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Items: 1 to 50 of 153

1.

Cancer in the HIV/AIDS Population in Iowa, 1991-2015.

Jacoby E, Kahl AR, Jatta A, Kolm-Valdivia N, Brubaker J, Charlton ME, Lynch CF.

J Registry Manag. 2019 Spring;46(1):4-14.

PMID:
31490916
2.

Use of Chimeric Antigen Receptor T Cell Therapy in Clinical Practice for Relapsed/Refractory Aggressive B Cell Non-Hodgkin Lymphoma: An Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy.

Jain T, Bar M, Kansagra AJ, Chong EA, Hashmi SK, Neelapu SS, Byrne M, Jacoby E, Lazaryan A, Jacobson CA, Ansell SM, Awan FT, Burns L, Bachanova V, Bollard CM, Carpenter PA, DiPersio JF, Hamadani M, Heslop HE, Hill JA, Komanduri KV, Kovitz CA, Lazarus HM, Serrette JM, Mohty M, Miklos D, Nagler A, Pavletic SZ, Savani BN, Schuster SJ, Kharfan-Dabaja MA, Perales MA, Lin Y.

Biol Blood Marrow Transplant. 2019 Aug 22. pii: S1083-8791(19)30529-4. doi: 10.1016/j.bbmt.2019.08.015. [Epub ahead of print] Review.

PMID:
31446199
3.

Haploidentical hematopoietic stem cell transplantation with αβTCR+/CD19+ depletion in pediatric patients with malignant and non-malignant disorders.

Bielorai B, Jacoby E, Varda-Bloom N, Hutt D, Churi C, Vernitsky H, Toren A.

Bone Marrow Transplant. 2019 Aug;54(Suppl 2):694-697. doi: 10.1038/s41409-019-0607-0.

PMID:
31431715
4.

The role of allogeneic HSCT after CAR T cells for acute lymphoblastic leukemia.

Jacoby E.

Bone Marrow Transplant. 2019 Aug;54(Suppl 2):810-814. doi: 10.1038/s41409-019-0604-3. Review.

PMID:
31431700
5.

Updates on CAR T-cell therapy in B-cell malignancies.

Jacoby E, Shahani SA, Shah NN.

Immunol Rev. 2019 Jul;290(1):39-59. doi: 10.1111/imr.12774. Review.

PMID:
31355492
6.

Blinatumomab as a bridge to further therapy in cases of overwhelming toxicity in pediatric B-cell precursor acute lymphoblastic leukemia: Report from the Israeli Study Group of Childhood Leukemia.

Elitzur S, Arad-Cohen N, Barzilai-Birenboim S, Ben-Harush M, Bielorai B, Elhasid R, Feuerstein T, Gilad G, Gural A, Kharit M, Litichever N, Nirel R, Weinreb S, Wolach O, Toren A, Izraeli S, Jacoby E.

Pediatr Blood Cancer. 2019 Oct;66(10):e27898. doi: 10.1002/pbc.27898. Epub 2019 Jul 2.

PMID:
31264788
7.

Role of Klotho Protein in Tumor Genesis, Cancer Progression, and Prognosis in Patients with High-Grade Glioma.

Peshes-Yeloz N, Ungar L, Wohl A, Jacoby E, Fisher T, Leitner M, Nass D, Rubinek T, Wolf I, Cohen ZR.

World Neurosurg. 2019 Jun 20. pii: S1878-8750(19)31634-1. doi: 10.1016/j.wneu.2019.06.082. [Epub ahead of print]

PMID:
31228703
8.

Clinical utilization of Chimeric Antigen Receptor T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL)-an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT).

