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Items: 1 to 50 of 65

1.

Endothelial Mineralocorticoid Receptors Contribute to Vascular Inflammation in Atherosclerosis in a Sex-Specific Manner.

Moss ME, Lu Q, Iyer SL, Engelbertsen D, Marzolla V, Caprio M, Lichtman AH, Jaffe IZ.

Arterioscler Thromb Vasc Biol. 2019 Jul 11:ATVBAHA119312954. doi: 10.1161/ATVBAHA.119.312954. [Epub ahead of print]

PMID:
31294624
2.

The Endothelial Mineralocorticoid Receptor: Contributions to Sex Differences in Cardiovascular Disease.

Moss ME, Carvajal B, Jaffe IZ.

Pharmacol Ther. 2019 Jul 1. pii: S0163-7258(19)30118-4. doi: 10.1016/j.pharmthera.2019.06.009. [Epub ahead of print] Review.

PMID:
31271793
3.

Diet-Induced Obesity Promotes Kidney Endothelial Stiffening and Fibrosis Dependent on the Endothelial Mineralocorticoid Receptor.

Aroor AR, Habibi J, Nistala R, Ramirez-Perez FI, Martinez-Lemus LA, Jaffe IZ, Sowers JR, Jia G, Whaley-Connell A.

Hypertension. 2019 Apr;73(4):849-858. doi: 10.1161/HYPERTENSIONAHA.118.12198.

PMID:
30827147
4.

Sex differences in mechanisms of arterial stiffness.

DuPont JJ, Kenney RM, Patel AR, Jaffe IZ.

Br J Pharmacol. 2019 Feb 14. doi: 10.1111/bph.14624. [Epub ahead of print] Review.

PMID:
30767200
5.

Vascular Mineralocorticoid Receptor: Evolutionary Mediator of Wound Healing Turned Harmful by Our Modern Lifestyle.

Biwer LA, Wallingford MC, Jaffe IZ.

Am J Hypertens. 2019 Jan 15;32(2):123-134. doi: 10.1093/ajh/hpy158.

PMID:
30380007
6.

Left Ventricular Unloading Before Reperfusion Promotes Functional Recovery After Acute Myocardial Infarction.

Esposito ML, Zhang Y, Qiao X, Reyelt L, Paruchuri V, Schnitzler GR, Morine KJ, Annamalai SK, Bogins C, Natov PS, Pedicini R, Breton C, Mullin A, Mackey EE, Patel A, Rowin E, Jaffe IZ, Karas RH, Kapur NK.

J Am Coll Cardiol. 2018 Jul 31;72(5):501-514. doi: 10.1016/j.jacc.2018.05.034.

PMID:
30049311
7.

No Significant Role for Smooth Muscle Cell Mineralocorticoid Receptors in Atherosclerosis in the Apolipoprotein-E Knockout Mouse Model.

Moss ME, DuPont JJ, Iyer SL, McGraw AP, Jaffe IZ.

Front Cardiovasc Med. 2018 Jul 9;5:81. doi: 10.3389/fcvm.2018.00081. eCollection 2018.

8.

A phosphoproteomic signature in endothelial cells predicts vascular toxicity of tyrosine kinase inhibitors used in CML.

Gopal S, Lu Q, Man JJ, Baur W, Rao SP, Litichevskiy L, Papanastasiou M, Creech AL, DeRuff KC, Mullahoo J, Officer A, Egri SB, Davison D, Jaffe JD, Jaffe IZ.

Blood Adv. 2018 Jul 24;2(14):1680-1684. doi: 10.1182/bloodadvances.2018020396. No abstract available.

9.

New roles of aldosterone and mineralocorticoid receptors in cardiovascular disease: translational and sex-specific effects.

Davel AP, Jaffe IZ, Tostes RC, Jaisser F, Belin de Chantemèle EJ.

Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H989-H999. doi: 10.1152/ajpheart.00073.2018. Epub 2018 Jun 29.

PMID:
29957022
10.

