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A Standard Numbering Scheme for Class C β-Lactamases.

Mack AR, Barnes MD, Taracila MA, Hujer AM, Hujer KM, Cabot G, Feldgarden M, Haft DH, Klimke W, van den Akker F, Vila AJ, Smania A, Haider S, Papp-Wallace KM, Bradford PA, Rossolini GM, Docquier JD, Frère JM, Galleni M, Hanson ND, Oliver A, Plésiat P, Poirel L, Nordmann P, Palzkill TG, Jacoby GA, Bush K, Bonomo RA.

Antimicrob Agents Chemother. 2020 Feb 21;64(3). pii: e01841-19. doi: 10.1128/AAC.01841-19. Print 2020 Feb 21.


Cold shock induces chromosomal qnr in Vibrio species and plasmid-mediated qnrS1 in Escherichia coli.

Jang HC, Wang Y, Chen C, Vinué L, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2019 Sep 30. pii: AAC.01472-19. doi: 10.1128/AAC.01472-19. [Epub ahead of print]


Multiple Copies of qnrA1 on an IncA/C2 Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant.

Vinué L, Sater MRA, Herriott I, Huntley MH, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00718-19. doi: 10.1128/AAC.00718-19. Print 2019 Aug.


Genes and Proteins Involved in qnrS1 Induction.

Monárrez R, Wang Y, Fu Y, Liao CH, Okumura R, Braun MR, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00806-18. doi: 10.1128/AAC.00806-18. Print 2018 Sep.


Chromosomal mutations that accompany qnr in clinical isolates of Escherichia coli.

Vinué L, Hooper DC, Jacoby GA.

Int J Antimicrob Agents. 2018 Mar;51(3):479-483. doi: 10.1016/j.ijantimicag.2018.01.012. Epub 2018 Jan 31.


Study of Plasmid-Mediated Quinolone Resistance in Bacteria.

Jacoby GA.

Methods Mol Biol. 2018;1703:317-325. doi: 10.1007/978-1-4939-7459-7_22.


Reply to Furlan et al., "Importance of Sequencing To Determine Functional blaTEM Variants".

Jacoby GA, Bush K.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e00260-17. doi: 10.1128/AAC.00260-17. Print 2017 May. No abstract available.


The Curious Case of TEM-116.

Jacoby GA, Bush K.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):7000. doi: 10.1128/AAC.01777-16. Print 2016 Nov. No abstract available.


Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance.

Hooper DC, Jacoby GA.

Cold Spring Harb Perspect Med. 2016 Sep 1;6(9). pii: a025320. doi: 10.1101/cshperspect.a025320. Review.


Comment on: Resistance gene naming and numbering: is it a new gene or not?

Jacoby GA, Bonomo RA, Bradford PA, Bush K, Doi Y, Feldgarden M, Haft D, Klimke W, Nordmann P, Palzkill T, Poirel L, Prasad A, Rossolini GM, Walsh T.

J Antimicrob Chemother. 2016 Sep;71(9):2677-8. doi: 10.1093/jac/dkw204. Epub 2016 Jun 3. No abstract available.


Mutations That Enhance the Ciprofloxacin Resistance of Escherichia coli with qnrA1.

Vinué L, Corcoran MA, Hooper DC, Jacoby GA.

Antimicrob Agents Chemother. 2015 Dec 28;60(3):1537-45. doi: 10.1128/AAC.02167-15.


Functions of a GyrBA fusion protein and its interaction with QnrB and quinolones.

Chen C, Villet R, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2015 Nov;59(11):7124-7. doi: 10.1128/AAC.01845-15. Epub 2015 Aug 31.


Protective effect of Qnr on agents other than quinolones that target DNA gyrase.

Jacoby GA, Corcoran MA, Hooper DC.

Antimicrob Agents Chemother. 2015 Nov;59(11):6689-95. doi: 10.1128/AAC.01292-15. Epub 2015 Aug 3.


Mechanisms of drug resistance: quinolone resistance.

Hooper DC, Jacoby GA.

Ann N Y Acad Sci. 2015 Sep;1354:12-31. doi: 10.1111/nyas.12830. Epub 2015 Jul 17. Review.


Interactions between QnrB, QnrB mutants, and DNA gyrase.

Kim ES, Chen C, Braun M, Kim HY, Okumura R, Wang Y, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2015 Sep;59(9):5413-9. doi: 10.1128/AAC.00771-15. Epub 2015 Jun 22.


Effect of Qnr on Plasmid Gyrase Toxins CcdB and ParE.

Kwak YG, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2015 Aug;59(8):5078-9. doi: 10.1128/AAC.00524-15. Epub 2015 Jun 8.


