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Genome-wide CRISPR screen for Zika virus resistance in human neural cells.

Li Y, Muffat J, Omer Javed A, Keys HR, Lungjangwa T, Bosch I, Khan M, Virgilio MC, Gehrke L, Sabatini DM, Jaenisch R.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9527-9532. doi: 10.1073/pnas.1900867116. Epub 2019 Apr 24.


Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs.

Pontis J, Planet E, Offner S, Turelli P, Duc J, Coudray A, Theunissen TW, Jaenisch R, Trono D.

Cell Stem Cell. 2019 May 2;24(5):724-735.e5. doi: 10.1016/j.stem.2019.03.012. Epub 2019 Apr 18.


Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.

Schiebinger G, Shu J, Tabaka M, Cleary B, Subramanian V, Solomon A, Gould J, Liu S, Lin S, Berube P, Lee L, Chen J, Brumbaugh J, Rigollet P, Hochedlinger K, Jaenisch R, Regev A, Lander ES.

Cell. 2019 Mar 7;176(6):1517. doi: 10.1016/j.cell.2019.02.026. No abstract available.


Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.

Schiebinger G, Shu J, Tabaka M, Cleary B, Subramanian V, Solomon A, Gould J, Liu S, Lin S, Berube P, Lee L, Chen J, Brumbaugh J, Rigollet P, Hochedlinger K, Jaenisch R, Regev A, Lander ES.

Cell. 2019 Feb 7;176(4):928-943.e22. doi: 10.1016/j.cell.2019.01.006. Epub 2019 Jan 31. Erratum in: Cell. 2019 Mar 7;176(6):1517.


Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D.

Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4.


JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell-derived neural progenitors and cortical neurons.

Roessler R, Goldmann J, Shivalila C, Jaenisch R.

Life Sci Alliance. 2018 Jun 25;1(4):e201800094. doi: 10.26508/lsa.201800094. eCollection 2018 Aug.


Stem Cells, Genome Editing, and the Path to Translational Medicine.

Soldner F, Jaenisch R.

Cell. 2018 Oct 18;175(3):615-632. doi: 10.1016/j.cell.2018.09.010. Review.


Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype.

Omer Javed A, Li Y, Muffat J, Su KC, Cohen MA, Lungjangwa T, Aubourg P, Cheeseman IM, Jaenisch R.

Cell Rep. 2018 Oct 9;25(2):368-382.e5. doi: 10.1016/j.celrep.2018.09.032.


One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation.

Jacobsen JT, Mesin L, Markoulaki S, Schiepers A, Cavazzoni CB, Bousbaine D, Jaenisch R, Victora GD.

J Exp Med. 2018 Oct 1;215(10):2686-2695. doi: 10.1084/jem.20172064. Epub 2018 Sep 4.


Flow-mediated dilation and heart failure: a review with implications to physical rehabilitation.

Areas GPT, Mazzuco A, Caruso FR, Jaenisch RB, Cabiddu R, Phillips SA, Arena R, Borghi-Silva A.

Heart Fail Rev. 2019 Jan;24(1):69-80. doi: 10.1007/s10741-018-9719-7. Review.


Noninvasive Ventilation as an Important Adjunct to an Exercise Training Program in Subjects With Moderate to Severe COPD.

Marrara KT, Di Lorenzo VAP, Jaenisch RB, Cabiddu R, de Oliveira Sato T, Mendes RG, Oliveira CR, Costa D, Borghi-Silva A.

Respir Care. 2018 Nov;63(11):1388-1398. doi: 10.4187/respcare.05763. Epub 2018 Jun 26.


Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections.

Muffat J, Li Y, Omer A, Durbin A, Bosch I, Bakiasi G, Richards E, Meyer A, Gehrke L, Jaenisch R.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7117-7122. doi: 10.1073/pnas.1719266115. Epub 2018 Jun 18.


Building Capacity for a Global Genome Editing Observatory: Institutional Design.

Saha K, Hurlbut JB, Jasanoff S, Ahmed A, Appiah A, Bartholet E, Baylis F, Bennett G, Church G, Cohen IG, Daley G, Finneran K, Hurlbut W, Jaenisch R, Lwoff L, Kimes JP, Mills P, Moses J, Park BS, Parens E, Salzman R, Saxena A, Simmet H, Simoncelli T, Snead OC, Rajan KS, Truog RD, Williams P, Woopen C.

Trends Biotechnol. 2018 Aug;36(8):741-743. doi: 10.1016/j.tibtech.2018.04.008. Epub 2018 Jun 8.


