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Temozolomide induces the expression of the glioma Big Potassium (gBK) ion channel, while inhibiting fascin-1 expression: possible targets for glioma therapy.

Hoa NT, Ge L, Martini F, Chau V, Ahluwalia A, Kruse CA, Jadus MR.

Expert Opin Ther Targets. 2016 Oct;20(10):1155-67. doi: 10.1080/14728222.2016.1208172. Epub 2016 Jul 13.


Changes in tumor-antigen expression profile as human small-cell lung cancers progress.

Ge LS, Hoa NT, Lambrecht N, Dacosta-Iyer M, Ouyang Y, Abolhoda A, Jadus MR.

Cancer Biol Med. 2015 Jun;12(2):96-105. doi: 10.7497/j.issn.2095-3941.2015.0027.


Dynamics of Circulating γδ T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma.

Beck BH, Kim H, O'Brien R, Jadus MR, Gillespie GY, Cloud GA, Hoa NT, Langford CP, Lopez RD, Harkins LE, Lamb LS Jr.

PLoS One. 2015 May 8;10(5):e0122387. doi: 10.1371/journal.pone.0122387. eCollection 2015.


Fascin-1 knock-down of human glioma cells reduces their microvilli/filopodia while improving their susceptibility to lymphocyte-mediated cytotoxicity.

Hoa NT, Ge L, Erickson KL, Kruse CA, Cornforth AN, Kuznetsov Y, McPherson A, Martini F, Jadus MR.

Am J Transl Res. 2015 Feb 15;7(2):271-84. eCollection 2015.


Therapeutic targeting of malignant glioma.

Alexandru-Abrams D, Jadus MR, Hsu FP, Stathopoulos A, Bota DA.

Anticancer Agents Med Chem. 2014;14(8):1075-84. Review.


Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy.

Ge L, Hoa NT, Wilson Z, Arismendi-Morillo G, Kong XT, Tajhya RB, Beeton C, Jadus MR.

Int Immunopharmacol. 2014 Oct;22(2):427-43. doi: 10.1016/j.intimp.2014.06.040. Epub 2014 Jul 12. Review.


HCA519/TPX2: a potential T-cell tumor-associated antigen for human hepatocellular carcinoma.

Aref AM, Hoa NT, Ge L, Agrawal A, Dacosta-Iyer M, Lambrecht N, Ouyang Y, Cornforth AN, Jadus MR.

Onco Targets Ther. 2014 Jun 13;7:1061-70. doi: 10.2147/OTT.S61442. eCollection 2014.


Small cell lung cancer cells express the late stage gBK tumor antigen: a possible immunotarget for the terminal disease.

Hoa NT, Ge L, Tajhya RB, Beeton C, Cornforth AN, Abolhoda A, Lambrecht N, DaCosta-Iyer M, Ouyang Y, Mai AP, Hong E, Shon J, Hickey MJ, Erickson KL, Kruse CA, Jadus MR.

Am J Transl Res. 2014 May 15;6(3):188-205. eCollection 2014.


Indomethacin promotes apoptosis in gastric cancer cells through concomitant degradation of Survivin and Aurora B kinase proteins.

Chiou SK, Hoa N, Hodges A, Ge L, Jadus MR.

Apoptosis. 2014 Sep;19(9):1378-88. doi: 10.1007/s10495-014-1002-3.


Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity.

Hu Y, Ru N, Xiao H, Chaturbedi A, Hoa NT, Tian XJ, Zhang H, Ke C, Yan F, Nelson J, Li Z, Gramer R, Yu L, Siegel E, Zhang X, Jia Z, Jadus MR, Limoli CL, Linskey ME, Xing J, Zhou YH.

PLoS One. 2013 Nov 25;8(11):e80898. doi: 10.1371/journal.pone.0080898. eCollection 2013.


Nutrient availability alters the effect of autophagy on sulindac sulfide-induced colon cancer cell apoptosis.

Chiou SK, Hoa N, Ge L, Jadus MR.

