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Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila.

Gospodaryov DV, Strilbytska OM, Semaniuk UV, Perkhulyn NV, Rovenko BM, Yurkevych IS, Barata AG, Dick TP, Lushchak OV, Jacobs HT.

Biogerontology. 2019 Nov 20. doi: 10.1007/s10522-019-09849-8. [Epub ahead of print]


Sagittal Stability and Implant Design Affect Patient Reported Outcomes After Total Knee Arthroplasty.

Jones CW, Jacobs H, Shumborski S, Talbot S, Redgment A, Brighton R, Walter WL.

J Arthroplasty. 2019 Oct 16. pii: S0883-5403(19)30978-7. doi: 10.1016/j.arth.2019.10.020. [Epub ahead of print]


Linking APOE-ε4, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology.

Riphagen JM, Ramakers IHGM, Freeze WM, Pagen LHG, Hanseeuw BJ, Verbeek MM, Verhey FRJ, Jacobs HIL.

Neurobiol Aging. 2019 Oct 15. pii: S0197-4580(19)30355-0. doi: 10.1016/j.neurobiolaging.2019.09.020. [Epub ahead of print]


White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed.

Freeze WM, Jacobs HIL, de Jong JJ, Verheggen ICM, Gronenschild EHBM, Palm WM, Hoff EI, Wardlaw JM, Jansen JFA, Verhey FR, Backes WH.

Neurobiol Aging. 2019 Sep 27. pii: S0197-4580(19)30338-0. doi: 10.1016/j.neurobiolaging.2019.09.017. [Epub ahead of print]


Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults.

d'Oleire Uquillas F, Jacobs HIL, Schultz AP, Hanseeuw BJ, Buckley RF, Sepulcre J, Pascual-Leone A, Donovan NJ, Johnson KA, Sperling RA, Vannini P.

Cereb Cortex. 2019 Nov 6. pii: bhz217. doi: 10.1093/cercor/bhz217. [Epub ahead of print]


No effect of cold pressor test-induced arousal on attentional benefits and costs in an endogenous spatial orienting paradigm.

Duecker F, Mayrhofer HC, Jacobs HIL, Sack AT.

Neuropsychologia. 2019 Nov 1;135:107250. doi: 10.1016/j.neuropsychologia.2019.107250. [Epub ahead of print]


Integrated multilayer stretchable printed circuit boards paving the way for deformable active matrix.

Biswas S, Schoeberl A, Hao Y, Reiprich J, Stauden T, Pezoldt J, Jacobs HO.

Nat Commun. 2019 Oct 28;10(1):4909. doi: 10.1038/s41467-019-12870-7.


Functional Characterization of CD11c+ Age-Associated B Cells as Memory B Cells.

Du SW, Arkatkar T, Al Qureshah F, Jacobs HM, Thouvenel CD, Chiang K, Largent AD, Li QZ, Hou B, Rawlings DJ, Jackson SW.

J Immunol. 2019 Dec 1;203(11):2817-2826. doi: 10.4049/jimmunol.1900404. Epub 2019 Oct 21.


Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms.

Bahhir D, Yalgin C, Ots L, Järvinen S, George J, Naudí A, Krama T, Krams I, Tamm M, Andjelković A, Dufour E, González de Cózar JM, Gerards M, Parhiala M, Pamplona R, Jacobs HT, Jõers P.

PLoS Genet. 2019 Oct 4;15(10):e1008410. doi: 10.1371/journal.pgen.1008410. eCollection 2019 Oct.


Mitochondrial dysfunction generates a growth-restraining signal linked to pyruvate in Drosophila larvae.

George J, Tuomela T, Kemppainen E, Nurminen A, Braun S, Yalgin C, Jacobs HT.

Fly (Austin). 2019 Sep 17:1-17. doi: 10.1080/19336934.2019.1662266. [Epub ahead of print]


Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans.

