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Organophosphorus Pesticides Induce Cytokine Release from Differentiated Human THP1 Cells.

Proskocil BJ, Grodzki ACG, Jacoby DB, Lein PJ, Fryer AD.

Am J Respir Cell Mol Biol. 2019 Apr 12. doi: 10.1165/rcmb.2018-0257OC. [Epub ahead of print]


Eosinophils increase airway sensory nerve density in mice and in human asthma.

Drake MG, Scott GD, Blum ED, Lebold KM, Nie Z, Lee JJ, Fryer AD, Costello RW, Jacoby DB.

Sci Transl Med. 2018 Sep 5;10(457). pii: eaar8477. doi: 10.1126/scitranslmed.aar8477.


Protective Role of Eosinophils and TNFa after Ozone Inhalation.

Fryer AD, Jacoby DB, Wicher SA.

Res Rep Health Eff Inst. 2017 Mar;(191):1-41.


Eosinophil and airway nerve interactions in asthma.

Drake MG, Lebold KM, Roth-Carter QR, Pincus AB, Blum ED, Proskocil BJ, Jacoby DB, Fryer AD, Nie Z.

J Leukoc Biol. 2018 Jul;104(1):61-67. doi: 10.1002/JLB.3MR1117-426R. Epub 2018 Apr 6. Review.


Ozone-induced eosinophil recruitment to airways is altered by antigen sensitization and tumor necrosis factor-α blockade.

Wicher SA, Lawson KL, Jacoby DB, Fryer AD, Drake MG.

Physiol Rep. 2017 Dec;5(24). pii: e13538. doi: 10.14814/phy2.13538.


In Memory and Celebration: Dr. James J. Lee.

Rosenberg HF, Fryer AD, Munitz A, Bochner BS, Jacoby DB, Levi-Schaffer F, Gleich GJ, Furuta GT, Rothenberg ME, Lacy P, Fulkerson PC, Hogan SP, Ackerman SJ, Foster PS.

Clin Exp Allergy. 2017 Jul;47(7):980-981. doi: 10.1111/cea.12959. No abstract available.


Newly divided eosinophils limit ozone-induced airway hyperreactivity in nonsensitized guinea pigs.

Wicher SA, Jacoby DB, Fryer AD.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L969-L982. doi: 10.1152/ajplung.00530.2016. Epub 2017 Mar 3.


Toll-Like Receptor 7-Targeted Therapy in Respiratory Disease.

Lebold KM, Jacoby DB, Drake MG.

Transfus Med Hemother. 2016 Mar;43(2):114-9. doi: 10.1159/000445324. Epub 2016 Mar 22. Review.


Human and Mouse Eosinophils Have Antiviral Activity against Parainfluenza Virus.

Drake MG, Bivins-Smith ER, Proskocil BJ, Nie Z, Scott GD, Lee JJ, Lee NA, Fryer AD, Jacoby DB.

Am J Respir Cell Mol Biol. 2016 Sep;55(3):387-94. doi: 10.1165/rcmb.2015-0405OC.


The influence of sensitization on mechanisms of organophosphorus pesticide-induced airway hyperreactivity.

Proskocil BJ, Bruun DA, Garg JA, Villagomez CC, Jacoby DB, Lein PJ, Fryer AD.

Am J Respir Cell Mol Biol. 2015 Nov;53(5):738-47. doi: 10.1165/rcmb.2014-0444OC.


Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice.

Lee JJ, Protheroe CA, Luo H, Ochkur SI, Scott GD, Zellner KR, Raish RJ, Dahl MV, Vega ML, Conley O, Condjella RM, Kloeber JA, Neely JL, Patel YS, Maizer P, Mazzolini A, Fryer AD, Jacoby NW, Jacoby DB, Lee NA.

J Allergy Clin Immunol. 2015 Feb;135(2):477-87. doi: 10.1016/j.jaci.2014.07.003. Epub 2014 Aug 13.


Interactions of eosinophils with nerves.

Roth-Carter QR, Jacoby DB, Nie Z.

Methods Mol Biol. 2014;1178:215-29. doi: 10.1007/978-1-4939-1016-8_19.


Interleukin-1β mediates virus-induced m2 muscarinic receptor dysfunction and airway hyperreactivity.

Rynko AE, Fryer AD, Jacoby DB.

Am J Respir Cell Mol Biol. 2014 Oct;51(4):494-501. doi: 10.1165/rcmb.2014-0009OC.


Hyperinsulinemia potentiates airway responsiveness to parasympathetic nerve stimulation in obese rats.

Nie Z, Jacoby DB, Fryer AD.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):251-61. doi: 10.1165/rcmb.2013-0452OC.


Tissue optical clearing, three-dimensional imaging, and computer morphometry in whole mouse lungs and human airways.

Scott GD, Blum ED, Fryer AD, Jacoby DB.

Am J Respir Cell Mol Biol. 2014 Jul;51(1):43-55. doi: 10.1165/rcmb.2013-0284OC.