Gastroenterol Res Pract. 2012;2012:897678. doi: 10.1155/2012/897678. Epub 2012 Dec 9.


Mitochondrial network in glioma's invadopodia displays an activated state both in situ and in vitro: potential functional implications.

Arismendi-Morillo G, Hoa NT, Ge L, Jadus MR.

Ultrastruct Pathol. 2012 Dec;36(6):409-14. doi: 10.3109/01913123.2012.694582.


Differential glioma-associated tumor antigen expression profiles of human glioma cells grown in hypoxia.

Ge L, Cornforth AN, Hoa NT, Delgado C, Chiou SK, Zhou YH, Jadus MR.

PLoS One. 2012;7(9):e42661. doi: 10.1371/journal.pone.0042661. Epub 2012 Sep 5.


Lung cancer: a classic example of tumor escape and progression while providing opportunities for immunological intervention.

Jadus MR, Natividad J, Mai A, Ouyang Y, Lambrecht N, Szabo S, Ge L, Hoa N, Dacosta-Iyer MG.

Clin Dev Immunol. 2012;2012:160724. doi: 10.1155/2012/160724. Epub 2012 Jul 29. Review.


Glioma big potassium channel expression in human cancers and possible T cell epitopes for their immunotherapy.

Ge L, Hoa NT, Cornforth AN, Bota DA, Mai A, Kim DI, Chiou SK, Hickey MJ, Kruse CA, Jadus MR.

J Immunol. 2012 Sep 1;189(5):2625-34. doi: 10.4049/jimmunol.1102965. Epub 2012 Jul 27.


Exploring the Therapeutic Efficacy of Glioma Vaccines Based on Allo- and Syngeneic Antigens and Distinct Immunological Costimulation Activators.

Stathopoulos A, Pretto C, Devillers L, Pierre D, Hofman FM, Epstein AL, Farghadani H, Kruse CA, Jadus MR, Chen TC, Schijns VE.

J Clin Cell Immunol. 2012;Suppl 5:004.


Cellular and vaccine therapeutic approaches for gliomas.

Hickey MJ, Malone CC, Erickson KL, Jadus MR, Prins RM, Liau LM, Kruse CA.

J Transl Med. 2010 Oct 14;8:100. doi: 10.1186/1479-5876-8-100. Review.


Glioma cells display complex cell surface topographies that resist the actions of cytolytic effector lymphocytes.

Hoa N, Ge L, Kuznetsov Y, McPherson A, Cornforth AN, Pham JT, Myers MP, Ahmed N, Salsman VS, Lamb LS Jr, Bowersock JE, Hu Y, Zhou YH, Jadus MR.

J Immunol. 2010 Oct 15;185(8):4793-803. doi: 10.4049/jimmunol.1001526. Epub 2010 Sep 20.


Immunotherapy of brain cancers: the past, the present, and future directions.

Ge L, Hoa N, Bota DA, Natividad J, Howat A, Jadus MR.

Clin Dev Immunol. 2010;2010:296453. doi: 10.1155/2010/296453. Epub 2011 Mar 8. Review.


Immunotherapy of pediatric brain tumor patients should include an immunoprevention strategy: a medical hypothesis paper.

Driggers L, Zhang JG, Newcomb EW, Ge L, Hoa N, Jadus MR.

J Neurooncol. 2010 Apr;97(2):159-69. doi: 10.1007/s11060-009-0016-0. Epub 2009 Oct 4. Review.


Cytotoxic T cell immunity against the non-immunogenic, murine, hepatocellular carcinoma Hepa1-6 is directed towards the novel alternative form of macrophage colony stimulating factor.

Ge L, Zhang JG, Samathanam CA, Delgado C, Tarbiyat-Boldaji M, Dan Q, Hoa N, Nguyen TV, Alipanah R, Pham JT, Sanchez R, Wepsic HT, Morgan TR, Jadus MR.

Cell Immunol. 2009;259(2):117-27. doi: 10.1016/j.cellimm.2009.06.008. Epub 2009 Jun 23.


Molecular mechanisms of paraptosis induction: implications for a non-genetically modified tumor vaccine.

