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Items: 47

1.

The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease.

Neumann U, Ufer M, Jacobson LH, Rouzade-Dominguez ML, Huledal G, Kolly C, Lüönd RM, Machauer R, Veenstra SJ, Hurth K, Rueeger H, Tintelnot-Blomley M, Staufenbiel M, Shimshek DR, Perrot L, Frieauff W, Dubost V, Schiller H, Vogg B, Beltz K, Avrameas A, Kretz S, Pezous N, Rondeau JM, Beckmann N, Hartmann A, Vormfelde S, David OJ, Galli B, Ramos R, Graf A, Lopez Lopez C.

EMBO Mol Med. 2018 Sep 17. pii: e9316. doi: 10.15252/emmm.201809316. [Epub ahead of print]

2.

Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death.

Richards KL, Milligan CJ, Richardson RJ, Jancovski N, Grunnet M, Jacobson LH, Undheim EAB, Mobli M, Chow CY, Herzig V, Csoti A, Panyi G, Reid CA, King GF, Petrou S.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8077-E8085. doi: 10.1073/pnas.1804764115. Epub 2018 Aug 3.

3.

The Gamma-Aminobutyric Acid B Receptor in Depression and Reward.

Jacobson LH, Vlachou S, Slattery DA, Li X, Cryan JF.

Biol Psychiatry. 2018 Jun 1;83(11):963-976. doi: 10.1016/j.biopsych.2018.02.006. Epub 2018 Feb 22. Review.

PMID:
29759132
4.

Blunted 5-HT1A receptor-mediated responses and antidepressant-like behavior in mice lacking the GABAB1a but not GABAB1b subunit isoforms.

Jacobson LH, Hoyer D, Fehlmann D, Bettler B, Kaupmann K, Cryan JF.

Psychopharmacology (Berl). 2017 May;234(9-10):1511-1523. doi: 10.1007/s00213-016-4521-5. Epub 2017 Jan 9.

PMID:
28070618
5.

Orexin OX2 Receptor Antagonists as Sleep Aids.

Jacobson LH, Chen S, Mir S, Hoyer D.

Curr Top Behav Neurosci. 2017;33:105-136. doi: 10.1007/7854_2016_47. Review.

PMID:
27909987
6.

Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice.

Beckmann N, Doelemeyer A, Zurbruegg S, Bigot K, Theil D, Frieauff W, Kolly C, Moulin P, Neddermann D, Kreutzer R, Perrot L, Brzak I, Jacobson LH, Staufenbiel M, Neumann U, Shimshek DR.

Neurobiol Aging. 2016 Sep;45:50-60. doi: 10.1016/j.neurobiolaging.2016.05.009. Epub 2016 May 17.

7.

Neurological Dysfunction in Early Maturity of a Model for Niemann-Pick C1 Carrier Status.

Hung YH, Walterfang M, Churilov L, Bray L, Jacobson LH, Barnham KJ, Jones NC, O'Brien TJ, Velakoulis D, Bush AI.

Neurotherapeutics. 2016 Jul;13(3):614-22. doi: 10.1007/s13311-016-0427-5.

8.

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.

Shimshek DR, Jacobson LH, Kolly C, Zamurovic N, Balavenkatraman KK, Morawiec L, Kreutzer R, Schelle J, Jucker M, Bertschi B, Theil D, Heier A, Bigot K, Beltz K, Machauer R, Brzak I, Perrot L, Neumann U.

Sci Rep. 2016 Feb 25;6:21917. doi: 10.1038/srep21917.

9.

Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs).

Behnke D, Cotesta S, Hintermann S, Fendt M, Gee CE, Jacobson LH, Laue G, Meyer A, Wagner T, Badiger S, Chaudhari V, Chebrolu M, Pandit C, Hoyer D, Betschart C.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5555-60. doi: 10.1016/j.bmcl.2015.10.055. Epub 2015 Oct 19.

PMID:
26522950
10.

Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine.

Jacobson LH, Sweeney FF, Kaupmann K, O'Leary OF, Gassmann M, Bettler B, Cryan JF.

Behav Brain Res. 2016 Feb 1;298(Pt B):12-6. doi: 10.1016/j.bbr.2015.10.039. Epub 2015 Oct 27.

PMID:
26518330
11.

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.

Neumann U, Rueeger H, Machauer R, Veenstra SJ, Lueoend RM, Tintelnot-Blomley M, Laue G, Beltz K, Vogg B, Schmid P, Frieauff W, Shimshek DR, Staufenbiel M, Jacobson LH.

Mol Neurodegener. 2015 Sep 3;10:44. doi: 10.1186/s13024-015-0033-8.

12.

Suvorexant for the treatment of insomnia.

Jacobson LH, Callander GE, Hoyer D.

Expert Rev Clin Pharmacol. 2014 Nov;7(6):711-30. doi: 10.1586/17512433.2014.966813. Review.

PMID:
25318834
13.

Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors.

Callander GE, Olorunda M, Monna D, Schuepbach E, Langenegger D, Betschart C, Hintermann S, Behnke D, Cotesta S, Fendt M, Laue G, Ofner S, Briard E, Gee CE, Jacobson LH, Hoyer D.

