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Follicle-stimulating hormone and luteinizing hormone increase Ca2+ in the granulosa cells of mouse ovarian follicles†.

Egbert JR, Fahey PG, Reimer J, Owen CM, Evsikov AV, Nikolaev VO, Griesbeck O, Ray RS, Tolias AS, Jaffe LA.

Biol Reprod. 2019 Aug 1;101(2):433-444. doi: 10.1093/biolre/ioz085.


The fast block to polyspermy: New insight into a century-old problem.

Jaffe LA.

J Gen Physiol. 2018 Sep 3;150(9):1233-1234. doi: 10.1085/jgp.201812145. Epub 2018 Aug 6. No abstract available.


Multiple cAMP Phosphodiesterases Act Together to Prevent Premature Oocyte Meiosis and Ovulation.

Vigone G, Shuhaibar LC, Egbert JR, Uliasz TF, Movsesian MA, Jaffe LA.

Endocrinology. 2018 May 1;159(5):2142-2152. doi: 10.1210/en.2018-00017.


Shedding light on spawning in jellyfish.

Jaffe LA.

Elife. 2018 Jan 22;7. pii: e34258. doi: 10.7554/eLife.34258.


Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor.

Shuhaibar LC, Robinson JW, Vigone G, Shuhaibar NP, Egbert JR, Baena V, Uliasz TF, Kaback D, Yee SP, Feil R, Fisher MC, Dealy CN, Potter LR, Jaffe LA.

Elife. 2017 Dec 4;6. pii: e31343. doi: 10.7554/eLife.31343.


Dephosphorylation is the mechanism of fibroblast growth factor inhibition of guanylyl cyclase-B.

Robinson JW, Egbert JR, Davydova J, Schmidt H, Jaffe LA, Potter LR.

Cell Signal. 2017 Dec;40:222-229. doi: 10.1016/j.cellsig.2017.09.021. Epub 2017 Sep 28.


Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle.

Jaffe LA, Egbert JR.

Annu Rev Physiol. 2017 Feb 10;79:237-260. doi: 10.1146/annurev-physiol-022516-034102. Epub 2016 Nov 14. Review.


Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis.

Egbert JR, Uliasz TF, Shuhaibar LC, Geerts A, Wunder F, Kleiman RJ, Humphrey JM, Lampe PD, Artemyev NO, Rybalkin SD, Beavo JA, Movsesian MA, Jaffe LA.

Biol Reprod. 2016 May;94(5):110. doi: 10.1095/biolreprod.115.135897. Epub 2016 Mar 23.


Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone.

Shuhaibar LC, Egbert JR, Edmund AB, Uliasz TF, Dickey DM, Yee SP, Potter LR, Jaffe LA.

Dev Biol. 2016 Jan 1;409(1):194-201. doi: 10.1016/j.ydbio.2015.10.025. Epub 2015 Oct 30.


Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles.

Shuhaibar LC, Egbert JR, Norris RP, Lampe PD, Nikolaev VO, Thunemann M, Wen L, Feil R, Jaffe LA.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5527-32. doi: 10.1073/pnas.1423598112. Epub 2015 Mar 16.


Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.

Egbert JR, Shuhaibar LC, Edmund AB, Van Helden DA, Robinson JW, Uliasz TF, Baena V, Geerts A, Wunder F, Potter LR, Jaffe LA.

Development. 2014 Sep;141(18):3594-604. doi: 10.1242/dev.112219.


Hormonal coordination of natriuretic peptide type C and natriuretic peptide receptor 3 expression in mouse granulosa cells.

Lee KB, Zhang M, Sugiura K, Wigglesworth K, Uliasz T, Jaffe LA, Eppig JJ.

Biol Reprod. 2013 Feb 21;88(2):42. doi: 10.1095/biolreprod.112.104810. Print 2013 Feb.


Luteinizing hormone reduces the activity of the NPR2 guanylyl cyclase in mouse ovarian follicles, contributing to the cyclic GMP decrease that promotes resumption of meiosis in oocytes.

Robinson JW, Zhang M, Shuhaibar LC, Norris RP, Geerts A, Wunder F, Eppig JJ, Potter LR, Jaffe LA.

Dev Biol. 2012 Jun 15;366(2):308-16. doi: 10.1016/j.ydbio.2012.04.019. Epub 2012 Apr 21.


Voltage sensitive phosphoinositide phosphatases of Xenopus: their tissue distribution and voltage dependence.

Ratzan WJ, Evsikov AV, Okamura Y, Jaffe LA.

J Cell Physiol. 2011 Nov;226(11):2740-6. doi: 10.1002/jcp.22854.


Epidermal growth factor receptor kinase activity is required for gap junction closure and for part of the decrease in ovarian follicle cGMP in response to LH.

Norris RP, Freudzon M, Nikolaev VO, Jaffe LA.

Reproduction. 2010 Nov;140(5):655-62. doi: 10.1530/REP-10-0288. Epub 2010 Sep 8.


Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte.

Norris RP, Ratzan WJ, Freudzon M, Mehlmann LM, Krall J, Movsesian MA, Wang H, Ke H, Nikolaev VO, Jaffe LA.

Development. 2009 Jun;136(11):1869-78. doi: 10.1242/dev.035238.


Microinjection of follicle-enclosed mouse oocytes.

Jaffe LA, Norris RP, Freudzon M, Ratzan WJ, Mehlmann LM.

Methods Mol Biol. 2009;518:157-73. doi: 10.1007/978-1-59745-202-1_12.


Luteinizing hormone causes MAP kinase-dependent phosphorylation and closure of connexin 43 gap junctions in mouse ovarian follicles: one of two paths to meiotic resumption.

