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Items: 1 to 50 of 140

1.

CAR T cells induce a complete response in refractory Burkitt Lymphoma.

Avigdor A, Shouval R, Jacoby E, Davidson T, Shimoni A, Besser M, Nagler A.

Bone Marrow Transplant. 2018 May 24. doi: 10.1038/s41409-018-0235-0. [Epub ahead of print] No abstract available.

PMID:
29795432
2.

Accessing the Open PHACTS Discovery Platform with Workflow Tools.

Digles D, Caracoti A, Jacoby E.

Methods Mol Biol. 2018;1787:183-193. doi: 10.1007/978-1-4939-7847-2_14.

PMID:
29736719
3.

Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways.

Gough SM, Goldberg L, Pineda M, Walker RL, Zhu YJ, Bilke S, Chung YJ, Dufraine J, Kundu S, Jacoby E, Fry TJ, Fischer S, Panzer-Grümayer R, Meltzer PS, Aplan PD.

Blood Adv. 2017 Sep 8;1(20):1749-1759. doi: 10.1182/bloodadvances.2017009837. eCollection 2017 Sep 12.

4.

Public Health Nutrition special issue on ultra-processed foods.

Kelly B, Jacoby E.

Public Health Nutr. 2018 Jan;21(1):1-4. doi: 10.1017/S1368980017002853. No abstract available.

PMID:
29227217
5.

TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance.

Yang Y, Kohler ME, Chien CD, Sauter CT, Jacoby E, Yan C, Hu Y, Wanhainen K, Qin H, Fry TJ.

Sci Transl Med. 2017 Nov 22;9(417). pii: eaag1209. doi: 10.1126/scitranslmed.aag1209.

PMID:
29167392
6.

Protocols for the Design of Kinase-focused Compound Libraries.

Jacoby E, Wroblowski B, Buyck C, Neefs JM, Meyer C, Cummings MD, van Vlijmen H.

Mol Inform. 2018 May;37(5):e1700119. doi: 10.1002/minf.201700119. Epub 2017 Nov 8.

PMID:
29116686
7.

Comparison of two cytoreductive regimens for αβ-T-cell-depleted haploidentical HSCT in pediatric malignancies: Improved engraftment and outcome with TBI-based regimen.

Jacoby E, Varda-Bloom N, Goldstein G, Hutt D, Churi C, Vernitsky H, Toren A, Bielorai B.

Pediatr Blood Cancer. 2018 Feb;65(2). doi: 10.1002/pbc.26839. Epub 2017 Oct 8.

PMID:
28988422
8.

Viral to metazoan marine plankton nucleotide sequences from the Tara Oceans expedition.

Alberti A, Poulain J, Engelen S, Labadie K, Romac S, Ferrera I, Albini G, Aury JM, Belser C, Bertrand A, Cruaud C, Da Silva C, Dossat C, Gavory F, Gas S, Guy J, Haquelle M, Jacoby E, Jaillon O, Lemainque A, Pelletier E, Samson G, Wessner M; Genoscope Technical Team, Acinas SG, Royo-Llonch M, Cornejo-Castillo FM, Logares R, Fernández-Gómez B, Bowler C, Cochrane G, Amid C, Hoopen PT, De Vargas C, Grimsley N, Desgranges E, Kandels-Lewis S, Ogata H, Poulton N, Sieracki ME, Stepanauskas R, Sullivan MB, Brum JR, Duhaime MB, Poulos BT, Hurwitz BL; Tara Oceans Consortium Coordinators, Pesant S, Karsenti E, Wincker P.

Sci Data. 2017 Aug 1;4:170093. doi: 10.1038/sdata.2017.93.

9.

Prevention of childhood obesity and food policies in Latin America: from research to practice.

Pérez-Escamilla R, Lutter CK, Rabadan-Diehl C, Rubinstein A, Calvillo A, Corvalán C, Batis C, Jacoby E, Vorkoper S, Kline L, Ewart-Pierce E, Rivera JA.

Obes Rev. 2017 Jul;18 Suppl 2:28-38. doi: 10.1111/obr.12574.

PMID:
28741904
10.

Progress towards elimination of trans-fatty acids in foods commonly consumed in four Latin American cities.

