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Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7.

Jaeger K, Bruenle S, Weinert T, Guba W, Muehle J, Miyazaki T, Weber M, Furrer A, Haenggi N, Tetaz T, Huang CY, Mattle D, Vonach JM, Gast A, Kuglstatter A, Rudolph MG, Nogly P, Benz J, Dawson RJP, Standfuss J.

Cell. 2019 Aug 22;178(5):1222-1230.e10. doi: 10.1016/j.cell.2019.07.028.


Genome-wide transcription factor binding in leaves from C3 and C4 grasses.

Burgess SJ, Reyna-Llorens I, Stevenson SR, Singh P, Jaeger K, Hibberd JM.

Plant Cell. 2019 Aug 19. pii: tpc.00078.2019. doi: 10.1105/tpc.19.00078. [Epub ahead of print]


Ternary Complex Formation and Photoactivation of a Photoenzyme Results in Altered Protein Dynamics.

Stadler AM, Schneidewind J, Zamponi M, Knieps-Grünhagen E, Gholami S, Schwaneberg U, Rivalta I, Garavelli M, Davari MD, Jaeger KE, Krauss U.

J Phys Chem B. 2019 Aug 29;123(34):7372-7384. doi: 10.1021/acs.jpcb.9b06608. Epub 2019 Aug 19.


Marine Biosurfactants: Biosynthesis, Structural Diversity and Biotechnological Applications.

Kubicki S, Bollinger A, Katzke N, Jaeger KE, Loeschcke A, Thies S.

Mar Drugs. 2019 Jul 9;17(7). pii: E408. doi: 10.3390/md17070408. Review.


Using the Fragile Families and Child Wellbeing Study (FFCWS) in Life Course Health Development Research.

Geller A, Jaeger K, Pace G.

In: Halfon N, Forrest CB, Lerner RM, Faustman EM, editors. Handbook of Life Course Health Development [Internet]. Cham (CH): Springer; 2018.
2017 Nov 21.


Targeting 16S rDNA for Stable Recombinant Gene Expression in Pseudomonas.

Otto M, Wynands B, Drepper T, Jaeger KE, Thies S, Loeschcke A, Blank LM, Wierckx N.

ACS Synth Biol. 2019 Aug 16;8(8):1901-1912. doi: 10.1021/acssynbio.9b00195. Epub 2019 Jul 23.


LHY2 Integrates Night-Length Information to Determine Timing of Poplar Photoperiodic Growth.

Ramos-Sánchez JM, Triozzi PM, Alique D, Geng F, Gao M, Jaeger KE, Wigge PA, Allona I, Perales M.

Curr Biol. 2019 Jul 22;29(14):2402-2406.e4. doi: 10.1016/j.cub.2019.06.003. Epub 2019 Jun 27.


Protocols for yTREX/Tn5-based gene cluster expression in Pseudomonas putida.

Weihmann R, Domröse A, Drepper T, Jaeger KE, Loeschcke A.

Microb Biotechnol. 2019 Jun 4. doi: 10.1111/1751-7915.13402. [Epub ahead of print]


Properties of cardiac conduction in a cell-based computational model.

Jæger KH, Edwards AG, McCulloch A, Tveito A.

PLoS Comput Biol. 2019 May 31;15(5):e1007042. doi: 10.1371/journal.pcbi.1007042. eCollection 2019 May.


A thermostable flavin-based fluorescent protein from Chloroflexus aggregans: a framework for ultra-high resolution structural studies.

Nazarenko VV, Remeeva A, Yudenko A, Kovalev K, Dubenko A, Goncharov IM, Kuzmichev P, Rogachev AV, Buslaev P, Borshchevskiy V, Mishin A, Dhoke GV, Schwaneberg U, Davari MD, Jaeger KE, Krauss U, Gordeliy V, Gushchin I.

Photochem Photobiol Sci. 2019 Jul 10;18(7):1793-1805. doi: 10.1039/c9pp00067d.


Pseudomonas putida rDNA is a favored site for the expression of biosynthetic genes.

Domröse A, Hage-Hülsmann J, Thies S, Weihmann R, Kruse L, Otto M, Wierckx N, Jaeger KE, Drepper T, Loeschcke A.