Norris RP, Freudzon M, Mehlmann LM, Cowan AE, Simon AM, Paul DL, Lampe PD, Jaffe LA.

Development. 2008 Oct;135(19):3229-38. doi: 10.1242/dev.025494.


A G(s)-linked receptor maintains meiotic arrest in mouse oocytes, but luteinizing hormone does not cause meiotic resumption by terminating receptor-G(s) signaling.

Norris RP, Freudzon L, Freudzon M, Hand AR, Mehlmann LM, Jaffe LA.

Dev Biol. 2007 Oct 15;310(2):240-9. Epub 2007 Jul 24.


Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte.

Mehlmann LM, Kalinowski RR, Ross LF, Parlow AF, Hewlett EL, Jaffe LA.

Dev Biol. 2006 Nov 15;299(2):345-55. Epub 2006 Aug 5.


Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein.

Freudzon L, Norris RP, Hand AR, Tanaka S, Saeki Y, Jones TL, Rasenick MM, Berlot CH, Mehlmann LM, Jaffe LA.

J Cell Biol. 2005 Oct 24;171(2):255-65.


The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes.

Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA.

Science. 2004 Dec 10;306(5703):1947-50.


Labeling of cell membranes and compartments for live cell fluorescence microscopy.

Terasaki M, Jaffe LA.

Methods Cell Biol. 2004;74:469-89. Review. No abstract available.


Quantitative microinjection of oocytes, eggs, and embryos.

Jaffe LA, Terasaki M.

Methods Cell Biol. 2004;74:219-42. Review. No abstract available.


Maintenance of meiotic prophase arrest in vertebrate oocytes by a Gs protein-mediated pathway.

Kalinowski RR, Berlot CH, Jones TL, Ross LF, Jaffe LA, Mehlmann LM.

Dev Biol. 2004 Mar 1;267(1):1-13.


Function of a sea urchin egg Src family kinase in initiating Ca2+ release at fertilization.

Giusti AF, O'Neill FJ, Yamasu K, Foltz KR, Jaffe LA.

Dev Biol. 2003 Apr 15;256(2):367-78.


A receptor linked to a Gi-family G-protein functions in initiating oocyte maturation in starfish but not frogs.

Kalinowski RR, Jaffe LA, Foltz KR, Giusti AF.

Dev Biol. 2003 Jan 1;253(1):139-49.


Meiotic arrest in the mouse follicle maintained by a Gs protein in the oocyte.

Mehlmann LM, Jones TL, Jaffe LA.

Science. 2002 Aug 23;297(5585):1343-5.


Egg activation at fertilization: where it all begins.

Runft LL, Jaffe LA, Mehlmann LM.

Dev Biol. 2002 May 15;245(2):237-54. Review.


Evidence that phospholipase C from the sperm is not responsible for initiating Ca(2+) release at fertilization in mouse eggs.

Mehlmann LM, Chattopadhyay A, Carpenter G, Jaffe LA.

Dev Biol. 2001 Aug 15;236(2):492-501.


The role of Src family kinases in starfish egg fertilisation.

Giusti AF, Foltz KR, Jaffe LA.

Zygote. 2000;8 Suppl 1:S16-7. Review. No abstract available.


Ca2+ signalling during fertilization of echinoderm eggs.

Jaffe LA, Giusti AF, Carroll DJ, Foltz KR.

Semin Cell Dev Biol. 2001 Feb;12(1):45-51. Review.


Evidence that fertilization activates starfish eggs by sequential activation of a Src-like kinase and phospholipase cgamma.

Giusti AF, Xu W, Hinkle B, Terasaki M, Jaffe LA.

J Biol Chem. 2000 Jun 2;275(22):16788-94.


Requirement of a Src family kinase for initiating calcium release at fertilization in starfish eggs.

Giusti AF, Carroll DJ, Abassi YA, Terasaki M, Foltz KR, Jaffe LA.

J Biol Chem. 1999 Oct 8;274(41):29318-22.


Identification of PLCgamma-dependent and -independent events during fertilization of sea urchin eggs.

Carroll DJ, Albay DT, Terasaki M, Jaffe LA, Foltz KR.

Dev Biol. 1999 Feb 15;206(2):232-47.


Evidence that Gq family G proteins do not function in mouse egg activation at fertilization.

Williams CJ, Mehlmann LM, Jaffe LA, Kopf GS, Schultz RM.

Dev Biol. 1998 Jun 1;198(1):116-27.


Calcium release at fertilization in starfish eggs is mediated by phospholipase Cgamma.

Carroll DJ, Ramarao CS, Mehlmann LM, Roche S, Terasaki M, Jaffe LA.

J Cell Biol. 1997 Sep 22;138(6):1303-11.


Proteases stimulate fertilization-like responses in starfish eggs.

Carroll DJ, Jaffe LA.

Dev Biol. 1995 Aug;170(2):690-700.


Reorganization of the endoplasmic reticulum during meiotic maturation of the mouse oocyte.

Mehlmann LM, Terasaki M, Jaffe LA, Kline D.

Dev Biol. 1995 Aug;170(2):607-15.


Evidence for both tyrosine kinase and G-protein-coupled pathways leading to starfish egg activation.

Shilling FM, Carroll DJ, Muslin AJ, Escobedo JA, Williams LT, Jaffe LA.

Dev Biol. 1994 Apr;162(2):590-9.


Oocyte maturation in starfish is mediated by the beta gamma-subunit complex of a G-protein.

Jaffe LA, Gallo CJ, Lee RH, Ho YK, Jones TL.

J Cell Biol. 1993 May;121(4):775-83.

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