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CD137 deficiency causes immune dysregulation with predisposition to lymphomagenesis.

Somekh I, Thian M, Medgyesi D, Gülez N, Magg T, Gallón Duque A, Stauber T, Lev A, Genel F, Unal E, Simon AJ, Lee YN, Kalinichenko A, Dmytrus J, Kraakman MJ, Schiby G, Rohlfs M, Jacobson JM, Özer E, Akcal Ö, Conca R, Patiroglu T, Karakukcu M, Ozcan A, Shahin T, Appella E, Tatematsu M, Martinez-Jaramillo C, Chinn IK, Orange JS, Trujillo-Vargas CM, Franco JL, Hauck F, Somech R, Klein C, Boztug K.

Blood. 2019 Sep 9. pii: blood.2019000644. doi: 10.1182/blood.2019000644. [Epub ahead of print]


Investigating the distribution of HIV-1 Tat lengths present in the Drexel Medicine CARES cohort.

Link RW, Mele AR, Antell GC, Pirrone V, Zhong W, Kercher K, Passic S, Szep Z, Malone K, Jacobson JM, Dampier W, Wigdahl B, Nonnemacher MR.

Virus Res. 2019 Oct 15;272:197727. doi: 10.1016/j.virusres.2019.197727. Epub 2019 Aug 19.


Fetuin-A deficiency is associated with infantile cortical hyperostosis (Caffey disease).

Merdler-Rabinowicz R, Grinberg A, Jacobson JM, Somekh I, Klein C, Lev A, Ihsan S, Habib A, Somech R, Simon AJ.

Pediatr Res. 2019 Jul 9. doi: 10.1038/s41390-019-0499-0. [Epub ahead of print]


Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice.

Dash PK, Kaminski R, Bella R, Su H, Mathews S, Ahooyi TM, Chen C, Mancuso P, Sariyer R, Ferrante P, Donadoni M, Robinson JA, Sillman B, Lin Z, Hilaire JR, Banoub M, Elango M, Gautam N, Mosley RL, Poluektova LY, McMillan J, Bade AN, Gorantla S, Sariyer IK, Burdo TH, Young WB, Amini S, Gordon J, Jacobson JM, Edagwa B, Khalili K, Gendelman HE.

Nat Commun. 2019 Jul 2;10(1):2753. doi: 10.1038/s41467-019-10366-y.


NK Response Correlates with HIV Decrease in Pegylated IFN-α2a-Treated Antiretroviral Therapy-Suppressed Subjects.

Papasavvas E, Azzoni L, Kossenkov AV, Dawany N, Morales KH, Fair M, Ross BN, Lynn K, Mackiewicz A, Mounzer K, Tebas P, Jacobson JM, Kostman JR, Showe L, Montaner LJ.

J Immunol. 2019 Aug 1;203(3):705-717. doi: 10.4049/jimmunol.1801511. Epub 2019 Jun 28.


Pharmacokinetic stability of macrocyclic peptide triazole HIV-1 inactivators alone and in liposomes.

Aneja R, Grigoletto A, Nangarlia A, Rashad AA, Wrenn S, Jacobson JM, Pasut G, Chaiken I.

J Pept Sci. 2019 Apr;25(4):e3155. doi: 10.1002/psc.3155. Epub 2019 Feb 27.


Toward the Cure of HIV-1 Infection: Lessons Learned and Yet to be Learned as New Strategies are Developed.

Jacobson JM, Khalili K.

AIDS Rev. 2018;20(4):220-225. doi: 10.24875/AIDSRev.18000027. Review.


Minimal PAM specificity of a highly similar SpCas9 ortholog.

Chatterjee P, Jakimo N, Jacobson JM.

Sci Adv. 2018 Oct 24;4(10):eaau0766. doi: 10.1126/sciadv.aau0766. eCollection 2018 Oct.


Removal of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice.

Bella R, Kaminski R, Mancuso P, Young WB, Chen C, Sariyer R, Fischer T, Amini S, Ferrante P, Jacobson JM, Kashanchi F, Khalili K.

Mol Ther Nucleic Acids. 2018 Sep 7;12:275-282. doi: 10.1016/j.omtn.2018.05.021. Epub 2018 Jun 19.


The Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical Studies.

Namazi G, Fajnzylber JM, Aga E, Bosch RJ, Acosta EP, Sharaf R, Hartogensis W, Jacobson JM, Connick E, Volberding P, Skiest D, Margolis D, Sneller MC, Little SJ, Gianella S, Smith DM, Kuritzkes DR, Gulick RM, Mellors JW, Mehraj V, Gandhi RT, Mitsuyasu R, Schooley RT, Henry K, Tebas P, Deeks SG, Chun TW, Collier AC, Routy JP, Hecht FM, Walker BD, Li JZ.