Front Neurosci. 2013 Dec 3;7:230. doi: 10.3389/fnins.2013.00230. eCollection 2013.

14.

Distinct effects of IPSU and suvorexant on mouse sleep architecture.

Hoyer D, Dürst T, Fendt M, Jacobson LH, Betschart C, Hintermann S, Behnke D, Cotesta S, Laue G, Ofner S, Legangneux E, Gee CE.

Front Neurosci. 2013 Dec 10;7:235. doi: 10.3389/fnins.2013.00235. eCollection 2013.

15.

Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?

Hoyer D, Jacobson LH.

Neuropeptides. 2013 Dec;47(6):477-88. doi: 10.1016/j.npep.2013.10.009. Epub 2013 Oct 23. Review.

PMID:
24215799
16.

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid β-peptides.

Rueeger H, Lueoend R, Machauer R, Veenstra SJ, Jacobson LH, Staufenbiel M, Desrayaud S, Rondeau JM, Möbitz H, Neumann U.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5300-6. doi: 10.1016/j.bmcl.2013.07.071. Epub 2013 Aug 9.

PMID:
23981898
17.

Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia.

Betschart C, Hintermann S, Behnke D, Cotesta S, Fendt M, Gee CE, Jacobson LH, Laue G, Ofner S, Chaudhari V, Badiger S, Pandit C, Wagner J, Hoyer D.

J Med Chem. 2013 Oct 10;56(19):7590-607. doi: 10.1021/jm4007627. Epub 2013 Sep 18.

PMID:
23964859
18.

Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice.

Walker JR, Pacoma R, Watson J, Ou W, Alves J, Mason DE, Peters EC, Urbina HD, Welzel G, Althage A, Liu B, Tuntland T, Jacobson LH, Harris JL, Schumacher AM.

J Neurosci. 2013 Feb 6;33(6):2457-64. doi: 10.1523/JNEUROSCI.3407-12.2013.

19.

BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system.

Mattsson N, Rajendran L, Zetterberg H, Gustavsson M, Andreasson U, Olsson M, Brinkmalm G, Lundkvist J, Jacobson LH, Perrot L, Neumann U, Borghys H, Mercken M, Dhuyvetter D, Jeppsson F, Blennow K, Portelius E.

PLoS One. 2012;7(2):e31084. doi: 10.1371/journal.pone.0031084. Epub 2012 Feb 6.

20.

Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity.

Jacobson LH, Commerford SR, Gerber SP, Chen YA, Dardik B, Chaperon F, Schwartzkopf C, Nguyen-Tran V, Hollenbeck T, McNamara P, He X, Liu H, Seidel HM, Jaton AL, Gromada J, Teixeira S.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Dec;384(6):565-81. doi: 10.1007/s00210-011-0686-y. Epub 2011 Sep 25.

PMID:
21947251
21.

The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.

Wiessner C, Wiederhold KH, Tissot AC, Frey P, Danner S, Jacobson LH, Jennings GT, Lüönd R, Ortmann R, Reichwald J, Zurini M, Mir A, Bachmann MF, Staufenbiel M.

J Neurosci. 2011 Jun 22;31(25):9323-31. doi: 10.1523/JNEUROSCI.0293-11.2011.

22.

Genetic approaches to modeling anxiety in animals.

Jacobson LH, Cryan JF.

Curr Top Behav Neurosci. 2010;2:161-201. Review.

PMID:
21309110
23.

Examining face and construct validity of a noninvasive model of panic disorder in Lister-hooded rats.

Klein S, Nicolas LB, Lopez-Lopez C, Jacobson LH, McArthur SG, Grundschober C, Prinssen EP.

Psychopharmacology (Berl). 2010 Aug;211(2):197-208. doi: 10.1007/s00213-010-1882-z. Epub 2010 Jun 1.

PMID:
20514481
24.

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation.

Eisele YS, Bolmont T, Heikenwalder M, Langer F, Jacobson LH, Yan ZX, Roth K, Aguzzi A, Staufenbiel M, Walker LC, Jucker M.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12926-31. doi: 10.1073/pnas.0903200106. Epub 2009 Jul 21.

25.

Evaluation of the anxiolytic-like profile of the GABAB receptor positive modulator CGP7930 in rodents.

Jacobson LH, Cryan JF.

Neuropharmacology. 2008 Apr;54(5):854-62. doi: 10.1016/j.neuropharm.2008.01.004. Epub 2008 Jan 13.

PMID:
18328507
26.

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity.

Fendt M, Schmid S, Thakker DR, Jacobson LH, Yamamoto R, Mitsukawa K, Maier R, Natt F, Hüsken D, Kelly PH, McAllister KH, Hoyer D, van der Putten H, Cryan JF, Flor PJ.

Mol Psychiatry. 2008 Oct;13(10):970-9. Epub 2007 Aug 21.

PMID:
17712315
27.

Specific roles of GABA(B(1)) receptor isoforms in cognition.