Hoa N, Myers MP, Douglass TG, Zhang JG, Delgado C, Driggers L, Callahan LL, VanDeusen G, Pham JT, Bhakta N, Ge L, Jadus MR.

PLoS One. 2009;4(2):e4631. doi: 10.1371/journal.pone.0004631. Epub 2009 Feb 27.


Ginger's (Zingiber officinale Roscoe) inhibition of rat colonic adenocarcinoma cells proliferation and angiogenesis in vitro.

Brown AC, Shah C, Liu J, Pham JT, Zhang JG, Jadus MR.

Phytother Res. 2009 May;23(5):640-5. doi: 10.1002/ptr.2677.


Macrophage colony stimulating factor: not just for macrophages anymore! A gateway into complex biologies.

Douglass TG, Driggers L, Zhang JG, Hoa N, Delgado C, Williams CC, Dan Q, Sanchez R, Jeffes EW, Wepsic HT, Myers MP, Koths K, Jadus MR.

Int Immunopharmacol. 2008 Oct;8(10):1354-76. doi: 10.1016/j.intimp.2008.04.016. Epub 2008 Jun 2. Review.


Tumor antigen precursor protein profiles of adult and pediatric brain tumors identify potential targets for immunotherapy.

Zhang JG, Kruse CA, Driggers L, Hoa N, Wisoff J, Allen JC, Zagzag D, Newcomb EW, Jadus MR.

J Neurooncol. 2008 May;88(1):65-76. doi: 10.1007/s11060-008-9534-4. Epub 2008 Feb 8.


Human allogeneic and murine xenogeneic dendritic cells are cytotoxic to human tumor cells via two distinct pathways.

Schiltz PM, Lee GJ, Zhang JG, Hoa N, Wepsic HT, Dillman RO, Jadus MR.

Cancer Biother Radiopharm. 2007 Oct;22(5):672-83.


Cosegregation of gastrointestinal ulcers and schizophrenia in a large national inpatient discharge database: revisiting the "brain-gut axis" hypothesis in ulcer pathogenesis.

Ozdemir V, Jamal MM, Osapay K, Jadus MR, Sandor Z, Hashemzadeh M, Szabo S.

J Investig Med. 2007 Sep;55(6):315-20. doi: 10.2310/6650.2007.00014.


Generation of human innate immune responses towards membrane macrophage colony stimulating factor (mM-CSF) expressing U251 glioma cells within immunodeficient (NIH-nu/beige/xid) mice.

Delgado C, Hoa N, Callahan LL, Schiltz PM, Jahroudi RA, Zhang JG, Wepsic HT, Jadus MR.

Cytokine. 2007 Jun;38(3):165-76. Epub 2007 Aug 6.


Detection of duodenal ulcer-associated genes in rats.

Deng X, Szabo S, Khomenko T, Jadus MR, Yoshida M, Chen L.

Dig Dis Sci. 2008 Feb;53(2):375-84. Epub 2007 Aug 4.


Human monocytes kill M-CSF-expressing glioma cells by BK channel activation.

Hoa NT, Zhang JG, Delgado CL, Myers MP, Callahan LL, Vandeusen G, Schiltz PM, Wepsic HT, Jadus MR.

Lab Invest. 2007 Feb;87(2):115-29.


Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics.

Zhang JG, Eguchi J, Kruse CA, Gomez GG, Fakhrai H, Schroter S, Ma W, Hoa N, Minev B, Delgado C, Wepsic HT, Okada H, Jadus MR.

Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):566-575. doi: 10.1158/1078-0432.CCR-06-1576.


Suppression of early growth response factor-1 with egr-1 antisense oligodeoxynucleotide aggravates experimental duodenal ulcers.

Khomenko T, Szabo S, Deng X, Jadus MR, Ishikawa H, Osapay K, Sandor Z, Chen L.

Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1211-8. Epub 2006 Feb 16.


The anti-cancer effects of poi (Colocasia esculenta) on colonic adenocarcinoma cells In vitro.

Brown AC, Reitzenstein JE, Liu J, Jadus MR.

