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Items: 1 to 50 of 85

1.
2.

Synthetic pseudopterosin analogues: A novel class of antiinflammatory drug candidates.

Flachsmann F, Schellhaas K, Moya CE, Jacobs RS, Fenical W.

Bioorg Med Chem. 2010 Dec 1;18(23):8324-33. doi: 10.1016/j.bmc.2010.09.067. Epub 2010 Oct 7.

PMID:
21041093
3.

The odyssey of marine pharmaceuticals: a current pipeline perspective.

Mayer AM, Glaser KB, Cuevas C, Jacobs RS, Kem W, Little RD, McIntosh JM, Newman DJ, Potts BC, Shuster DE.

Trends Pharmacol Sci. 2010 Jun;31(6):255-65. doi: 10.1016/j.tips.2010.02.005. Epub 2010 Apr 2. Review.

PMID:
20363514
4.

Electromyographic analysis of the gluteus medius in five weight-bearing exercises.

Krause DA, Jacobs RS, Pilger KE, Sather BR, Sibunka SP, Hollman JH.

J Strength Cond Res. 2009 Dec;23(9):2689-94. doi: 10.1519/JSC.0b013e3181bbe861.

PMID:
19910807
5.

Synthesis and an evaluation of the bioactivity of the C-glycoside of pseudopterosin A methyl ether.

Zhong W, Moya C, Jacobs RS, Little RD.

J Org Chem. 2008 Sep 19;73(18):7011-6. doi: 10.1021/jo801432t. Epub 2008 Aug 19.

PMID:
18710290
6.

7,11-epi-thyrsiferol: completion of its synthesis, evaluation of its antimitotic properties, and the further development of an SAR model.

Nishiguchi GA, Graham J, Bouraoui A, Jacobs RS, Little RD.

J Org Chem. 2006 Aug 4;71(16):5936-41.

PMID:
16872175
7.

Pseudopterosin A inhibits phagocytosis and alters intracellular calcium turnover in a pertussis toxin sensitive site in Tetrahymena thermophila.

Moya CE, Jacobs RS.

Comp Biochem Physiol C Toxicol Pharmacol. 2006 Aug;143(4):436-43. Epub 2006 Apr 28.

PMID:
16759914
8.
9.

Comparison of fatty acid composition of cell homogenates and isolated chloroplasts in Acetabularia crenulata (Lamouroux).

Santiago-Vázquez LZ, Jacobs RS.

Z Naturforsch C. 2005 Sep-Oct;60(9-10):757-63.

PMID:
16320619
10.
11.
12.

Identification of hydroxy fatty acids by liquid chromatography-atmospheric pressure chemical ionization mass spectroscopy in Euglena gracilis.

Santiago-Vázquez LZ, Mydlarz LD, Pavlovich JG, Jacobs RS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr 25;803(2):233-6.

PMID:
15063330
13.

Pseudopterosin biosynthesis in Symbiodinium sp., the dinoflagellate symbiont of Pseudopterogorgia elisabethae.

Mydlarz LD, Jacobs RS, Boehnlein J, Kerr RG.

Chem Biol. 2003 Nov;10(11):1051-6.

PMID:
14652072
14.

Dicoumarol: a unique microtubule stabilizing natural product that is synergistic with Taxol.

Madari H, Panda D, Wilson L, Jacobs RS.

Cancer Res. 2003 Mar 15;63(6):1214-20.

15.

The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore.

Stevenson CS, Capper EA, Roshak AK, Marquez B, Eichman C, Jackson JR, Mattern M, Gerwick WH, Jacobs RS, Marshall LA.

J Pharmacol Exp Ther. 2002 Nov;303(2):858-66.

PMID:
12388673
16.

Scytonemin--a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases.

Stevenson CS, Capper EA, Roshak AK, Marquez B, Grace K, Gerwick WH, Jacobs RS, Marshall LA.

Inflamm Res. 2002 Feb;51(2):112-4. No abstract available.

PMID:
11926312
18.

Homo- and nor-plakotenin, new carboxylic acids from the Palauan sponge Plakortis lita.

Qureshi A, Stevenson CS, Albert CL, Jacobs RS, Faulkner DJ.

J Nat Prod. 1999 Aug;62(8):1205-7.

PMID:
10479343
19.

The effect of temperature and solution pH on the nucleation of tetragonal lysozyme crystals.

Judge RA, Jacobs RS, Frazier T, Snell EH, Pusey ML.

Biophys J. 1999 Sep;77(3):1585-93.

20.

Phospholipid composition of the granular amebocyte from the horseshoe crab, Limulus polyphemus.

MacPherson JC, Pavlovich JG, Jacobs RS.

Lipids. 1998 Sep;33(9):931-40.

PMID:
9778141
22.

Inflammatory PGE2 production is maintained during hypoxia in rheumatoid synovial fibroblasts.

McGough KA, Jackson JR, Minton JA, Marshall LA, Jacobs RS, Winkler JD.

Inflamm Res. 1997 Aug;46 Suppl 2:S147-8. No abstract available.

PMID:
9297554
23.

Pheochromocytoma and bowel ischemia.

Salehi A, Legome EL, Eichhorn K, Jacobs RS.

J Emerg Med. 1997 Jan-Feb;15(1):35-8.

PMID:
9017485
24.
25.

CNS role: an experience in retitling and role clarification.

Chase LK, Johnson SK, Laffoon TA, Jacobs RS, Johnson ME.

Clin Nurse Spec. 1996 Jan;10(1):41-5. Review.

