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A kinesin Klp10A mediates cell cycle-dependent shuttling of Piwi between nucleus and nuage.

Venkei ZG, Choi CP, Feng S, Chen C, Jacobsen SE, Kim JK, Yamashita YM.

PLoS Genet. 2020 Mar 13;16(3):e1008648. doi: 10.1371/journal.pgen.1008648. eCollection 2020 Mar.


Assessing the Nutritional Value of Root and Tuber Crops from Bolivia and Peru.

Choquechambi LA, Callisaya IR, Ramos A, Bosque H, Mújica A, Jacobsen SE, Sørensen M, Leidi EO.

Foods. 2019 Oct 23;8(11). pii: E526. doi: 10.3390/foods8110526.


CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation.

Wongpalee SP, Liu S, Gallego-Bartolomé J, Leitner A, Aebersold R, Liu W, Yen L, Nohales MA, Kuo PH, Vashisht AA, Wohlschlegel JA, Feng S, Kay SA, Zhou ZH, Jacobsen SE.

Nat Commun. 2019 Sep 2;10(1):3916. doi: 10.1038/s41467-019-11759-9.


The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction.

Kim H, Yen L, Wongpalee SP, Kirshner JA, Mehta N, Xue Y, Johnston JB, Burlingame AL, Kim JK, Loparo JJ, Jacobsen SE.

Mol Cell. 2019 Aug 22;75(4):700-710.e6. doi: 10.1016/j.molcel.2019.07.032.


Calcium-Sensing Receptor Internalization Is β-Arrestin-Dependent and Modulated by Allosteric Ligands.

Mos I, Jacobsen SE, Foster SR, Bräuner-Osborne H.

Mol Pharmacol. 2019 Oct;96(4):463-474. doi: 10.1124/mol.119.116772. Epub 2019 Aug 9.


Arabidopsis SWR1-associated protein methyl-CpG-binding domain 9 is required for histone H2A.Z deposition.

Potok ME, Wang Y, Xu L, Zhong Z, Liu W, Feng S, Naranbaatar B, Rayatpisheh S, Wang Z, Wohlschlegel JA, Ausin I, Jacobsen SE.

Nat Commun. 2019 Jul 26;10(1):3352. doi: 10.1038/s41467-019-11291-w.


Amaranth as a Dual-Use Crop for Leafy Greens and Seeds: Stable Responses to Leaf Harvest Across Genotypes and Environments.

Hoidal N, Díaz Gallardo M, Jacobsen SE, Alandia G.

Front Plant Sci. 2019 Jun 26;10:817. doi: 10.3389/fpls.2019.00817. eCollection 2019.


Multi-level Modulation of Light Signaling by GIGANTEA Regulates Both the Output and Pace of the Circadian Clock.

Nohales MA, Liu W, Duffy T, Nozue K, Sawa M, Pruneda-Paz JL, Maloof JN, Jacobsen SE, Kay SA.

Dev Cell. 2019 Jun 17;49(6):840-851.e8. doi: 10.1016/j.devcel.2019.04.030. Epub 2019 May 16.


Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant.

Chen M, Liu Q, Gao SS, Young AE, Jacobsen SE, Tang Y.

Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5499-5504. doi: 10.1073/pnas.1819998116. Epub 2019 Mar 6.


Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing.

Rodriguez-Meira A, Buck G, Clark SA, Povinelli BJ, Alcolea V, Louka E, McGowan S, Hamblin A, Sousos N, Barkas N, Giustacchini A, Psaila B, Jacobsen SEW, Thongjuea S, Mead AJ.

Mol Cell. 2019 Mar 21;73(6):1292-1305.e8. doi: 10.1016/j.molcel.2019.01.009. Epub 2019 Feb 12.


Correction: Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients.

