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Items: 1 to 50 of 408

1.

Identification of mycobacterial ribosomal proteins as targets for CD4+ T cells that enhance protective immunity in tuberculosis.

Kennedy SC, Johnson AJ, Bharrhan S, Lindestam Arlehamn CS, Xu J, Garforth SJ, Chan J, Jacobs WR Jr, Sette A, Almo SC, Porcelli SA.

Infect Immun. 2018 Jun 11. pii: IAI.00009-18. doi: 10.1128/IAI.00009-18. [Epub ahead of print]

PMID:
29891545
2.

Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy.

Vilchèze C, Copeland J, Keiser TL, Weisbrod T, Washington J, Jain P, Malek A, Weinrick B, Jacobs WR Jr.

MBio. 2018 May 29;9(3). pii: e00938-18. doi: 10.1128/mBio.00938-18.

3.

Simultaneous Force Regression and Movement Classification of Fingers via Surface EMG within a Unified Bayesian Framework.

Baldacchino T, Jacobs WR, Anderson SR, Worden K, Rowson J.

Front Bioeng Biotechnol. 2018 Feb 26;6:13. doi: 10.3389/fbioe.2018.00013. eCollection 2018.

4.

Small Molecules Targeting Mycobacterium tuberculosis Type II NADH Dehydrogenase Exhibit Antimycobacterial Activity.

Harbut MB, Yang B, Liu R, Yano T, Vilchèze C, Cheng B, Lockner J, Guo H, Yu C, Franzblau SG, Petrassi HM, Jacobs WR Jr, Rubin H, Chatterjee AK, Wang F.

Angew Chem Int Ed Engl. 2018 Mar 19;57(13):3478-3482. doi: 10.1002/anie.201800260. Epub 2018 Feb 22.

PMID:
29388301
5.

Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence.

Vilchèze C, Weinrick B, Leung LW, Jacobs WR Jr.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1599-1604. doi: 10.1073/pnas.1721545115. Epub 2018 Jan 30.

PMID:
29382761
6.

Vitamin C Potentiates the Killing of Mycobacterium tuberculosis by the First-Line Tuberculosis Drugs Isoniazid and Rifampin in Mice.

Vilchèze C, Kim J, Jacobs WR Jr.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02165-17. doi: 10.1128/AAC.02165-17. Print 2018 Mar.

PMID:
29298757
7.

A Herpes Simplex Virus (HSV)-2 Single-Cycle Candidate Vaccine Deleted in Glycoprotein D Protects Male Mice From Lethal Skin Challenge With Clinical Isolates of HSV-1 and HSV-2.

Burn C, Ramsey N, Garforth SJ, Almo S, Jacobs WR Jr, Herold BC.

J Infect Dis. 2018 Feb 14;217(5):754-758. doi: 10.1093/infdis/jix628.

PMID:
29216362
8.

An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning.

Hanauer DI, Graham MJ; SEA-PHAGES, Betancur L, Bobrownicki A, Cresawn SG, Garlena RA, Jacobs-Sera D, Kaufmann N, Pope WH, Russell DA, Jacobs WR Jr, Sivanathan V, Asai DJ, Hatfull GF.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13531-13536. doi: 10.1073/pnas.1718188115. Epub 2017 Dec 5.

9.

US6 Gene Deletion in Herpes Simplex Virus Type 2 Enhances Dendritic Cell Function and T Cell Activation.

Retamal-Díaz A, Weiss KA, Tognarelli EI, Freire M, Bueno SM, Herold BC, Jacobs WR Jr, González PA.

Front Immunol. 2017 Nov 10;8:1523. doi: 10.3389/fimmu.2017.01523. eCollection 2017.

10.

Addressing the Metabolic Stability of Antituberculars through Machine Learning.

Stratton TP, Perryman AL, Vilchèze C, Russo R, Li SG, Patel JS, Singleton E, Ekins S, Connell N, Jacobs WR Jr, Freundlich JS.

ACS Med Chem Lett. 2017 Sep 14;8(10):1099-1104. doi: 10.1021/acsmedchemlett.7b00299. eCollection 2017 Oct 12.