IJspeert H, van Schouwenburg PA, Pico-Knijnenburg I, Loeffen J, Brugieres L, Driessen GJ, Blattmann C, Suerink M, Januszkiewicz-Lewandowska D, Azizi AA, Seidel MG, Jacobs H, van der Burg M.

Front Immunol. 2019 Aug 27;10:1913. doi: 10.3389/fimmu.2019.01913. eCollection 2019.


Focus on the blue locus for learning.

Jacobs HIL.

Nat Hum Behav. 2019 Nov;3(11):1143-1144. doi: 10.1038/s41562-019-0731-2. No abstract available.


Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy.

Dhandapani PK, Begines-Moreno IM, Brea-Calvo G, Gärtner U, Graeber TG, Javier Sanchez G, Morty RE, Schönig K, Hoeve JT, Wietelmann A, Braun T, Jacobs HT, Szibor M.

Sci Rep. 2019 Sep 4;9(1):12741. doi: 10.1038/s41598-019-49231-9.


Germline knockdown of spargel (PGC-1) produces embryonic lethality in Drosophila.

George J, Jacobs HT.

Mitochondrion. 2019 Aug 29;49:189-199. doi: 10.1016/j.mito.2019.08.006. [Epub ahead of print]


"Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis": Answer to Wang and colleagues.

Wolters AF, van de Weijer SCF, Leentjens AFG, Duits AA, Jacobs HIL, Kuijf ML.

Parkinsonism Relat Disord. 2019 Sep;66:253-254. doi: 10.1016/j.parkreldis.2019.07.014. Epub 2019 Jul 12. No abstract available.


Gas Phase Electrodeposition Enabling the Programmable Three-Dimensional Growth of a Multimodal Room Temperature Nanobridge Gas Sensor Array.

Isaac NA, Schlag L, Reiprich J, Katzer S, Nahrstedt H, Pezoldt J, Stauden T, Jacobs HO.

ACS Appl Mater Interfaces. 2019 Sep 11;11(36):33497-33504. doi: 10.1021/acsami.9b12545. Epub 2019 Aug 29.


Spatial distributions of cholinergic impairment and neuronal hypometabolism differ in MCI due to AD.

Richter N, Nellessen N, Dronse J, Dillen K, Jacobs HIL, Langen KJ, Dietlein M, Kracht L, Neumaier B, Fink GR, Kukolja J, Onur OA.

Neuroimage Clin. 2019 Aug 9;24:101978. doi: 10.1016/j.nicl.2019.101978. [Epub ahead of print]


In vivo imaging of the nucleus of the solitary tract with Magnetization Transfer at 7 Tesla.

Priovoulos N, Poser BA, Ivanov D, Verhey FRJ, Jacobs HIL.

Neuroimage. 2019 Nov 1;201:116071. doi: 10.1016/j.neuroimage.2019.116071. Epub 2019 Aug 6.


Optimal Detection of Subtle Gadolinium Leakage in CSF with Heavily T2-Weighted Fluid-Attenuated Inversion Recovery Imaging.

Freeze WM, Ter Weele DN, Palm WM, van Hooren RW, Hoff EI, Jansen JFA, Jacobs HIL, Verhey FR, Backes WH.

AJNR Am J Neuroradiol. 2019 Sep;40(9):1481-1483. doi: 10.3174/ajnr.A6145. Epub 2019 Aug 8.


Fluidic Self-Assembly on Electroplated Multilayer Solder Bumps with Tailored Transformation Imprinted Melting Points.

Kaltwasser M, Schmidt U, Lösing L, Biswas S, Stauden T, Bund A, Jacobs HO.

Sci Rep. 2019 Aug 5;9(1):11325. doi: 10.1038/s41598-019-47690-8.


Tropomyosin-related kinase A (TrkA) inhibition for the treatment of painful knee osteoarthritis: results from a randomized controlled phase 2a trial.