Canet LM, Sánchez-Maldonado JM, Cáliz R, Rodríguez-Ramos A, Lupiañez CB, Canhão H, Martínez-Bueno M, Escudero A, Segura-Catena J, Sorensen SB, Hetland ML, Soto-Pino MJ, Ferrer MA, García A, Glintborg B, Filipescu I, Pérez-Pampin E, González-Utrilla A, Nevot MÁL, Conesa-Zamora P, den Broeder A, De Vita S, Jacobsen SEH, Collantes-Estevez E, Quartuccio L, Canzian F, Fonseca JE, Coenen MJH, Andersen V, Sainz J.

Pharmacogenomics J. 2019 Dec;19(6):582. doi: 10.1038/s41397-019-0084-2.


Site-specific manipulation of Arabidopsis loci using CRISPR-Cas9 SunTag systems.

Papikian A, Liu W, Gallego-Bartolomé J, Jacobsen SE.

Nat Commun. 2019 Feb 13;10(1):729. doi: 10.1038/s41467-019-08736-7.


Co-targeting RNA Polymerases IV and V Promotes Efficient De Novo DNA Methylation in Arabidopsis.

Gallego-Bartolomé J, Liu W, Kuo PH, Feng S, Ghoshal B, Gardiner J, Zhao JM, Park SY, Chory J, Jacobsen SE.

Cell. 2019 Feb 21;176(5):1068-1082.e19. doi: 10.1016/j.cell.2019.01.029. Epub 2019 Feb 7.


Comparative physiological and biochemical evaluation of salt and nickel tolerance mechanisms in two contrasting tomato genotypes.

Amjad M, Ameen N, Murtaza B, Imran M, Shahid M, Abbas G, Naeem MA, Jacobsen SE.

Physiol Plant. 2020 Jan;168(1):27-37. doi: 10.1111/ppl.12930. Epub 2019 Mar 18.


Origins of ETP leukemia.

Booth CAG, Jacobsen SEW, Mead AJ.

Oncoscience. 2018 Aug 22;5(11-12):271-272. doi: 10.18632/oncoscience.456. eCollection 2018 Nov. No abstract available.


Haematopoiesis in the era of advanced single-cell technologies.

Jacobsen SEW, Nerlov C.

Nat Cell Biol. 2019 Jan;21(1):2-8. doi: 10.1038/s41556-018-0227-8. Epub 2019 Jan 2. Review.


Direct role of FLT3 in regulation of early lymphoid progenitors.

Zriwil A, Böiers C, Kristiansen TA, Wittmann L, Yuan J, Nerlov C, Sitnicka E, Jacobsen SEW.

Br J Haematol. 2018 Nov;183(4):588-600. doi: 10.1111/bjh.15578. Epub 2018 Sep 14.


The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation.

Chen D, Liu W, Zimmerman J, Pastor WA, Kim R, Hosohama L, Ho J, Aslanyan M, Gell JJ, Jacobsen SE, Clark AT.

Cell Rep. 2018 Dec 26;25(13):3591-3602.e5. doi: 10.1016/j.celrep.2018.12.011.


A DNA methylation reader complex that enhances gene transcription.

Harris CJ, Scheibe M, Wongpalee SP, Liu W, Cornett EM, Vaughan RM, Li X, Chen W, Xue Y, Zhong Z, Yen L, Barshop WD, Rayatpisheh S, Gallego-Bartolome J, Groth M, Wang Z, Wohlschlegel JA, Du J, Rothbart SB, Butter F, Jacobsen SE.

Science. 2018 Dec 7;362(6419):1182-1186. doi: 10.1126/science.aar7854.


ADCP1: a novel plant H3K9me2 reader.

Harris CJ, Jacobsen SE.

Cell Res. 2019 Jan;29(1):6-7. doi: 10.1038/s41422-018-0119-2. No abstract available.


A Nucleosome Bridging Mechanism for Activation of a Maintenance DNA Methyltransferase.

Stoddard CI, Feng S, Campbell MG, Liu W, Wang H, Zhong X, Bernatavichute Y, Cheng Y, Jacobsen SE, Narlikar GJ.

Mol Cell. 2019 Jan 3;73(1):73-83.e6. doi: 10.1016/j.molcel.2018.10.006. Epub 2018 Nov 8.


