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Items: 7


The anticonvulsive Phenhydan® suppresses extrinsic cell death.

Moerke C, Jaco I, Dewitz C, Müller T, Jacobsen AV, Gautheron J, Fritsch J, Schmitz J, Bräsen JH, Günther C, Murphy JM, Kunzendorf U, Meier P, Krautwald S.

Cell Death Differ. 2018 Nov 15. doi: 10.1038/s41418-018-0232-2. [Epub ahead of print]


Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

Petrie EJ, Sandow JJ, Jacobsen AV, Smith BJ, Griffin MDW, Lucet IS, Dai W, Young SN, Tanzer MC, Wardak A, Liang LY, Cowan AD, Hildebrand JM, Kersten WJA, Lessene G, Silke J, Czabotar PE, Webb AI, Murphy JM.

Nat Commun. 2018 Jun 21;9(1):2422. doi: 10.1038/s41467-018-04714-7.


Effects of perfluorooctane sulfonate on genes controlling hepatic fatty acid metabolism in livers of chicken embryos.

Jacobsen AV, Nordén M, Engwall M, Scherbak N.

Environ Sci Pollut Res Int. 2018 Aug;25(23):23074-23081. doi: 10.1007/s11356-018-2358-7. Epub 2018 Jun 2.


The secret life of kinases: insights into non-catalytic signalling functions from pseudokinases.

Jacobsen AV, Murphy JM.

Biochem Soc Trans. 2017 Jun 15;45(3):665-681. doi: 10.1042/BST20160331. Review.


The importance of being chaperoned: HSP90 and necroptosis.

Jacobsen AV, Silke J.

Cell Chem Biol. 2016 Feb 18;23(2):205-207. doi: 10.1016/j.chembiol.2016.02.003.


HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death.

Jacobsen AV, Lowes KN, Tanzer MC, Lucet IS, Hildebrand JM, Petrie EJ, van Delft MF, Liu Z, Conos SA, Zhang JG, Huang DC, Silke J, Lessene G, Murphy JM.

Cell Death Dis. 2016 Jan 14;7:e2051. doi: 10.1038/cddis.2015.386.


Reference gene selection for qPCR is dependent on cell type rather than treatment in colonic and vaginal human epithelial cell lines.

Jacobsen AV, Yemaneab BT, Jass J, Scherbak N.

PLoS One. 2014 Dec 19;9(12):e115592. doi: 10.1371/journal.pone.0115592. eCollection 2014.

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