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The impact of Aβ and tau on prospective cognitive decline in older individuals.

Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, Hanseeuw BJ, Buckley R, Chhatwal J, Hedden T, Marshall GA, Quiroz YT, Donovan NJ, Jackson J, Gatchel JR, Rabin JS, Jacobs H, Yang HS, Properzi M, Kirn DR, Rentz DM, Johnson KA.

Ann Neurol. 2018 Dec 14. doi: 10.1002/ana.25395. [Epub ahead of print]


Where do white matter alterations dovetail with the cascade model of Alzheimer's disease?

Jacobs HIL, Buckley RF.

Brain. 2018 Oct 1;141(10):2830-2833. doi: 10.1093/brain/awy243. No abstract available.


Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy.

Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J.

EMBO Mol Med. 2018 Dec 10. pii: e9456. doi: 10.15252/emmm.201809456. [Epub ahead of print]


Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage.

Freeze WM, Jacobs HIL, Schreuder FHBM, van Oostenbrugge RJ, Backes WH, Verhey FR, Klijn CJM.

Front Neurol. 2018 Nov 12;9:926. doi: 10.3389/fneur.2018.00926. eCollection 2018.


[Non-drug treatment of rheumatoid arthritis : An analysis of claims data and a survey of insured persons (Project PROCLAIR)].

Jacobs H, Callhoff J, Hoffmann F, Zink A, Albrecht K.

Z Rheumatol. 2018 Nov 26. doi: 10.1007/s00393-018-0567-6. [Epub ahead of print] German.


Core-Shell Transformation-Imprinted Solder Bumps Enabling Low-Temperature Fluidic Self-Assembly and Self-Alignment of Chips and High Melting Point Interconnects.

Kaltwasser M, Schmidt U, Biswas S, Reiprich J, Schlag L, Isaac NA, Stauden T, Jacobs HO.

ACS Appl Mater Interfaces. 2018 Nov 28;10(47):40608-40613. doi: 10.1021/acsami.8b12390. Epub 2018 Nov 15.


Neurogenetic contributions to amyloid beta and tau spreading in the human cortex.

Sepulcre J, Grothe MJ, d'Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang HS, Jacobs HIL, Hanseeuw BJ, Li Q, El-Fakhri G, Sperling RA, Johnson KA.

Nat Med. 2018 Dec;24(12):1910-1918. doi: 10.1038/s41591-018-0206-4. Epub 2018 Oct 29.


Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B Cells.

Du SW, Jacobs HM, Arkatkar T, Rawlings DJ, Jackson SW.

J Immunol. 2018 Dec 1;201(11):3258-3268. doi: 10.4049/jimmunol.1800393. Epub 2018 Oct 29.


Generation of functional murine CD11c+ age-associated B cells in the absence of B cell T-bet expression.

Du SW, Arkatkar T, Jacobs HM, Rawlings DJ, Jackson SW.

Eur J Immunol. 2018 Oct 24. doi: 10.1002/eji.201847641. [Epub ahead of print]


Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls.

Saari S, Garcia GS, Bremer K, Chioda MM, Andjelković A, Debes PV, Nikinmaa M, Szibor M, Dufour E, Rustin P, Oliveira MT, Jacobs HT.

Biochim Biophys Acta Mol Basis Dis. 2018 Oct 17. pii: S0925-4439(18)30389-2. doi: 10.1016/j.bbadis.2018.10.012. [Epub ahead of print]


Alternative Oxidase Attenuates Cigarette Smoke-Induced Lung Dysfunction and Tissue Damage.

Giordano L, Farnham A, Dhandapani PK, Salminen L, Bhaskaran J, Voswinckel R, Rauschkolb P, Scheibe S, Sommer N, Beisswenger C, Weissmann N, Braun T, Jacobs HT, Bals R, Herr C, Szibor M.

Am J Respir Cell Mol Biol. 2018 Oct 19. doi: 10.1165/rcmb.2018-0261OC. [Epub ahead of print]


On the Extraction and Analysis of Graphs From Resting-State fMRI to Support a Correct and Robust Diagnostic Tool for Alzheimer's Disease.

Bachmann C, Jacobs HIL, Porta Mana P, Dillen K, Richter N, von Reutern B, Dronse J, Onur OA, Langen KJ, Fink GR, Kukolja J, Morrison A.

Front Neurosci. 2018 Sep 28;12:528. doi: 10.3389/fnins.2018.00528. eCollection 2018.


Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes.

Müller-Ehrenberg L, Riphagen JM, Verhey FRJ, Sack AT, Jacobs HIL; Alzheimer’s Disease Neuroimaging Initiative.