Sci Rep. 2019 May 7;9(1):7028. doi: 10.1038/s41598-019-43405-1.


Agar plate-based screening methods for the identification of polyester hydrolysis by Pseudomonas species.

Molitor R, Bollinger A, Kubicki S, Loeschcke A, Jaeger KE, Thies S.

Microb Biotechnol. 2019 Apr 23. doi: 10.1111/1751-7915.13418. [Epub ahead of print]


Interaction of carbohydrate-binding modules with poly(ethylene terephthalate).

Weber J, Petrović D, Strodel B, Smits SHJ, Kolkenbrock S, Leggewie C, Jaeger KE.

Appl Microbiol Biotechnol. 2019 Jun;103(12):4801-4812. doi: 10.1007/s00253-019-09760-9. Epub 2019 Apr 16.


Igni18, a novel metallo-hydrolase from the hyperthermophilic archaeon Ignicoccus hospitalis KIN4/I: cloning, expression, purification and X-ray analysis.

Kobus S, Perez-Garcia P, Hoeppner A, Holzscheck N, Kovacic F, Streit WR, Jaeger KE, Chow J, Smits SHJ.

Acta Crystallogr F Struct Biol Commun. 2019 Apr 1;75(Pt 4):307-311. doi: 10.1107/S2053230X19002851. Epub 2019 Apr 2.


Pseudomonas aeruginosa esterase PA2949, a bacterial homolog of the human membrane esterase ABHD6: expression, purification and crystallization.

Bleffert F, Granzin J, Gohlke H, Batra-Safferling R, Jaeger KE, Kovacic F.

Acta Crystallogr F Struct Biol Commun. 2019 Apr 1;75(Pt 4):270-277. doi: 10.1107/S2053230X19002152. Epub 2019 Apr 2.


Video-assisted thoracic lobectomy versus stereotactic body radiotherapy for stage I nonsmall cell lung cancer in elderly patients: a propensity matched comparative analysis.

Detillon DDEMA, Aarts MJ, De Jaeger K, Van Eijck CHJ, Veen EJ.

Eur Respir J. 2019 Jun 20;53(6). pii: 1801561. doi: 10.1183/13993003.01561-2018. Print 2019 Jun.


Phototrophic purple bacteria as optoacoustic in vivo reporters of macrophage activity.

Peters L, Weidenfeld I, Klemm U, Loeschcke A, Weihmann R, Jaeger KE, Drepper T, Ntziachristos V, Stiel AC.

Nat Commun. 2019 Mar 13;10(1):1191. doi: 10.1038/s41467-019-09081-5.


Tailoring the properties of (catalytically)-active inclusion bodies.

Jäger VD, Kloss R, Grünberger A, Seide S, Hahn D, Karmainski T, Piqueray M, Embruch J, Longerich S, Mackfeld U, Jaeger KE, Wiechert W, Pohl M, Krauss U.

Microb Cell Fact. 2019 Feb 7;18(1):33. doi: 10.1186/s12934-019-1081-5.


How does the presence of neural probes affect extracellular potentials?

Buccino AP, Kuchta M, Jæger KH, Ness TV, Berthet P, Mardal KA, Cauwenberghs G, Tveito A.

J Neural Eng. 2019 Apr;16(2):026030. doi: 10.1088/1741-2552/ab03a1. Epub 2019 Jan 31.


Cornification of nail keratinocytes requires autophagy for bulk degradation of intracellular proteins while sparing components of the cytoskeleton.

Jaeger K, Sukseree S, Zhong S, Phinney BS, Mlitz V, Buchberger M, Narzt MS, Gruber F, Tschachler E, Rice RH, Eckhart L.

Apoptosis. 2019 Feb;24(1-2):62-73. doi: 10.1007/s10495-018-1505-4.


Decoding the ocean's microbiological secrets for marine enzyme biodiscovery.

Ferrer M, Méndez-García C, Bargiela R, Chow J, Alonso S, García-Moyano A, Bjerga GEK, Steen IH, Schwabe T, Blom C, Vester J, Weckbecker A, Shahgaldian P, de Carvalho CCCR, Meskys R, Zanaroli G, Glöckner FO, Fernández-Guerra A, Thambisetty S, de la Calle F, Golyshina OV, Yakimov MM, Jaeger KE, Yakunin AF, Streit WR, McMeel O, Calewaert JB, Tonné N, Golyshin PN; INMARE Consortium.