Plasmid-mediated quinolone resistance.

Jacoby GA, Strahilevitz J, Hooper DC.

Microbiol Spectr. 2014 Oct;2(5). doi: 10.1128/microbiolspec.PLAS-0006-2013. Review.


In vitro susceptibility of characterized β-lactamase-producing strains tested with avibactam combinations.

Li H, Estabrook M, Jacoby GA, Nichols WW, Testa RT, Bush K.

Antimicrob Agents Chemother. 2015 Mar;59(3):1789-93. doi: 10.1128/AAC.04191-14. Epub 2014 Dec 22.


In memoriam: Robert C. Moellering, Jr.

Rice LB, Eliopoulos GM, Jacoby GA.

Antimicrob Agents Chemother. 2014 Jul;58(7):3583-4. doi: 10.1128/AAC.03199-14. Epub 2014 May 5. No abstract available.


QnrS1 structure-activity relationships.

Tavío MM, Jacoby GA, Hooper DC.

J Antimicrob Chemother. 2014 Aug;69(8):2102-9. doi: 10.1093/jac/dku102. Epub 2014 Apr 11.


Mutational analysis of quinolone resistance protein QnrB1.

Jacoby GA, Corcoran MA, Mills DM, Griffin CM, Hooper DC.

Antimicrob Agents Chemother. 2013 Nov;57(11):5733-6. doi: 10.1128/AAC.01533-13. Epub 2013 Aug 26.


Risk factors and clinical characteristics of patients with qnr-positive Klebsiella pneumoniae bacteraemia.

Liao CH, Hsueh PR, Jacoby GA, Hooper DC.

J Antimicrob Chemother. 2013 Dec;68(12):2907-14. doi: 10.1093/jac/dkt295. Epub 2013 Aug 16.


Induction of plasmid-carried qnrS1 in Escherichia coli by naturally occurring quinolones and quorum-sensing signal molecules.

Kwak YG, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2013 Aug;57(8):4031-4. doi: 10.1128/AAC.00337-13. Epub 2013 May 20.


Phylogenetic analysis of chromosomally determined qnr and related proteins.

Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2013 Apr;57(4):1930-4. doi: 10.1128/AAC.02080-12. Epub 2013 Jan 14.


Tackling antibiotic resistance.

Bush K, Courvalin P, Dantas G, Davies J, Eisenstein B, Huovinen P, Jacoby GA, Kishony R, Kreiswirth BN, Kutter E, Lerner SA, Levy S, Lewis K, Lomovskaya O, Miller JH, Mobashery S, Piddock LJ, Projan S, Thomas CM, Tomasz A, Tulkens PM, Walsh TR, Watson JD, Witkowski J, Witte W, Wright G, Yeh P, Zgurskaya HI.

Nat Rev Microbiol. 2011 Nov 2;9(12):894-6. doi: 10.1038/nrmicro2693. Review.


Quinolone induction of qnrVS1 in Vibrio splendidus and plasmid-carried qnrS1 in Escherichia coli, a mechanism independent of the SOS system.

Okumura R, Liao CH, Gavin M, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2011 Dec;55(12):5942-5. doi: 10.1128/AAC.05142-11. Epub 2011 Sep 19.


Citrobacter spp. as a source of qnrB Alleles.

Jacoby GA, Griffin CM, Hooper DC.

Antimicrob Agents Chemother. 2011 Nov;55(11):4979-84. doi: 10.1128/AAC.05187-11. Epub 2011 Aug 15.


Structure of QnrB1, a plasmid-mediated fluoroquinolone resistance factor.

Vetting MW, Hegde SS, Wang M, Jacoby GA, Hooper DC, Blanchard JS.

J Biol Chem. 2011 Jul 15;286(28):25265-73. doi: 10.1074/jbc.M111.226936. Epub 2011 May 19.


Cold shock induces qnrA expression in Shewanella algae.

Kim HB, Park CH, Gavin M, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2011 Jan;55(1):414-6. doi: 10.1128/AAC.00991-10. Epub 2010 Nov 15.


vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium.

Xu X, Lin D, Yan G, Ye X, Wu S, Guo Y, Zhu D, Hu F, Zhang Y, Wang F, Jacoby GA, Wang M.

Antimicrob Agents Chemother. 2010 Nov;54(11):4643-7. doi: 10.1128/AAC.01710-09. Epub 2010 Aug 23.


Updated functional classification of beta-lactamases.

Bush K, Jacoby GA.

Antimicrob Agents Chemother. 2010 Mar;54(3):969-76. doi: 10.1128/AAC.01009-09. Epub 2009 Dec 7. Review.