Monge-Rojas R, Colón-Ramos U, Jacoby E, Alfaro T, Tavares do Carmo MDG, Villalpando S, Bernal C.

Public Health Nutr. 2017 Sep;20(13):2440-2449. doi: 10.1017/S1368980017001227. Epub 2017 Jun 23.

PMID:
28641598
11.

Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns.

Digles D, Zdrazil B, Neefs JM, Van Vlijmen H, Herhaus C, Caracoti A, Brea J, Roibás B, Loza MI, Queralt-Rosinach N, Furlong LI, Gaulton A, Bartek L, Senger S, Chichester C, Engkvist O, Evelo CT, Franklin NI, Marren D, Ecker GF, Jacoby E.

Medchemcomm. 2016 Jun 1;7(6):1237-1244. Epub 2016 May 11.

12.

CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity.

Jacoby E, Nguyen SM, Fountaine TJ, Welp K, Gryder B, Qin H, Yang Y, Chien CD, Seif AE, Lei H, Song YK, Khan J, Lee DW, Mackall CL, Gardner RA, Jensen MC, Shern JF, Fry TJ.

Nat Commun. 2016 Jul 27;7:12320. doi: 10.1038/ncomms12320.

13.

Correction to Structural Investigation of B-Raf Paradox Breaker and Inducer Inhibitors.

Arora R, Di Michele M, Stes E, Vandermarliere E, Martens L, Gevaert K, Van Heerde E, Linders JT, Brehmer D, Jacoby E, Bonnet P.

J Med Chem. 2016 Jul 28;59(14):6973. doi: 10.1021/acs.jmedchem.6b00941. Epub 2016 Jul 6. No abstract available.

PMID:
27385554
14.

Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling.

Wandinger SK, Lahortiga I, Jacobs K, Klammer M, Jordan N, Elschenbroich S, Parade M, Jacoby E, Linders JT, Brehmer D, Cools J, Daub H.

PLoS One. 2016 Jan 8;11(1):e0146100. doi: 10.1371/journal.pone.0146100. eCollection 2016.

15.

Murine allogeneic CD19 CAR T cells harbor potent antileukemic activity but have the potential to mediate lethal GVHD.

Jacoby E, Yang Y, Qin H, Chien CD, Kochenderfer JN, Fry TJ.

Blood. 2016 Mar 10;127(10):1361-70. doi: 10.1182/blood-2015-08-664250. Epub 2015 Dec 11.

16.

Social conditions and urban environment associated with participation in the Ciclovia program among adults from Cali, Colombia.

Gómez LF, Mosquera J, Gómez OL, Moreno J, Pinzon JD, Jacoby E, Cepeda M, Parra DC.

Cad Saude Publica. 2015 Nov;31 Suppl 1:257-66. doi: 10.1590/0102-311X00086814.

17.

Sperm deoxyribonucleic acid fragmentation assessment in normozoospermic male partners of couples with unexplained recurrent pregnancy loss: a prospective study.

Bareh GM, Jacoby E, Binkley P, Chang TC, Schenken RS, Robinson RD.

Fertil Steril. 2016 Feb;105(2):329-36.e1. doi: 10.1016/j.fertnstert.2015.10.033. Epub 2015 Nov 19.

PMID:
26607021
18.

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.

Sotillo E, Barrett DM, Black KL, Bagashev A, Oldridge D, Wu G, Sussman R, Lanauze C, Ruella M, Gazzara MR, Martinez NM, Harrington CT, Chung EY, Perazzelli J, Hofmann TJ, Maude SL, Raman P, Barrera A, Gill S, Lacey SF, Melenhorst JJ, Allman D, Jacoby E, Fry T, Mackall C, Barash Y, Lynch KW, Maris JM, Grupp SA, Thomas-Tikhonenko A.

Cancer Discov. 2015 Dec;5(12):1282-95. doi: 10.1158/2159-8290.CD-15-1020. Epub 2015 Oct 29.

19.

Challenges and opportunities of allogeneic donor-derived CAR T cells.

Yang Y, Jacoby E, Fry TJ.

Curr Opin Hematol. 2015 Nov;22(6):509-515. doi: 10.1097/MOH.0000000000000181. Review.

20.