FEMS Microbiol Lett. 2019 Jan 1;366(1). doi: 10.1093/femsle/fny285.


Directed Evolution Empowered Redesign of Natural Proteins for the Sustainable Production of Chemicals and Pharmaceuticals.

Bornscheuer UT, Hauer B, Jaeger KE, Schwaneberg U.

Angew Chem Int Ed Engl. 2019 Jan 2;58(1):36-40. doi: 10.1002/anie.201812717. Epub 2018 Dec 6. Review.


Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems.

Tveito A, Jæger KH, Huebsch N, Charrez B, Edwards AG, Wall S, Healy KE.

Sci Rep. 2018 Dec 4;8(1):17626. doi: 10.1038/s41598-018-35858-7.


Bioprospecting Reveals Class III ω-Transaminases Converting Bulky Ketones and Environmentally Relevant Polyamines.

Coscolín C, Katzke N, García-Moyano A, Navarro-Fernández J, Almendral D, Martínez-Martínez M, Bollinger A, Bargiela R, Gertler C, Chernikova TN, Rojo D, Barbas C, Tran H, Golyshina OV, Koch R, Yakimov MM, Bjerga GEK, Golyshin PN, Jaeger KE, Ferrer M.

Appl Environ Microbiol. 2019 Jan 9;85(2). pii: e02404-18. doi: 10.1128/AEM.02404-18. Print 2019 Jan 15.


An optogenetic toolbox of LOV-based photosensitizers for light-driven killing of bacteria.

Endres S, Wingen M, Torra J, Ruiz-González R, Polen T, Bosio G, Bitzenhofer NL, Hilgers F, Gensch T, Nonell S, Jaeger KE, Drepper T.

Sci Rep. 2018 Oct 9;8(1):15021. doi: 10.1038/s41598-018-33291-4.


A Synthetic Reaction Cascade Implemented by Colocalization of Two Proteins within Catalytically Active Inclusion Bodies.

Jäger VD, Lamm R, Kloß R, Kaganovitch E, Grünberger A, Pohl M, Büchs J, Jaeger KE, Krauss U.

ACS Synth Biol. 2018 Sep 21;7(9):2282-2295. doi: 10.1021/acssynbio.8b00274. Epub 2018 Aug 20.


Natural biocide cocktails: Combinatorial antibiotic effects of prodigiosin and biosurfactants.

Hage-Hülsmann J, Grünberger A, Thies S, Santiago-Schübel B, Klein AS, Pietruszka J, Binder D, Hilgers F, Domröse A, Drepper T, Kohlheyer D, Jaeger KE, Loeschcke A.

PLoS One. 2018 Jul 19;13(7):e0200940. doi: 10.1371/journal.pone.0200940. eCollection 2018.


Mechanistic Basis of the Fast Dark Recovery of the Short LOV Protein DsLOV from Dinoroseobacter shibae.

Fettweiss T, Röllen K, Granzin J, Reiners O, Endres S, Drepper T, Willbold D, Jaeger KE, Batra-Safferling R, Krauss U.

Biochemistry. 2018 Aug 14;57(32):4833-4847. doi: 10.1021/acs.biochem.8b00645. Epub 2018 Jul 24.


Disruption of microbial community composition and identification of plant growth promoting microorganisms after exposure of soil to rapeseed-derived glucosinolates.

Siebers M, Rohr T, Ventura M, Schütz V, Thies S, Kovacic F, Jaeger KE, Berg M, Dörmann P, Schulz M.

PLoS One. 2018 Jul 3;13(7):e0200160. doi: 10.1371/journal.pone.0200160. eCollection 2018.


The biotechnological potential of marine bacteria in the novel lineage of Pseudomonas pertucinogena.

Bollinger A, Thies S, Katzke N, Jaeger KE.

Microb Biotechnol. 2018 Jun 25. doi: 10.1111/1751-7915.13288. [Epub ahead of print] Review.


Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser.