J Infect Dis. 2018 Nov 5;218(12):1954-1963. doi: 10.1093/infdis/jiy479.


HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers.

Sharaf R, Lee GQ, Sun X, Etemad B, Aboukhater LM, Hu Z, Brumme ZL, Aga E, Bosch RJ, Wen Y, Namazi G, Gao C, Acosta EP, Gandhi RT, Jacobson JM, Skiest D, Margolis DM, Mitsuyasu R, Volberding P, Connick E, Kuritzkes DR, Lederman MM, Yu XG, Lichterfeld M, Li JZ.

J Clin Invest. 2018 Aug 31;128(9):4074-4085. doi: 10.1172/JCI120549. Epub 2018 Aug 20.


Broad-Spectrum and Personalized Guide RNAs for CRISPR/Cas9 HIV-1 Therapeutics.

Dampier W, Sullivan NT, Mell JC, Pirrone V, Ehrlich GD, Chung CH, Allen AG, DeSimone M, Zhong W, Kercher K, Passic S, Williams JW, Szep Z, Khalili K, Jacobson JM, Nonnemacher MR, Wigdahl B.

AIDS Res Hum Retroviruses. 2018 Nov;34(11):950-960. doi: 10.1089/AID.2017.0274. Epub 2018 Aug 27.


The North-South Divide: Substance Use Risk, Care Engagement, and Viral Suppression Among Hospitalized Human Immunodeficiency Virus-Infected Patients in 11 US Cities.

Philbin MM, Feaster DJ, Gooden L, Duan R, Das M, Jacobs P, Lucas GM, Batey DS, Nijhawan A, Jacobson JM, Mandler R, Daar E, McMahon DK, Armstrong WS, Del Rio C, Metsch LR.

Clin Infect Dis. 2019 Jan 1;68(1):146-149. doi: 10.1093/cid/ciy506.


Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine.

Ippolito MM, Jacobson JM, Lederman MM, Winterberg M, Tarning J, Shapiro TA, Flexner C.

Clin Infect Dis. 2018 Oct 30;67(10):1617-1620. doi: 10.1093/cid/ciy405.



Bettiker RL, Koren DE, Jacobson JM.

Curr Opin HIV AIDS. 2018 Jul;13(4):354-358. doi: 10.1097/COH.0000000000000473. Review.


Phenotype variability in Hajdu-Cheney syndrome.

Regev M, Pode-Shakked B, Jacobson JM, Raas-Rothschild A, Goldstein DB, Anikster Y.

Eur J Med Genet. 2019 Jan;62(1):35-38. doi: 10.1016/j.ejmg.2018.04.015. Epub 2018 Apr 23.


The Added Value of the Lateral Chest Radiograph for Diagnosing Community Acquired Pneumonia in the Pediatric Emergency Department.

Soudack M, Plotkin S, Ben-Shlush A, Raviv-Zilka L, Jacobson JM, Benacon M, Augarten A.

Isr Med Assoc J. 2018 Jan;20(1):5-8.


Effect of Short-Term Antiretroviral Therapy Interruption on Levels of Integrated HIV DNA.

Strongin Z, Sharaf R, VanBelzen DJ, Jacobson JM, Connick E, Volberding P, Skiest DJ, Gandhi RT, Kuritzkes DR, O'Doherty U, Li JZ.

J Virol. 2018 May 29;92(12). pii: e00285-18. doi: 10.1128/JVI.00285-18. Print 2018 Jun 15.


Enantioselective Total Synthesis of Cannabinoids-A Route for Analogue Development.

Shultz ZP, Lawrence GA, Jacobson JM, Cruz EJ, Leahy JW.

Org Lett. 2018 Jan 19;20(2):381-384. doi: 10.1021/acs.orglett.7b03668. Epub 2018 Jan 2.


Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences.

Antell GC, Dampier W, Aiamkitsumrit B, Nonnemacher MR, Pirrone V, Zhong W, Kercher K, Passic S, Williams J, Liu Y, James T, Jacobson JM, Szep Z, Wigdahl B, Krebs FC.

Int J Genomics. 2017;2017:4081585. doi: 10.1155/2017/4081585. Epub 2017 May 17.


Natural history of fetal isolated ventriculomegaly: Comparison between pre- and post-natal imaging.

Perlman S, Bar-Yosef O, Jacobson JM, Gilboa Y, Derazne E, Achiron R, Katorza E.