Single-Agent Post-Transplantation Cyclophosphamide as Graft-versus-Host Disease Prophylaxis after Human Leukocyte Antigen-Matched Related Bone Marrow Transplantation for Pediatric and Young Adult Patients with Hematologic Malignancies.

Jacoby E, Chen A, Loeb DM, Gamper CJ, Zambidis E, Llosa NJ, Huo J, Cooke KR, Jones R, Fuchs E, Luznik L, Symons HJ.

Biol Blood Marrow Transplant. 2016 Jan;22(1):112-8. doi: 10.1016/j.bbmt.2015.08.034. Epub 2015 Sep 4.

21.

Limited Proteolysis Combined with Stable Isotope Labeling Reveals Conformational Changes in Protein (Pseudo)kinases upon Binding Small Molecules.

Di Michele M, Stes E, Vandermarliere E, Arora R, Astorga-Wells J, Vandenbussche J, van Heerde E, Zubarev R, Bonnet P, Linders JT, Jacoby E, Brehmer D, Martens L, Gevaert K.

J Proteome Res. 2015 Oct 2;14(10):4179-93. doi: 10.1021/acs.jproteome.5b00282. Epub 2015 Aug 25.

PMID:
26293246
22.

Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode.

Gessier F, Kallen J, Jacoby E, Chène P, Stachyra-Valat T, Ruetz S, Jeay S, Holzer P, Masuya K, Furet P.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3621-5. doi: 10.1016/j.bmcl.2015.06.058. Epub 2015 Jun 23.

PMID:
26141769
23.

Opportunities and challenges in delivering influenza vaccine by microneedle patch.

Jacoby E, Jarrahian C, Hull HF, Zehrung D.

Vaccine. 2015 Sep 8;33(37):4699-704. doi: 10.1016/j.vaccine.2015.03.062. Epub 2015 Apr 1.

24.

An economic model assessing the value of microneedle patch delivery of the seasonal influenza vaccine.

Lee BY, Bartsch SM, Mvundura M, Jarrahian C, Zapf KM, Marinan K, Wateska AR, Snyder B, Swaminathan S, Jacoby E, Norman JJ, Prausnitz MR, Zehrung D.

Vaccine. 2015 Sep 8;33(37):4727-36. doi: 10.1016/j.vaccine.2015.02.076. Epub 2015 Mar 13.

25.

PepShell: visualization of conformational proteomics data.

Vandermarliere E, Maddelein D, Hulstaert N, Stes E, Di Michele M, Gevaert K, Jacoby E, Brehmer D, Martens L.

J Proteome Res. 2015 Apr 3;14(4):1987-90. doi: 10.1021/pr5012125. Epub 2015 Mar 12.

PMID:
25728987
26.

Structural investigation of B-Raf paradox breaker and inducer inhibitors.

Arora R, Di Michele M, Stes E, Vandermarliere E, Martens L, Gevaert K, Van Heerde E, Linders JT, Brehmer D, Jacoby E, Bonnet P.

J Med Chem. 2015 Feb 26;58(4):1818-31. doi: 10.1021/jm501667n. Epub 2015 Feb 10. Erratum in: J Med Chem. 2016 Jul 28;59(14):6973.

PMID:
25611072
27.

Extending kinome coverage by analysis of kinase inhibitor broad profiling data.

Jacoby E, Tresadern G, Bembenek S, Wroblowski B, Buyck C, Neefs JM, Rassokhin D, Poncelet A, Hunt J, van Vlijmen H.

Drug Discov Today. 2015 Jun;20(6):652-8. doi: 10.1016/j.drudis.2015.01.002. Epub 2015 Jan 14. Review.

PMID:
25596550
28.

The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research.

Ratnam J, Zdrazil B, Digles D, Cuadrado-Rodriguez E, Neefs JM, Tipney H, Siebes R, Waagmeester A, Bradley G, Chau CH, Richter L, Brea J, Evelo CT, Jacoby E, Senger S, Loza MI, Ecker GF, Chichester C.

PLoS One. 2014 Dec 18;9(12):e115460. doi: 10.1371/journal.pone.0115460. eCollection 2014.

29.

Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma.