Kansagra AJ, Frey NV, Bar M, Laetsch TW, Carpenter PA, Savani BN, Heslop HE, Bollard CM, Komanduri KV, Gastineau DA, Chabannon C, Perales MA, Hudecek M, Aljurf M, Andritsos L, Barrett JA, Bachanova V, Bonini C, Ghobadi A, Gill SI, Hill JA, Kenderian S, Kebriaei P, Nagler A, Maloney D, Liu HD, Shah NN, Kharfan-Dabaja MA, Shpall EJ, Mufti GJ, Johnston L, Jacoby E, Bazarbachi A, DiPersio JF, Pavletic SZ, Porter DL, Grupp SA, Sadelain M, Litzow MR, Mohty M, Hashmi SK.

Bone Marrow Transplant. 2019 May 15. doi: 10.1038/s41409-019-0451-2. [Epub ahead of print]

PMID:
31092900
9.

Donor assessment and follow-up: not a minor issue.

Jacoby E, Hutt D.

Bone Marrow Transplant. 2019 Apr 10. doi: 10.1038/s41409-019-0529-x. [Epub ahead of print] No abstract available.

PMID:
30971778
10.

Early and late hematologic toxicity following CD19 CAR-T cells.

Fried S, Avigdor A, Bielorai B, Meir A, Besser MJ, Schachter J, Shimoni A, Nagler A, Toren A, Jacoby E.

Bone Marrow Transplant. 2019 Feb 26. doi: 10.1038/s41409-019-0487-3. [Epub ahead of print]

PMID:
30809033
11.

Clinical Utilization of Chimeric Antigen Receptor T Cells in B Cell Acute Lymphoblastic Leukemia: An Expert Opinion from the European Society for Blood and Marrow Transplantation and the American Society for Blood and Marrow Transplantation.

Kansagra AJ, Frey NV, Bar M, Laetsch TW, Carpenter PA, Savani BN, Heslop HE, Bollard CM, Komanduri KV, Gastineau DA, Chabannon C, Perales MA, Hudecek M, Aljurf M, Andritsos L, Barrett JA, Bachanova V, Bonini C, Ghobadi A, Gill SI, Hill J, Kenderian S, Kebriaei P, Nagler A, Maloney D, Liu HD, Shah NN, Kharfan-Dabaja MA, Shpall EJ, Mufti GJ, Johnston L, Jacoby E, Bazarbachi A, DiPersio JF, Pavletic SZ, Porter DL, Grupp SA, Sadelain M, Litzow MR, Mohty M, Hashmi SK.

Biol Blood Marrow Transplant. 2019 Mar;25(3):e76-e85. doi: 10.1016/j.bbmt.2018.12.068. Epub 2018 Dec 18.

PMID:
30576834
12.

The Future of Computational Chemogenomics.

Jacoby E, Brown JB.

Methods Mol Biol. 2018;1825:425-450. doi: 10.1007/978-1-4939-8639-2_15.

PMID:
30334216
13.

Locally produced CD19 CAR T cells leading to clinical remissions in medullary and extramedullary relapsed acute lymphoblastic leukemia.

Jacoby E, Bielorai B, Avigdor A, Itzhaki O, Hutt D, Nussboim V, Meir A, Kubi A, Levy M, Zikich D, Zeltzer LA, Brezinger K, Schachter J, Nagler A, Besser MJ, Toren A.

Am J Hematol. 2018 Dec;93(12):1485-1492. doi: 10.1002/ajh.25274. Epub 2018 Sep 26.

PMID:
30187944
14.

CAR T cells induce a complete response in refractory Burkitt Lymphoma.

Avigdor A, Shouval R, Jacoby E, Davidson T, Shimoni A, Besser M, Nagler A.

Bone Marrow Transplant. 2018 Dec;53(12):1583-1585. doi: 10.1038/s41409-018-0235-0. Epub 2018 May 24. No abstract available.

PMID:
29795432
15.

Accessing the Open PHACTS Discovery Platform with Workflow Tools.

Digles D, Caracoti A, Jacoby E.

Methods Mol Biol. 2018;1787:183-193. doi: 10.1007/978-1-4939-7847-2_14.