Loss of Canonical Notch Signaling Affects Multiple Steps in NK Cell Development in Mice.

Chaves P, Zriwil A, Wittmann L, Boukarabila H, Peitzsch C, Jacobsen SEW, Sitnicka E.

J Immunol. 2018 Dec 1;201(11):3307-3319. doi: 10.4049/jimmunol.1701675. Epub 2018 Oct 26.


The impact and prospect of natural product discovery in agriculture: New technologies to explore the diversity of secondary metabolites in plants and microorganisms for applications in agriculture.

Yan Y, Liu Q, Jacobsen SE, Tang Y.

EMBO Rep. 2018 Nov;19(11). pii: e46824. doi: 10.15252/embr.201846824. Epub 2018 Oct 25. No abstract available.


Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients.

Canet LM, Sánchez-Maldonado JM, Cáliz R, Rodríguez-Ramos A, Lupiañez CB, Canhão H, Martínez-Bueno M, Escudero A, Segura-Catena J, Sorensen SB, Hetland ML, Soto-Pino MJ, Ferrer MA, García A, Glintborg B, Filipescu I, Pérez-Pampin E, González-Utrilla A, Nevot MÁL, Conesa-Zamora P, Broeder AD, De Vita S, Jacobsen SEH, Collantes-Estevez E, Quartuccio L, Canzian F, Fonseca JE, Coenen MJH, Andersen V, Sainz J.

Pharmacogenomics J. 2019 Feb;19(1):83-96. doi: 10.1038/s41397-018-0057-x. Epub 2018 Oct 5. Erratum in: Pharmacogenomics J. 2019 Feb 14;:.


Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.

Azzoni E, Frontera V, McGrath KE, Harman J, Carrelha J, Nerlov C, Palis J, Jacobsen SEW, de Bruijn MF.

EMBO Rep. 2018 Oct;19(10). pii: e45477. doi: 10.15252/embr.201745477. Epub 2018 Aug 30.


Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.

Li X, Harris CJ, Zhong Z, Chen W, Liu R, Jia B, Wang Z, Li S, Jacobsen SE, Du J.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8793-E8802. doi: 10.1073/pnas.1809841115. Epub 2018 Aug 27.


Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action.

Yan Y, Liu Q, Zang X, Yuan S, Bat-Erdene U, Nguyen C, Gan J, Zhou J, Jacobsen SE, Tang Y.

Nature. 2018 Jul;559(7714):415-418. doi: 10.1038/s41586-018-0319-4. Epub 2018 Jul 11.


TFAP2C regulates transcription in human naive pluripotency by opening enhancers.

Pastor WA, Liu W, Chen D, Ho J, Kim R, Hunt TJ, Lukianchikov A, Liu X, Polo JM, Jacobsen SE, Clark AT.

Nat Cell Biol. 2018 May;20(5):553-564. doi: 10.1038/s41556-018-0089-0. Epub 2018 Apr 25.


Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.

Neo WH, Booth CAG, Azzoni E, Chi L, Delgado-Olguín P, de Bruijn MFTR, Jacobsen SEW, Mead AJ.

Blood. 2018 May 17;131(20):2223-2234. doi: 10.1182/blood-2017-10-811455. Epub 2018 Mar 19.


In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche.

Breitbach M, Kimura K, Luis TC, Fuegemann CJ, Woll PS, Hesse M, Facchini R, Rieck S, Jobin K, Reinhardt J, Ohneda O, Wenzel D, Geisen C, Kurts C, Kastenmüller W, Hölzel M, Jacobsen SEW, Fleischmann BK.

Cell Stem Cell. 2018 Feb 1;22(2):262-276.e7. doi: 10.1016/j.stem.2018.01.008.


Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain.

Gallego-Bartolomé J, Gardiner J, Liu W, Papikian A, Ghoshal B, Kuo HY, Zhao JM, Segal DJ, Jacobsen SE.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2125-E2134. doi: 10.1073/pnas.1716945115. Epub 2018 Feb 14.


Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Booth CAG, Barkas N, Neo WH, Boukarabila H, Soilleux EJ, Giotopoulos G, Farnoud N, Giustacchini A, Ashley N, Carrelha J, Jamieson L, Atkinson D, Bouriez-Jones T, Prinjha RK, Milne TA, Teachey DT, Papaemmanuil E, Huntly BJP, Jacobsen SEW, Mead AJ.

Cancer Cell. 2018 Feb 12;33(2):274-291.e8. doi: 10.1016/j.ccell.2018.01.006.


RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis.

Liu W, Duttke SH, Hetzel J, Groth M, Feng S, Gallego-Bartolome J, Zhong Z, Kuo HY, Wang Z, Zhai J, Chory J, Jacobsen SE.

Nat Plants. 2018 Mar;4(3):181-188. doi: 10.1038/s41477-017-0100-y. Epub 2018 Jan 29.


Large-scale comparative epigenomics reveals hierarchical regulation of non-CG methylation in Arabidopsis.

Zhang Y, Harris CJ, Liu Q, Liu W, Ausin I, Long Y, Xiao L, Feng L, Chen X, Xie Y, Chen X, Zhan L, Feng S, Li JJ, Wang H, Zhai J, Jacobsen SE.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E1069-E1074. doi: 10.1073/pnas.1716300115. Epub 2018 Jan 16.


Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis.

Duarte S, Woll PS, Buza-Vidas N, Chin DWL, Boukarabila H, Luís TC, Stenson L, Bouriez-Jones T, Ferry H, Mead AJ, Atkinson D, Jin S, Clark SA, Wu B, Repapi E, Gray N, Taylor S, Mutvei AP, Tsoi YL, Nerlov C, Lendahl U, Jacobsen SEW.

Blood. 2018 Apr 12;131(15):1712-1719. doi: 10.1182/blood-2017-06-788505. Epub 2018 Jan 16.


Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells.

Carrelha J, Meng Y, Kettyle LM, Luis TC, Norfo R, Alcolea V, Boukarabila H, Grasso F, Gambardella A, Grover A, Högstrand K, Lord AM, Sanjuan-Pla A, Woll PS, Nerlov C, Jacobsen SEW.

Nature. 2018 Feb 1;554(7690):106-111. doi: 10.1038/nature25455. Epub 2018 Jan 3.


A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.

Böiers C, Richardson SE, Laycock E, Zriwil A, Turati VA, Brown J, Wray JP, Wang D, James C, Herrero J, Sitnicka E, Karlsson S, Smith AJH, Jacobsen SEW, Enver T.

Dev Cell. 2018 Feb 5;44(3):362-377.e7. doi: 10.1016/j.devcel.2017.12.005. Epub 2017 Dec 28.


Germline competency of human embryonic stem cells depends on eomesodermin.

Chen D, Liu W, Lukianchikov A, Hancock GV, Zimmerman J, Lowe MG, Kim R, Galic Z, Irie N, Surani MA, Jacobsen SE, Clark AT.

Biol Reprod. 2017 Jan 1;97(6):850-861. doi: 10.1093/biolre/iox138.


Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation.

Riffelmacher T, Clarke A, Richter FC, Stranks A, Pandey S, Danielli S, Hublitz P, Yu Z, Johnson E, Schwerd T, McCullagh J, Uhlig H, Jacobsen SEW, Simon AK.

Immunity. 2017 Sep 19;47(3):466-480.e5. doi: 10.1016/j.immuni.2017.08.005. Epub 2017 Sep 12.


Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program.

Loughran SJ, Comoglio F, Hamey FK, Giustacchini A, Errami Y, Earp E, Göttgens B, Jacobsen SEW, Mead AJ, Hendrich B, Green AR.

J Exp Med. 2017 Oct 2;214(10):3085-3104. doi: 10.1084/jem.20161827. Epub 2017 Sep 12.


Correction: In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse.