Jacoby E, Yalon M, Leitner M, Cohen ZR, Cohen Y, Fisher T, Eder S, Amariglio N, Rechavi G, Cazacu S, Xiang C, Mikkelsen T, Brodie C, Toren A.

Oncol Lett. 2014 Apr;7(4):1209-1212. Epub 2014 Jan 27.

30.

Murine models of acute leukemia: important tools in current pediatric leukemia research.

Jacoby E, Chien CD, Fry TJ.

Front Oncol. 2014 May 7;4:95. doi: 10.3389/fonc.2014.00095. eCollection 2014. Review.

31.

Neonatal hyperpigmentation: diagnosis of familial glucocorticoid deficiency with a novel mutation in the melanocortin-2 receptor gene.

Jacoby E, Barzilai A, Laufer J, Pade S, Anikster Y, Pinhas-Hamiel O, Greenberger S.

Pediatr Dermatol. 2014 Jan-Feb;31(1):e13-7. doi: 10.1111/pde.12247. Epub 2013 Nov 14.

PMID:
24224542
32.

MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.

Nemlich Y, Greenberg E, Ortenberg R, Besser MJ, Barshack I, Jacob-Hirsch J, Jacoby E, Eyal E, Rivkin L, Prieto VG, Chakravarti N, Duncan LM, Kallenberg DM, Galun E, Bennett DC, Amariglio N, Bar-Eli M, Schachter J, Rechavi G, Markel G.

J Clin Invest. 2013 Jun;123(6):2703-18.

33.

The epidemic of childhood obesity in the Americas must be stopped: Governmental and PAHO leadership are crucial.

Jacoby E, Grajeda R, Contreras A, Hospedales J.

Int J Obes Suppl. 2013 Jun;3(Suppl 1):S15-7. doi: 10.1038/ijosup.2013.6. Epub 2013 May 16. Review.

34.

MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1.

Bier A, Giladi N, Kronfeld N, Lee HK, Cazacu S, Finniss S, Xiang C, Poisson L, deCarvalho AC, Slavin S, Jacoby E, Yalon M, Toren A, Mikkelsen T, Brodie C.

Oncotarget. 2013 May;4(5):665-76.

35.

Scientific competency questions as the basis for semantically enriched open pharmacological space development.

Azzaoui K, Jacoby E, Senger S, Rodríguez EC, Loza M, Zdrazil B, Pinto M, Williams AJ, de la Torre V, Mestres J, Pastor M, Taboureau O, Rarey M, Chichester C, Pettifer S, Blomberg N, Harland L, Williams-Jones B, Ecker GF.

Drug Discov Today. 2013 Sep;18(17-18):843-52. doi: 10.1016/j.drudis.2013.05.008. Epub 2013 May 20. Review.

36.

Transport and health: a look at three Latin American cities.

Becerra JM, Reis RS, Frank LD, Ramirez-Marrero FA, Welle B, Arriaga Cordero E, Mendez Paz F, Crespo C, Dujon V, Jacoby E, Dill J, Weigand L, Padin CM.

Cad Saude Publica. 2013 Apr;29(4):654-66. Review.

37.

The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.

Lorthiois E, Breitenstein W, Cumin F, Ehrhardt C, Francotte E, Jacoby E, Ostermann N, Sellner H, Kosaka T, Webb RL, Rigel DF, Hassiepen U, Richert P, Wagner T, Maibaum J.

J Med Chem. 2013 Mar 28;56(6):2207-17. doi: 10.1021/jm3017078. Epub 2013 Mar 15.

PMID:
23425156
38.

MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor.

Lee HK, Bier A, Cazacu S, Finniss S, Xiang C, Twito H, Poisson LM, Mikkelsen T, Slavin S, Jacoby E, Yalon M, Toren A, Rempel SA, Brodie C.

PLoS One. 2013;8(2):e54652. doi: 10.1371/journal.pone.0054652. Epub 2013 Feb 4.

39.

A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.

Ostermann N, Ruedisser S, Ehrhardt C, Breitenstein W, Marzinzik A, Jacoby E, Vangrevelinghe E, Ottl J, Klumpp M, Hartwieg JC, Cumin F, Hassiepen U, Trappe J, Sedrani R, Geisse S, Gerhartz B, Richert P, Francotte E, Wagner T, Krömer M, Kosaka T, Webb RL, Rigel DF, Maibaum J, Baeschlin DK.