Watt FE, Blauwet MB, Fakhoury A, Jacobs H, Smulders R, Lane NE.

Osteoarthritis Cartilage. 2019 Nov;27(11):1590-1598. doi: 10.1016/j.joca.2019.05.029. Epub 2019 Jul 26.



Song TA, Roy Chowdhury S, Yang F, Jacobs H, El Fakhri G, Li Q, Johnson K, Dutta J.

Proc IEEE Int Symp Biomed Imaging. 2019 Apr;2019:414-417. doi: 10.1109/ISBI.2019.8759531. Epub 2019 Jul 11.


Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.

Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF, Lambert C, Cardenas-Blanco A, Pine K, Passamonti L, Loane C, Keuken MC, Trujillo P, Lüsebrink F, Mattern H, Liu KY, Priovoulos N, Fliessbach K, Dahl MJ, Maaß A, Madelung CF, Meder D, Ehrenberg AJ, Speck O, Weiskopf N, Dolan R, Inglis B, Tosun D, Morawski M, Zucca FA, Siebner HR, Mather M, Uludag K, Heinsen H, Poser BA, Howard R, Zecca L, Rowe JB, Grinberg LT, Jacobs HIL, Düzel E, Hämmerer D.

Brain. 2019 Sep 1;142(9):2558-2571. doi: 10.1093/brain/awz193.


Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.

Vlaming H, McLean CM, Korthout T, Alemdehy MF, Hendriks S, Lancini C, Palit S, Klarenbeek S, Kwesi-Maliepaard EM, Molenaar TM, Hoekman L, Schmidlin TT, Altelaar AM, van Welsem T, Dannenberg JH, Jacobs H, van Leeuwen F.

EMBO J. 2019 Jul 15;38(14):e101564. doi: 10.15252/embj.2019101564. Epub 2019 Jun 17.


Minimal effects of spargel (PGC-1) overexpression in a Drosophila mitochondrial disease model.

George J, Jacobs HT.

Biol Open. 2019 Jul 19;8(7). pii: bio042135. doi: 10.1242/bio.042135.


[Utilization of individual out-of-pocket health services (IGeL) in persons with osteoarthritis in Germany : Results of a survey from the PROCLAIR study].

Jacobs H, Hoffmann F, Callhoff J, Postler A, Saam J, Zink A, Günther KP, Goronzy J.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Aug;62(8):1013-1019. doi: 10.1007/s00103-019-02986-y. German.


Phenotypic effects of dietary stress in combination with a respiratory chain bypass in mice.

Dhandapani PK, Lyyski AM, Paulin L, Khan NA, Suomalainen A, Auvinen P, Dufour E, Szibor M, Jacobs HT.

Physiol Rep. 2019 Aug;7(13):e14159. doi: 10.14814/phy2.14159.


DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy.

Pilzecker B, Buoninfante OA, Jacobs H.

Nucleic Acids Res. 2019 Aug 22;47(14):7163-7181. doi: 10.1093/nar/gkz531.


Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults.

Biddle KD, d'Oleire Uquillas F, Jacobs HIL, Zide B, Kirn DR, Rentz DM, Johnson KA, Sperling RA, Donovan NJ.

Am J Geriatr Psychiatry. 2019 Nov;27(11):1247-1256. doi: 10.1016/j.jagp.2019.05.005. Epub 2019 May 10.


The Impact of a Group-Based Multidisciplinary Rehabilitation Program on the Quality of Life in Patients With Fibromyalgia: Results From the QUALIFIBRO Study.

Jacobs H, Bockaert M, Bonte J, DʼHaese M, Degrande J, Descamps L, Detaeye U, Goethals W, Janssens J, Matthys K, Muller L, Van de Walle H, Viane I, Vlieghe B, Grillet M, Asher R, Grillet B, De Bacquer D.