J Alzheimers Dis. 2018;66(2):811-823. doi: 10.3233/JAD-180676.


Practice makes perfect: High performance gains in older adults engaged in selective attention within and across sensory modalities.

Rienäcker F, Jacobs HIL, Van Heugten CM, Van Gerven PWM.

Acta Psychol (Amst). 2018 Nov;191:101-111. doi: 10.1016/j.actpsy.2018.09.005. Epub 2018 Sep 18.


Hemifield-specific Correlations between Cue-related Blood Oxygen Level Dependent Activity in Bilateral Nodes of the Dorsal Attention Network and Attentional Benefits in a Spatial Orienting Paradigm.

Mayrhofer HC, Duecker F, van de Ven V, Jacobs HIL, Sack AT.

J Cogn Neurosci. 2018 Sep 21:1-14. doi: 10.1162/jocn_a_01338. [Epub ahead of print]


Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration.

Andjelković A, Mordas A, Bruinsma L, Ketola A, Cannino G, Giordano L, Dhandapani PK, Szibor M, Dufour E, Jacobs HT.

Mol Cell Biol. 2018 Nov 28;38(24). pii: e00110-18. doi: 10.1128/MCB.00110-18. Print 2018 Dec 15.


[Prescription frequency of physical therapy and analgesics before total hip and knee arthroplasy : An epidemiological analysis of routine health care data from Germany].

Lange T, Luque Ramos A, Albrecht K, Günther KP, Jacobs H, Schmitt J, Hoffmann F, Goronzy J, Postler A.

Orthopade. 2018 Dec;47(12):1015-1023. doi: 10.1007/s00132-018-3629-1. German.


Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer's disease: a longitudinal cohort study.

Van Hooren RWE, Riphagen JM, Jacobs HIL; Alzheimer’s Disease Neuroimaging Initiative.

Alzheimers Res Ther. 2018 Aug 28;10(1):88. doi: 10.1186/s13195-018-0420-9.


Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.

Dogan SA, Cerutti R, Benincá C, Brea-Calvo G, Jacobs HT, Zeviani M, Szibor M, Viscomi C.

Cell Metab. 2018 Nov 6;28(5):764-775.e5. doi: 10.1016/j.cmet.2018.07.012. Epub 2018 Aug 16.


Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase.

Rodrigues APC, Camargo AF, Andjelković A, Jacobs HT, Oliveira MT.

Sci Rep. 2018 Jul 18;8(1):10882. doi: 10.1038/s41598-018-29150-x.


A schoolwide approach to promoting student bystander behavior in response to the use of the word "retard".

Siperstein GN, Albert AB, Jacobs HE, Osborne KJ, Stokes JE.

Res Dev Disabil. 2018 Sep;80:142-152. doi: 10.1016/j.ridd.2018.06.016. Epub 2018 Jul 10.


Chronotype differences in cortical thickness: grey matter reflects when you go to bed.

Rosenberg J, Jacobs HIL, Maximov II, Reske M, Shah NJ.

Brain Struct Funct. 2018 Sep;223(7):3411-3421. doi: 10.1007/s00429-018-1697-y. Epub 2018 Jun 15.


Correction to: Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline.

Bos I, Verhey FR, Ramakers IHGB, Jacobs HIL, Soininen H, Freund-Levi Y, Hampel H, Tsolaki M, Wallin ÅK, van Buchem MA, Oleksik A, Verbeek MM, Rikkert MO, van der Flier WM, Scheltens P, Aalten P, Visser PJ, Vos SJB.

Alzheimers Res Ther. 2018 Jun 20;10(1):56. doi: 10.1186/s13195-018-0391-x.


Curvilinear locus coeruleus functional connectivity trajectories over the adult lifespan: a 7T MRI study.

Jacobs HIL, Müller-Ehrenberg L, Priovoulos N, Roebroeck A.

Neurobiol Aging. 2018 Sep;69:167-176. doi: 10.1016/j.neurobiolaging.2018.05.021. Epub 2018 May 24.


TACI deletion protects against progressive murine lupus nephritis induced by BAFF overexpression.

Arkatkar T, Jacobs HM, Du SW, Li QZ, Hudkins KL, Alpers CE, Rawlings DJ, Jackson SW.

Kidney Int. 2018 Oct;94(4):728-740. doi: 10.1016/j.kint.2018.03.012. Epub 2018 Jun 12.


Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts.