J Matern Fetal Neonatal Med. 2018 Jul;31(13):1762-1767. doi: 10.1080/14767058.2017.1326903. Epub 2017 May 19.


HCV viraemia associates with NK cell activation and dysfunction in antiretroviral therapy-treated HIV/HCV-co-infected subjects.

Papasavvas E, Azzoni L, Yin X, Liu Q, Joseph J, Mackiewicz A, Ross B, Lynn KM, Jacobson JM, Mounzer K, Kostman JR, Montaner LJ.

J Viral Hepat. 2017 Oct;24(10):865-876. doi: 10.1111/jvh.12714. Epub 2017 May 11.


Universal antiretroviral regimens: thinking beyond one-pill-once-a-day.

Jacobson JM, Flexner CW.

Curr Opin HIV AIDS. 2017 Jul;12(4):343-350. doi: 10.1097/COH.0000000000000374. Review.


Novel AIDS therapies based on gene editing.

Khalili K, White MK, Jacobson JM.

Cell Mol Life Sci. 2017 Jul;74(13):2439-2450. doi: 10.1007/s00018-017-2479-z. Epub 2017 Feb 16. Review.


Mitochondrial Haplogroup Influences Motor Function in Long-Term HIV-1-Infected Individuals.

Azar A, Devlin K, Mell JC, Giovannetti T, Pirrone V, Nonnemacher MR, Passic S, Kercher K, Williams JW, Jacobson JM, Wigdahl B, Dampier W, Libon DJ, Sell C.

PLoS One. 2016 Oct 6;11(10):e0163772. doi: 10.1371/journal.pone.0163772. eCollection 2016.


Effect of Patient Navigation With or Without Financial Incentives on Viral Suppression Among Hospitalized Patients With HIV Infection and Substance Use: A Randomized Clinical Trial.

Metsch LR, Feaster DJ, Gooden L, Matheson T, Stitzer M, Das M, Jain MK, Rodriguez AE, Armstrong WS, Lucas GM, Nijhawan AE, Drainoni ML, Herrera P, Vergara-Rodriguez P, Jacobson JM, Mugavero MJ, Sullivan M, Daar ES, McMahon DK, Ferris DC, Lindblad R, VanVeldhuisen P, Oden N, Castellón PC, Tross S, Haynes LF, Douaihy A, Sorensen JL, Metzger DS, Mandler RN, Colfax GN, del Rio C.

JAMA. 2016 Jul 12;316(2):156-70. doi: 10.1001/jama.2016.8914.


Specific amino acids in HIV-1 Vpr are significantly associated with differences in patient neurocognitive status.

Dampier W, Antell GC, Aiamkitsumrit B, Nonnemacher MR, Jacobson JM, Pirrone V, Zhong W, Kercher K, Passic S, Williams JW, James T, Devlin KN, Giovannetti T, Libon DJ, Szep Z, Ehrlich GD, Wigdahl B, Krebs FC.

J Neurovirol. 2017 Feb;23(1):113-124. doi: 10.1007/s13365-016-0462-3. Epub 2016 Jul 11.


IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection.

Younes SA, Freeman ML, Mudd JC, Shive CL, Reynaldi A, Panigrahi S, Estes JD, Deleage C, Lucero C, Anderson J, Schacker TW, Davenport MP, McCune JM, Hunt PW, Lee SA, Serrano-Villar S, Debernardo RL, Jacobson JM, Canaday DH, Sekaly RP, Rodriguez B, Sieg SF, Lederman MM.

J Clin Invest. 2016 Jul 1;126(7):2745-56. doi: 10.1172/JCI85996. Epub 2016 Jun 20.


HIV-1 Genetic Variation Resulting in the Development of New Quasispecies Continues to Be Encountered in the Peripheral Blood of Well-Suppressed Patients.

Dampier W, Nonnemacher MR, Mell J, Earl J, Ehrlich GD, Pirrone V, Aiamkitsumrit B, Zhong W, Kercher K, Passic S, Williams JW, Jacobson JM, Wigdahl B.

PLoS One. 2016 May 19;11(5):e0155382. doi: 10.1371/journal.pone.0155382. eCollection 2016.


Utilization of HIV-1 envelope V3 to identify X4- and R5-specific Tat and LTR sequence signatures.

Antell GC, Dampier W, Aiamkitsumrit B, Nonnemacher MR, Jacobson JM, Pirrone V, Zhong W, Kercher K, Passic S, Williams JW, Schwartz G, Hershberg U, Krebs FC, Wigdahl B.

