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Items: 1 to 50 of 281

1.

Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids.

Cai NS, Quiroz C, Bonaventura J, Bonifazi A, Cole TO, Purks J, Billing AS, Massey E, Wagner M, Wish ED, Guitart X, Rea W, Lam S, Moreno E, Casadó-Anguera V, Greenblatt AD, Jacobson AE, Rice KC, Casadó V, Newman AH, Winkelman JW, Michaelides M, Weintraub E, Volkow ND, Belcher AM, Ferré S.

J Clin Invest. 2019 Mar 26;129(7):2730-2744. doi: 10.1172/JCI126912.

2.

Patterns of von Willebrand Disease Screening in Girls and Adolescents With Heavy Menstrual Bleeding.

Jacobson AE, Vesely SK, Koch T, Campbell J, OʼBrien SH.

Obstet Gynecol. 2018 Jun;131(6):1121-1129. doi: 10.1097/AOG.0000000000002620.

PMID:
29742662
3.

A rapid solution-based method for determining the affinity of heroin hapten-induced antibodies to heroin, its metabolites, and other opioids.

Torres OB, Duval AJ, Sulima A, Antoline JFG, Jacobson AE, Rice KC, Alving CR, Matyas GR.

Anal Bioanal Chem. 2018 Jun;410(16):3885-3903. doi: 10.1007/s00216-018-1060-4. Epub 2018 Apr 19.

4.

Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvant.

Torres OB, Matyas GR, Rao M, Peachman KK, Jalah R, Beck Z, Michael NL, Rice KC, Jacobson AE, Alving CR.

NPJ Vaccines. 2017 May 2;2:13. doi: 10.1038/s41541-017-0013-9. eCollection 2017.

5.

A Stable Heroin Analogue That Can Serve as a Vaccine Hapten to Induce Antibodies That Block the Effects of Heroin and Its Metabolites in Rodents and That Cross-React Immunologically with Related Drugs of Abuse.

Sulima A, Jalah R, Antoline JFG, Torres OB, Imler GH, Deschamps JR, Beck Z, Alving CR, Jacobson AE, Rice KC, Matyas GR.

J Med Chem. 2018 Jan 11;61(1):329-343. doi: 10.1021/acs.jmedchem.7b01427. Epub 2017 Dec 29.

6.

Mobile Application vs Paper Pictorial Blood Assessment Chart to Track Menses in Young Women: A Randomized Cross-over Design.

Jacobson AE, Vesely SK, Haamid F, Christian-Rancy M, O'Brien SH.

J Pediatr Adolesc Gynecol. 2018 Apr;31(2):84-88. doi: 10.1016/j.jpag.2017.09.009. Epub 2017 Oct 10.

PMID:
29030160
7.

Refractory cytopenias secondary to copper deficiency in children receiving exclusive jejunal nutrition.

Jacobson AE, Kahwash SB, Chawla A.

Pediatr Blood Cancer. 2017 Nov;64(11). doi: 10.1002/pbc.26617. Epub 2017 May 5.

PMID:
28475294
8.

Modulation of opioid receptor affinity and efficacy via N-substitution of 9β-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study.

Truong PM, Hassan SA, Lee YS, Kopajtic TA, Katz JL, Chadderdon AM, Traynor JR, Deschamps JR, Jacobson AE, Rice KC.

Bioorg Med Chem. 2017 Apr 15;25(8):2406-2422. doi: 10.1016/j.bmc.2017.02.064. Epub 2017 Mar 1.

9.

Romiplostim for therapy-related thrombocytopenia in pediatric malignancies.

Jacobson AE, Shah N, Setty BA.

Pediatr Blood Cancer. 2017 Aug;64(8). doi: 10.1002/pbc.26473. Epub 2017 Feb 2.

PMID:
28150377
10.

A simple nonradioactive method for the determination of the binding affinities of antibodies induced by hapten bioconjugates for drugs of abuse.

