Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 280


Scalable, semi-automated fluorescence reduction neutralization assay for qualitative assessment of Ebola virus-neutralizing antibodies in human clinical samples.

Postnikova EN, Pettitt J, Van Ryn CJ, Holbrook MR, Bollinger L, Yú S, Caì Y, Liang J, Sneller MC, Jahrling PB, Hensley LE, Kuhn JH, Fallah MP, Bennett RS, Reilly C.

PLoS One. 2019 Aug 27;14(8):e0221407. doi: 10.1371/journal.pone.0221407. eCollection 2019.


Inhibition of Ebola Virus by a Molecularly Engineered Banana Lectin.

Covés-Datson EM, Dyall J, DeWald LE, King SR, Dube D, Legendre M, Nelson E, Drews KC, Gross R, Gerhardt DM, Torzewski L, Postnikova E, Liang JY, Ban B, Shetty J, Hensley LE, Jahrling PB, Olinger GG Jr, White JM, Markovitz DM.

PLoS Negl Trop Dis. 2019 Jul 29;13(7):e0007595. doi: 10.1371/journal.pntd.0007595. eCollection 2019 Jul.


Peripheral immune response in the African green monkey model following Nipah-Malaysia virus exposure by intermediate-size particle aerosol.

Lara A, Cong Y, Jahrling PB, Mednikov M, Postnikova E, Yu S, Munster V, Holbrook MR.

PLoS Negl Trop Dis. 2019 Jun 5;13(6):e0007454. doi: 10.1371/journal.pntd.0007454. eCollection 2019 Jun.


Ebola Virus Isolation Using Huh-7 Cells has Methodological Advantages and Similar Sensitivity to Isolation Using Other Cell Types and Suckling BALB/c Laboratory Mice.

Logue J, Vargas Licona W, Cooper TK, Reeder B, Byrum R, Qin J, Deiuliis Murphy N, Cong Y, Bonilla A, Sword J, Weaver W, Kocher G, Olinger GG, Jahrling PB, Hensley LE, Bennett RS.

Viruses. 2019 Feb 16;11(2). pii: E161. doi: 10.3390/v11020161.


Clinical Characterization of Host Response to Simian Hemorrhagic Fever Virus Infection in Permissive and Refractory Hosts: A Model for Determining Mechanisms of VHF Pathogenesis.

Cornish JP, Moore IN, Perry DL, Lara A, Minai M, Promeneur D, Hagen KR, Virtaneva K, Paneru M, Buechler CR, O'Connor DH, Bailey AL, Cooper K, Mazur S, Bernbaum JG, Pettitt J, Jahrling PB, Kuhn JH, Johnson RF.

Viruses. 2019 Jan 15;11(1). pii: E67. doi: 10.3390/v11010067.


The Human Sodium Iodide Symporter as a Reporter Gene for Studying Middle East Respiratory Syndrome Coronavirus Pathogenesis.

Chefer S, Seidel J, Cockrell AS, Yount B, Solomon J, Hagen KR, Liu DX, Huzella LM, Kumar MR, Postnikova E, Bohannon JK, Lackemeyer MG, Cooper K, Endlich-Frazier A, Sharma H, Thomasson D, Bartos C, Sayre PJ, Sims A, Dyall J, Holbrook MR, Jahrling PB, Baric RS, Johnson RF.

mSphere. 2018 Dec 12;3(6). pii: e00540-18. doi: 10.1128/mSphere.00540-18.


Ebola virus, but not Marburg virus, replicates efficiently and without required adaptation in snake cells.

Fedewa G, Radoshitzky SR, Chī X, Dǒng L, Zeng X, Spear M, Strauli N, Ng M, Chandran K, Stenglein MD, Hernandez RD, Jahrling PB, Kuhn JH, DeRisi JL.

Virus Evol. 2018 Nov 28;4(2):vey034. doi: 10.1093/ve/vey034. eCollection 2018 Jul.


Persistence of Lassa Virus Associated With Severe Systemic Arteritis in Convalescing Guinea Pigs (Cavia porcellus).