PMID:
29057058
11.

Transcriptome Analysis of Mycobacteria-Specific CD4+ T Cells Identified by Activation-Induced Expression of CD154.

Kunnath-Velayudhan S, Goldberg MF, Saini NK, Johndrow CT, Ng TW, Johnson AJ, Xu J, Chan J, Jacobs WR Jr, Porcelli SA.

J Immunol. 2017 Oct 1;199(7):2596-2606. doi: 10.4049/jimmunol.1700654. Epub 2017 Aug 18.

PMID:
28821584
12.

Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.

Liu R, Lyu X, Batt SM, Hsu MH, Harbut MB, Vilchèze C, Cheng B, Ajayi K, Yang B, Yang Y, Guo H, Lin C, Gan F, Wang C, Franzblau SG, Jacobs WR Jr, Besra GS, Johnson EF, Petrassi M, Chatterjee AK, Fütterer K, Wang F.

Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13011-13015. doi: 10.1002/anie.201707324. Epub 2017 Sep 7.

13.

Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth.

Glass LN, Swapna G, Chavadi SS, Tufariello JM, Mi K, Drumm JE, Lam TT, Zhu G, Zhan C, Vilchéze C, Arcos J, Chen Y, Bi L, Mehta S, Porcelli SA, Almo SC, Yeh SR, Jacobs WR Jr, Torrelles JB, Chan J.

PLoS Pathog. 2017 Jul 28;13(7):e1006515. doi: 10.1371/journal.ppat.1006515. eCollection 2017 Jul.

14.

Defining a temporal order of genetic requirements for development of mycobacterial biofilms.

Yang Y, Thomas J, Li Y, Vilchèze C, Derbyshire KM, Jacobs WR Jr, Ojha AK.

Mol Microbiol. 2017 Sep;105(5):794-809. doi: 10.1111/mmi.13734. Epub 2017 Jul 7.

PMID:
28628249
15.

Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.

Saito K, Warrier T, Somersan-Karakaya S, Kaminski L, Mi J, Jiang X, Park S, Shigyo K, Gold B, Roberts J, Weber E, Jacobs WR Jr, Nathan CF.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4832-E4840. doi: 10.1073/pnas.1705385114. Epub 2017 May 30.

16.

Adoptive Transfer of Phosphoantigen-Specific γδ T Cell Subset Attenuates Mycobacterium tuberculosis Infection in Nonhuman Primates.

Qaqish A, Huang D, Chen CY, Zhang Z, Wang R, Li S, Yang E, Lu Y, Larsen MH, Jacobs WR Jr, Qian L, Frencher J, Shen L, Chen ZW.

J Immunol. 2017 Jun 15;198(12):4753-4763. doi: 10.4049/jimmunol.1602019. Epub 2017 May 19.

17.

Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis.

Vilchèze C, Hartman T, Weinrick B, Jain P, Weisbrod TR, Leung LW, Freundlich JS, Jacobs WR Jr.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4495-4500. doi: 10.1073/pnas.1704376114. Epub 2017 Apr 10.

18.

Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.

Ryan A, Polycarpou E, Lack NA, Evangelopoulos D, Sieg C, Halman A, Bhakta S, Eleftheriadou O, McHugh TD, Keany S, Lowe ED, Ballet R, Abuhammad A, Jacobs WR Jr, Ciulli A, Sim E.

Br J Pharmacol. 2017 Jul;174(14):2209-2224. doi: 10.1111/bph.13810. Epub 2017 May 9.

19.

Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application.

Kerantzas CA, Jacobs WR Jr.

MBio. 2017 Mar 14;8(2). pii: e01586-16. doi: 10.1128/mBio.01586-16. Review.

20.

Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine.

Prados-Rosales R, Carreño L, Cheng T, Blanc C, Weinrick B, Malek A, Lowary TL, Baena A, Joe M, Bai Y, Kalscheuer R, Batista-Gonzalez A, Saavedra NA, Sampedro L, Tomás J, Anguita J, Hung SC, Tripathi A, Xu J, Glatman-Freedman A, Jacobs WR Jr, Chan J, Porcelli SA, Achkar JM, Casadevall A.