Torres OB, Antoline JF, Li F, Jalah R, Jacobson AE, Rice KC, Alving CR, Matyas GR.

Anal Bioanal Chem. 2016 Feb;408(4):1191-204. doi: 10.1007/s00216-015-9223-z. Epub 2015 Dec 16.

11.

Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.

Selfridge BR, Wang X, Zhang Y, Yin H, Grace PM, Watkins LR, Jacobson AE, Rice KC.

J Med Chem. 2015 Jun 25;58(12):5038-52. doi: 10.1021/acs.jmedchem.5b00426. Epub 2015 Jun 5.

12.

Efficacy, but not antibody titer or affinity, of a heroin hapten conjugate vaccine correlates with increasing hapten densities on tetanus toxoid, but not on CRM197 carriers.

Jalah R, Torres OB, Mayorov AV, Li F, Antoline JF, Jacobson AE, Rice KC, Deschamps JR, Beck Z, Alving CR, Matyas GR.

Bioconjug Chem. 2015 Jun 17;26(6):1041-53. doi: 10.1021/acs.bioconjchem.5b00085. Epub 2015 Jun 5.

13.

Chiral resolution and absolute configuration of the enantiomers of the psychoactive "designer drug" 3,4-methylenedioxypyrovalerone.

Suzuki M, Deschamps JR, Jacobson AE, Rice KC.

Chirality. 2015 Apr;27(4):287-93. doi: 10.1002/chir.22423. Epub 2015 Feb 26.

14.

Probes for narcotic receptor mediated phenomena 49. N-substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.

Iyer MR, Rothman RB, Dersch CM, Jacobson AE, Rice KC.

Eur J Med Chem. 2015 Mar 6;92:531-9. doi: 10.1016/j.ejmech.2015.01.025. Epub 2015 Jan 13.

15.

Characterization and optimization of heroin hapten-BSA conjugates: method development for the synthesis of reproducible hapten-based vaccines.

Torres OB, Jalah R, Rice KC, Li F, Antoline JF, Iyer MR, Jacobson AE, Boutaghou MN, Alving CR, Matyas GR.

Anal Bioanal Chem. 2014 Sep;406(24):5927-37. doi: 10.1007/s00216-014-8035-x. Epub 2014 Aug 2.

16.

Synthesis and immunological effects of heroin vaccines.

Li F, Cheng K, Antoline JF, Iyer MR, Matyas GR, Torres OB, Jalah R, Beck Z, Alving CR, Parrish DA, Deschamps JR, Jacobson AE, Rice KC.

Org Biomol Chem. 2014 Oct 7;12(37):7211-32. doi: 10.1039/c4ob01053a.

17.

Synthesis of enantiopure 10-nornaltrexones in the search for Toll-like receptor 4 antagonists and opioid ligands.

Selfridge BR, Deschamps JR, Jacobson AE, Rice KC.

J Org Chem. 2014 Jun 6;79(11):5007-18. doi: 10.1021/jo500568s. Epub 2014 May 6.

18.

Facial recognition of heroin vaccine opiates: type 1 cross-reactivities of antibodies induced by hydrolytically stable haptenic surrogates of heroin, 6-acetylmorphine, and morphine.

Matyas GR, Rice KC, Cheng K, Li F, Antoline JF, Iyer MR, Jacobson AE, Mayorov AV, Beck Z, Torres OB, Alving CR.

Vaccine. 2014 Mar 14;32(13):1473-9. doi: 10.1016/j.vaccine.2014.01.028. Epub 2014 Jan 28.

19.

Probes for narcotic receptor mediated phenomena. 48. C7- and C8-substituted 5-phenylmorphan opioids from diastereoselective alkylation.

Lim HJ, Dersch CM, Rothman RB, Deschamps JR, Jacobson AE, Rice KC.

Eur J Med Chem. 2013 Sep;67:335-43. doi: 10.1016/j.ejmech.2013.06.030. Epub 2013 Jun 25.