Jacobson LH, Kelly PH, Bettler B, Kaupmann K, Cryan JF.

Behav Brain Res. 2007 Jul 19;181(1):158-62. Epub 2007 Apr 5.

28.

Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety.

Jacobson LH, Bettler B, Kaupmann K, Cryan JF.

Psychopharmacology (Berl). 2007 Mar;190(4):541-53. Epub 2006 Dec 15.

PMID:
17171558
29.

A genetic upper limit to whole-body protein deposition in a strain of growing pigs.

Moughan PJ, Jacobson LH, Morel PC.

J Anim Sci. 2006 Dec;84(12):3301-9.

PMID:
17093222
30.

Feeling strained? Influence of genetic background on depression-related behavior in mice: a review.

Jacobson LH, Cryan JF.

Behav Genet. 2007 Jan;37(1):171-213. Epub 2006 Sep 23. Review.

PMID:
17029009
31.

GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice.

Jacobson LH, Bettler B, Kaupmann K, Cryan JF.

J Pharmacol Exp Ther. 2006 Dec;319(3):1317-26. Epub 2006 Sep 21.

32.

GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories.

Jacobson LH, Kelly PH, Bettler B, Kaupmann K, Cryan JF.

J Neurosci. 2006 Aug 23;26(34):8800-3.

33.

Differential compartmentalization and distinct functions of GABAB receptor variants.

Vigot R, Barbieri S, Bräuner-Osborne H, Turecek R, Shigemoto R, Zhang YP, Luján R, Jacobson LH, Biermann B, Fritschy JM, Vacher CM, Müller M, Sansig G, Guetg N, Cryan JF, Kaupmann K, Gassmann M, Oertner TG, Bettler B.

Neuron. 2006 May 18;50(4):589-601.

34.

Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains.

Jacobson LH, Cryan JF.

Psychopharmacology (Berl). 2005 May;179(3):688-99. Epub 2005 Jan 25.

PMID:
15668819
35.

Effect of feeding pasture-finished cattle different conserved forages on Escherichia coli in the rumen and faeces.

Jacobson LH, Nagle TA, Gregory NG, Graham Bell R, Le Roux G, Haines JM.

Meat Sci. 2002 Sep;62(1):93-106.

PMID:
22061197
36.

Heart failure: strategies to enhance patient self-management.

Dunbar SB, Jacobson LH, Deaton C.

AACN Clin Issues. 1998 May;9(2):244-56. Review.

PMID:
9633275
37.

Partitioning psychological and physical sources of transport-related stress in young cattle.

Jacobson LH, Cook CJ.

Vet J. 1998 Mar;155(2):205-8. No abstract available.

PMID:
9564276
38.

Heart rate as a measure of adaptation to stress in cattle.

Cook CJ, Jacobson LH.

Aust Vet J. 1996 Dec;74(6):471-2. No abstract available.

PMID:
9006871
39.

Salivary cortisol as an indicator of stress in sheep (Ovis ovis).

Cook CJ, Jacobson LH.

N Z Vet J. 1995 Nov;43(6):248. No abstract available.

PMID:
16031862
40.

Electrical head-only stunning of fallow deer (Dama dama).

Cook CJ, Devine CE, Gilbert KV, Jacobson LH, Blackmore DK.

N Z Vet J. 1994 Feb;42(1):38-9. No abstract available.

PMID:
16031743
41.

Management of elderly patients with primary breast cancer.

Toonkel LM, Fix I, Jacobson LH, Bamberg N.

Int J Radiat Oncol Biol Phys. 1988 Apr;14(4):677-81.

PMID:
3350723
42.

Locally advanced breast carcinoma: results with combined regional therapy.

Toonkel LM, Fix I, Jacobson LH, Bamberg N, Wallach CB.

Int J Radiat Oncol Biol Phys. 1986 Sep;12(9):1583-7.

PMID:
3759583
43.

Myometrial penetration of endometrial carcinoma as a prognostic factor for patients receiving pre- or postoperative radiation therapy.

Toonkel LM, Fix I, Jacobson LH, Bamberg N, Wallach CB.

Am J Clin Oncol. 1984 Dec;7(6):669-73.

PMID:
6442100
44.

The significance of local recurrence of carcinoma of the breast.

Toonkel LM, Fix I, Jacobson LH, Wallach CB.

Int J Radiat Oncol Biol Phys. 1983 Jan;9(1):33-9.

PMID:
6404864
45.

Postoperative radiation therapy for carcinoma of the breast: improved results with elective irradiation of the chest wall.

Toonkel LM, Fix I, Jacobson LH, Schneider JJ, Wallach CB.

Int J Radiat Oncol Biol Phys. 1982 Jun;8(6):977-82. No abstract available.

PMID:
7107439
46.

X rays and childhood cancer.

Jacobson LH.

Lancet. 1968 May 4;1(7549):980. No abstract available.

PMID:
4171604
47.

A simple way to lower the shoulders in cervical myelography.

Jacobson LH.

Radiology. 1966 Apr;86(4):745. No abstract available.

PMID:
5934332

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