PLoS Pathog. 2017 Mar 9;13(3):e1006250. doi: 10.1371/journal.ppat.1006250. eCollection 2017 Mar.

21.

Identification of Mycobacterial RplJ/L10 and RpsA/S1 Proteins as Novel Targets for CD4+ T Cells.

Johnson AJ, Kennedy SC, Lindestam Arlehamn CS, Goldberg MF, Saini NK, Xu J, Paul S, Hegde SS, Blanchard JS, Chan J, Jacobs WR Jr, Sette A, Porcelli SA.

Infect Immun. 2017 Mar 23;85(4). pii: e01023-16. doi: 10.1128/IAI.01023-16. Print 2017 Apr.

22.

Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.

Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR Jr, Bornemann S, Ioerger TR, Ehrt S, Kalscheuer R.

PLoS Pathog. 2016 Dec 9;12(12):e1006043. doi: 10.1371/journal.ppat.1006043. eCollection 2016 Dec.

23.

Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation.

Portal-Celhay C, Tufariello JM, Srivastava S, Zahra A, Klevorn T, Grace PS, Mehra A, Park HS, Ernst JD, Jacobs WR Jr, Philips JA.

Nat Microbiol. 2016 Dec 5;2:16232. doi: 10.1038/nmicrobiol.2016.232.

24.

Increased TNF-α/IFN-γ/IL-2 and Decreased TNF-α/IFN-γ Production by Central Memory T Cells Are Associated with Protective Responses against Bovine Tuberculosis Following BCG Vaccination.

Maggioli MF, Palmer MV, Thacker TC, Vordermeier HM, McGill JL, Whelan AO, Larsen MH, Jacobs WR Jr, Waters WR.

Front Immunol. 2016 Oct 17;7:421. eCollection 2016.

25.

Dual-Reporter Mycobacteriophages (Φ2DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum.

Jain P, Weinrick BC, Kalivoda EJ, Yang H, Munsamy V, Vilcheze C, Weisbrod TR, Larsen MH, O'Donnell MR, Pym A, Jacobs WR Jr.

MBio. 2016 Oct 25;7(5). pii: e01023-16. doi: 10.1128/mBio.01023-16.

26.

Fluorescent Reporter DS6A Mycobacteriophages Reveal Unique Variations in Infectibility and Phage Production in Mycobacteria.

Mayer O, Jain P, Weisbrod TR, Biro D, Ho L, Jacobs-Sera D, Hatfull GF, Jacobs WR Jr.

J Bacteriol. 2016 Nov 4;198(23):3220-3232. Print 2016 Dec 1.

27.

Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine.

Jensen K, Dela Pena-Ponce MG, Piatak M Jr, Shoemaker R, Oswald K, Jacobs WR Jr, Fennelly G, Lucero C, Mollan KR, Hudgens MG, Amedee A, Kozlowski PA, Estes JD, Lifson JD, Van Rompay KK, Larsen M, De Paris K.

Clin Vaccine Immunol. 2017 Jan 5;24(1). pii: e00360-16. doi: 10.1128/CVI.00360-16. Print 2017 Jan.

28.

CD4+ T-cell-independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection.

Foreman TW, Mehra S, LoBato DN, Malek A, Alvarez X, Golden NA, Bucşan AN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Roy CJ, Blanchard J, Kuroda MJ, Lackner AA, Chan J, Khader SA, Jacobs WR Jr, Kaushal D.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5636-44. doi: 10.1073/pnas.1611987113. Epub 2016 Sep 6.

29.

Post-translational Acetylation of MbtA Modulates Mycobacterial Siderophore Biosynthesis.

Vergnolle O, Xu H, Tufariello JM, Favrot L, Malek AA, Jacobs WR Jr, Blanchard JS.

J Biol Chem. 2016 Oct 14;291(42):22315-22326. Epub 2016 Aug 26.

30.

Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.

Saini NK, Baena A, Ng TW, Venkataswamy MM, Kennedy SC, Kunnath-Velayudhan S, Carreño LJ, Xu J, Chan J, Larsen MH, Jacobs WR Jr, Porcelli SA.