Response by Good et al to Letter Regarding Article, "Pannexin-1 Channels as an Unexpected New Target of the Antihypertensive Drug Spironolactone".

Good ME, Chiu YH, Poon IKH, Jaffe IZ, Bayliss DA, Isakson BE, Ravichandran KS.

Circ Res. 2018 May 25;122(11):e88-e89. doi: 10.1161/CIRCRESAHA.118.313080. No abstract available.

11.

Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II.

Shukri MZ, Tan JW, Manosroi W, Pojoga LH, Rivera A, Williams JS, Seely EW, Adler GK, Jaffe IZ, Karas RH, Williams GH, Romero JR.

Hypertension. 2018 Jun;71(6):1083-1090. doi: 10.1161/HYPERTENSIONAHA.117.11087. Epub 2018 Apr 23.

12.

Effect of Spironolactone on Myocardial Fibrosis and Other Clinical Variables in Patients with Hypertrophic Cardiomyopathy.

Maron MS, Chan RH, Kapur NK, Jaffe IZ, McGraw AP, Kerur R, Maron BJ, Udelson JE.

Am J Med. 2018 Jul;131(7):837-841. doi: 10.1016/j.amjmed.2018.02.025. Epub 2018 Mar 28.

PMID:
29604289
13.

Smooth Muscle Cell-Mineralocorticoid Receptor as a Mediator of Cardiovascular Stiffness With Aging.

Kim SK, McCurley AT, DuPont JJ, Aronovitz M, Moss ME, Stillman IE, Karumanchi SA, Christou DD, Jaffe IZ.

Hypertension. 2018 Apr;71(4):609-621. doi: 10.1161/HYPERTENSIONAHA.117.10437. Epub 2018 Feb 20.

14.

Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors.

Davel AP, Lu Q, Moss ME, Rao S, Anwar IJ, DuPont JJ, Jaffe IZ.

J Am Heart Assoc. 2018 Feb 16;7(4). pii: e007675. doi: 10.1161/JAHA.117.007675.

15.

Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone.

Good ME, Chiu YH, Poon IKH, Medina CB, Butcher JT, Mendu SK, DeLalio LJ, Lohman AW, Leitinger N, Barrett E, Lorenz UM, Desai BN, Jaffe IZ, Bayliss DA, Isakson BE, Ravichandran KS.

Circ Res. 2018 Feb 16;122(4):606-615. doi: 10.1161/CIRCRESAHA.117.312380. Epub 2017 Dec 13.

16.

Endothelial Mineralocorticoid Receptor Mediates Parenchymal Arteriole and Posterior Cerebral Artery Remodeling During Angiotensin II-Induced Hypertension.

Diaz-Otero JM, Fisher C, Downs K, Moss ME, Jaffe IZ, Jackson WF, Dorrance AM.

Hypertension. 2017 Dec;70(6):1113-1121. doi: 10.1161/HYPERTENSIONAHA.117.09598. Epub 2017 Oct 3.

17.

Short-Term Administration of Serelaxin Produces Predominantly Vascular Benefits in the Angiotensin II/L-NAME Chronic Heart Failure Model.

McCarthy JC, Aronovitz M, DuPont JJ, Calamaras TD, Jaffe IZ, Blanton RM.

JACC Basic Transl Sci. 2017 Jun 26;2(3):285-296. doi: 10.1016/j.jacbts.2017.03.011. eCollection 2017 Jun.

18.

Endothelial mineralocorticoid receptor contributes to systolic dysfunction induced by pressure overload without modulating cardiac hypertrophy or inflammation.

Salvador AM, Moss ME, Aronovitz M, Mueller KB, Blanton RM, Jaffe IZ, Alcaide P.

Physiol Rep. 2017 Jun;5(12). pii: e13313. doi: 10.14814/phy2.13313.

19.

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The role of the mineralocorticoid receptor in the vasculature.

DuPont JJ, Jaffe IZ.