Building Capacity for a Global Genome Editing Observatory: Conceptual Challenges.

Hurlbut JB, Jasanoff S, Saha K, Ahmed A, Appiah A, Bartholet E, Baylis F, Bennett G, Church G, Cohen IG, Daley G, Finneran K, Hurlbut W, Jaenisch R, Lwoff L, Kimes JP, Mills P, Moses J, Park BS, Parens E, Salzman R, Saxena A, Simmet H, Simoncelli T, Snead OC, Rajan KS, Truog RD, Williams P, Woopen C.

Trends Biotechnol. 2018 Jul;36(7):639-641. doi: 10.1016/j.tibtech.2018.04.009. Epub 2018 Jun 2.


Ultra-short-term heart rate variability during resistance exercise in the elderly.

Arêas GPT, Caruso FCR, Simões RP, Castello-Simões V, Jaenisch RB, Sato TO, Cabiddu R, Mendes R, Arena R, Borghi-Silva A.

Braz J Med Biol Res. 2018;51(6):e6962. doi: 10.1590/1414-431x20186962. Epub 2018 May 21.


Matched Developmental Timing of Donor Cells with the Host Is Crucial for Chimera Formation.

Cohen MA, Markoulaki S, Jaenisch R.

Stem Cell Reports. 2018 May 8;10(5):1445-1452. doi: 10.1016/j.stemcr.2018.03.004. Epub 2018 Mar 29.


Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas.

Ma H, Wert KJ, Shvartsman D, Melton DA, Jaenisch R.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3924-3929. doi: 10.1073/pnas.1702059115. Epub 2018 Mar 29.


Cytotoxic Escherichia coli strains encoding colibactin isolated from immunocompromised mice with urosepsis and meningitis.

Bakthavatchalu V, Wert KJ, Feng Y, Mannion A, Ge Z, Garcia A, Scott KE, Caron TJ, Madden CM, Jacobsen JT, Victora G, Jaenisch R, Fox JG.

PLoS One. 2018 Mar 19;13(3):e0194443. doi: 10.1371/journal.pone.0194443. eCollection 2018.


Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene.

Liu XS, Wu H, Krzisch M, Wu X, Graef J, Muffat J, Hnisz D, Li CH, Yuan B, Xu C, Li Y, Vershkov D, Cacace A, Young RA, Jaenisch R.

Cell. 2018 Feb 22;172(5):979-992.e6. doi: 10.1016/j.cell.2018.01.012. Epub 2018 Feb 15.


High-intensity resistance training alone or combined with aerobic training improves strength, heart function and collagen in rats with heart failure.

Alves JP, Nunes RB, Ferreira DDC, Stefani GP, Jaenisch RB, Lago PD.

Am J Transl Res. 2017 Dec 15;9(12):5432-5441. eCollection 2017.


Mechanisms of gene regulation in human embryos and pluripotent stem cells.

Theunissen TW, Jaenisch R.

Development. 2017 Dec 15;144(24):4496-4509. doi: 10.1242/dev.157404. Review.


YY1 Is a Structural Regulator of Enhancer-Promoter Loops.

Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, Young RA.

Cell. 2017 Dec 14;171(7):1573-1588.e28. doi: 10.1016/j.cell.2017.11.008. Epub 2017 Dec 7.


S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models.

Oh CK, Sultan A, Platzer J, Dolatabadi N, Soldner F, McClatchy DB, Diedrich JK, Yates JR 3rd, Ambasudhan R, Nakamura T, Jaenisch R, Lipton SA.

Cell Rep. 2017 Nov 21;21(8):2171-2182. doi: 10.1016/j.celrep.2017.10.068.


Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells.

Semrau S, Goldmann JE, Soumillon M, Mikkelsen TS, Jaenisch R, van Oudenaarden A.

Nat Commun. 2017 Oct 23;8(1):1096. doi: 10.1038/s41467-017-01076-4.


Effects of l-arginine supplementation associated with continuous or interval aerobic training on chronic heart failure rats.

Barcelos GT, Rossato DD, Perini JL, Pinheiro LP, Carvalho C, Jaenisch RB, Rhoden CR, Lago PD, Nunes RB.

Metabolism. 2017 Nov;76:1-10. doi: 10.1016/j.metabol.2017.06.009. Epub 2017 Jul 5.


Human Embryo Editing: Opportunities and Importance of Transnational Cooperation.

Pei D, Beier DW, Levy-Lahad E, Marchant G, Rossant J, Izpisua Belmonte JC, Lovell-Badge R, Jaenisch R, Charo A, Baltimore D.