Dual p38/JNK mitogen activated protein kinase inhibitors prevent ozone-induced airway hyperreactivity in guinea pigs.

Verhein KC, Salituro FG, Ledeboer MW, Fryer AD, Jacoby DB.

PLoS One. 2013 Sep 18;8(9):e75351. doi: 10.1371/journal.pone.0075351. eCollection 2013.


Toll-like receptor 7 rapidly relaxes human airways.

Drake MG, Scott GD, Proskocil BJ, Fryer AD, Jacoby DB, Kaufman EH.

Am J Respir Crit Care Med. 2013 Sep 15;188(6):664-72. doi: 10.1164/rccm.201303-0442OC.


Toll-like receptor-2/6 and Toll-like receptor-9 agonists suppress viral replication but not airway hyperreactivity in guinea pigs.

Drake MG, Evans SE, Dickey BF, Fryer AD, Jacoby DB.

Am J Respir Cell Mol Biol. 2013 Jun;48(6):790-6. doi: 10.1165/rcmb.2012-0498OC.


Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs.

Proskocil BJ, Bruun DA, Jacoby DB, van Rooijen N, Lein PJ, Fryer AD.

Am J Physiol Lung Cell Mol Physiol. 2013 Apr 15;304(8):L519-29. doi: 10.1152/ajplung.00381.2012. Epub 2013 Feb 1.


Quantifying nerve architecture in murine and human airways using three-dimensional computational mapping.

Scott GD, Fryer AD, Jacoby DB.

Am J Respir Cell Mol Biol. 2013 Jan;48(1):10-6. doi: 10.1165/rcmb.2012-0290MA. Epub 2012 Oct 25.


The therapeutic potential of Toll-like receptor 7 stimulation in asthma.

Drake MG, Kaufman EH, Fryer AD, Jacoby DB.

Inflamm Allergy Drug Targets. 2012 Dec;11(6):484-91. Review.


β2-Agonists inhibit TNF-α-induced ICAM-1 expression in human airway parasympathetic neurons.

Nie Z, Fryer AD, Jacoby DB.

PLoS One. 2012;7(9):e44780. doi: 10.1371/journal.pone.0044780. Epub 2012 Sep 25.


Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.

Koguchi Y, Buenafe AC, Thauland TJ, Gardell JL, Bivins-Smith ER, Jacoby DB, Slifka MK, Parker DC.

PLoS One. 2012;7(2):e31296. doi: 10.1371/journal.pone.0031296. Epub 2012 Feb 21.


Muscarinic receptor agonists and antagonists: effects on inflammation and immunity.

Verbout NG, Jacoby DB.

Handb Exp Pharmacol. 2012;(208):403-27. doi: 10.1007/978-3-642-23274-9_17. Review.


Upping the antedrug: is a novel anti-inflammatory Toll-like receptor 7 agonist also a bronchodilator?

Kaufman EH, Jacoby DB.

Br J Pharmacol. 2012 May;166(2):569-72. doi: 10.1111/j.1476-5381.2011.01758.x.


Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma.

Buels KS, Jacoby DB, Fryer AD.

Br J Pharmacol. 2012 Mar;165(5):1501-14. doi: 10.1111/j.1476-5381.2011.01632.x.


Eosinophils increase neuron branching in human and murine skin and in vitro.

Foster EL, Simpson EL, Fredrikson LJ, Lee JJ, Lee NA, Fryer AD, Jacoby DB.

PLoS One. 2011;6(7):e22029. doi: 10.1371/journal.pone.0022029. Epub 2011 Jul 21.


Role of TNF-α in virus-induced airway hyperresponsiveness and neuronal M₂ muscarinic receptor dysfunction.

Nie Z, Scott GD, Weis PD, Itakura A, Fryer AD, Jacoby DB.

Br J Pharmacol. 2011 Sep;164(2b):444-52. doi: 10.1111/j.1476-5381.2011.01393.x.


Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs.

Kaufman EH, Fryer AD, Jacoby DB.

J Allergy Clin Immunol. 2011 Feb;127(2):462-9. doi: 10.1016/j.jaci.2010.10.029. Epub 2010 Dec 17.


Three days after a single exposure to ozone, the mechanism of airway hyperreactivity is dependent on substance P and nerve growth factor.

Verhein KC, Hazari MS, Moulton BC, Jacoby IW, Jacoby DB, Fryer AD.

Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L176-84. doi: 10.1152/ajplung.00060.2010. Epub 2010 Nov 5.


Human mucosal associated invariant T cells detect bacterially infected cells.

Gold MC, Cerri S, Smyk-Pearson S, Cansler ME, Vogt TM, Delepine J, Winata E, Swarbrick GM, Chua WJ, Yu YY, Lantz O, Cook MS, Null MD, Jacoby DB, Harriff MJ, Lewinsohn DA, Hansen TH, Lewinsohn DM.

PLoS Biol. 2010 Jun 29;8(6):e1000407. doi: 10.1371/journal.pbio.1000407.


