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Items: 15


Chemical synthesis of Shiga toxin subunit B using a next-generation traceless "helping hand" solubilizing tag.

Fulcher JM, Petersen ME, Giesler RJ, Cruz ZS, Eckert DM, Francis JN, Kawamoto EM, Jacobsen MT, Kay MS.

Org Biomol Chem. 2019 Dec 3. doi: 10.1039/c9ob02012h. [Epub ahead of print]


Amine Landscaping to Maximize Protein-Dye Fluorescence and Ultrastable Protein-Ligand Interaction.

Jacobsen MT, Fairhead M, Fogelstrand P, Howarth M.

Cell Chem Biol. 2017 Aug 17;24(8):1040-1047.e4. doi: 10.1016/j.chembiol.2017.06.015. Epub 2017 Jul 27.


Aligator: A computational tool for optimizing total chemical synthesis of large proteins.

Jacobsen MT, Erickson PW, Kay MS.

Bioorg Med Chem. 2017 Sep 15;25(18):4946-4952. doi: 10.1016/j.bmc.2017.05.061. Epub 2017 Jun 3. Review.


A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis.

Jacobsen MT, Petersen ME, Ye X, Galibert M, Lorimer GH, Aucagne V, Kay MS.

J Am Chem Soc. 2016 Sep 14;138(36):11775-82. doi: 10.1021/jacs.6b05719. Epub 2016 Sep 1.


Synthesis of tumor necrosis factor α for use as a mirror-image phage display target.

Petersen ME, Jacobsen MT, Kay MS.

Org Biomol Chem. 2016 Jun 21;14(23):5298-303. doi: 10.1039/c6ob00824k. Epub 2016 May 23.


Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets.

Clinton TR, Weinstock MT, Jacobsen MT, Szabo-Fresnais N, Pandya MJ, Whitby FG, Herbert AS, Prugar LI, McKinnon R, Hill CP, Welch BD, Dye JM, Eckert DM, Kay MS.

Protein Sci. 2015 Apr;24(4):446-63. doi: 10.1002/pro.2578. Epub 2014 Oct 31.


Synthesis and folding of a mirror-image enzyme reveals ambidextrous chaperone activity.

Weinstock MT, Jacobsen MT, Kay MS.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11679-84. doi: 10.1073/pnas.1410900111. Epub 2014 Jul 28.


FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders.

Kiyota T, Ingraham KL, Jacobsen MT, Xiong H, Ikezu T.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1339-48. doi: 10.1073/pnas.1102349108. Epub 2011 Oct 31. Erratum in: Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21282.


AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice.

Kiyota T, Ingraham KL, Swan RJ, Jacobsen MT, Andrews SJ, Ikezu T.

Gene Ther. 2012 Jul;19(7):724-33. doi: 10.1038/gt.2011.126. Epub 2011 Sep 15.


CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice.

Kiyota T, Okuyama S, Swan RJ, Jacobsen MT, Gendelman HE, Ikezu T.

FASEB J. 2010 Aug;24(8):3093-102. doi: 10.1096/fj.10-155317. Epub 2010 Apr 6.


Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice.

Xu J, Sato S, Okuyama S, Swan RJ, Jacobsen MT, Strunk E, Ikezu T.

FASEB J. 2010 Aug;24(8):2904-15. doi: 10.1096/fj.09-150144. Epub 2010 Mar 30.


Synthesis and characterization of enzymatically degradable PEG-based peptide-containing hydrogels.

Yang J, Jacobsen MT, Pan H, Kopecek J.

Macromol Biosci. 2010 Apr 8;10(4):445-54. doi: 10.1002/mabi.200900295.


AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice.

Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T.

Mol Ther. 2009 May;17(5):803-9. doi: 10.1038/mt.2009.44. Epub 2009 Mar 10.


Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, Swan RJ, Schlautman JD, Ciborowski P, Ikezu T.

J Neurosci. 2008 Dec 31;28(53):14511-21. doi: 10.1523/JNEUROSCI.3417-08.2008.


Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET.

Martinez LB, Walsh SM, Jacobsen MT, Sato S, Wiederin J, Ciborowski P, Ikezu T.

J Neuroimmune Pharmacol. 2009 Mar;4(1):116-28. doi: 10.1007/s11481-008-9140-4. Epub 2008 Nov 26.

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