Nat Microbiol. 2016 Aug 15;1(9):16133. doi: 10.1038/nmicrobiol.2016.133.

31.

HSV-2 ΔgD elicits FcγR-effector antibodies that protect against clinical isolates.

Petro CD, Weinrick B, Khajoueinejad N, Burn C, Sellers R, Jacobs WR Jr, Herold BC.

JCI Insight. 2016 Aug 4;1(12). pii: e88529.

32.

Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis.

Koliwer-Brandl H, Syson K, van de Weerd R, Chandra G, Appelmelk B, Alber M, Ioerger TR, Jacobs WR Jr, Geurtsen J, Bornemann S, Kalscheuer R.

PLoS Pathog. 2016 Aug 11;12(8):e1005768. doi: 10.1371/journal.ppat.1005768. eCollection 2016 Aug.

33.

Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent.

Halloum I, Carrère-Kremer S, Blaise M, Viljoen A, Bernut A, Le Moigne V, Vilchèze C, Guérardel Y, Lutfalla G, Herrmann JL, Jacobs WR Jr, Kremer L.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4228-37. doi: 10.1073/pnas.1605477113. Epub 2016 Jul 6.

34.

Evaluation of a High-Intensity Green Fluorescent Protein Fluorophage Method for Drug- Resistance Diagnosis in Tuberculosis for Isoniazid, Rifampin, and Streptomycin.

Yu X, Gu Y, Jiang G, Ma Y, Zhao L, Sun Z, Jain P, O'Donnell M, Larsen M, Jacobs WR Jr, Huang H.

Front Microbiol. 2016 Jun 17;7:922. doi: 10.3389/fmicb.2016.00922. eCollection 2016.

35.

Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques.

Jensen K, Nabi R, Van Rompay KKA, Robichaux S, Lifson JD, Piatak M Jr, Jacobs WR Jr, Fennelly G, Canfield D, Mollan KR, Hudgens MG, Larsen MH, Amedee AM, Kozlowski PA, De Paris K.

J Virol. 2016 Jul 27;90(16):7285-7302. doi: 10.1128/JVI.00481-16. Print 2016 Aug 15.

36.

Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines.

Olsen A, Chen Y, Ji Q, Zhu G, De Silva AD, Vilchèze C, Weisbrod T, Li W, Xu J, Larsen M, Zhang J, Porcelli SA, Jacobs WR Jr, Chan J.

MBio. 2016 May 31;7(3). pii: e01023-15. doi: 10.1128/mBio.01023-15.

37.

The Type of Growth Medium Affects the Presence of a Mycobacterial Capsule and Is Associated With Differences in Protective Efficacy of BCG Vaccination Against Mycobacterium tuberculosis.

Prados-Rosales R, Carreño LJ, Weinrick B, Batista-Gonzalez A, Glatman-Freedman A, Xu J, Chan J, Jacobs WR Jr, Porcelli SA, Casadevall A.

J Infect Dis. 2016 Aug 1;214(3):426-37. doi: 10.1093/infdis/jiw153. Epub 2016 Apr 18.

38.

Central Role of Pyruvate Kinase in Carbon Co-catabolism of Mycobacterium tuberculosis.

Noy T, Vergnolle O, Hartman TE, Rhee KY, Jacobs WR Jr, Berney M, Blanchard JS.

J Biol Chem. 2016 Mar 25;291(13):7060-9. doi: 10.1074/jbc.M115.707430. Epub 2016 Feb 8.

39.

Postprimary Tuberculosis and Macrophage Necrosis: Is There a Big ConNECtion?

Wong KW, Jacobs WR Jr.

MBio. 2016 Jan 12;7(1):e01589-15. doi: 10.1128/mBio.01589-15.

40.

Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.

Tufariello JM, Chapman JR, Kerantzas CA, Wong KW, Vilchèze C, Jones CM, Cole LE, Tinaztepe E, Thompson V, Fenyö D, Niederweis M, Ueberheide B, Philips JA, Jacobs WR Jr.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E348-57. doi: 10.1073/pnas.1523321113. Epub 2016 Jan 4.

41.