Buckley RF, Mormino EC, Amariglio RE, Properzi MJ, Rabin JS, Lim YY, Papp KV, Jacobs HIL, Burnham S, Hanseeuw BJ, Doré V, Dobson A, Masters CL, Waller M, Rowe CC, Maruff P, Donohue MC, Rentz DM, Kirn D, Hedden T, Chhatwal J, Schultz AP, Johnson KA, Villemagne VL, Sperling RA; Alzheimer's Disease Neuroimaging Initiative; Australian Imaging, Biomarker and Lifestyle study of ageing; Harvard Aging Brain Study.

Alzheimers Dement. 2018 Sep;14(9):1193-1203. doi: 10.1016/j.jalz.2018.04.010. Epub 2018 May 24.


Severe combined immunodeficiency in stimulator of interferon genes (STING) V154M/wild-type mice.

Bouis D, Kirstetter P, Arbogast F, Lamon D, Delgado V, Jung S, Ebel C, Jacobs H, Knapp AM, Jeremiah N, Belot A, Martin T, Crow YJ, André-Schmutz I, Korganow AS, Rieux-Laucat F, Soulas-Sprauel P.

J Allergy Clin Immunol. 2018 May 23. pii: S0091-6749(18)30758-9. doi: 10.1016/j.jaci.2018.04.034. [Epub ahead of print]


PET staging of amyloidosis using striatum.

Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vannini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA; Alzheimer's Disease Neuroimaging Initiative; Harvard Aging Brain Study.

Alzheimers Dement. 2018 Oct;14(10):1281-1292. doi: 10.1016/j.jalz.2018.04.011. Epub 2018 May 21.


Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.

Buoninfante OA, Pilzecker B, Aslam MA, Zavrakidis I, van der Wiel R, van de Ven M, van den Berk PCM, Jacobs H.

Oncotarget. 2018 Apr 10;9(27):18832-18843. doi: 10.18632/oncotarget.24777. eCollection 2018 Apr 10.


Shades of white: diffusion properties of T1- and FLAIR-defined white matter signal abnormalities differ in stages from cognitively normal to dementia.

Riphagen JM, Gronenschild EHBM, Salat DH, Freeze WM, Ivanov D, Clerx L, Verhey FRJ, Aalten P, Jacobs HIL.

Neurobiol Aging. 2018 Aug;68:48-58. doi: 10.1016/j.neurobiolaging.2018.03.029. Epub 2018 Apr 5.


18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal.

Lee CM, Jacobs HIL, Marquié M, Becker JA, Andrea NV, Jin DS, Schultz AP, Frosch MP, Gómez-Isla T, Sperling RA, Johnson KA.

J Alzheimers Dis. 2018;62(4):1691-1702. doi: 10.3233/JAD-170840.


Nrf2a modulates the embryonic antioxidant response to perfluorooctanesulfonic acid (PFOS) in the zebrafish, Danio rerio.

Sant KE, Sinno PP, Jacobs HM, Timme-Laragy AR.

Aquat Toxicol. 2018 May;198:92-102. doi: 10.1016/j.aquatox.2018.02.010. Epub 2018 Feb 20.


Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cells.

Toompuu M, Tuomela T, Laine P, Paulin L, Dufour E, Jacobs HT.

Nucleic Acids Res. 2018 Jun 1;46(10):5209-5226. doi: 10.1093/nar/gky159.


Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase.

Ciesielski GL, Nadalutti CA, Oliveira MT, Jacobs HT, Griffith JD, Kaguni LS.

Nucleic Acids Res. 2018 Apr 6;46(6):3034-3046. doi: 10.1093/nar/gky094.


Incidence Rates of and Mortality after Hip Fracture among German Nursing Home Residents.

Jacobs H, Zeeb H, Hoffmann F.

Int J Environ Res Public Health. 2018 Feb 7;15(2). pii: E289. doi: 10.3390/ijerph15020289.


Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals.

Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA.

Nat Neurosci. 2018 Mar;21(3):424-431. doi: 10.1038/s41593-018-0070-z. Epub 2018 Feb 5.


Xenotopic expression of alternative electron transport enzymes in animal mitochondria and their impact in health and disease.

Camargo AF, Chioda MM, Rodrigues APC, Garcia GS, McKinney EA, Jacobs HT, Oliveira MT.

Cell Biol Int. 2018 Jun;42(6):664-669. doi: 10.1002/cbin.10943. Epub 2018 Feb 23. Review.


Mitochondria are physiologically maintained at close to 50 °C.

Chrétien D, Bénit P, Ha HH, Keipert S, El-Khoury R, Chang YT, Jastroch M, Jacobs HT, Rustin P, Rak M.

PLoS Biol. 2018 Jan 25;16(1):e2003992. doi: 10.1371/journal.pbio.2003992. eCollection 2018 Jan.