20.

Liposomes containing monophosphoryl lipid A: a potent adjuvant system for inducing antibodies to heroin hapten analogs.

Matyas GR, Mayorov AV, Rice KC, Jacobson AE, Cheng K, Iyer MR, Li F, Beck Z, Janda KD, Alving CR.

Vaccine. 2013 Jun 10;31(26):2804-10. doi: 10.1016/j.vaccine.2013.04.027. Epub 2013 Apr 23.

21.

Probes for narcotic receptor mediated phenomena. 47. Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.

Iyer MR, Rothman RB, Dersch CM, Jacobson AE, Rice KC.

Bioorg Med Chem. 2013 Jun 1;21(11):3298-309. doi: 10.1016/j.bmc.2013.02.060. Epub 2013 Apr 3.

22.

Z and E rotamers of N-formyl-1-bromo-4-hydroxy-3-methoxymorphinan-6-one and their interconversion as studied by 1H/13C NMR spectroscopy and quantum chemical calculations.

Sulima A, Cheng K, Jacobson AE, Rice KC, Gawrisch K, Lee YS.

Magn Reson Chem. 2013 Feb;51(2):82-8. doi: 10.1002/mrc.3909. Epub 2012 Dec 11.

23.

Probes for narcotic receptor mediated phenomena. 46. N-substituted-2,3,4,9,10,10a-hexahydro-1H-1,4a-(epiminoethano)phenanthren-6- and 8-ols - carbocyclic relatives of f-oxide-bridged phenylmorphans.

Li F, Deck JA, Dersch CM, Rothman RB, Deschamps JR, Jacobson AE, Rice KC.

Eur J Med Chem. 2012 Dec;58:557-67. doi: 10.1016/j.ejmech.2012.10.041. Epub 2012 Oct 30.

24.

Configurational reassignment and improved preparation of the competitive IL-6 receptor antagonist 20R,21R-epoxyresibufogenin-3-formate.

Boos TL, Cheng K, Greiner E, Deschamps JR, Jacobson AE, Rice KC.

J Nat Prod. 2012 Apr 27;75(4):661-8. doi: 10.1021/np2008957. Epub 2012 Feb 23.

25.

Probes for narcotic receptor mediated phenomena. 44. Synthesis of an N-substituted 4-hydroxy-5-(3-hydroxyphenyl)morphan with high affinity and selective μ-antagonist activity.

Iyer MR, Lee YS, Deschamps JR, Dersch CM, Rothman RB, Jacobson AE, Rice KC.

Eur J Med Chem. 2012 Apr;50:44-54. doi: 10.1016/j.ejmech.2012.01.025. Epub 2012 Jan 20.

26.

Diastereoselective one-pot synthesis of 7- and 8-substituted 5-phenylmorphans.

Lim HJ, Deschamps JR, Jacobson AE, Rice KC.

Org Lett. 2011 Oct 7;13(19):5322-5. doi: 10.1021/ol2021862. Epub 2011 Sep 12.

27.

Probes for narcotic receptor mediated phenomena. 43. Synthesis of the ortho-a and para-a, and improved synthesis and optical resolution of the ortho-b and para-b oxide-bridged phenylmorphans: compounds with moderate to low opioid-receptor affinity.

Li F, Folk JE, Cheng K, Kurimura M, Deck JA, Deschamps JR, Rothman RB, Dersch CM, Jacobson AE, Rice KC.

Bioorg Med Chem. 2011 Jul 15;19(14):4330-7. doi: 10.1016/j.bmc.2011.05.035. Epub 2011 May 24.

28.

Probes for narcotic receptor mediated phenomena. Part 42: synthesis and in vitro pharmacological characterization of the N-methyl and N-phenethyl analogues of the racemic ortho-c and para-c oxide-bridged phenylmorphans.