J Clin Rheumatol. 2019 Jun 19. doi: 10.1097/RHU.0000000000001120. [Epub ahead of print]


Alternative oxidase confers nutritional limitation on Drosophila development.

Saari S, Kemppainen E, Tuomela T, Oliveira MT, Dufour E, Jacobs HT.

J Exp Zool A Ecol Integr Physiol. 2019 Jul;331(6):341-356. doi: 10.1002/jez.2274. Epub 2019 Jun 20.


Subthreshold amyloid and its biological and clinical meaning: Long way ahead.

Bischof GN, Jacobs HIL.

Neurology. 2019 Jul 9;93(2):72-79. doi: 10.1212/WNL.0000000000007747. Epub 2019 Jun 5. Review.


Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study.

Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, Cosio DMO, Farrell M, Quiroz YT, Mormino EC, Buckley RF, Papp KV, Amariglio RA, Dewachter I, Ivanoiu A, Huijbers W, Hedden T, Marshall GA, Chhatwal JP, Rentz DM, Sperling RA, Johnson K.

JAMA Neurol. 2019 Jun 3. doi: 10.1001/jamaneurol.2019.1424. [Epub ahead of print] Erratum in: JAMA Neurol. 2019 Aug 1;76(8):986.


A longitudinal model for tau aggregation in Alzheimer's disease based on structural connectivity.

Yang F, Roy Chowdhury S, Jacobs HIL, Johnson KA, Dutta J.

Inf Process Med Imaging. 2019;11492:384-393. doi: 10.1007/978-3-030-20351-1_29. Epub 2019 May 22.


Ultrasound-Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma.

Bou About G, Thiebault E, Wattenhofer-Donzé M, Jacobs H, Guimond A, Sorg T, Robinet E, Baumert TF, Monassier L, Herault Y.

Curr Protoc Mouse Biol. 2019 Jun;9(2):e62. doi: 10.1002/cpmo.62. Epub 2019 May 30.


Alzheimer's disease pathology: pathways between central norepinephrine activity, memory, and neuropsychiatric symptoms.

Jacobs HIL, Riphagen JM, Ramakers IHGB, Verhey FRJ.

Mol Psychiatry. 2019 May 28. doi: 10.1038/s41380-019-0437-x. [Epub ahead of print]


Recurrent MSC E116K mutations in ALK-negative anaplastic large cell lymphoma.

Luchtel RA, Zimmermann MT, Hu G, Dasari S, Jiang M, Oishi N, Jacobs HK, Zeng Y, Hundal T, Rech KL, Ketterling RP, Lee JH, Eckloff BW, Yan H, Gaonkar KS, Tian S, Ye Z, Kadin ME, Sidhu J, Jiang L, Voss J, Link BK, Syrbu SI, Facchetti F, Bennani NN, Slager SL, Ordog T, Kocher JP, Cerhan JR, Ansell SM, Feldman AL.

Blood. 2019 Jun 27;133(26):2776-2789. doi: 10.1182/blood.2019000626. Epub 2019 May 17.


Lethal Interaction of Nuclear and Mitochondrial Genotypes in Drosophila melanogaster.

Salminen TS, Cannino G, Oliveira MT, Lillsunde P, Jacobs HT, Kaguni LS.

G3 (Bethesda). 2019 Jul 9;9(7):2225-2234. doi: 10.1534/g3.119.400315.


Premonitory Symptoms in Episodic and Chronic Migraine From a Pediatric Headache Clinic.

Jacobs H, Pakalnis A.

Pediatr Neurol. 2019 Aug;97:26-29. doi: 10.1016/j.pediatrneurol.2019.03.023. Epub 2019 Mar 29.


Water use indicators at farm scale - An agro-hydrological software solution.

Kraatz S, Libra JA, Drastig K, Hunstock U, Zare M, Jacobs H.

Sci Total Environ. 2019 Aug 15;678:133-145. doi: 10.1016/j.scitotenv.2019.04.368. Epub 2019 Apr 27.


Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid.

Buckley RF, Mormino EC, Chhatwal J, Schultz AP, Rabin JS, Rentz DM, Acar D, Properzi MJ, Dumurgier J, Jacobs H, Gomez-Isla T, Johnson KA, Sperling RA, Hanseeuw BJ; Alzheimer's Disease Neuroimaging Initiative.

Neurobiol Aging. 2019 Jun;78:178-185. doi: 10.1016/j.neurobiolaging.2019.02.019. Epub 2019 Mar 7.


Mutating for Good: DNA Damage Responses During Somatic Hypermutation.

Pilzecker B, Jacobs H.

Front Immunol. 2019 Mar 12;10:438. doi: 10.3389/fimmu.2019.00438. eCollection 2019. Review.


Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer's Disease: A Comprehensive Review of the Colombian Kindred.

Fuller JT, Cronin-Golomb A, Gatchel JR, Norton DJ, Guzmán-Vélez E, Jacobs HIL, Hanseeuw B, Pardilla-Delgado E, Artola A, Baena A, Bocanegra Y, Kosik KS, Chen K, Tariot PN, Johnson K, Sperling RA, Reiman EM, Lopera F, Quiroz YT.

J Prev Alzheimers Dis. 2019;6(2):112-120. doi: 10.14283/jpad.2019.6.


Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults.

Buckley RF, Mormino EC, Rabin JS, Hohman TJ, Landau S, Hanseeuw BJ, Jacobs HIL, Papp KV, Amariglio RE, Properzi MJ, Schultz AP, Kirn D, Scott MR, Hedden T, Farrell M, Price J, Chhatwal J, Rentz DM, Villemagne VL, Johnson KA, Sperling RA.

JAMA Neurol. 2019 May 1;76(5):542-551. doi: 10.1001/jamaneurol.2018.4693.


AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress.

Villafañez F, García IA, Carbajosa S, Pansa MF, Mansilla S, Llorens MC, Angiolini V, Guantay L, Jacobs H, Madauss KP, Gloger I, Gottifredi V, Bocco JL, Soria G.

Oncogene. 2019 May;38(22):4310-4324. doi: 10.1038/s41388-019-0724-7. Epub 2019 Jan 31.


Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy.

Freeze WM, Bacskai BJ, Frosch MP, Jacobs HIL, Backes WH, Greenberg SM, van Veluw SJ.

Stroke. 2019 Feb;50(2):328-335. doi: 10.1161/STROKEAHA.118.023788.


RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA.

González de Cózar JM, Gerards M, Teeri E, George J, Dufour E, Jacobs HT, Jõers P.

J Biol Chem. 2019 Mar 22;294(12):4331-4344. doi: 10.1074/jbc.RA118.007015. Epub 2019 Jan 11.


Towards an understanding of C9orf82 protein/CAAP1 function.

Aslam MA, Alemdehy MF, Pritchard CEJ, Song JY, Muhaimin FI, Wijdeven RH, Huijbers IJ, Neefjes J, Jacobs H.

PLoS One. 2019 Jan 10;14(1):e0210526. doi: 10.1371/journal.pone.0210526. eCollection 2019.


Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis.

Wolters AF, van de Weijer SCF, Leentjens AFG, Duits AA, Jacobs HIL, Kuijf ML.

Parkinsonism Relat Disord. 2019 May;62:16-27. doi: 10.1016/j.parkreldis.2018.12.016. Epub 2018 Dec 17. Review.


STIM1 over-activation generates a multi-systemic phenotype affecting the skeletal muscle, spleen, eye, skin, bones and immune system in mice.

Silva-Rojas R, Treves S, Jacobs H, Kessler P, Messaddeq N, Laporte J, Böhm J.

Hum Mol Genet. 2019 May 15;28(10):1579-1593. doi: 10.1093/hmg/ddy446.


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