Cell Stem Cell. 2017 Oct 5;21(4):423-426. doi: 10.1016/j.stem.2017.09.010.


An Endogenously Tagged Fluorescent Fusion Protein Library in Mouse Embryonic Stem Cells.

Harikumar A, Edupuganti RR, Sorek M, Azad GK, Markoulaki S, Sehnalová P, Legartová S, Bártová E, Farkash-Amar S, Jaenisch R, Alon U, Meshorer E.

Stem Cell Reports. 2017 Oct 10;9(4):1304-1314. doi: 10.1016/j.stemcr.2017.08.022. Epub 2017 Sep 28.


Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation.

Edupuganti RR, Harikumar A, Aaronson Y, Biran A, Sailaja BS, Nissim-Rafinia M, Azad GK, Cohen MA, Park JE, Shivalila CS, Markoulaki S, Sze SK, Jaenisch R, Meshorer E.

Stem Cell Reports. 2017 Oct 10;9(4):1291-1303. doi: 10.1016/j.stemcr.2017.08.021. Epub 2017 Sep 28.


Respiratory muscle training decreases diaphragm DNA damage in rats with heart failure.

Jaenisch RB, Stefani GP, Durante C, Chechi C, Hentschke VS, Rossato DD, Sonza A, Rhoden CR, Dal Lago P.

Can J Physiol Pharmacol. 2018 Mar;96(3):221-226. doi: 10.1139/cjpp-2017-0069. Epub 2017 Aug 8.


Exploring Vascular Function Biomarkers: Implications for Rehabilitation.

Phillips SA, Andaku DK, Mendes RG, Caruso FR, Cabiddu R, Jaenisch RB, Arena R, Borghi-Silva A.

Braz J Cardiovasc Surg. 2017 Mar-Apr;32(2):125-135. doi: 10.21470/1678-9741-2016-0085. Review.


Respiratory Muscle Training Improves Diaphragm Citrate Synthase Activity and Hemodynamic Function in Rats with Heart Failure.

Jaenisch RB, Bertagnolli M, Borghi-Silva A, Arena R, Lago PD.

Braz J Cardiovasc Surg. 2017 Mar-Apr;32(2):104-110. doi: 10.21470/1678-9741-2017-0002.


MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling.

Mellios N, Feldman DA, Sheridan SD, Ip JPK, Kwok S, Amoah SK, Rosen B, Rodriguez BA, Crawford B, Swaminathan R, Chou S, Li Y, Ziats M, Ernst C, Jaenisch R, Haggarty SJ, Sur M.

Mol Psychiatry. 2018 Apr;23(4):1051-1065. doi: 10.1038/mp.2017.86. Epub 2017 Apr 25.


SMARCE1 is required for the invasive progression of in situ cancers.

Sokol ES, Feng YX, Jin DX, Tizabi MD, Miller DH, Cohen MA, Sanduja S, Reinhardt F, Pandey J, Superville DA, Jaenisch R, Gupta PB.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4153-4158. doi: 10.1073/pnas.1703931114. Epub 2017 Apr 4.


Respiratory Muscle Training Improves Chemoreflex Response, Heart Rate Variability, and Respiratory Mechanics in Rats With Heart Failure.

Jaenisch RB, Quagliotto E, Chechi C, Calegari L, Dos Santos F, Borghi-Silva A, Dal Lago P.

Can J Cardiol. 2017 Apr;33(4):508-514. doi: 10.1016/j.cjca.2016.11.004. Epub 2016 Nov 11.


Tet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors.

Feng J, Pena CJ, Purushothaman I, Engmann O, Walker D, Brown AN, Issler O, Doyle M, Harrigan E, Mouzon E, Vialou V, Shen L, Dawlaty MM, Jaenisch R, Nestler EJ.

Neuropsychopharmacology. 2017 Jul;42(8):1657-1669. doi: 10.1038/npp.2017.6. Epub 2017 Jan 11.


Induction of Expansion and Folding in Human Cerebral Organoids.

Li Y, Muffat J, Omer A, Bosch I, Lancaster MA, Sur M, Gehrke L, Knoblich JA, Jaenisch R.

Cell Stem Cell. 2017 Mar 2;20(3):385-396.e3. doi: 10.1016/j.stem.2016.11.017. Epub 2016 Dec 29.


Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation.

Sahakyan A, Kim R, Chronis C, Sabri S, Bonora G, Theunissen TW, Kuoy E, Langerman J, Clark AT, Jaenisch R, Plath K.