Liu DX, Perry DL, DeWald LE, Cai Y, Hagen KR, Cooper TK, Huzella LM, Hart R, Bonilla A, Bernbaum JG, Janosko KB, Adams R, Johnson RF, Kuhn JH, Schnell MJ, Crozier I, Jahrling PB, de la Torre JC.

J Infect Dis. 2019 May 5;219(11):1818-1822. doi: 10.1093/infdis/jiy641.


Recombinant Lassa Virus Expressing Green Fluorescent Protein as a Tool for High-Throughput Drug Screens and Neutralizing Antibody Assays.

Caì Y, Iwasaki M, Beitzel BF, Yú S, Postnikova EN, Cubitt B, DeWald LE, Radoshitzky SR, Bollinger L, Jahrling PB, Palacios GF, de la Torre JC, Kuhn JH.

Viruses. 2018 Nov 20;10(11). pii: E655. doi: 10.3390/v10110655.


Aerosol exposure to intermediate size Nipah virus particles induces neurological disease in African green monkeys.

Hammoud DA, Lentz MR, Lara A, Bohannon JK, Feuerstein I, Huzella L, Jahrling PB, Lackemeyer M, Laux J, Rojas O, Sayre P, Solomon J, Cong Y, Munster V, Holbrook MR.

PLoS Negl Trop Dis. 2018 Nov 21;12(11):e0006978. doi: 10.1371/journal.pntd.0006978. eCollection 2018 Nov.


Non-neutralizing antibodies elicited by recombinant Lassa-Rabies vaccine are critical for protection against Lassa fever.

Abreu-Mota T, Hagen KR, Cooper K, Jahrling PB, Tan G, Wirblich C, Johnson RF, Schnell MJ.

Nat Commun. 2018 Oct 11;9(1):4223. doi: 10.1038/s41467-018-06741-w.


Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells.

Tamhankar M, Gerhardt DM, Bennett RS, Murphy N, Jahrling PB, Patterson JL.

Virol J. 2018 Aug 31;15(1):135. doi: 10.1186/s12985-018-1045-0.


New Insights Into Marburg Virus Disease Pathogenesis in the Rhesus Macaque Model.

Cooper TK, Sword J, Johnson JC, Bonilla A, Hart R, Liu DX, Bernbaum JG, Cooper K, Jahrling PB, Hensley LE.

J Infect Dis. 2018 Nov 22;218(suppl_5):S423-S433. doi: 10.1093/infdis/jiy367.


In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus.

Dyall J, Johnson JC, Hart BJ, Postnikova E, Cong Y, Zhou H, Gerhardt DM, Michelotti J, Honko AN, Kern S, DeWald LE, O'Loughlin KG, Green CE, Mirsalis JC, Bennett RS, Olinger GG Jr, Jahrling PB, Hensley LE.

J Infect Dis. 2018 Nov 22;218(suppl_5):S592-S596. doi: 10.1093/infdis/jiy345.


Fully Human Immunoglobulin G From Transchromosomic Bovines Treats Nonhuman Primates Infected With Ebola Virus Makona Isolate.

Luke T, Bennett RS, Gerhardt DM, Burdette T, Postnikova E, Mazur S, Honko AN, Oberlander N, Byrum R, Ragland D, St Claire M, Janosko KB, Smith G, Glenn G, Hooper J, Dye J, Pal S, Bishop-Lilly KA, Hamilton T, Frey K, Bollinger L, Wada J, Wu H, Jiao JA, Olinger GG, Gunn B, Alter G, Khurana S, Hensley LE, Sullivan E, Jahrling PB.

J Infect Dis. 2018 Nov 22;218(suppl_5):S636-S648. doi: 10.1093/infdis/jiy377.


The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease.

DeWald LE, Dyall J, Sword JM, Torzewski L, Zhou H, Postnikova E, Kollins E, Alexander I, Gross R, Cong Y, Gerhardt DM, Johnson RF, Olinger GG Jr, Holbrook MR, Hensley LE, Jahrling PB.