Retrovirology. 2016 May 3;13(1):32. doi: 10.1186/s12977-016-0266-9.


Diversity and Tropism of HIV-1 Rebound Virus Populations in Plasma Level After Treatment Discontinuation.

Bednar MM, Hauser BM, Zhou S, Jacobson JM, Eron JJ Jr, Frank I, Swanstrom R.

J Infect Dis. 2016 Aug 1;214(3):403-7. doi: 10.1093/infdis/jiw172. Epub 2016 Apr 30.


HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity.

Nonnemacher MR, Pirrone V, Feng R, Moldover B, Passic S, Aiamkitsumrit B, Dampier W, Wojno A, Kilareski E, Blakey B, Ku TS, Shah S, Sullivan NT, Jacobson JM, Wigdahl B.

PLoS One. 2016 Apr 21;11(4):e0150835. doi: 10.1371/journal.pone.0150835. eCollection 2016.


Sonographic Detection of Accessory Adrenal Tissue in Neonates.

Ben-Mordechay D, Ben-Shlush A, Raviv-Zilka L, Jacobson JM, Soudack M.

J Ultrasound Med. 2016 May;35(5):959-63. doi: 10.7863/ultra.15.05048. Epub 2016 Apr 12.


The Effect of Chloroquine on Immune Activation and Interferon Signatures Associated with HIV-1.

Jacobson JM, Bosinger SE, Kang M, Belaunzaran-Zamudio P, Matining RM, Wilson CC, Flexner C, Clagett B, Plants J, Read S, Purdue L, Myers L, Boone L, Tebas P, Kumar P, Clifford D, Douek D, Silvestri G, Landay AL, Lederman MM.

AIDS Res Hum Retroviruses. 2016 Jul;32(7):636-47. doi: 10.1089/AID.2015.0336. Epub 2016 Apr 19.


The Safety and Immunogenicity of an Interleukin-12-Enhanced Multiantigen DNA Vaccine Delivered by Electroporation for the Treatment of HIV-1 Infection.

Jacobson JM, Zheng L, Wilson CC, Tebas P, Matining RM, Egan MA, Eldridge J, Landay AL, Clifford DB, Luetkemeyer AF, Tiu J, Martinez AL, Janik J, Spitz TA, Hural J, McElrath J, Frahm N; ACTG A5281 Protocol Team.

J Acquir Immune Defic Syndr. 2016 Feb 1;71(2):163-71. doi: 10.1097/QAI.0000000000000830.


Dendritic Cell Immunotherapy for HIV-1 Infection Using Autologous HIV-1 RNA: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Jacobson JM, Routy JP, Welles S, DeBenedette M, Tcherepanova I, Angel JB, Asmuth DM, Stein DK, Baril JG, McKellar M, Margolis DM, Trottier B, Wood K, Nicolette C.

J Acquir Immune Defic Syndr. 2016 May 1;72(1):31-8. doi: 10.1097/QAI.0000000000000926.


Abnormal body mass index at diagnosis in patients with Ewing sarcoma is associated with inferior tumor necrosis.

Goldstein G, Shemesh E, Frenkel T, Jacobson JM, Toren A.

Pediatr Blood Cancer. 2015 Nov;62(11):1892-6. doi: 10.1002/pbc.25589. Epub 2015 Jun 5.


HIV Excision Utilizing CRISPR/Cas9 Technology: Attacking the Proviral Quasispecies in Reservoirs to Achieve a Cure.

Dampier W, Nonnemacher MR, Sullivan NT, Jacobson JM, Wigdahl B.

MOJ Immunol. 2014 Oct 17;1(4). pii: 00022.


Sonographic appearances of torsion of the appendix testis and appendix epididymis in children.

Lev M, Ramon J, Mor Y, Jacobson JM, Soudack M.

J Clin Ultrasound. 2015 Oct;43(8):485-9. doi: 10.1002/jcu.22265. Epub 2015 Feb 20.


Strong HCV NS3/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine.

Latimer B, Toporovski R, Yan J, Pankhong P, Morrow MP, Khan AS, Sardesai NY, Welles SL, Jacobson JM, Weiner DB, Kutzler MA.

Hum Vaccin Immunother. 2014;10(8):2357-65. doi: 10.4161/hv.29590.


Defining differential genetic signatures in CXCR4- and the CCR5-utilizing HIV-1 co-linear sequences.

Aiamkitsumrit B, Dampier W, Martin-Garcia J, Nonnemacher MR, Pirrone V, Ivanova T, Zhong W, Kilareski E, Aldigun H, Frantz B, Rimbey M, Wojno A, Passic S, Williams JW, Shah S, Blakey B, Parikh N, Jacobson JM, Moldover B, Wigdahl B.