PMID:
29736719
16.

Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways.

Gough SM, Goldberg L, Pineda M, Walker RL, Zhu YJ, Bilke S, Chung YJ, Dufraine J, Kundu S, Jacoby E, Fry TJ, Fischer S, Panzer-Grümayer R, Meltzer PS, Aplan PD.

Blood Adv. 2017 Sep 8;1(20):1749-1759. doi: 10.1182/bloodadvances.2017009837. eCollection 2017 Sep 12.

17.

Public Health Nutrition special issue on ultra-processed foods.

Kelly B, Jacoby E.

Public Health Nutr. 2018 Jan;21(1):1-4. doi: 10.1017/S1368980017002853. No abstract available.

PMID:
29227217
18.

TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance.

Yang Y, Kohler ME, Chien CD, Sauter CT, Jacoby E, Yan C, Hu Y, Wanhainen K, Qin H, Fry TJ.

Sci Transl Med. 2017 Nov 22;9(417). pii: eaag1209. doi: 10.1126/scitranslmed.aag1209.

PMID:
29167392
19.

Protocols for the Design of Kinase-focused Compound Libraries.

Jacoby E, Wroblowski B, Buyck C, Neefs JM, Meyer C, Cummings MD, van Vlijmen H.

Mol Inform. 2018 May;37(5):e1700119. doi: 10.1002/minf.201700119. Epub 2017 Nov 8.

PMID:
29116686
20.

Comparison of two cytoreductive regimens for αβ-T-cell-depleted haploidentical HSCT in pediatric malignancies: Improved engraftment and outcome with TBI-based regimen.

Jacoby E, Varda-Bloom N, Goldstein G, Hutt D, Churi C, Vernitsky H, Toren A, Bielorai B.

Pediatr Blood Cancer. 2018 Feb;65(2). doi: 10.1002/pbc.26839. Epub 2017 Oct 8.

PMID:
28988422
21.

Viral to metazoan marine plankton nucleotide sequences from the Tara Oceans expedition.

Alberti A, Poulain J, Engelen S, Labadie K, Romac S, Ferrera I, Albini G, Aury JM, Belser C, Bertrand A, Cruaud C, Da Silva C, Dossat C, Gavory F, Gas S, Guy J, Haquelle M, Jacoby E, Jaillon O, Lemainque A, Pelletier E, Samson G, Wessner M; Genoscope Technical Team, Acinas SG, Royo-Llonch M, Cornejo-Castillo FM, Logares R, Fernández-Gómez B, Bowler C, Cochrane G, Amid C, Hoopen PT, De Vargas C, Grimsley N, Desgranges E, Kandels-Lewis S, Ogata H, Poulton N, Sieracki ME, Stepanauskas R, Sullivan MB, Brum JR, Duhaime MB, Poulos BT, Hurwitz BL; Tara Oceans Consortium Coordinators, Pesant S, Karsenti E, Wincker P.

Sci Data. 2017 Aug 1;4:170093. doi: 10.1038/sdata.2017.93.

22.

Prevention of childhood obesity and food policies in Latin America: from research to practice.

Pérez-Escamilla R, Lutter CK, Rabadan-Diehl C, Rubinstein A, Calvillo A, Corvalán C, Batis C, Jacoby E, Vorkoper S, Kline L, Ewart-Pierce E, Rivera JA.

Obes Rev. 2017 Jul;18 Suppl 2:28-38. doi: 10.1111/obr.12574.

PMID:
28741904
23.

Progress towards elimination of trans-fatty acids in foods commonly consumed in four Latin American cities.

Monge-Rojas R, Colón-Ramos U, Jacoby E, Alfaro T, Tavares do Carmo MDG, Villalpando S, Bernal C.

Public Health Nutr. 2017 Sep;20(13):2440-2449. doi: 10.1017/S1368980017001227. Epub 2017 Jun 23.