Phytother Res. 2005 Sep;19(9):767-71.


Macrophage colony-stimulating factor expression in retrovirally transduced cells is dependent upon both the adherence status of the target cells and its 5' flanking untranslated region.

Zhang JG, Dan Q, Fong TC, Williams CC, Avina MD, Tarbiyat-Boldaji M, Khalaghizadeh S, Irwin M, Nguyen A, Zhuang JL, Hoa N, Wepsic HT, Jadus MR.

Biochem Biophys Res Commun. 2005 May 20;330(4):1275-84.


Antiangiogenic drugs synergize with a membrane macrophage colony-stimulating factor-based tumor vaccine to therapeutically treat rats with an established malignant intracranial glioma.

Jeffes EW, Zhang JG, Hoa N, Petkar A, Delgado C, Chong S, Obenaus A, Sanchez R, Khalaghizadeh S, Khomenko T, Knight BA, Alipanah R, Nguyen TV, Shah C, Vohra S, Zhuang JL, Liu J, Wepsic HT, Jadus MR.

J Immunol. 2005 Mar 1;174(5):2533-43.


Intrapleural injection of transforming growth factor-beta antibody inhibits pleural fibrosis in empyema.

Kunz CR, Jadus MR, Kukes GD, Kramer F, Nguyen VN, Sasse SA.

Chest. 2004 Nov;126(5):1636-44.


Gene therapy with adenoviral plasmids or naked DNA of vascular endothelial growth factor and platelet-derived growth factor accelerates healing of duodenal ulcer in rats.

Deng X, Szabo S, Khomenko T, Jadus MR, Yoshida M.

J Pharmacol Exp Ther. 2004 Dec;311(3):982-8. Epub 2004 Aug 9.


Effect of cysteamine on redox-sensitive thiol-containing proteins in the duodenal mucosa.

Khomenko T, Deng X, Jadus MR, Szabo S.

Biochem Biophys Res Commun. 2003 Oct 3;309(4):910-6.


Pleural fluid transforming growth factor-beta1 correlates with pleural fibrosis in experimental empyema.

Sasse SA, Jadus MR, Kukes GD.

Am J Respir Crit Care Med. 2003 Sep 15;168(6):700-5.


T9 glioma cells expressing membrane-macrophage colony stimulating factor produce CD4+ T cell-associated protective immunity against T9 intracranial gliomas and systemic immunity against different syngeneic gliomas.

Sanchez R, Williams C, Daza JL, Dan Q, Xu Q, Chen Y, Delgado C, Arpajirakul N, Jeffes EW, Kim RC, Douglass T, Al Atar U, Terry Wepsic H, Jadus MR.

Cell Immunol. 2002 Jan;215(1):1-11.


Gene expression and gene therapy in experimental duodenal ulceration.

Szabo S, Deng X, Khomenko T, Yoshida M, Jadus MR, Sandor Z, Gombos Z, Matsumoto H.

J Physiol Paris. 2001 Jan-Dec;95(1-6):325-35. Review.


Membrane macrophage colony-stimulating factor on MADB106 breast cancer cells does not activate cytotoxic macrophages but immunizes rats against breast cancer.

Williams CC, Trinh H, Tran TV, Dan Q, Sanchez R, Delgado C, Chen Y, Sippel B, Jeffes EW, Wepsic HT, Jadus MR.

Mol Ther. 2001 Feb;3(2):216-24.


Review article: transcription factors and growth factors in ulcer healing.

Szabo S, Khomenko T, Gombos Z, Deng XM, Jadus MR, Yoshida M.

Aliment Pharmacol Ther. 2000 Apr;14 Suppl 1:33-43. Review.


Macrophages kill T9 glioma tumor cells bearing the membrane isoform of macrophage colony stimulating factor through a phagocytosis-dependent pathway.

Jadus MR, Williams CC, Avina MD, Ly M, Kim S, Liu Y, Narasaki R, Lowell CA, Wepsic HT.

J Immunol. 1998 Jan 1;160(1):361-8.

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