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High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model.

Luchtel RA, Bhagat T, Pradhan K, Jacobs WR Jr, Levine M, Verma A, Shenoy N.

Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1666-1677. doi: 10.1073/pnas.1908158117. Epub 2020 Jan 7.


Helicobacter pylori infections in the Bronx, New York: Surveying Antibiotic Susceptibility and Strain Lineage by Whole-genome Sequencing.

Saranathan R, Levi MH, Wattam AR, Malek A, Asare E, Behin DS, Pan DH, Jacobs WR, Szymczak WA.

J Clin Microbiol. 2019 Dec 4. pii: JCM.01591-19. doi: 10.1128/JCM.01591-19. [Epub ahead of print]


Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection.

Hasenoehrl EJ, Rae Sajorda D, Berney-Meyer L, Johnson S, Tufariello JM, Fuhrer T, Cook GM, Jacobs WR Jr, Berney M.

Nat Commun. 2019 Sep 16;10(1):4215. doi: 10.1038/s41467-019-12224-3.


Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex.

Chiner-Oms Á, Berney M, Boinett C, González-Candelas F, Young DB, Gagneux S, Jacobs WR Jr, Parkhill J, Cortes T, Comas I.

Nat Commun. 2019 Sep 5;10(1):3994. doi: 10.1038/s41467-019-11948-6.


Generation of IL-3-Secreting CD4+ T Cells by Microbial Challenge at Skin and Mucosal Barriers.

Kunnath-Velayudhan S, Goldberg MF, Saini NK, Ng TW, Arora P, Johndrow CT, Saavedra-Avila NA, Johnson AJ, Xu J, Kim J, Khajoueinejad N, Petro CD, Herold BC, Lauvau G, Chan J, Jacobs WR Jr, Porcelli SA.

Immunohorizons. 2019 May 16;3(5):161-171. doi: 10.4049/immunohorizons.1900028.


The Mycobacterium tuberculosis capsule: a cell structure with key implications in pathogenesis.

Kalscheuer R, Palacios A, Anso I, Cifuente J, Anguita J, Jacobs WR Jr, Guerin ME, Prados-Rosales R.

Biochem J. 2019 Jul 18;476(14):1995-2016. doi: 10.1042/BCJ20190324. Review.


Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1.

Tiwari S, Casey R, Goulding CW, Hingley-Wilson S, Jacobs WR Jr.

Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0024-2019.


Erratum for O'Donnell et al., "Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing".

O'Donnell MR, Larsen MH, Brown TS, Jain P, Munsamy V, Wolf A, Uccellini L, Karim F, de Oliveira T, Mathema B, Jacobs WR, Pym A.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00764-19. doi: 10.1128/AAC.00764-19. Print 2019 Jun. No abstract available.


Exacting Edward Jenner's revenge: The quest for a new tuberculosis vaccine.

Porcelli SA, Jacobs WR Jr.

Sci Transl Med. 2019 May 1;11(490). pii: eaax4219. doi: 10.1126/scitranslmed.aax4219. Review.


Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates.

Shen L, Frencher J, Huang D, Wang W, Yang E, Chen CY, Zhang Z, Wang R, Qaqish A, Larsen MH, Shen H, Porcelli SA, Jacobs WR Jr, Chen ZW.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6371-6378. doi: 10.1073/pnas.1811380116. Epub 2019 Mar 8.


The Isoniazid Paradigm of Killing, Resistance, and Persistence in Mycobacterium tuberculosis.

Vilchèze C, Jacobs WR Jr.

J Mol Biol. 2019 Aug 23;431(18):3450-3461. doi: 10.1016/j.jmb.2019.02.016. Epub 2019 Feb 21. Review.


Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing.

O'Donnell MR, Larsen MH, Brown TS, Jain P, Munsamy V, Wolf A, Uccellini L, Karim F, de Oliveira T, Mathema B, Jacobs WR, Pym A.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e01834-18. doi: 10.1128/AAC.01834-18. Print 2019 Apr. Erratum in: Antimicrob Agents Chemother. 2019 May 24;63(6):.


Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2+ Monocytes.

Johndrow CT, Goldberg MF, Johnson AJ, Ng TW, Kunnath-Velayudhan S, Lauvau G, Kaplan DH, Gossel GH, Kadolsky UD, Yates AJ, Chan J, Jacobs WR Jr, Porcelli SA.

J Immunol. 2018 Dec 15;201(12):3604-3616. doi: 10.4049/jimmunol.1801185. Epub 2018 Nov 19.


A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis.

Bhatt K, Machado H, Osório NS, Sousa J, Cardoso F, Magalhães C, Chen B, Chen M, Kim J, Singh A, Ferreira CM, Castro AG, Torrado E, Jacobs WR Jr, Bhatt A, Saraiva M.

mSphere. 2018 Oct 31;3(5). pii: e00352-18. doi: 10.1128/mSphere.00352-18.