J Infect Dis. 2018 Nov 22;218(suppl_5):S588-S591. doi: 10.1093/infdis/jiy332.


Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures.

Dyall J, Nelson EA, DeWald LE, Guha R, Hart BJ, Zhou H, Postnikova E, Logue J, Vargas WM, Gross R, Michelotti J, Deiuliis N, Bennett RS, Crozier I, Holbrook MR, Morris PJ, Klumpp-Thomas C, McKnight C, Mierzwa T, Shinn P, Glass PJ, Johansen LM, Jahrling PB, Hensley LE, Olinger GG Jr, Thomas C, White JM.

J Infect Dis. 2018 Nov 22;218(suppl_5):S672-S678. doi: 10.1093/infdis/jiy304.


Development of a novel real-time polymerase chain reaction assay for the quantitative detection of Nipah virus replicative viral RNA.

Jensen KS, Adams R, Bennett RS, Bernbaum J, Jahrling PB, Holbrook MR.

PLoS One. 2018 Jun 19;13(6):e0199534. doi: 10.1371/journal.pone.0199534. eCollection 2018.


Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs.

Postnikova E, Cong Y, DeWald LE, Dyall J, Yu S, Hart BJ, Zhou H, Gross R, Logue J, Cai Y, Deiuliis N, Michelotti J, Honko AN, Bennett RS, Holbrook MR, Olinger GG, Hensley LE, Jahrling PB.

PLoS One. 2018 Mar 22;13(3):e0194880. doi: 10.1371/journal.pone.0194880. eCollection 2018.


MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells.

Cong Y, Hart BJ, Gross R, Zhou H, Frieman M, Bollinger L, Wada J, Hensley LE, Jahrling PB, Dyall J, Holbrook MR.

PLoS One. 2018 Mar 22;13(3):e0194868. doi: 10.1371/journal.pone.0194868. eCollection 2018.


Ebola Virus Localization in the Macaque Reproductive Tract during Acute Ebola Virus Disease.

Perry DL, Huzella LM, Bernbaum JG, Holbrook MR, Jahrling PB, Hagen KR, Schnell MJ, Johnson RF.

Am J Pathol. 2018 Mar;188(3):550-558. doi: 10.1016/j.ajpath.2017.11.004. Epub 2018 Feb 14.


Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues in the Ebola virus disease guinea pig model.

Cooper TK, Huzella L, Johnson JC, Rojas O, Yellayi S, Sun MG, Bavari S, Bonilla A, Hart R, Jahrling PB, Kuhn JH, Zeng X.

Sci Rep. 2018 Jan 19;8(1):1250. doi: 10.1038/s41598-018-19638-x.


A VLP-based vaccine provides complete protection against Nipah virus challenge following multiple-dose or single-dose vaccination schedules in a hamster model.

Walpita P, Cong Y, Jahrling PB, Rojas O, Postnikova E, Yu S, Johns L, Holbrook MR.

NPJ Vaccines. 2017 Aug 8;2:21. doi: 10.1038/s41541-017-0023-7. eCollection 2017.


Quantification of regional aerosol deposition patterns as a function of aerodynamic particle size in rhesus macaques using PET/CT imaging.

Dabisch PA, Xu Z, Boydston JA, Solomon J, Bohannon JK, Yeager JJ, Taylor JR, Reeder RJ, Sayre P, Seidel J, Mollura DJ, Hevey MC, Jahrling PB, Lackemeyer MG.

Inhal Toxicol. 2017 Sep;29(11):506-515. doi: 10.1080/08958378.2017.1409848. Epub 2017 Dec 11.


Ebola virus disease: an update on post-exposure prophylaxis.

Fischer WA 2nd, Vetter P, Bausch DG, Burgess T, Davey RT Jr, Fowler R, Hayden FG, Jahrling PB, Kalil AC, Mayers DL, Mehta AK, Uyeki TM, Jacobs M.

Lancet Infect Dis. 2018 Jun;18(6):e183-e192. doi: 10.1016/S1473-3099(17)30677-1. Epub 2017 Nov 15. Review.


Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies.

Dyall J, Gross R, Kindrachuk J, Johnson RF, Olinger GG Jr, Hensley LE, Frieman MB, Jahrling PB.

Drugs. 2017 Dec;77(18):1935-1966. doi: 10.1007/s40265-017-0830-1. Review.


[18F]-Fluorodeoxyglucose Uptake in Lymphoid Tissue Serves as a Predictor of Disease Outcome in the Nonhuman Primate Model of Monkeypox Virus Infection.

Dyall J, Johnson RF, Chefer S, Leyson C, Thomasson D, Seidel J, Ragland DR, Byrum R, Jett C, Cann JA, St Claire M, Jagoda E, Reba RC, Hammoud D, Blaney JE, Jahrling PB.

J Virol. 2017 Oct 13;91(21). pii: e00897-17. doi: 10.1128/JVI.00897-17. Print 2017 Nov 1.


High dose sertraline monotherapy fails to protect rhesus macaques from lethal challenge with Ebola virus Makona.

Honko AN, Johnson JC, Marchand JS, Huzella L, Adams RD, Oberlander N, Torzewski LM, Bennett RS, Hensley LE, Jahrling PB, Olinger GG.

Sci Rep. 2017 Jul 19;7(1):5886. doi: 10.1038/s41598-017-06179-y.


Animal Models of Ebolavirus Infection.

St Claire MC, Ragland DR, Bollinger L, Jahrling PB.

Comp Med. 2017 Jun 1;67(3):253-262. Review.


Nonhuman Primate Models of Ebola Virus Disease.

Bennett RS, Huzella LM, Jahrling PB, Bollinger L, Olinger GG Jr, Hensley LE.

Curr Top Microbiol Immunol. 2017;411:171-193. doi: 10.1007/82_2017_20. Review.


The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection.

Nelson EA, Dyall J, Hoenen T, Barnes AB, Zhou H, Liang JY, Michelotti J, Dewey WH, DeWald LE, Bennett RS, Morris PJ, Guha R, Klumpp-Thomas C, McKnight C, Chen YC, Xu X, Wang A, Hughes E, Martin S, Thomas C, Jahrling PB, Hensley LE, Olinger GG Jr, White JM.

PLoS Negl Trop Dis. 2017 Apr 12;11(4):e0005540. doi: 10.1371/journal.pntd.0005540. eCollection 2017 Apr.


Loss in lung volume and changes in the immune response demonstrate disease progression in African green monkeys infected by small-particle aerosol and intratracheal exposure to Nipah virus.

Cong Y, Lentz MR, Lara A, Alexander I, Bartos C, Bohannon JK, Hammoud D, Huzella L, Jahrling PB, Janosko K, Jett C, Kollins E, Lackemeyer M, Mollura D, Ragland D, Rojas O, Solomon J, Xu Z, Munster V, Holbrook MR.

PLoS Negl Trop Dis. 2017 Apr 7;11(4):e0005532. doi: 10.1371/journal.pntd.0005532. eCollection 2017 Apr.


Interferon-β and Interferon-γ Are Weak Inhibitors of Ebola Virus in Cell-Based Assays.

Dyall J, Hart BJ, Postnikova E, Cong Y, Zhou H, Gerhardt DM, Freeburger D, Michelotti J, Honko AN, DeWald LE, Bennett RS, Olinger GG Jr, Jahrling PB, Hensley LE.

J Infect Dis. 2017 May 1;215(9):1416-1420. doi: 10.1093/infdis/jix134.


Sequence of Reston Virus Isolate AZ-1435, an Ebolavirus Isolate Obtained during the 1989-1990 Reston Virus Epizootic in the United States.

Cornish JP, Diaz L, Ricklefs SM, Kanakabandi K, Sword J, Jahrling PB, Kuhn JH, Porcella SF, Johnson RF.

Genome Announc. 2017 Jan 12;5(2). pii: e01448-16. doi: 10.1128/genomeA.01448-16.


Within-Host Evolution of Simian Arteriviruses in Crab-Eating Macaques.