Cell Stem Cell. 2017 Jan 5;20(1):87-101. doi: 10.1016/j.stem.2016.10.006. Epub 2016 Dec 15.


Stem cells and interspecies chimaeras.

Wu J, Greely HT, Jaenisch R, Nakauchi H, Rossant J, Belmonte JC.

Nature. 2016 Dec 1;540(7631):51-59. doi: 10.1038/nature20573. Review.


Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome.

Banerjee A, Rikhye RV, Breton-Provencher V, Tang X, Li C, Li K, Runyan CA, Fu Z, Jaenisch R, Sur M.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7287-E7296. Epub 2016 Nov 1.


Efficient derivation of microglia-like cells from human pluripotent stem cells.

Muffat J, Li Y, Yuan B, Mitalipova M, Omer A, Corcoran S, Bakiasi G, Tsai LH, Aubourg P, Ransohoff RM, Jaenisch R.

Nat Med. 2016 Nov;22(11):1358-1367. doi: 10.1038/nm.4189. Epub 2016 Sep 26.


CNS disease models with human pluripotent stem cells in the CRISPR age.

Muffat J, Li Y, Jaenisch R.

Curr Opin Cell Biol. 2016 Dec;43:96-103. doi: 10.1016/ Epub 2016 Oct 19. Review.


Editing DNA Methylation in the Mammalian Genome.

Liu XS, Wu H, Ji X, Stelzer Y, Wu X, Czauderna S, Shu J, Dadon D, Young RA, Jaenisch R.

Cell. 2016 Sep 22;167(1):233-247.e17. doi: 10.1016/j.cell.2016.08.056.


Parent-of-Origin DNA Methylation Dynamics during Mouse Development.

Stelzer Y, Wu H, Song Y, Shivalila CS, Markoulaki S, Jaenisch R.

Cell Rep. 2016 Sep 20;16(12):3167-3180. doi: 10.1016/j.celrep.2016.08.066.


Molecular Criteria for Defining the Naive Human Pluripotent State.

Theunissen TW, Friedli M, He Y, Planet E, O'Neil RC, Markoulaki S, Pontis J, Wang H, Iouranova A, Imbeault M, Duc J, Cohen MA, Wert KJ, Castanon R, Zhang Z, Huang Y, Nery JR, Drotar J, Lungjangwa T, Trono D, Ecker JR, Jaenisch R.

Cell Stem Cell. 2016 Oct 6;19(4):502-515. doi: 10.1016/j.stem.2016.06.011. Epub 2016 Jul 14.


Induced Pluripotent Stem Cells Meet Genome Editing.

Hockemeyer D, Jaenisch R.

Cell Stem Cell. 2016 May 5;18(5):573-86. doi: 10.1016/j.stem.2016.04.013. Review.


Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression.

Soldner F, Stelzer Y, Shivalila CS, Abraham BJ, Latourelle JC, Barrasa MI, Goldmann J, Myers RH, Young RA, Jaenisch R.

Nature. 2016 May 5;533(7601):95-9. doi: 10.1038/nature17939. Epub 2016 Apr 20.


Activation of proto-oncogenes by disruption of chromosome neighborhoods.

Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH, Goldmann J, Lajoie BR, Fan ZP, Sigova AA, Reddy J, Borges-Rivera D, Lee TI, Jaenisch R, Porteus MH, Dekker J, Young RA.

Science. 2016 Mar 25;351(6280):1454-1458. doi: 10.1126/science.aad9024. Epub 2016 Mar 3.


Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos.

Cohen MA, Wert KJ, Goldmann J, Markoulaki S, Buganim Y, Fu D, Jaenisch R.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1570-5. doi: 10.1073/pnas.1525518113. Epub 2016 Jan 25.


Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.

Carroll B, Maetzel D, Maddocks OD, Otten G, Ratcliff M, Smith GR, Dunlop EA, Passos JF, Davies OR, Jaenisch R, Tee AR, Sarkar S, Korolchuk VI.

Elife. 2016 Jan 7;5. pii: e11058. doi: 10.7554/eLife.11058.


3D Chromosome Regulatory Landscape of Human Pluripotent Cells.

Ji X, Dadon DB, Powell BE, Fan ZP, Borges-Rivera D, Shachar S, Weintraub AS, Hnisz D, Pegoraro G, Lee TI, Misteli T, Jaenisch R, Young RA.

Cell Stem Cell. 2016 Feb 4;18(2):262-75. doi: 10.1016/j.stem.2015.11.007. Epub 2015 Dec 10.

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