Kim JH, Deschamps JR, Rothman RB, Dersch CM, Folk JE, Cheng K, Jacobson AE, Rice KC.

Bioorg Med Chem. 2011 Jun 1;19(11):3434-43. doi: 10.1016/j.bmc.2011.04.028. Epub 2011 Apr 22.

29.

Probes for narcotic receptor mediated phenomena. 41. Unusual inverse μ-agonists and potent μ-opioid antagonists by modification of the N-substituent in enantiomeric 5-(3-hydroxyphenyl)morphans.

Cheng K, Lee YS, Rothman RB, Dersch CM, Bittman RW, Jacobson AE, Rice KC.

J Med Chem. 2011 Feb 24;54(4):957-69. doi: 10.1021/jm1011676. Epub 2011 Jan 19.

30.

Evidence for noncompetitive modulation of substrate-induced serotonin release.

Rothman RB, Baumann MH, Blough BE, Jacobson AE, Rice KC, Partilla JS.

Synapse. 2010 Nov;64(11):862-9. doi: 10.1002/syn.20804.

31.

Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist.

Vardanyan M, Melemedjian OK, Price TJ, Ossipov MH, Lai J, Roberts E, Boos TL, Deschamps JR, Jacobson AE, Rice KC, Porreca F.

Pain. 2010 Nov;151(2):257-65. doi: 10.1016/j.pain.2010.05.022. Epub 2010 Jul 4.

33.

Probes for narcotic receptor mediated phenomena. 40. N-substituted cis-4a-ethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-8-ols.

Iyer MR, Lee YS, Deschamps JR, Rothman RB, Dersch CM, Jacobson AE, Rice KC.

Bioorg Med Chem. 2010 Jan 1;18(1):91-9. doi: 10.1016/j.bmc.2009.11.022. Epub 2009 Nov 18.

34.

Identification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor.

Sally EJ, Xu H, Dersch CM, Hsin LW, Chang LT, Prisinzano TE, Simpson DS, Giuvelis D, Rice KC, Jacobson AE, Cheng K, Bilsky EJ, Rothman RB.

Synapse. 2010 Apr;64(4):280-8. doi: 10.1002/syn.20723.

35.

Synthesis of 2-(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamidoethyl-d(4) Dihydrogen Phosphate, Tetra-deuterated pAEA.

Cheng K, Saha B, Mahadevan A, Razdan RK, Kunos G, Jacobson AE, Rice KC.

J Labelled Comp Radiopharm. 2008 Oct 9;51(12):389-390.

36.

Improved algal harvesting using suspended air flotation.

Wiley PE, Brenneman KJ, Jacobson AE.

Water Environ Res. 2009 Jul;81(7):702-8.

PMID:
19691251
37.

Probes for narcotic receptor mediated phenomena. 39. Enantiomeric N-substituted benzofuro[2,3-c]pyridin-6-ols: synthesis and topological relationship to oxide-bridged phenylmorphans.

Zhang Y, Lee YS, Rothman RB, Dersch CM, Deschamps JR, Jacobson AE, Rice KC.

J Med Chem. 2009 Dec 10;52(23):7570-9. doi: 10.1021/jm9004225.

38.

Probes for narcotic receptor mediated phenomena. 37. Synthesis and opioid binding affinity of the final pair of oxide-bridged phenylmorphans, the ortho- and para-b-isomers and their N-phenethyl analogues, and the synthesis of the N-phenethyl analogues of the ortho- and para-d-isomers.

Kurimura M, Liu H, Sulima A, Hashimoto A, Przybyl AK, Ohshima E, Kodato S, Deschamps JR, Dersch CM, Rothman RB, Lee YS, Jacobson AE, Rice KC.

J Med Chem. 2008 Dec 25;51(24):7866-81. doi: 10.1021/jm800913d. Erratum in: J Med Chem. 2009 Feb 26;52(4):1229.

39.

The relationship between alcohol use, eating habits and weight change in college freshmen.

