tan J, Jakob C, Rossow WB, Tselioudis G.

Nature. 2015 Mar 26;519(7544):451-4. doi: 10.1038/nature14339.

PMID:
25810207
27.

Practical considerations in comprehensive two-dimensional liquid chromatography systems (LCxLC) with reversed-phases in both dimensions.

Li D, Jakob C, Schmitz O.

Anal Bioanal Chem. 2015 Jan;407(1):153-67. doi: 10.1007/s00216-014-8179-8. Epub 2014 Oct 14.

PMID:
25311191
28.

Unusual relapse of an angioimmunoblastic T cell lymphoma 11 years after initial manifestation.

Lohneis P, Jakob C, Hummel M, Jöhrens K, Anagnostopoulos I.

Ann Hematol. 2015 Feb;94(2):347-9. doi: 10.1007/s00277-014-2129-6. Epub 2014 Jun 13. No abstract available.

PMID:
24923452
29.

Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development.

Mamlouk S, Kalucka J, Singh RP, Franke K, Muschter A, Langer A, Jakob C, Gassmann M, Baretton GB, Wielockx B.

Int J Cancer. 2014 Feb 15;134(4):849-58. doi: 10.1002/ijc.28409. Epub 2013 Aug 29.

30.

The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen.

Correia I, Sung J, Burton R, Jakob CG, Carragher B, Ghayur T, Radziejewski C.

MAbs. 2013 May-Jun;5(3):364-72. doi: 10.4161/mabs.24258. Epub 2013 Apr 9.

31.

Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig™) molecule.

Jakob CG, Edalji R, Judge RA, DiGiammarino E, Li Y, Gu J, Ghayur T.

MAbs. 2013 May-Jun;5(3):358-63. doi: 10.4161/mabs.23977. Epub 2013 Apr 2.

32.

The histone demethylase UTX regulates stem cell migration and hematopoiesis.

Thieme S, Gyárfás T, Richter C, Özhan G, Fu J, Alexopoulou D, Muders MH, Michalk I, Jakob C, Dahl A, Klink B, Bandola J, Bachmann M, Schröck E, Buchholz F, Stewart AF, Weidinger G, Anastassiadis K, Brenner S.

Blood. 2013 Mar 28;121(13):2462-73. doi: 10.1182/blood-2012-08-452003. Epub 2013 Jan 30.

PMID:
23365460
33.

Semi-automatic catheter reconstruction from two views.

Hoffmann M, Brost A, Jakob C, Bourier F, Koch M, Kurzidim K, Hornegger J, Strobel N.

Med Image Comput Comput Assist Interv. 2012;15(Pt 2):584-91.

PMID:
23286096
34.

Impact of the adaptor protein GIPC1/Synectin on radioresistance and survival after irradiation of prostate cancer.

Singer A, Deuse Y, Koch U, Hölscher T, Pfitzmann D, Jakob C, Hehlgans S, Baretton GB, Rentsch A, Baumann M, Muders MH, Krause M.

Strahlenther Onkol. 2012 Dec;188(12):1125-32. doi: 10.1007/s00066-012-0228-7. Epub 2012 Nov 7.

PMID:
23128896
35.

Eltrombopag fails to improve severe thrombocytopenia in late-stage dyskeratosis congenita and diamond-blackfan-anaemia.

Trautmann K, Jakob C, von Grünhagen U, Schleyer E, Brümmendorf TH, Siegert G, Ehninger G, Platzbecker U.

Thromb Haemost. 2012 Aug;108(2):397-8. doi: 10.1160/TH12-02-0121. Epub 2012 Jun 28. No abstract available.

PMID:
22739569
36.

Lymphangiogenesis in regional lymph nodes is an independent prognostic marker in rectal cancer patients after neoadjuvant treatment.

Jakob C, Aust DE, Liebscher B, Baretton GB, Datta K, Muders MH.

PLoS One. 2011;6(11):e27402. doi: 10.1371/journal.pone.0027402. Epub 2011 Nov 7.

37.

Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design.

Digiammarino EL, Harlan JE, Walter KA, Ladror US, Edalji RP, Hutchins CW, Lake MR, Greischar AJ, Liu J, Ghayur T, Jakob CG.

MAbs. 2011 Sep-Oct;3(5):487-94. doi: 10.4161/mabs.3.5.16326. Epub 2011 Sep 1.

38.

Role of meprins to protect ileal mucosa of Crohn's disease patients from colonization by adherent-invasive E. coli.

Vazeille E, Bringer MA, Gardarin A, Chambon C, Becker-Pauly C, Pender SL, Jakob C, Müller S, Lottaz D, Darfeuille-Michaud A.