J Endocrinol. 2017 Jul;234(1):T67-T82. doi: 10.1530/JOE-17-0009. Review.

20.

Essential role of ICAM-1 in aldosterone-induced atherosclerosis.

Marzolla V, Armani A, Mammi C, Moss ME, Pagliarini V, Pontecorvo L, Antelmi A, Fabbri A, Rosano G, Jaffe IZ, Caprio M.

Int J Cardiol. 2017 Apr 1;232:233-242. doi: 10.1016/j.ijcard.2017.01.013. Epub 2017 Jan 5.

21.

The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease.

Davel AP, Anwar IJ, Jaffe IZ.

Curr Opin Nephrol Hypertens. 2017 Mar;26(2):97-104. doi: 10.1097/MNH.0000000000000306. Review.

22.

Unliganded estrogen receptor alpha regulates vascular cell function and gene expression.

Lu Q, Schnitzler GR, Vallaster CS, Ueda K, Erdkamp S, Briggs CE, Iyer LK, Jaffe IZ, Karas RH.

Mol Cell Endocrinol. 2017 Feb 15;442:12-23. doi: 10.1016/j.mce.2016.11.019. Epub 2016 Nov 22.

PMID:
27888004
23.

Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging.

DuPont JJ, McCurley A, Davel AP, McCarthy J, Bender SB, Hong K, Yang Y, Yoo JK, Aronovitz M, Baur WE, Christou DD, Hill MA, Jaffe IZ.

JCI Insight. 2016 Sep 8;1(14):e88942. doi: 10.1172/jci.insight.88942.

24.

Molecular mechanisms for vascular complications of targeted cancer therapies.

Gopal S, Miller KB, Jaffe IZ.

Clin Sci (Lond). 2016 Oct 1;130(20):1763-79. doi: 10.1042/CS20160246. Review.

PMID:
27612952
25.

Spironolactone Prevents Endothelial Nitric Oxide Synthase Uncoupling and Vascular Dysfunction Induced by β-Adrenergic Overstimulation: Role of Perivascular Adipose Tissue.

Victorio JA, Clerici SP, Palacios R, Alonso MJ, Vassallo DV, Jaffe IZ, Rossoni LV, Davel AP.

Hypertension. 2016 Sep;68(3):726-35. doi: 10.1161/HYPERTENSIONAHA.116.07911. Epub 2016 Jul 18.

26.

Gene expression in term placentas is regulated more by spinal or epidural anesthesia than by late-onset preeclampsia or gestational diabetes mellitus.

Lekva T, Lyle R, Roland MC, Friis C, Bianchi DW, Jaffe IZ, Norwitz ER, Bollerslev J, Henriksen T, Ueland T.

Sci Rep. 2016 Jul 11;6:29715. doi: 10.1038/srep29715.

27.

Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia.

Burke SD, Zsengellér ZK, Khankin EV, Lo AS, Rajakumar A, DuPont JJ, McCurley A, Moss ME, Zhang D, Clark CD, Wang A, Seely EW, Kang PM, Stillman IE, Jaffe IZ, Karumanchi SA.

J Clin Invest. 2016 Jul 1;126(7):2561-74. doi: 10.1172/JCI83918. Epub 2016 Jun 6.

28.

Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload-Induced Heart Failure.

Salvador AM, Nevers T, Velázquez F, Aronovitz M, Wang B, Abadía Molina A, Jaffe IZ, Karas RH, Blanton RM, Alcaide P.

J Am Heart Assoc. 2016 Mar 15;5(3):e003126. doi: 10.1161/JAHA.115.003126.

29.

Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in Females.

Jia G, Habibi J, Aroor AR, Martinez-Lemus LA, DeMarco VG, Ramirez-Perez FI, Sun Z, Hayden MR, Meininger GA, Mueller KB, Jaffe IZ, Sowers JR.

Circ Res. 2016 Mar 18;118(6):935-943. doi: 10.1161/CIRCRESAHA.115.308269. Epub 2016 Feb 15.

30.