Moncla LH, Weiler AM, Barry G, Weinfurter JT, Dinis JM, Charlier O, Lauck M, Bailey AL, Wahl-Jensen V, Nelson CW, Johnson JC, Caì Y, Goldberg TL, O'Connor DH, Jahrling PB, Kuhn JH, Friedrich TC.

J Virol. 2017 Jan 31;91(4). pii: e02231-16. doi: 10.1128/JVI.02231-16. Print 2017 Feb 15.


Comparison of respiratory inductive plethysmography versus head-out plethysmography for anesthetized nonhuman primates in an animal biosafety level 4 facility.

Bohannon JK, Honko AN, Reeder RJ, Cooper K, Byrum R, Bollinger L, Kuhn JH, Wada J, Qin J, Jahrling PB, Lackemeyer MG.

Inhal Toxicol. 2016 Dec;28(14):670-676. Epub 2016 Dec 5.


Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus.

Cong Y, Dyall J, Hart BJ, DeWald LE, Johnson JC, Postnikova E, Zhou H, Gross R, Rojas O, Alexander I, Josleyn N, Zhang T, Michelotti J, Janosko K, Glass PJ, Flint M, McMullan LK, Spiropoulou CF, Mierzwa T, Guha R, Shinn P, Michael S, Klumpp-Thomas C, McKnight C, Thomas C, Eakin AE, O'Loughlin KG, Green CE, Catz P, Mirsalis JC, Honko AN, Olinger GG Jr, Bennett RS, Holbrook MR, Hensley LE, Jahrling PB.

PLoS One. 2016 Nov 30;11(11):e0166318. doi: 10.1371/journal.pone.0166318. eCollection 2016.


One-Health: a Safe, Efficient, Dual-Use Vaccine for Humans and Animals against Middle East Respiratory Syndrome Coronavirus and Rabies Virus.

Wirblich C, Coleman CM, Kurup D, Abraham TS, Bernbaum JG, Jahrling PB, Hensley LE, Johnson RF, Frieman MB, Schnell MJ.

J Virol. 2017 Jan 3;91(2). pii: e02040-16. doi: 10.1128/JVI.02040-16. Print 2017 Jan 15.


Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 2. General Practices.

Mazur S, Holbrook MR, Burdette T, Joselyn N, Barr J, Pusl D, Bollinger L, Coe L, Jahrling PB, Lackemeyer MG, Wada J, Kuhn JH, Janosko K.

J Vis Exp. 2016 Oct 3;(116). doi: 10.3791/53600.


Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures.

Janosko K, Holbrook MR, Adams R, Barr J, Bollinger L, Newton JT, Ntiforo C, Coe L, Wada J, Pusl D, Jahrling PB, Kuhn JH, Lackemeyer MG.

J Vis Exp. 2016 Oct 3;(116). doi: 10.3791/52317.


Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 4. Medical Imaging Procedures.

Byrum R, Keith L, Bartos C, St Claire M, Lackemeyer MG, Holbrook MR, Janosko K, Barr J, Pusl D, Bollinger L, Wada J, Coe L, Hensley LE, Jahrling PB, Kuhn JH, Lentz MR.

J Vis Exp. 2016 Oct 3;(116). doi: 10.3791/53601.


Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 3. Aerobiology.

Bohannon JK, Janosko K, Holbrook MR, Barr J, Pusl D, Bollinger L, Coe L, Hensley LE, Jahrling PB, Wada J, Kuhn JH, Lackemeyer MG.

J Vis Exp. 2016 Oct 3;(116). doi: 10.3791/53602.


Overlooking the importance of immunoassays - Authors' reply.

Cnops L, van Griensven J, Honko AN, Bausch DG, Sprecher A, Hill CE, Colebunders R, Johnson JC, Griffiths A, Palacios GF, Kraft CS, Kobinger G, Hewlett A, Norwood DA, Sabeti P, Jahrling PB, Formenty P, Kuhn JH, Ariën KK.