Lloyd-Richardson EE, Lucero ML, Dibello JR, Jacobson AE, Wing RR.

Eat Behav. 2008 Dec;9(4):504-8. doi: 10.1016/j.eatbeh.2008.06.005. Epub 2008 Jun 18.

40.

Synthesis and pharmacological effects of the enantiomers of the N-phenethyl analogues of the ortho and para e- and f-oxide-bridged phenylmorphans.

Zezula J, Singer L, Przybył AK, Hashimoto A, Dersch CM, Rothman RB, Deschamps J, Lee YS, Jacobson AE, Rice KC.

Org Biomol Chem. 2008 Aug 21;6(16):2868-83. doi: 10.1039/b803433h. Epub 2008 Jun 13.

42.

Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series.

Hiebel AC, Lee YS, Bilsky E, Giuvelis D, Deschamps JR, Parrish DA, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Partilla JS, Rothman RB, Cheng K, Jacobson AE, Rice KC.

J Med Chem. 2007 Aug 9;50(16):3765-76. Epub 2007 Jul 11.

PMID:
17625813
43.

Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists.

Cheng K, Kim IJ, Lee MJ, Adah SA, Raymond TJ, Bilsky EJ, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Rothman RB, Jacobson AE, Rice KC.

Org Biomol Chem. 2007 Apr 21;5(8):1177-1190. doi: 10.1039/b618875c. Epub 2007 Mar 1.

PMID:
17406716
44.

DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods.

Gilbert KM, Boos TL, Dersch CM, Greiner E, Jacobson AE, Lewis D, Matecka D, Prisinzano TE, Zhang Y, Rothman RB, Rice KC, Venanzi CA.

Bioorg Med Chem. 2007 Jan 15;15(2):1146-59. Epub 2006 Oct 1.

45.

Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter.

Boos TL, Greiner E, Calhoun WJ, Prisinzano TE, Nightingale B, Dersch CM, Rothman RB, Jacobson AE, Rice KC.

Bioorg Med Chem. 2006 Jun 1;14(11):3967-73. Epub 2006 Mar 24.

PMID:
16563775
46.

Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity.

Greiner E, Boos TL, Prisinzano TE, De Martino MG, Zeglis B, Dersch CM, Marcus J, Partilla JS, Rothman RB, Jacobson AE, Rice KC.

J Med Chem. 2006 Mar 9;49(5):1766-72.

PMID:
16509591
47.

A concise method for the preparation of deuterium-labeled cortisone: synthesis of [6,7-2H]cortisone.

Sulima A, Prisinzano TE, Spande T, Deschamps JR, Whittaker N, Hochberg Z, Jacobson AE, Rice KC.

Steroids. 2005 Oct;70(11):763-9.

PMID:
16005918
48.

Studies of the biogenic amine transporters. XI. Identification of a 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR12909) analog that allosterically modulates the serotonin transporter.

Nightingale B, Dersch CM, Boos TL, Greiner E, Calhoun WJ, Jacobson AE, Rice KC, Rothman RB.

J Pharmacol Exp Ther. 2005 Aug;314(2):906-15. Epub 2005 Apr 28.

PMID:
15860577
49.

Probes for narcotic receptor-mediated phenomena. 33. Construction of a strained trans-5,6-ring system by displacement of a nitro-activated aromatic fluorine. synthesis of the penultimate oxide-bridged phenylmorphans.

Hashimoto A, Przybyl AK, Linders JT, Kodato S, Tian X, Deschamps JR, George C, Flippen-Anderson JL, Jacobson AE, Rice KC.

J Org Chem. 2004 Aug 6;69(16):5322-7.

PMID:
15287777
50.

A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans.

Kim IJ, Dersch CM, Rothman RB, Jacobson AE, Rice KC.

Bioorg Med Chem. 2004 Aug 15;12(16):4543-50.

PMID:
15265502

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