PMID:
28641598
24.

Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns.

Digles D, Zdrazil B, Neefs JM, Van Vlijmen H, Herhaus C, Caracoti A, Brea J, Roibás B, Loza MI, Queralt-Rosinach N, Furlong LI, Gaulton A, Bartek L, Senger S, Chichester C, Engkvist O, Evelo CT, Franklin NI, Marren D, Ecker GF, Jacoby E.

Medchemcomm. 2016 Jun 1;7(6):1237-1244. Epub 2016 May 11.

25.

CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity.

Jacoby E, Nguyen SM, Fountaine TJ, Welp K, Gryder B, Qin H, Yang Y, Chien CD, Seif AE, Lei H, Song YK, Khan J, Lee DW, Mackall CL, Gardner RA, Jensen MC, Shern JF, Fry TJ.

Nat Commun. 2016 Jul 27;7:12320. doi: 10.1038/ncomms12320.

26.

Correction to Structural Investigation of B-Raf Paradox Breaker and Inducer Inhibitors.

Arora R, Di Michele M, Stes E, Vandermarliere E, Martens L, Gevaert K, Van Heerde E, Linders JT, Brehmer D, Jacoby E, Bonnet P.

J Med Chem. 2016 Jul 28;59(14):6973. doi: 10.1021/acs.jmedchem.6b00941. Epub 2016 Jul 6. No abstract available.

PMID:
27385554
27.

Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling.

Wandinger SK, Lahortiga I, Jacobs K, Klammer M, Jordan N, Elschenbroich S, Parade M, Jacoby E, Linders JT, Brehmer D, Cools J, Daub H.

PLoS One. 2016 Jan 8;11(1):e0146100. doi: 10.1371/journal.pone.0146100. eCollection 2016.

28.

Murine allogeneic CD19 CAR T cells harbor potent antileukemic activity but have the potential to mediate lethal GVHD.

Jacoby E, Yang Y, Qin H, Chien CD, Kochenderfer JN, Fry TJ.

Blood. 2016 Mar 10;127(10):1361-70. doi: 10.1182/blood-2015-08-664250. Epub 2015 Dec 11.

29.

Social conditions and urban environment associated with participation in the Ciclovia program among adults from Cali, Colombia.

Gómez LF, Mosquera J, Gómez OL, Moreno J, Pinzon JD, Jacoby E, Cepeda M, Parra DC.

Cad Saude Publica. 2015 Nov;31 Suppl 1:257-66. doi: 10.1590/0102-311X00086814.

30.

Sperm deoxyribonucleic acid fragmentation assessment in normozoospermic male partners of couples with unexplained recurrent pregnancy loss: a prospective study.

Bareh GM, Jacoby E, Binkley P, Chang TC, Schenken RS, Robinson RD.

Fertil Steril. 2016 Feb;105(2):329-36.e1. doi: 10.1016/j.fertnstert.2015.10.033. Epub 2015 Nov 19.

PMID:
26607021
31.

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.

Sotillo E, Barrett DM, Black KL, Bagashev A, Oldridge D, Wu G, Sussman R, Lanauze C, Ruella M, Gazzara MR, Martinez NM, Harrington CT, Chung EY, Perazzelli J, Hofmann TJ, Maude SL, Raman P, Barrera A, Gill S, Lacey SF, Melenhorst JJ, Allman D, Jacoby E, Fry T, Mackall C, Barash Y, Lynch KW, Maris JM, Grupp SA, Thomas-Tikhonenko A.

Cancer Discov. 2015 Dec;5(12):1282-95. doi: 10.1158/2159-8290.CD-15-1020. Epub 2015 Oct 29.

32.

Challenges and opportunities of allogeneic donor-derived CAR T cells.

Yang Y, Jacoby E, Fry TJ.

Curr Opin Hematol. 2015 Nov;22(6):509-515. doi: 10.1097/MOH.0000000000000181. Review.