Lancet Infect Dis. 2016 Oct;16(10):1110. doi: 10.1016/S1473-3099(16)30339-5. Epub 2016 Sep 19. No abstract available.


An Inactivated Rabies Virus-Based Ebola Vaccine, FILORAB1, Adjuvanted With Glucopyranosyl Lipid A in Stable Emulsion Confers Complete Protection in Nonhuman Primate Challenge Models.

Johnson RF, Kurup D, Hagen KR, Fisher C, Keshwara R, Papaneri A, Perry DL, Cooper K, Jahrling PB, Wang JT, Ter Meulen J, Wirblich C, Schnell MJ.

J Infect Dis. 2016 Oct 15;214(suppl 3):S342-S354. Epub 2016 Jul 24.


Reduced evolutionary rate in reemerged Ebola virus transmission chains.

Blackley DJ, Wiley MR, Ladner JT, Fallah M, Lo T, Gilbert ML, Gregory C, D'ambrozio J, Coulter S, Mate S, Balogun Z, Kugelman J, Nwachukwu W, Prieto K, Yeiah A, Amegashie F, Kearney B, Wisniewski M, Saindon J, Schroth G, Fakoli L, Diclaro JW 2nd, Kuhn JH, Hensley LE, Jahrling PB, Ströher U, Nichol ST, Massaquoi M, Kateh F, Clement P, Gasasira A, Bolay F, Monroe SS, Rambaut A, Sanchez-Lockhart M, Scott Laney A, Nyenswah T, Christie A, Palacios G.

Sci Adv. 2016 Apr 29;2(4):e1600378. doi: 10.1126/sciadv.1600378. eCollection 2016 Apr.


Essentials of filoviral load quantification.

Cnops L, van Griensven J, Honko AN, Bausch DG, Sprecher A, Hill CE, Colebunders R, Johnson JC, Griffiths A, Palacios GF, Kraft CS, Kobinger G, Hewlett A, Norwood DA, Sabeti P, Jahrling PB, Formenty P, Kuhn JH, Ariën KK.

Lancet Infect Dis. 2016 Jul;16(7):e134-e138. doi: 10.1016/S1473-3099(16)30063-9. Epub 2016 Jun 10. Review.


Genomic Characterization of the Genus Nairovirus (Family Bunyaviridae).

Kuhn JH, Wiley MR, Rodriguez SE, Bào Y, Prieto K, Travassos da Rosa AP, Guzman H, Savji N, Ladner JT, Tesh RB, Wada J, Jahrling PB, Bente DA, Palacios G.

Viruses. 2016 Jun 10;8(6). pii: E164. doi: 10.3390/v8060164.


Neglected filoviruses.

Burk R, Bollinger L, Johnson JC, Wada J, Radoshitzky SR, Palacios G, Bavari S, Jahrling PB, Kuhn JH.

FEMS Microbiol Rev. 2016 Jul;40(4):494-519. doi: 10.1093/femsre/fuw010. Epub 2016 Jun 5. Review.


Development, Evaluation, and Integration of a Quantitative Reverse-Transcription Polymerase Chain Reaction Diagnostic Test for Ebola Virus on a Molecular Diagnostics Platform.

Cnops L, Van den Eede P, Pettitt J, Heyndrickx L, De Smet B, Coppens S, Andries I, Pattery T, Van Hove L, Meersseman G, Van Den Herrewegen S, Vergauwe N, Thijs R, Jahrling PB, Nauwelaers D, Ariën KK.

J Infect Dis. 2016 Oct 15;214(suppl 3):S192-S202. Epub 2016 May 30.


Characterization of Yellow Fever Virus Infection of Human and Non-human Primate Antigen Presenting Cells and Their Interaction with CD4+ T Cells.

Cong Y, McArthur MA, Cohen M, Jahrling PB, Janosko KB, Josleyn N, Kang K, Zhang T, Holbrook MR.

PLoS Negl Trop Dis. 2016 May 18;10(5):e0004709. doi: 10.1371/journal.pntd.0004709. eCollection 2016 May.

Supplemental Content

Loading ...
Support Center