PLoS One. 2014 Sep 29;9(9):e107389. doi: 10.1371/journal.pone.0107389. eCollection 2014.


Rifaximin has a marginal impact on microbial translocation, T-cell activation and inflammation in HIV-positive immune non-responders to antiretroviral therapy - ACTG A5286.

Tenorio AR, Chan ES, Bosch RJ, Macatangay BJ, Read SW, Yesmin S, Taiwo B, Margolis DM, Jacobson JM, Landay AL, Wilson CC; A5286 Team.

J Infect Dis. 2015 Mar 1;211(5):780-90. doi: 10.1093/infdis/jiu515. Epub 2014 Sep 11.


An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of Clostridium difficile induces protective antibody responses in vivo.

Baliban SM, Michael A, Shammassian B, Mudakha S, Khan AS, Cocklin S, Zentner I, Latimer BP, Bouillaut L, Hunter M, Marx P, Sardesai NY, Welles SL, Jacobson JM, Weiner DB, Kutzler MA.

Infect Immun. 2014 Oct;82(10):4080-91. doi: 10.1128/IAI.01950-14. Epub 2014 Jul 14.


Sevelamer does not decrease lipopolysaccharide or soluble CD14 levels but decreases soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol levels in individuals with untreated HIV infection.

Sandler NG, Zhang X, Bosch RJ, Funderburg NT, Choi AI, Robinson JK, Fine DM, Coombs RW, Jacobson JM, Landay AL, Douek DC, Tressler R, Read SW, Wilson CC, Deeks SG, Lederman MM, Gandhi RT; AIDS Clinical Trials Group A5296 Team.

J Infect Dis. 2014 Nov 15;210(10):1549-54. doi: 10.1093/infdis/jiu305. Epub 2014 May 26.


A randomized controlled trial of palifermin (recombinant human keratinocyte growth factor) for the treatment of inadequate CD4+ T-lymphocyte recovery in patients with HIV-1 infection on antiretroviral therapy.

Jacobson JM, Wang H, Bordi R, Zheng L, Gross BH, Landay AL, Spritzler J, Routy JP, Benson C, Aberg J, Tebas P, Haas DW, Tiu J, Coughlin K, Purdue L, Sekaly RP; AIDS Clinical Trials Group (ACTG) A5212 Protocol Team.

J Acquir Immune Defic Syndr. 2014 Aug 1;66(4):399-406. doi: 10.1097/QAI.0000000000000195.


Cocaine alters cytokine profiles in HIV-1-infected African American individuals in the DrexelMed HIV/AIDS genetic analysis cohort.

Parikh N, Dampier W, Feng R, Passic SR, Zhong W, Frantz B, Blakey B, Aiamkitsumrit B, Pirrone V, Nonnemacher MR, Jacobson JM, Wigdahl B.

J Acquir Immune Defic Syndr. 2014 Jul 1;66(3):256-64. doi: 10.1097/QAI.0000000000000163.


Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease.

Shive CL, Mudd JC, Funderburg NT, Sieg SF, Kyi B, Bazdar DA, Mangioni D, Gori A, Jacobson JM, Brooks AD, Hardacre J, Ammori J, Estes JD, Schacker TW, Rodriguez B, Lederman MM.

J Infect Dis. 2014 Aug 15;210(4):619-29. doi: 10.1093/infdis/jiu125. Epub 2014 Feb 28.


Purulent pericarditis caused by Haemophilus parainfluenzae.

Latyshev Y, Mathew A, Jacobson JM, Sturm E.

Tex Heart Inst J. 2013;40(5):608-11.


Coronal approach for measuring both fetal lateral ventricles: is there an advantage over the axial view?

Katorza E, Duvdevani N, Jacobson JM, Gilboa Y, Hoffmann C, Achiron R.

Prenat Diagn. 2014 Mar;34(3):279-84. doi: 10.1002/pd.4310. Epub 2014 Jan 23.


Dynamics of immune reconstitution and activation markers in HIV+ treatment-naïve patients treated with raltegravir, tenofovir disoproxil fumarate and emtricitabine.

Funderburg NT, Andrade A, Chan ES, Rosenkranz SL, Lu D, Clagett B, Pilch-Cooper HA, Rodriguez B, Feinberg J, Daar E, Mellors J, Kuritzkes D, Jacobson JM, Lederman MM.

PLoS One. 2013 Dec 18;8(12):e83514. doi: 10.1371/journal.pone.0083514. eCollection 2013.

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