33.

Single-Agent Post-Transplantation Cyclophosphamide as Graft-versus-Host Disease Prophylaxis after Human Leukocyte Antigen-Matched Related Bone Marrow Transplantation for Pediatric and Young Adult Patients with Hematologic Malignancies.

Jacoby E, Chen A, Loeb DM, Gamper CJ, Zambidis E, Llosa NJ, Huo J, Cooke KR, Jones R, Fuchs E, Luznik L, Symons HJ.

Biol Blood Marrow Transplant. 2016 Jan;22(1):112-8. doi: 10.1016/j.bbmt.2015.08.034. Epub 2015 Sep 4.

34.

Limited Proteolysis Combined with Stable Isotope Labeling Reveals Conformational Changes in Protein (Pseudo)kinases upon Binding Small Molecules.

Di Michele M, Stes E, Vandermarliere E, Arora R, Astorga-Wells J, Vandenbussche J, van Heerde E, Zubarev R, Bonnet P, Linders JT, Jacoby E, Brehmer D, Martens L, Gevaert K.

J Proteome Res. 2015 Oct 2;14(10):4179-93. doi: 10.1021/acs.jproteome.5b00282. Epub 2015 Aug 25.

PMID:
26293246
35.

Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode.

Gessier F, Kallen J, Jacoby E, Chène P, Stachyra-Valat T, Ruetz S, Jeay S, Holzer P, Masuya K, Furet P.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3621-5. doi: 10.1016/j.bmcl.2015.06.058. Epub 2015 Jun 23.

PMID:
26141769
36.

Opportunities and challenges in delivering influenza vaccine by microneedle patch.

Jacoby E, Jarrahian C, Hull HF, Zehrung D.

Vaccine. 2015 Sep 8;33(37):4699-704. doi: 10.1016/j.vaccine.2015.03.062. Epub 2015 Apr 1.

37.

An economic model assessing the value of microneedle patch delivery of the seasonal influenza vaccine.

Lee BY, Bartsch SM, Mvundura M, Jarrahian C, Zapf KM, Marinan K, Wateska AR, Snyder B, Swaminathan S, Jacoby E, Norman JJ, Prausnitz MR, Zehrung D.

Vaccine. 2015 Sep 8;33(37):4727-36. doi: 10.1016/j.vaccine.2015.02.076. Epub 2015 Mar 13.

38.

PepShell: visualization of conformational proteomics data.

Vandermarliere E, Maddelein D, Hulstaert N, Stes E, Di Michele M, Gevaert K, Jacoby E, Brehmer D, Martens L.

J Proteome Res. 2015 Apr 3;14(4):1987-90. doi: 10.1021/pr5012125. Epub 2015 Mar 12.

PMID:
25728987
39.

Structural investigation of B-Raf paradox breaker and inducer inhibitors.

Arora R, Di Michele M, Stes E, Vandermarliere E, Martens L, Gevaert K, Van Heerde E, Linders JT, Brehmer D, Jacoby E, Bonnet P.

J Med Chem. 2015 Feb 26;58(4):1818-31. doi: 10.1021/jm501667n. Epub 2015 Feb 10. Erratum in: J Med Chem. 2016 Jul 28;59(14):6973.

PMID:
25611072
40.

Extending kinome coverage by analysis of kinase inhibitor broad profiling data.

Jacoby E, Tresadern G, Bembenek S, Wroblowski B, Buyck C, Neefs JM, Rassokhin D, Poncelet A, Hunt J, van Vlijmen H.

Drug Discov Today. 2015 Jun;20(6):652-8. doi: 10.1016/j.drudis.2015.01.002. Epub 2015 Jan 14. Review.

PMID:
25596550
41.

The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research.