Nogly P, Weinert T, James D, Carbajo S, Ozerov D, Furrer A, Gashi D, Borin V, Skopintsev P, Jaeger K, Nass K, Båth P, Bosman R, Koglin J, Seaberg M, Lane T, Kekilli D, Brünle S, Tanaka T, Wu W, Milne C, White T, Barty A, Weierstall U, Panneels V, Nango E, Iwata S, Hunter M, Schapiro I, Schertler G, Neutze R, Standfuss J.

Science. 2018 Jul 13;361(6398). pii: eaat0094. doi: 10.1126/science.aat0094. Epub 2018 Jun 14.


Inter-observer variation of hippocampus delineation in hippocampal avoidance prophylactic cranial irradiation.

Bartel F, van Herk M, Vrenken H, Vandaele F, Sunaert S, de Jaeger K, Dollekamp NJ, Carbaat C, Lamers E, Dieleman EMT, Lievens Y, de Ruysscher D, Schagen SB, de Ruiter MB, de Munck JC, Belderbos J.

Clin Transl Oncol. 2019 Feb;21(2):178-186. doi: 10.1007/s12094-018-1903-7. Epub 2018 Jun 6.


Preparation of Cyclic Prodiginines by Mutasynthesis in Pseudomonas putida KT2440.

Klein AS, Brass HUC, Klebl DP, Classen T, Loeschcke A, Drepper T, Sievers S, Jaeger KE, Pietruszka J.

Chembiochem. 2018 May 2. doi: 10.1002/cbic.201800154. [Epub ahead of print]


Impact of brachytherapy technique (2D versus 3D) on outcome following radiotherapy of cervical cancer.

Derks K, Steenhuijsen JLG, van den Berg HA, Houterman S, Cnossen J, van Haaren P, De Jaeger K.

J Contemp Brachytherapy. 2018 Feb;10(1):17-25. doi: 10.5114/jcb.2018.73955. Epub 2018 Feb 22.


Unraveling the effects of amino acid substitutions enhancing lipase resistance to an ionic liquid: a molecular dynamics study.

Zhao J, Frauenkron-Machedjou VJ, Fulton A, Zhu L, Davari MD, Jaeger KE, Schwaneberg U, Bocola M.

Phys Chem Chem Phys. 2018 Apr 4;20(14):9600-9609. doi: 10.1039/c7cp08470f.


Rapid generation of recombinant Pseudomonas putida secondary metabolite producers using yTREX.

Domröse A, Weihmann R, Thies S, Jaeger KE, Drepper T, Loeschcke A.

Synth Syst Biotechnol. 2017 Nov 15;2(4):310-319. doi: 10.1016/j.synbio.2017.11.001. eCollection 2017 Dec.


Chloroplast Signaling Gates Thermotolerance in Arabidopsis.

Dickinson PJ, Kumar M, Martinho C, Yoo SJ, Lan H, Artavanis G, Charoensawan V, Schöttler MA, Bock R, Jaeger KE, Wigge PA.

Cell Rep. 2018 Feb 13;22(7):1657-1665. doi: 10.1016/j.celrep.2018.01.054.


Online measurement of the respiratory activity in shake flasks enables the identification of cultivation phases and patterns indicating recombinant protein production in various Escherichia coli host strains.

Ihling N, Bittner N, Diederichs S, Schelden M, Korona A, Höfler GT, Fulton A, Jaeger KE, Honda K, Ohtake H, Büchs J.

Biotechnol Prog. 2018 Mar;34(2):315-327. doi: 10.1002/btpr.2600. Epub 2018 Jan 17.


Corrigendum: Directionality of substrate translocation of the hemolysin A Type I secretion system.

Lenders MHH, Weidtkamp-Peters S, Kleinschrodt D, Jaeger KE, Smits SHJ, Schmitt L.

Sci Rep. 2018 Jan 8;8:46926. doi: 10.1038/srep46926.


The photosynthetic bacteria Rhodobacter capsulatus and Synechocystis sp. PCC 6803 as new hosts for cyclic plant triterpene biosynthesis.

Loeschcke A, Dienst D, Wewer V, Hage-Hülsmann J, Dietsch M, Kranz-Finger S, Hüren V, Metzger S, Urlacher VB, Gigolashvili T, Kopriva S, Axmann IM, Drepper T, Jaeger KE.