Acute effect of mineralocorticoid receptor antagonism on vascular function in healthy older adults.

Hwang MH, Yoo JK, Luttrell M, Kim HK, Meade TH, English M, Talcott S, Jaffe IZ, Christou DD.

Exp Gerontol. 2016 Jan;73:86-94. doi: 10.1016/j.exger.2015.11.017. Epub 2015 Nov 27.

31.

Mineralocorticoid Receptors in the Pathophysiology of Vascular Inflammation and Atherosclerosis.

Moss ME, Jaffe IZ.

Front Endocrinol (Lausanne). 2015 Sep 28;6:153. doi: 10.3389/fendo.2015.00153. eCollection 2015. Review.

32.

Endothelial Mineralocorticoid Receptor Deletion Prevents Diet-Induced Cardiac Diastolic Dysfunction in Females.

Jia G, Habibi J, DeMarco VG, Martinez-Lemus LA, Ma L, Whaley-Connell AT, Aroor AR, Domeier TL, Zhu Y, Meininger GA, Mueller KB, Jaffe IZ, Sowers JR.

Hypertension. 2015 Dec;66(6):1159-1167. doi: 10.1161/HYPERTENSIONAHA.115.06015. Epub 2015 Oct 5.

33.

Deletion of mineralocorticoid receptors in smooth muscle cells blunts renal vascular resistance following acute cyclosporine administration.

Amador CA, Bertocchio JP, Andre-Gregoire G, Placier S, Duong Van Huyen JP, El Moghrabi S, Berger S, Warnock DG, Chatziantoniou C, Jaffe IZ, Rieu P, Jaisser F.

Kidney Int. 2016 Feb;89(2):354-62.

34.

Endothelial Mineralocorticoid Receptors Differentially Contribute to Coronary and Mesenteric Vascular Function Without Modulating Blood Pressure.

Mueller KB, Bender SB, Hong K, Yang Y, Aronovitz M, Jaisser F, Hill MA, Jaffe IZ.

Hypertension. 2015 Nov;66(5):988-97. doi: 10.1161/HYPERTENSIONAHA.115.06172. Epub 2015 Sep 8.

35.

Exposure to experimental preeclampsia in mice enhances the vascular response to future injury.

Pruthi D, Khankin EV, Blanton RM, Aronovitz M, Burke SD, McCurley A, Karumanchi SA, Jaffe IZ.

Hypertension. 2015 Apr;65(4):863-70. doi: 10.1161/HYPERTENSIONAHA.114.04971. Epub 2015 Feb 23.

36.

Mineralocorticoid receptor antagonism treats obesity-associated cardiac diastolic dysfunction.

Bender SB, DeMarco VG, Padilla J, Jenkins NT, Habibi J, Garro M, Pulakat L, Aroor AR, Jaffe IZ, Sowers JR.

Hypertension. 2015 May;65(5):1082-8. doi: 10.1161/HYPERTENSIONAHA.114.04912. Epub 2015 Feb 23.

37.

Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function.

Barrett Mueller K, Lu Q, Mohammad NN, Luu V, McCurley A, Williams GH, Adler GK, Karas RH, Jaffe IZ.

Endocrinology. 2014 Nov;155(11):4461-72. doi: 10.1210/en.2014-1270. Epub 2014 Jul 22.

38.

Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload.

Kapur NK, Qiao X, Paruchuri V, Mackey EE, Daly GH, Ughreja K, Morine KJ, Levine J, Aronovitz MJ, Hill NS, Jaffe IZ, Letarte M, Karas RH.

J Am Heart Assoc. 2014 Jul 11;3(4). pii: e000965. doi: 10.1161/JAHA.114.000965. Erratum in: J Am Heart Assoc. 2014 Aug;3(4):e000419. Ughreja, Kesahn [Corrected to Ughreja, Kishan].

39.

Mineralocorticoid receptors in immune cells: emerging role in cardiovascular disease.

Bene NC, Alcaide P, Wortis HH, Jaffe IZ.