Transferable quinolone resistance in Vibrio cholerae.

Kim HB, Wang M, Ahmed S, Park CH, LaRocque RC, Faruque AS, Salam MA, Khan WA, Qadri F, Calderwood SB, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2010 Feb;54(2):799-803. doi: 10.1128/AAC.01045-09. Epub 2009 Nov 30.


Plasmid-mediated quinolone resistance: a multifaceted threat.

Strahilevitz J, Jacoby GA, Hooper DC, Robicsek A.

Clin Microbiol Rev. 2009 Oct;22(4):664-89. doi: 10.1128/CMR.00016-09. Review.


oqxAB encoding a multidrug efflux pump in human clinical isolates of Enterobacteriaceae.

Kim HB, Wang M, Park CH, Kim EC, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2009 Aug;53(8):3582-4. doi: 10.1128/AAC.01574-08. Epub 2009 Jun 15.


Comment on: Redefining extended-spectrum beta-lactamases: balancing science and clinical need.

Bush K, Jacoby GA, Amicosante G, Bonomo RA, Bradford P, Cornaglia G, Garau J, Giamarellou H, Jarlier V, Martinez-Martinez L, Miriagou V, Palzkill T, Pascual A, Rodriguez-Baño J, Rossolini GM, Sougakoff W, Vatopoulos A.

J Antimicrob Chemother. 2009 Jul;64(1):212-3; author reply 213-5. doi: 10.1093/jac/dkp104. Epub 2009 Mar 24. No abstract available.


Temporal appearance of plasmid-mediated quinolone resistance genes.

Jacoby GA, Gacharna N, Black TA, Miller GH, Hooper DC.

Antimicrob Agents Chemother. 2009 Apr;53(4):1665-6. doi: 10.1128/AAC.01447-08. Epub 2009 Jan 21.


AmpC beta-lactamases.

Jacoby GA.

Clin Microbiol Rev. 2009 Jan;22(1):161-82, Table of Contents. doi: 10.1128/CMR.00036-08. Review.


Prevalence of plasmid-mediated quinolone resistance determinants over a 9-year period.

Kim HB, Park CH, Kim CJ, Kim EC, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2009 Feb;53(2):639-45. doi: 10.1128/AAC.01051-08. Epub 2008 Dec 8.


SOS regulation of qnrB expression.

Wang M, Jacoby GA, Mills DM, Hooper DC.

Antimicrob Agents Chemother. 2009 Feb;53(2):821-3. doi: 10.1128/AAC.00132-08. Epub 2008 Nov 24.


Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant.

Vetting MW, Park CH, Hegde SS, Jacoby GA, Hooper DC, Blanchard JS.

Biochemistry. 2008 Sep 16;47(37):9825-35. doi: 10.1021/bi800664x. Epub 2008 Aug 19.


Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

Whichard JM, Gay K, Stevenson JE, Joyce KJ, Cooper KL, Omondi M, Medalla F, Jacoby GA, Barrett TJ.

Emerg Infect Dis. 2007 Nov;13(11):1681-8. doi: 10.3201/eid1311.061438.


The worldwide emergence of plasmid-mediated quinolone resistance.

Robicsek A, Jacoby GA, Hooper DC.

Lancet Infect Dis. 2006 Oct;6(10):629-40. Review.


Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme.

Park CH, Robicsek A, Jacoby GA, Sahm D, Hooper DC.

Antimicrob Agents Chemother. 2006 Nov;50(11):3953-5. Epub 2006 Sep 5.


qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States.

Robicsek A, Strahilevitz J, Sahm DF, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2006 Aug;50(8):2872-4.


qnrB, another plasmid-mediated gene for quinolone resistance.

Jacoby GA, Walsh KE, Mills DM, Walker VJ, Oh H, Robicsek A, Hooper DC.

Antimicrob Agents Chemother. 2006 Apr;50(4):1178-82.


Beta-lactamase nomenclature.

Jacoby GA.

Antimicrob Agents Chemother. 2006 Apr;50(4):1123-9. Review. No abstract available.


Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase.

Robicsek A, Strahilevitz J, Jacoby GA, Macielag M, Abbanat D, Park CH, Bush K, Hooper DC.

Nat Med. 2006 Jan;12(1):83-8. Epub 2005 Dec 20.


Beta-lactamase nomenclature.

Jacoby GA, Bush K.

J Clin Microbiol. 2005 Dec;43(12):6220. No abstract available.


Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IV.

Tran JH, Jacoby GA, Hooper DC.

Antimicrob Agents Chemother. 2005 Jul;49(7):3050-2.

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