Reply to Yew et al., "Vitamin C and Mycobacterium tuberculosis Persisters".

Vilchèze C, Jacobs WR Jr.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01709-18. doi: 10.1128/AAC.01709-18. Print 2018 Nov. No abstract available.


Arginine-deprivation-induced oxidative damage sterilizes Mycobacterium tuberculosis.

Tiwari S, van Tonder AJ, Vilchèze C, Mendes V, Thomas SE, Malek A, Chen B, Chen M, Kim J, Blundell TL, Parkhill J, Weinrick B, Berney M, Jacobs WR Jr.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9779-9784. doi: 10.1073/pnas.1808874115. Epub 2018 Aug 24.


Identification of Mycobacterial Ribosomal Proteins as Targets for CD4+ T Cells That Enhance Protective Immunity in Tuberculosis.

Kennedy SC, Johnson AJ, Bharrhan S, Lindestam Arlehamn CS, Xu J, Garforth SJ, Chan J, Jacobs WR Jr, Sette A, Almo SC, Porcelli SA.

Infect Immun. 2018 Aug 22;86(9). pii: e00009-18. doi: 10.1128/IAI.00009-18. Print 2018 Sep.


Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy.

Vilchèze C, Copeland J, Keiser TL, Weisbrod T, Washington J, Jain P, Malek A, Weinrick B, Jacobs WR Jr.

mBio. 2018 May 29;9(3). pii: e00938-18. doi: 10.1128/mBio.00938-18.


Simultaneous Force Regression and Movement Classification of Fingers via Surface EMG within a Unified Bayesian Framework.

Baldacchino T, Jacobs WR, Anderson SR, Worden K, Rowson J.

Front Bioeng Biotechnol. 2018 Feb 26;6:13. doi: 10.3389/fbioe.2018.00013. eCollection 2018.


Small Molecules Targeting Mycobacterium tuberculosis Type II NADH Dehydrogenase Exhibit Antimycobacterial Activity.

Harbut MB, Yang B, Liu R, Yano T, Vilchèze C, Cheng B, Lockner J, Guo H, Yu C, Franzblau SG, Petrassi HM, Jacobs WR Jr, Rubin H, Chatterjee AK, Wang F.

Angew Chem Int Ed Engl. 2018 Mar 19;57(13):3478-3482. doi: 10.1002/anie.201800260. Epub 2018 Feb 22.


Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence.

Vilchèze C, Weinrick B, Leung LW, Jacobs WR Jr.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1599-1604. doi: 10.1073/pnas.1721545115. Epub 2018 Jan 30.


Vitamin C Potentiates the Killing of Mycobacterium tuberculosis by the First-Line Tuberculosis Drugs Isoniazid and Rifampin in Mice.

Vilchèze C, Kim J, Jacobs WR Jr.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02165-17. doi: 10.1128/AAC.02165-17. Print 2018 Mar.


A Herpes Simplex Virus (HSV)-2 Single-Cycle Candidate Vaccine Deleted in Glycoprotein D Protects Male Mice From Lethal Skin Challenge With Clinical Isolates of HSV-1 and HSV-2.

Burn C, Ramsey N, Garforth SJ, Almo S, Jacobs WR Jr, Herold BC.

J Infect Dis. 2018 Feb 14;217(5):754-758. doi: 10.1093/infdis/jix628.


An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning.

Hanauer DI, Graham MJ; SEA-PHAGES, Betancur L, Bobrownicki A, Cresawn SG, Garlena RA, Jacobs-Sera D, Kaufmann N, Pope WH, Russell DA, Jacobs WR Jr, Sivanathan V, Asai DJ, Hatfull GF.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13531-13536. doi: 10.1073/pnas.1718188115. Epub 2017 Dec 5.


US6 Gene Deletion in Herpes Simplex Virus Type 2 Enhances Dendritic Cell Function and T Cell Activation.

Retamal-Díaz A, Weiss KA, Tognarelli EI, Freire M, Bueno SM, Herold BC, Jacobs WR Jr, González PA.

Front Immunol. 2017 Nov 10;8:1523. doi: 10.3389/fimmu.2017.01523. eCollection 2017.


Addressing the Metabolic Stability of Antituberculars through Machine Learning.

Stratton TP, Perryman AL, Vilchèze C, Russo R, Li SG, Patel JS, Singleton E, Ekins S, Connell N, Jacobs WR Jr, Freundlich JS.

ACS Med Chem Lett. 2017 Sep 14;8(10):1099-1104. doi: 10.1021/acsmedchemlett.7b00299. eCollection 2017 Oct 12.


Transcriptome Analysis of Mycobacteria-Specific CD4+ T Cells Identified by Activation-Induced Expression of CD154.