PMID:
8705935
26.

Structure and biosynthesis of novel conjugated polyene fatty acids from the marine green alga Anadyomene stellata.

Mikhailova MV, Bemis DL, Wise ML, Gerwick WH, Norris JN, Jacobs RS.

Lipids. 1995 Jul;30(7):583-9.

PMID:
7564911
27.

Poster discussion lipid mediators--new agents.

DeVries GW, Jacobs RS.

Agents Actions Suppl. 1995;47:203-5. No abstract available.

PMID:
7785500
28.

Inactivation of bee venom phospholipase A2 by a sesquiterpene furanoic acid marine natural product.

Grace KJ, Zavortink D, Jacobs RS.

Biochem Pharmacol. 1994 Apr 20;47(8):1427-34.

PMID:
8185650
29.

A marine natural product, patellamide D, reverses multidrug resistance in a human leukemic cell line.

Williams AB, Jacobs RS.

Cancer Lett. 1993 Jul 30;71(1-3):97-102.

PMID:
8364904
30.

Phospholipase A2 inhibitors from marine organisms.

Potts BC, Faulkner DJ, Jacobs RS.

J Nat Prod. 1992 Dec;55(12):1701-17. Review.

PMID:
1294693
33.

Selective inhibition of cytokinesis in sea urchin embryos by the marine natural product pseudopterolide.

Grace KJ, Medina M, Jacobs RS, Wilson L.

Mol Pharmacol. 1992 Apr;41(4):631-8.

PMID:
1569918
34.

Two-step inactivation of bee venom phospholipase A2 by scalaradial.

de Carvalho MS, Jacobs RS.

Biochem Pharmacol. 1991 Sep 27;42(8):1621-6.

PMID:
1930288
35.

Structure and stereochemistry of brianolide, a new antiinflammatory diterpenoid from the Okinawan gorgonian Briareum sp.

Kobayashi J, Cheng JF, Nakamura H, Ohizumi Y, Tomotake Y, Matsuzaki T, Grace KJ, Jacobs RS, Kato Y, Brinen LS, et al.

Experientia. 1991 May 15;47(5):501-2.

PMID:
1675176
36.

Inactivation of human synovial fluid phospholipase A2 by the marine natural product, manoalide.

Jacobson PB, Marshall LA, Sung A, Jacobs RS.

Biochem Pharmacol. 1990 May 15;39(10):1557-64.

PMID:
2337412
37.

Partitioning of 2,4,5,2',4',5'-hexachlorobiphenyl between seawater and air.

Tjeerdema RS, Jacobs RS.

Bull Environ Contam Toxicol. 1990 Apr;44(4):572-8. No abstract available.

PMID:
2157508
38.

Manoalide: structure-activity studies and definition of the pharmacophore for phospholipase A2 inactivation.

Glaser KB, de Carvalho MS, Jacobs RS, Kernan MR, Faulkner DJ.

Mol Pharmacol. 1989 Nov;36(5):782-8.

PMID:
2586492
39.

Synthesis, in vitro acetylcholine-storage-blocking activities, and biological properties of derivatives and analogues of trans-2-(4-phenylpiperidino)cyclohexanol (vesamicol).

Rogers GA, Parsons SM, Anderson DC, Nilsson LM, Bahr BA, Kornreich WD, Kaufman R, Jacobs RS, Kirtman B.

J Med Chem. 1989 Jun;32(6):1217-30.

PMID:
2724295
40.
41.

Luffolide, a novel anti-inflammatory terpene from the sponge Luffariella sp..

Kernan MR, Faulkner DJ, Parkanyi L, Clardy J, de Carvalho MS, Jacobs RS.

Experientia. 1989 Apr 15;45(4):388-90.

PMID:
2707379
42.

Inactivation of phospholipase A2 by manoalide. Localization of the manoalide binding site on bee venom phospholipase A2.

Glaser KB, Vedvick TS, Jacobs RS.

Biochem Pharmacol. 1988 Oct 1;37(19):3639-46.

PMID:
3178877
43.

A further study of the neuromuscular effects of vesamicol (AH5183) and of its enantiomer specificity.

Estrella D, Green KL, Prior C, Dempster J, Halliwell RF, Jacobs RS, Parsons SM, Parsons RL, Marshall IG.

Br J Pharmacol. 1988 Apr;93(4):759-68.

44.
46.

Elimination of 2,4,5,2',4',5'-hexachlorobiphenyl by the purple sea urchin, Strongylocentrotus purpuratus, following single exposure.

Tjeerdema RS, Jacobs RS.

Bull Environ Contam Toxicol. 1987 Jun;38(6):1029-36. No abstract available.

PMID:
3107638
47.
48.

Mechanism of action of the marine natural product stypoldione: evidence for reaction with sulfhydryl groups.

O'Brien ET, Asai DJ, Groweiss A, Lipshutz BH, Fenical W, Jacobs RS, Wilson L.

J Med Chem. 1986 Oct;29(10):1851-5.

PMID:
3761306
49.

The pseudopterosins: anti-inflammatory and analgesic natural products from the sea whip Pseudopterogorgia elisabethae.

Look SA, Fenical W, Jacobs RS, Clardy J.

Proc Natl Acad Sci U S A. 1986 Sep;83(17):6238-40.

50.

Molecular pharmacology of manoalide. Inactivation of bee venom phospholipase A2.

Glaser KB, Jacobs RS.

Biochem Pharmacol. 1986 Feb 1;35(3):449-53.

PMID:
3947381

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