PLoS One. 2017 Dec 27;12(12):e0189816. doi: 10.1371/journal.pone.0189816. eCollection 2017.


Heterologous production of long-chain rhamnolipids from Burkholderia glumae in Pseudomonas putida-a step forward to tailor-made rhamnolipids.

Wittgens A, Santiago-Schuebel B, Henkel M, Tiso T, Blank LM, Hausmann R, Hofmann D, Wilhelm S, Jaeger KE, Rosenau F.

Appl Microbiol Biotechnol. 2018 Feb;102(3):1229-1239. doi: 10.1007/s00253-017-8702-x. Epub 2017 Dec 20.


Interobserver variability in the delineation of the primary lung cancer and lymph nodes on different four-dimensional computed tomography reconstructions.

Mercieca S, Belderbos JSA, De Jaeger K, Schinagl DAX, van der Voort Van Zijp N, Pomp J, Theuws J, Khalifa J, van de Vaart P, van Herk M.

Radiother Oncol. 2018 Feb;126(2):325-332. doi: 10.1016/j.radonc.2017.11.020. Epub 2017 Dec 5.


Fast automated online xylanase activity assay using HPAEC-PAD.

Cürten C, Anders N, Juchem N, Ihling N, Volkenborn K, Knapp A, Jaeger KE, Büchs J, Spiess AC.

Anal Bioanal Chem. 2018 Jan;410(1):57-69. doi: 10.1007/s00216-017-0712-0. Epub 2017 Nov 28.


Determinants and Prediction of Esterase Substrate Promiscuity Patterns.

Martínez-Martínez M, Coscolín C, Santiago G, Chow J, Stogios PJ, Bargiela R, Gertler C, Navarro-Fernández J, Bollinger A, Thies S, Méndez-García C, Popovic A, Brown G, Chernikova TN, García-Moyano A, Bjerga GEK, Pérez-García P, Hai T, Del Pozo MV, Stokke R, Steen IH, Cui H, Xu X, Nocek BP, Alcaide M, Distaso M, Mesa V, Peláez AI, Sánchez J, Buchholz PCF, Pleiss J, Fernández-Guerra A, Glöckner FO, Golyshina OV, Yakimov MM, Savchenko A, Jaeger KE, Yakunin AF, Streit WR, Golyshin PN, Guallar V, Ferrer M, The Inmare Consortium.

ACS Chem Biol. 2018 Jan 19;13(1):225-234. doi: 10.1021/acschembio.7b00996. Epub 2017 Dec 20.


High-Throughput Screening Assays for Lipolytic Enzymes.

Fulton A, Hayes MR, Schwaneberg U, Pietruszka J, Jaeger KE.

Methods Mol Biol. 2018;1685:209-231. doi: 10.1007/978-1-4939-7366-8_12.


Electron transfer pathways in a light, oxygen, voltage (LOV) protein devoid of the photoactive cysteine.

Kopka B, Magerl K, Savitsky A, Davari MD, Röllen K, Bocola M, Dick B, Schwaneberg U, Jaeger KE, Krauss U.

Sci Rep. 2017 Oct 17;7(1):13346. doi: 10.1038/s41598-017-13420-1.


An A/U-Rich Enhancer Region Is Required for High-Level Protein Secretion through the HlyA Type I Secretion System.

Khosa S, Scholz R, Schwarz C, Trilling M, Hengel H, Jaeger KE, Smits SHJ, Schmitt L.

Appl Environ Microbiol. 2017 Dec 15;84(1). pii: e01163-17. doi: 10.1128/AEM.01163-17. Print 2018 Jan 1.


Contribution of single amino acid and codon substitutions to the production and secretion of a lipase by Bacillus subtilis.

Skoczinski P, Volkenborn K, Fulton A, Bhadauriya A, Nutschel C, Gohlke H, Knapp A, Jaeger KE.

Microb Cell Fact. 2017 Sep 25;16(1):160. doi: 10.1186/s12934-017-0772-z.


Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.

Weinert T, Olieric N, Cheng R, Brünle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Doré AS, Geng T, Cooke RM, Liang M, Prota AE, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz MO, Wang M, Standfuss J.

Nat Commun. 2017 Sep 14;8(1):542. doi: 10.1038/s41467-017-00630-4.

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