Steroids. 2014 Dec;91:38-45. doi: 10.1016/j.steroids.2014.04.005. Epub 2014 Apr 21. Review.

40.

Direct role for smooth muscle cell mineralocorticoid receptors in vascular remodeling: novel mechanisms and clinical implications.

Koenig JB, Jaffe IZ.

Curr Hypertens Rep. 2014 May;16(5):427. doi: 10.1007/s11906-014-0427-y. Review.

41.

Endothelial cell mineralocorticoid receptors: turning cardiovascular risk factors into cardiovascular dysfunction.

Jaffe IZ, Jaisser F.

Hypertension. 2014 May;63(5):915-7. doi: 10.1161/HYPERTENSIONAHA.114.01997. Epub 2014 Feb 24. No abstract available.

42.

Pre-eclampsia and cardiovascular disease.

Chen CW, Jaffe IZ, Karumanchi SA.

Cardiovasc Res. 2014 Mar 15;101(4):579-86. doi: 10.1093/cvr/cvu018. Epub 2014 Feb 13. Review.

43.

Aldosterone and vascular mineralocorticoid receptors: regulators of ion channels beyond the kidney.

DuPont JJ, Hill MA, Bender SB, Jaisser F, Jaffe IZ.

Hypertension. 2014 Apr;63(4):632-7. doi: 10.1161/HYPERTENSIONAHA.113.01273. Epub 2013 Dec 30. Review. No abstract available.

44.

Hydrogen sulfide attenuates sFlt1-induced hypertension and renal damage by upregulating vascular endothelial growth factor.

Holwerda KM, Burke SD, Faas MM, Zsengeller Z, Stillman IE, Kang PM, van Goor H, McCurley A, Jaffe IZ, Karumanchi SA, Lely AT.

J Am Soc Nephrol. 2014 Apr;25(4):717-25. doi: 10.1681/ASN.2013030291. Epub 2013 Dec 12.

45.

Aldosterone promotes vascular remodeling by direct effects on smooth muscle cell mineralocorticoid receptors.

Pruthi D, McCurley A, Aronovitz M, Galayda C, Karumanchi SA, Jaffe IZ.

Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):355-64. doi: 10.1161/ATVBAHA.113.302854. Epub 2013 Dec 5.

46.

Smooth muscle cell mineralocorticoid receptors are mandatory for aldosterone-salt to induce vascular stiffness.

Galmiche G, Pizard A, Gueret A, El Moghrabi S, Ouvrard-Pascaud A, Berger S, Challande P, Jaffe IZ, Labat C, Lacolley P, Jaisser F.

Hypertension. 2014 Mar;63(3):520-526. doi: 10.1161/HYPERTENSIONAHA.113.01967. Epub 2013 Dec 2.

47.

Mineralocorticoid receptors in vascular disease: connecting molecular pathways to clinical implications.

McGraw AP, McCurley A, Preston IR, Jaffe IZ.

Curr Atheroscler Rep. 2013 Jul;15(7):340. doi: 10.1007/s11883-013-0340-x. Review.

48.

Direct contribution of vascular mineralocorticoid receptors to blood pressure regulation.

Barrett KV, McCurley AT, Jaffe IZ.

Clin Exp Pharmacol Physiol. 2013 Dec;40(12):902-9. doi: 10.1111/1440-1681.12125. Review.

49.

Smooth muscle cell mineralocorticoid receptors: role in vascular function and contribution to cardiovascular disease.

McCurley A, McGraw A, Pruthi D, Jaffe IZ.

Pflugers Arch. 2013 Dec;465(12):1661-70. doi: 10.1007/s00424-013-1282-4. Epub 2013 May 1. Review.

50.

Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanism.

McGraw AP, Bagley J, Chen WS, Galayda C, Nickerson H, Armani A, Caprio M, Carmeliet P, Jaffe IZ.

J Am Heart Assoc. 2013 Feb 22;2(1):e000018. doi: 10.1161/JAHA.112.000018.

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