Ratnam J, Zdrazil B, Digles D, Cuadrado-Rodriguez E, Neefs JM, Tipney H, Siebes R, Waagmeester A, Bradley G, Chau CH, Richter L, Brea J, Evelo CT, Jacoby E, Senger S, Loza MI, Ecker GF, Chichester C.

PLoS One. 2014 Dec 18;9(12):e115460. doi: 10.1371/journal.pone.0115460. eCollection 2014.

42.

Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma.

Jacoby E, Yalon M, Leitner M, Cohen ZR, Cohen Y, Fisher T, Eder S, Amariglio N, Rechavi G, Cazacu S, Xiang C, Mikkelsen T, Brodie C, Toren A.

Oncol Lett. 2014 Apr;7(4):1209-1212. Epub 2014 Jan 27.

43.

Murine models of acute leukemia: important tools in current pediatric leukemia research.

Jacoby E, Chien CD, Fry TJ.

Front Oncol. 2014 May 7;4:95. doi: 10.3389/fonc.2014.00095. eCollection 2014. Review.

44.

Neonatal hyperpigmentation: diagnosis of familial glucocorticoid deficiency with a novel mutation in the melanocortin-2 receptor gene.

Jacoby E, Barzilai A, Laufer J, Pade S, Anikster Y, Pinhas-Hamiel O, Greenberger S.

Pediatr Dermatol. 2014 Jan-Feb;31(1):e13-7. doi: 10.1111/pde.12247. Epub 2013 Nov 14.

PMID:
24224542
45.

MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.

Nemlich Y, Greenberg E, Ortenberg R, Besser MJ, Barshack I, Jacob-Hirsch J, Jacoby E, Eyal E, Rivkin L, Prieto VG, Chakravarti N, Duncan LM, Kallenberg DM, Galun E, Bennett DC, Amariglio N, Bar-Eli M, Schachter J, Rechavi G, Markel G.

J Clin Invest. 2013 Jun;123(6):2703-18.

46.

The epidemic of childhood obesity in the Americas must be stopped: Governmental and PAHO leadership are crucial.

Jacoby E, Grajeda R, Contreras A, Hospedales J.

Int J Obes Suppl. 2013 Jun;3(Suppl 1):S15-7. doi: 10.1038/ijosup.2013.6. Epub 2013 May 16. Review.

47.

MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1.

Bier A, Giladi N, Kronfeld N, Lee HK, Cazacu S, Finniss S, Xiang C, Poisson L, deCarvalho AC, Slavin S, Jacoby E, Yalon M, Toren A, Mikkelsen T, Brodie C.

Oncotarget. 2013 May;4(5):665-76.

48.

Scientific competency questions as the basis for semantically enriched open pharmacological space development.

Azzaoui K, Jacoby E, Senger S, Rodríguez EC, Loza M, Zdrazil B, Pinto M, Williams AJ, de la Torre V, Mestres J, Pastor M, Taboureau O, Rarey M, Chichester C, Pettifer S, Blomberg N, Harland L, Williams-Jones B, Ecker GF.

Drug Discov Today. 2013 Sep;18(17-18):843-52. doi: 10.1016/j.drudis.2013.05.008. Epub 2013 May 20. Review.

49.

Transport and health: a look at three Latin American cities.

Becerra JM, Reis RS, Frank LD, Ramirez-Marrero FA, Welle B, Arriaga Cordero E, Mendez Paz F, Crespo C, Dujon V, Jacoby E, Dill J, Weigand L, Padin CM.

Cad Saude Publica. 2013 Apr;29(4):654-66. Review.

50.

The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.

Lorthiois E, Breitenstein W, Cumin F, Ehrhardt C, Francotte E, Jacoby E, Ostermann N, Sellner H, Kosaka T, Webb RL, Rigel DF, Hassiepen U, Richert P, Wagner T, Maibaum J.

J Med Chem. 2013 Mar 28;56(6):2207-17. doi: 10.1021/jm3017078. Epub 2013 Mar 15.

PMID:
23425156

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