Kunnath-Velayudhan S, Goldberg MF, Saini NK, Johndrow CT, Ng TW, Johnson AJ, Xu J, Chan J, Jacobs WR Jr, Porcelli SA.

J Immunol. 2017 Oct 1;199(7):2596-2606. doi: 10.4049/jimmunol.1700654. Epub 2017 Aug 18.


Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.

Liu R, Lyu X, Batt SM, Hsu MH, Harbut MB, Vilchèze C, Cheng B, Ajayi K, Yang B, Yang Y, Guo H, Lin C, Gan F, Wang C, Franzblau SG, Jacobs WR Jr, Besra GS, Johnson EF, Petrassi M, Chatterjee AK, Fütterer K, Wang F.

Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13011-13015. doi: 10.1002/anie.201707324. Epub 2017 Sep 7.


Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth.

Glass LN, Swapna G, Chavadi SS, Tufariello JM, Mi K, Drumm JE, Lam TT, Zhu G, Zhan C, Vilchéze C, Arcos J, Chen Y, Bi L, Mehta S, Porcelli SA, Almo SC, Yeh SR, Jacobs WR Jr, Torrelles JB, Chan J.

PLoS Pathog. 2017 Jul 28;13(7):e1006515. doi: 10.1371/journal.ppat.1006515. eCollection 2017 Jul.


Defining a temporal order of genetic requirements for development of mycobacterial biofilms.

Yang Y, Thomas J, Li Y, Vilchèze C, Derbyshire KM, Jacobs WR Jr, Ojha AK.

Mol Microbiol. 2017 Sep;105(5):794-809. doi: 10.1111/mmi.13734. Epub 2017 Jul 7.


Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.

Saito K, Warrier T, Somersan-Karakaya S, Kaminski L, Mi J, Jiang X, Park S, Shigyo K, Gold B, Roberts J, Weber E, Jacobs WR Jr, Nathan CF.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4832-E4840. doi: 10.1073/pnas.1705385114. Epub 2017 May 30.


Adoptive Transfer of Phosphoantigen-Specific γδ T Cell Subset Attenuates Mycobacterium tuberculosis Infection in Nonhuman Primates.

Qaqish A, Huang D, Chen CY, Zhang Z, Wang R, Li S, Yang E, Lu Y, Larsen MH, Jacobs WR Jr, Qian L, Frencher J, Shen L, Chen ZW.

J Immunol. 2017 Jun 15;198(12):4753-4763. doi: 10.4049/jimmunol.1602019. Epub 2017 May 19.


Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis.

Vilchèze C, Hartman T, Weinrick B, Jain P, Weisbrod TR, Leung LW, Freundlich JS, Jacobs WR Jr.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4495-4500. doi: 10.1073/pnas.1704376114. Epub 2017 Apr 10.


Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.

Ryan A, Polycarpou E, Lack NA, Evangelopoulos D, Sieg C, Halman A, Bhakta S, Eleftheriadou O, McHugh TD, Keany S, Lowe ED, Ballet R, Abuhammad A, Jacobs WR Jr, Ciulli A, Sim E.

Br J Pharmacol. 2017 Jul;174(14):2209-2224. doi: 10.1111/bph.13810. Epub 2017 May 9.


Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application.

Kerantzas CA, Jacobs WR Jr.

mBio. 2017 Mar 14;8(2). pii: e01586-16. doi: 10.1128/mBio.01586-16. Review.


Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine.

Prados-Rosales R, Carreño L, Cheng T, Blanc C, Weinrick B, Malek A, Lowary TL, Baena A, Joe M, Bai Y, Kalscheuer R, Batista-Gonzalez A, Saavedra NA, Sampedro L, Tomás J, Anguita J, Hung SC, Tripathi A, Xu J, Glatman-Freedman A, Jacobs WR Jr, Chan J, Porcelli SA, Achkar JM, Casadevall A.

PLoS Pathog. 2017 Mar 9;13(3):e1006250. doi: 10.1371/journal.ppat.1006250. eCollection 2017 Mar.


Identification of Mycobacterial RplJ/L10 and RpsA/S1 Proteins as Novel Targets for CD4+ T Cells.

Johnson AJ, Kennedy SC, Lindestam Arlehamn CS, Goldberg MF, Saini NK, Xu J, Paul S, Hegde SS, Blanchard JS, Chan J, Jacobs WR Jr, Sette A, Porcelli SA.

Infect Immun. 2017 Mar 23;85(4). pii: e01023-16. doi: 10.1128/IAI.01023-16. Print 2017 Apr.


Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.

Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR Jr, Bornemann S, Ioerger TR, Ehrt S, Kalscheuer R.

PLoS Pathog. 2016 Dec 9;12(12):e1006043. doi: 10.1371/journal.ppat.1006043. eCollection 2016 Dec.


Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation.

Portal-Celhay C, Tufariello JM, Srivastava S, Zahra A, Klevorn T, Grace PS, Mehra A, Park HS, Ernst JD, Jacobs WR Jr, Philips JA.

Nat Microbiol. 2016 Dec 5;2:16232. doi: 10.1038/nmicrobiol.2016.232.


Increased TNF-α/IFN-γ/IL-2 and Decreased TNF-α/IFN-γ Production by Central Memory T Cells Are Associated with Protective Responses against Bovine Tuberculosis Following BCG Vaccination.

Maggioli MF, Palmer MV, Thacker TC, Vordermeier HM, McGill JL, Whelan AO, Larsen MH, Jacobs WR Jr, Waters WR.

Front Immunol. 2016 Oct 17;7:421. eCollection 2016.


Dual-Reporter Mycobacteriophages (Φ2DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum.

Jain P, Weinrick BC, Kalivoda EJ, Yang H, Munsamy V, Vilcheze C, Weisbrod TR, Larsen MH, O'Donnell MR, Pym A, Jacobs WR Jr.

mBio. 2016 Oct 25;7(5). pii: e01023-16. doi: 10.1128/mBio.01023-16.


Fluorescent Reporter DS6A Mycobacteriophages Reveal Unique Variations in Infectibility and Phage Production in Mycobacteria.

Mayer O, Jain P, Weisbrod TR, Biro D, Ho L, Jacobs-Sera D, Hatfull GF, Jacobs WR Jr.

J Bacteriol. 2016 Nov 4;198(23):3220-3232. Print 2016 Dec 1.


Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine.

Jensen K, Dela Pena-Ponce MG, Piatak M Jr, Shoemaker R, Oswald K, Jacobs WR Jr, Fennelly G, Lucero C, Mollan KR, Hudgens MG, Amedee A, Kozlowski PA, Estes JD, Lifson JD, Van Rompay KK, Larsen M, De Paris K.

Clin Vaccine Immunol. 2017 Jan 5;24(1). pii: e00360-16. doi: 10.1128/CVI.00360-16. Print 2017 Jan.


CD4+ T-cell-independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection.

Foreman TW, Mehra S, LoBato DN, Malek A, Alvarez X, Golden NA, Bucşan AN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Roy CJ, Blanchard J, Kuroda MJ, Lackner AA, Chan J, Khader SA, Jacobs WR Jr, Kaushal D.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5636-44. doi: 10.1073/pnas.1611987113. Epub 2016 Sep 6.


Post-translational Acetylation of MbtA Modulates Mycobacterial Siderophore Biosynthesis.

Vergnolle O, Xu H, Tufariello JM, Favrot L, Malek AA, Jacobs WR Jr, Blanchard JS.

J Biol Chem. 2016 Oct 14;291(42):22315-22326. Epub 2016 Aug 26.


Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.

Saini NK, Baena A, Ng TW, Venkataswamy MM, Kennedy SC, Kunnath-Velayudhan S, Carreño LJ, Xu J, Chan J, Larsen MH, Jacobs WR Jr, Porcelli SA.

Nat Microbiol. 2016 Aug 15;1(9):16133. doi: 10.1038/nmicrobiol.2016.133.


HSV-2 ΔgD elicits FcγR-effector antibodies that protect against clinical isolates.

Petro CD, Weinrick B, Khajoueinejad N, Burn C, Sellers R, Jacobs WR Jr, Herold BC.

JCI Insight. 2016 Aug 4;1(12). pii: e88529.


Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis.

Koliwer-Brandl H, Syson K, van de Weerd R, Chandra G, Appelmelk B, Alber M, Ioerger TR, Jacobs WR Jr, Geurtsen J, Bornemann S, Kalscheuer R.

PLoS Pathog. 2016 Aug 11;12(8):e1005768. doi: 10.1371/journal.ppat.1005768. eCollection 2016 Aug.


Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent.

Halloum I, Carrère-Kremer S, Blaise M, Viljoen A, Bernut A, Le Moigne V, Vilchèze C, Guérardel Y, Lutfalla G, Herrmann JL, Jacobs WR Jr, Kremer L.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4228-37. doi: 10.1073/pnas.1605477113. Epub 2016 Jul 6.


Evaluation of a High-Intensity Green Fluorescent Protein Fluorophage Method for Drug- Resistance Diagnosis in Tuberculosis for Isoniazid, Rifampin, and Streptomycin.

Yu X, Gu Y, Jiang G, Ma Y, Zhao L, Sun Z, Jain P, O'Donnell M, Larsen M, Jacobs WR Jr, Huang H.

Front Microbiol. 2016 Jun 17;7:922. doi: 10.3389/fmicb.2016.00922. eCollection 2016.

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