Agents that bind annexin A2 suppress ocular neovascularization.

Lima e Silva R, Shen J, Gong YY, Seidel CP, Hackett SF, Kesavan K, Jacoby DB, Campochiaro PA.

J Cell Physiol. 2010 Nov;225(3):855-64. doi: 10.1002/jcp.22296.


Potent pleiotropic anti-angiogenic effects of TM601, a synthetic chlorotoxin peptide.

Jacoby DB, Dyskin E, Yalcin M, Kesavan K, Dahlberg W, Ratliff J, Johnson EW, Mousa SA.

Anticancer Res. 2010 Jan;30(1):39-46.


Annexin A2 is a molecular target for TM601, a peptide with tumor-targeting and anti-angiogenic effects.

Kesavan K, Ratliff J, Johnson EW, Dahlberg W, Asara JM, Misra P, Frangioni JV, Jacoby DB.

J Biol Chem. 2010 Feb 12;285(7):4366-74. doi: 10.1074/jbc.M109.066092. Epub 2009 Dec 15.


Neural control of airway inflammation.

Verhein KC, Fryer AD, Jacoby DB.

Curr Allergy Asthma Rep. 2009 Nov;9(6):484-90. Review.


Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects.

Moreno-Vinasco L, Verbout NG, Fryer AD, Jacoby DB.

Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L340-6. doi: 10.1152/ajplung.90267.2008. Epub 2009 May 22.


Atropine-enhanced, antigen challenge-induced airway hyperreactivity in guinea pigs is mediated by eosinophils and nerve growth factor.

Verbout NG, Jacoby DB, Gleich GJ, Fryer AD.

Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L228-37. doi: 10.1152/ajplung.90540.2008. Epub 2009 May 15.


Etanercept prevents airway hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs.

Nie Z, Jacoby DB, Fryer AD.

Br J Pharmacol. 2009 Jan;156(1):201-10. doi: 10.1111/j.1476-5381.2008.00045.x.


Characterization of side population cells from human airway epithelium.

Hackett TL, Shaheen F, Johnson A, Wadsworth S, Pechkovsky DV, Jacoby DB, Kicic A, Stick SM, Knight DA.

Stem Cells. 2008 Oct;26(10):2576-85. doi: 10.1634/stemcells.2008-0171. Epub 2008 Jul 24.


IL-1 receptors mediate persistent, but not acute, airway hyperreactivity to ozone in guinea pigs.

Verhein KC, Jacoby DB, Fryer AD.

Am J Respir Cell Mol Biol. 2008 Dec;39(6):730-8. doi: 10.1165/rcmb.2008-0045OC. Epub 2008 Jul 10.


Cigarette smoke induces genetic instability in airway epithelial cells by suppressing FANCD2 expression.

Hays LE, Zodrow DM, Yates JE, Deffebach ME, Jacoby DB, Olson SB, Pankow JF, Bagby GC.

Br J Cancer. 2008 May 20;98(10):1653-61. doi: 10.1038/sj.bjc.6604362. Epub 2008 May 13.


Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity.

Proskocil BJ, Bruun DA, Lorton JK, Blensly KC, Jacoby DB, Lein PJ, Fryer AD.

Environ Health Perspect. 2008 Mar;116(3):381-8. doi: 10.1289/ehp.10694.


Proinflammatory responses of human airway cells to ricin involve stress-activated protein kinases and NF-kappaB.

Wong J, Korcheva V, Jacoby DB, Magun BE.

Am J Physiol Lung Cell Mol Physiol. 2007 Dec;293(6):L1385-94. Epub 2007 Sep 14.


Expression and regulation of intercellular adhesion molecule-1 on airway parasympathetic nerves.

Nie Z, Nelson CS, Jacoby DB, Fryer AD.

J Allergy Clin Immunol. 2007 Jun;119(6):1415-22. Epub 2007 Apr 5.


Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601).

Mamelak AN, Jacoby DB.

Expert Opin Drug Deliv. 2007 Mar;4(2):175-86. Review.


Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages.

Korcheva V, Wong J, Lindauer M, Jacoby DB, Iordanov MS, Magun B.

Mol Immunol. 2007 Apr;44(10):2761-71. Epub 2007 Jan 25.


Atropine pretreatment enhances airway hyperreactivity in antigen-challenged guinea pigs through an eosinophil-dependent mechanism.

Verbout NG, Lorton JK, Jacoby DB, Fryer AD.

Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1126-35. Epub 2007 Jan 12.


Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum.

Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA.

Am J Respir Cell Mol Biol. 2006 May;34(5):523-6. No abstract available.


Safety and feasibility of percutaneous autologous skeletal myoblast transplantation in the coil-infarcted swine myocardium.

Dib N, Campbell A, Jacoby DB, Zawadzka A, Ratliff J, Miedzybrocki BM, Gahremanpour A, Diethrich EB, Opie SR.

J Pharmacol Toxicol Methods. 2006 Jul-Aug;54(1):71-7. Epub 2006 Feb 3.


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