Arabinoxylo-Oligosaccharides and Inulin Impact Inter-Individual Variation on Microbial Metabolism and Composition, Which Immunomodulates Human Cells.

Van den Abbeele P, Taminiau B, Pinheiro I, Duysburgh C, Jacobs H, Pijls L, Marzorati M.

J Agric Food Chem. 2018 Feb 7;66(5):1121-1130. doi: 10.1021/acs.jafc.7b04611. Epub 2018 Jan 24.


Intracellular vesicle trafficking plays an essential role in mitochondrial quality control.

Gerards M, Cannino G, de Cózar JMG, Jacobs HT.

Mol Biol Cell. 2018 Jan 17. pii: mbc.E17-10-0619. doi: 10.1091/mbc.E17-10-0619. [Epub ahead of print]


Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline.

Bos I, Verhey FR, Ramakers IHGB, Jacobs HIL, Soininen H, Freund-Levi Y, Hampel H, Tsolaki M, Wallin ÅK, van Buchem MA, Oleksik A, Verbeek MM, Olde Rikkert M, van der Flier WM, Scheltens P, Aalten P, Visser PJ, Vos SJB.

Alzheimers Res Ther. 2017 Dec 29;9(1):101. doi: 10.1186/s13195-017-0328-9. Erratum in: Alzheimers Res Ther. 2018 Jun 20;10(1):56.


Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio).

Jacobs HM, Sant KE, Basnet A, Williams LM, Moss JB, Timme-Laragy AR.

Chemosphere. 2018 Mar;195:498-507. doi: 10.1016/j.chemosphere.2017.12.094. Epub 2017 Dec 15.


Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals.

d'Oleire Uquillas F, Jacobs HIL, Hanseeuw B, Marshall GA, Properzi M, Schultz AP, LaPoint MR, Johnson KA, Sperling RA, Vannini P.

Neuroimage Clin. 2017 Oct 31;17:388-396. doi: 10.1016/j.nicl.2017.10.034. eCollection 2018.


CD4+ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness.

Ahrends T, Spanjaard A, Pilzecker B, Bąbała N, Bovens A, Xiao Y, Jacobs H, Borst J.

Immunity. 2017 Nov 21;47(5):848-861.e5. doi: 10.1016/j.immuni.2017.10.009. Epub 2017 Nov 7.


Non-invasive quantitative imaging of hepatocellular carcinoma growth in mice by micro-CT using liver-targeted iodinated nano-emulsions.

Anton N, Parlog A, Bou About G, Attia MF, Wattenhofer-Donzé M, Jacobs H, Goncalves I, Robinet E, Sorg T, Vandamme TF.

Sci Rep. 2017 Oct 24;7(1):13935. doi: 10.1038/s41598-017-14270-7.


The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline.

Jacobs HIL, Hopkins DA, Mayrhofer HC, Bruner E, van Leeuwen FW, Raaijmakers W, Schmahmann JD.

Brain. 2018 Jan 1;141(1):37-47. doi: 10.1093/brain/awx194.


B cell-derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity.

Arkatkar T, Du SW, Jacobs HM, Dam EM, Hou B, Buckner JH, Rawlings DJ, Jackson SW.

J Exp Med. 2017 Nov 6;214(11):3207-3217. doi: 10.1084/jem.20170580. Epub 2017 Sep 12.


Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity.

Vujanovic M, Krietsch J, Raso MC, Terraneo N, Zellweger R, Schmid JA, Taglialatela A, Huang JW, Holland CL, Zwicky K, Herrador R, Jacobs H, Cortez D, Ciccia A, Penengo L, Lopes M.

Mol Cell. 2017 Sep 7;67(5):882-890.e5. doi: 10.1016/j.molcel.2017.08.010.


Atp6ap2 ablation in adult mice impairs viability through multiple organ deficiencies.

Wendling O, Champy MF, Jaubert S, Pavlovic G, Dubos A, Lindner L, Jacobs H, Mark M, Combe R, Da Cruz IG, Luche H, Mudgett JS, Rosahl T, Sorg T, Malissen M, Reilly PT, Hérault Y.

Sci Rep. 2017 Aug 29;7(1):9618. doi: 10.1038/s41598-017-08845-7.


DNA damage tolerance in hematopoietic stem and progenitor cells in mice.

Pilzecker B, Buoninfante OA, van den Berk P, Lancini C, Song JY, Citterio E, Jacobs H.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6875-E6883. doi: 10.1073/pnas.1706508114. Epub 2017 Jul 31.

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