J Med Chem. 2013 Mar 28;56(6):2196-206. doi: 10.1021/jm301706j. Epub 2013 Mar 15.

PMID:
23360239
40.

[Combination antifungal therapy in hematopoietic stem cell transplantation patients].

Jacoby E, Keller N, Barkai G.

Harefuah. 2012 Aug;151(8):455-7, 499, 498. Hebrew.

PMID:
23350288
41.

Theoretical and experimental relationships between percent inhibition and IC50 data observed in high-throughput screening.

Gubler H, Schopfer U, Jacoby E.

J Biomol Screen. 2013 Jan;18(1):1-13. doi: 10.1177/1087057112455219. Epub 2012 Aug 1.

PMID:
22853931
42.

Probing the bioactivity-relevant chemical space of robust reactions and common molecular building blocks.

Hartenfeller M, Eberle M, Meier P, Nieto-Oberhuber C, Altmann KH, Schneider G, Jacoby E, Renner S.

J Chem Inf Model. 2012 May 25;52(5):1167-78. doi: 10.1021/ci200618n. Epub 2012 Apr 19.

PMID:
22512717
43.

The effect of prolonged physical activity performed during extreme caloric deprivation on cardiac function.

Planer D, Leibowitz D, Hadid A, Erlich T, Sharon N, Paltiel O, Jacoby E, Lotan C, Moran DS.

PLoS One. 2012;7(2):e31266. doi: 10.1371/journal.pone.0031266. Epub 2012 Feb 24.

44.

Do health benefits outweigh the costs of mass recreational programs? An economic analysis of four Ciclovía programs.

Montes F, Sarmiento OL, Zarama R, Pratt M, Wang G, Jacoby E, Schmid TL, Ramos M, Ruiz O, Vargas O, Michel G, Zieff SG, Valdivia JA, Cavill N, Kahlmeier S.

J Urban Health. 2012 Feb;89(1):153-70. doi: 10.1007/s11524-011-9628-8.

45.

A collection of robust organic synthesis reactions for in silico molecule design.

Hartenfeller M, Eberle M, Meier P, Nieto-Oberhuber C, Altmann KH, Schneider G, Jacoby E, Renner S.

J Chem Inf Model. 2011 Dec 27;51(12):3093-8. doi: 10.1021/ci200379p. Epub 2011 Nov 11.

PMID:
22077721
46.

An inside look at active transportation in Bogotá: a qualitative study.

Mosquera J, Parra DC, Gomez LF, Sarmiento O, Schmid T, Jacoby E.

J Phys Act Health. 2012 Aug;9(6):776-85. Epub 2011 Sep 13.

PMID:
21951947
47.

Recent trends and observations in the design of high-quality screening collections.

Renner S, Popov M, Schuffenhauer A, Roth HJ, Breitenstein W, Marzinzik A, Lewis I, Krastel P, Nigsch F, Jenkins J, Jacoby E.

Future Med Chem. 2011 Apr;3(6):751-66. doi: 10.4155/fmc.11.15. Review.

PMID:
21554080
48.

Interspecies chimera between primate embryonic stem cells and mouse embryos: monkey ESCs engraft into mouse embryos, but not post-implantation fetuses.

Simerly C, McFarland D, Castro C, Lin CC, Redinger C, Jacoby E, Mich-Basso J, Orwig K, Mills P, Ahrens E, Navara C, Schatten G.

Stem Cell Res. 2011 Jul;7(1):28-40. doi: 10.1016/j.scr.2011.03.002. Epub 2011 Mar 25.

49.

Voluntary reduction of trans-fatty acids in Latin America and the Caribbean: current situation.

Monge-Rojas R, Colón-Ramos U, Jacoby E, Mozaffarian D.

Rev Panam Salud Publica. 2011 Feb;29(2):126-9.

50.

The role of computational methods in the identification of bioactive compounds.

Glick M, Jacoby E.

Curr Opin Chem Biol. 2011 Aug;15(4):540-6. doi: 10.1016/j.cbpa.2011.02.021. Epub 2011 Mar 14. Review.

PMID:
21411361

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