Morselli M, Pastor WA, Montanini B, Nee K, Ferrari R, Fu K, Bonora G, Rubbi L, Clark AT, Ottonello S, Jacobsen SE, Pellegrini M.

Elife. 2017 Aug 31;6. pii: e30948. doi: 10.7554/eLife.30948. No abstract available.


Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes.

Unnikrishnan A, Papaemmanuil E, Beck D, Deshpande NP, Verma A, Kumari A, Woll PS, Richards LA, Knezevic K, Chandrakanthan V, Thoms JAI, Tursky ML, Huang Y, Ali Z, Olivier J, Galbraith S, Kulasekararaj AG, Tobiasson M, Karimi M, Pellagatti A, Wilson SR, Lindeman R, Young B, Ramakrishna R, Arthur C, Stark R, Crispin P, Curnow J, Warburton P, Roncolato F, Boultwood J, Lynch K, Jacobsen SEW, Mufti GJ, Hellstrom-Lindberg E, Wilkins MR, MacKenzie KL, Wong JWH, Campbell PJ, Pimanda JE.

Cell Rep. 2017 Jul 18;20(3):572-585. doi: 10.1016/j.celrep.2017.06.067.


Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.

Mead AJ, Neo WH, Barkas N, Matsuoka S, Giustacchini A, Facchini R, Thongjuea S, Jamieson L, Booth CAG, Fordham N, Di Genua C, Atkinson D, Chowdhury O, Repapi E, Gray N, Kharazi S, Clark SA, Bouriez T, Woll P, Suda T, Nerlov C, Jacobsen SEW.

J Exp Med. 2017 Jul 3;214(7):2005-2021. doi: 10.1084/jem.20161418. Epub 2017 Jun 21.


SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells.

Mortera-Blanco T, Dimitriou M, Woll PS, Karimi M, Elvarsdottir E, Conte S, Tobiasson M, Jansson M, Douagi I, Moarii M, Saft L, Papaemmanuil E, Jacobsen SEW, Hellström-Lindberg E.

Blood. 2017 Aug 17;130(7):881-890. doi: 10.1182/blood-2017-03-776070. Epub 2017 Jun 20.


MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality.

Weiser NE, Yang DX, Feng S, Kalinava N, Brown KC, Khanikar J, Freeberg MA, Snyder MJ, Csankovszki G, Chan RC, Gu SG, Montgomery TA, Jacobsen SE, Kim JK.

Dev Cell. 2017 May 22;41(4):408-423.e7. doi: 10.1016/j.devcel.2017.04.023.


The histone H3 variant H3.3 regulates gene body DNA methylation in Arabidopsis thaliana.

Wollmann H, Stroud H, Yelagandula R, Tarutani Y, Jiang D, Jing L, Jamge B, Takeuchi H, Holec S, Nie X, Kakutani T, Jacobsen SE, Berger F.

Genome Biol. 2017 May 18;18(1):94. doi: 10.1186/s13059-017-1221-3.


Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia.

Giustacchini A, Thongjuea S, Barkas N, Woll PS, Povinelli BJ, Booth CAG, Sopp P, Norfo R, Rodriguez-Meira A, Ashley N, Jamieson L, Vyas P, Anderson K, Segerstolpe Å, Qian H, Olsson-Strömberg U, Mustjoki S, Sandberg R, Jacobsen SEW, Mead AJ.

Nat Med. 2017 Jun;23(6):692-702. doi: 10.1038/nm.4336. Epub 2017 May 15.


Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer.

Jacobsen SE, Gether U, Bräuner-Osborne H.

Sci Rep. 2017 Apr 18;7:46355. doi: 10.1038/srep46355.


The GPRC6A receptor displays constitutive internalization and sorting to the slow recycling pathway.

Jacobsen SE, Ammendrup-Johnsen I, Jansen AM, Gether U, Madsen KL, Bräuner-Osborne H.

J Biol Chem. 2017 Apr 28;292(17):6910-6926. doi: 10.1074/jbc.M116.762385. Epub 2017 Mar 9.

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