PLoS One. 2011;6(6):e21199. doi: 10.1371/journal.pone.0021199. Epub 2011 Jun 16.

39.

Intimal pulmonary artery sarcoma presenting as severe dyspnea and right heart insufficiency.

Halank M, Jakob C, Kolditz M, Hoeffken G, Kappert U, Ehninger G, Weise M.

Onkologie. 2010;33(6):313-6. doi: 10.1159/000313861. Epub 2010 May 11.

PMID:
20523095
40.

Coexistence of diploid and triploid hybrid water frogs: population differences persist in the apparent absence of differential survival.

Christiansen DG, Jakob C, Arioli M, Roethlisberger S, Reyer HU.

BMC Ecol. 2010 May 27;10:14. doi: 10.1186/1472-6785-10-14.

41.

Genetic diversity in water frog hybrids (Pelophylax esculentus) varies with population structure and geographic location.

Arioli M, Jakob C, Reyer HU.

Mol Ecol. 2010 May;19(9):1814-28. doi: 10.1111/j.1365-294X.2010.04603.x. Epub 2010 Apr 6.

PMID:
20374490
42.

BSc2118 is a novel proteasome inhibitor with activity against multiple myeloma.

Sterz J, Jakob C, Kuckelkorn U, Heider U, Mieth M, Kleeberg L, Kaiser M, Kloetzel PM, Sezer O, von Metzler I.

Eur J Haematol. 2010 Aug;85(2):99-107. doi: 10.1111/j.1600-0609.2010.01450.x. Epub 2010 Mar 31.

PMID:
20374272
43.

Serum levels of total-RANKL in multiple myeloma.

Jakob C, Goerke A, Terpos E, Sterz J, Heider U, Kühnhardt D, Ziefle S, Kleeberg L, Mieth M, Metzler Iv, Müller C, Sezer O.

Clin Lymphoma Myeloma. 2009 Dec;9(6):430-5. doi: 10.3816/CLM.2009.n.085.

PMID:
19951882
44.

Detection of renal impairment as one specific comorbidity factor in multiple myeloma: multicenter study in 198 consecutive patients.

Kleber M, Ihorst G, Deschler B, Jakob C, Liebisch P, Koch B, Sezer O, Engelhardt M.

Eur J Haematol. 2009 Dec 1;83(6):519-27. doi: 10.1111/j.1600-0609.2009.01318.x. Epub 2009 Jul 14.

PMID:
19614956
45.

Synergistic interaction of proteasome and topoisomerase II inhibition in multiple myeloma.

von Metzler I, Heider U, Mieth M, Lamottke B, Kaiser M, Jakob C, Sezer O.

Exp Cell Res. 2009 Aug 15;315(14):2471-8. doi: 10.1016/j.yexcr.2009.04.019. Epub 2009 May 3.

PMID:
19410573
46.

Novel renal replacement strategies for the elimination of serum free light chains in patients with kappa light chain nephropathy.

Kleeberg L, Morgera S, Jakob C, Hocher B, Schneider M, Peters H, Rötzer S, Müller C, Kaiser M, Fleissner C, Heider U, Neumayer HH, Sezer O.

Eur J Med Res. 2009;14:47-54.

47.

Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum.

Clerc S, Hirsch C, Oggier DM, Deprez P, Jakob C, Sommer T, Aebi M.

J Cell Biol. 2009 Jan 12;184(1):159-72. doi: 10.1083/jcb.200809198. Epub 2009 Jan 5.

48.

Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment.

Heider U, Kaiser M, Mieth M, Lamottke B, Rademacher J, Jakob C, Braendle E, Stover D, Sezer O.

Eur J Haematol. 2009 Jan;82(1):31-8. doi: 10.1111/j.1600-0609.2008.01164.x. Epub 2008 Nov 10.

PMID:
19067746
49.

Curcumin diminishes human osteoclastogenesis by inhibition of the signalosome-associated I kappaB kinase.

von Metzler I, Krebbel H, Kuckelkorn U, Heider U, Jakob C, Kaiser M, Fleissner C, Terpos E, Sezer O.

J Cancer Res Clin Oncol. 2009 Feb;135(2):173-9. doi: 10.1007/s00432-008-0461-8. Epub 2008 Sep 3.

PMID:
18766375
50.

Thymidylate synthase genotypes and tumour regression in stage II/III rectal cancer patients after neoadjuvant fluorouracil-based chemoradiation.

Stoehlmacher J, Goekkurt E, Mogck U, Aust DE, Kramer M, Baretton GB, Liersch T, Ehninger G, Jakob C.

Cancer Lett. 2008 Dec 18;272(2):221-5. doi: 10.1016/j.canlet.2008.07.008. Epub 2008 Aug 21.

PMID:
18722050

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