Interleukin-17A as a Biomarker for Bovine Tuberculosis.

Waters WR, Maggioli MF, Palmer MV, Thacker TC, McGill JL, Vordermeier HM, Berney-Meyer L, Jacobs WR Jr, Larsen MH.

Clin Vaccine Immunol. 2015 Dec 16;23(2):168-80. doi: 10.1128/CVI.00637-15. Print 2016 Feb.

42.

The Complete Genome Sequence of the Emerging Pathogen Mycobacterium haemophilum Explains Its Unique Culture Requirements.

Tufariello JM, Kerantzas CA, Vilchèze C, Calder RB, Nordberg EK, Fischer JA, Hartman TE, Yang E, Driscoll T, Cole LE, Sebra R, Maqbool SB, Wattam AR, Jacobs WR Jr.

MBio. 2015 Nov 17;6(6):e01313-15. doi: 10.1128/mBio.01313-15.

43.

Structural characterization of muropeptides from Chlamydia trachomatis peptidoglycan by mass spectrometry resolves "chlamydial anomaly".

Packiam M, Weinrick B, Jacobs WR Jr, Maurelli AT.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11660-5. doi: 10.1073/pnas.1514026112. Epub 2015 Aug 19.

44.

Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights.

Li SG, Vilchèze C, Chakraborty S, Wang X, Kim H, Anisetti M, Ekins S, Rhee KY, Jacobs WR Jr, Freundlich JS.

Tetrahedron Lett. 2015 Jun 3;56(23):3246-3250.

45.

Synthesis and biological activity of alkynoic acids derivatives against mycobacteria.

Vilchèze C, Leung LW, Bittman R, Jacobs WR Jr.

Chem Phys Lipids. 2016 Jan;194:125-38. doi: 10.1016/j.chemphyslip.2015.08.001. Epub 2015 Aug 6.

46.

Essential roles of methionine and S-adenosylmethionine in the autarkic lifestyle of Mycobacterium tuberculosis.

Berney M, Berney-Meyer L, Wong KW, Chen B, Chen M, Kim J, Wang J, Harris D, Parkhill J, Chan J, Wang F, Jacobs WR Jr.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):10008-13. doi: 10.1073/pnas.1513033112. Epub 2015 Jul 28.

47.

Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities.

Vilchèze C, Jacobs WR Jr.

Microbiol Spectr. 2014 Aug;2(4):MGM2-0014-2013. doi: 10.1128/microbiolspec.MGM2-0014-2013. Review.

PMID:
26104204
48.

Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance.

Zolla V, Nizamutdinova IT, Scharf B, Clement CC, Maejima D, Akl T, Nagai T, Luciani P, Leroux JC, Halin C, Stukes S, Tiwari S, Casadevall A, Jacobs WR Jr, Entenberg D, Zawieja DC, Condeelis J, Fooksman DR, Gashev AA, Santambrogio L.

Aging Cell. 2015 Aug;14(4):582-94. doi: 10.1111/acel.12330. Epub 2015 May 15.

49.

A Novel Reporter Phage To Detect Tuberculosis and Rifampin Resistance in a High-HIV-Burden Population.

O'Donnell MR, Pym A, Jain P, Munsamy V, Wolf A, Karim F, Jacobs WR Jr, Larsen MH.

J Clin Microbiol. 2015 Jul;53(7):2188-94. doi: 10.1128/JCM.03530-14. Epub 2015 Apr 29.

50.

Stable Expression of Lentiviral Antigens by Quality-Controlled Recombinant Mycobacterium bovis BCG Vectors.

Hart BE, Asrican R, Lim SY, Sixsmith JD, Lukose R, Souther SJ, Rayasam SD, Saelens JW, Chen CJ, Seay SA, Berney-Meyer L, Magtanong L, Vermeul K, Pajanirassa P, Jimenez AE, Ng TW, Tobin DM, Porcelli SA, Larsen MH, Schmitz JE, Haynes BF, Jacobs WR Jr, Lee S, Frothingham R.

Clin Vaccine Immunol. 2015 Jul;22(7):726-41. doi: 10.1128/CVI.00075-15. Epub 2015 Apr 29.

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