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Safety, Resistance, and Efficacy Results from a Phase IIIb Study of Conventional- and Double-Dose Oseltamivir Regimens for Treatment of Influenza in Immunocompromised Patients.

Mitha E, Krivan G, Jacobs F, Nagler A, Alrabaa S, Mykietiuk A, Kenwright A, Le Pogam S, Clinch B, Vareikiene L.

Infect Dis Ther. 2019 Oct 30. doi: 10.1007/s40121-019-00271-8. [Epub ahead of print]


Implications of the movement behaviour of African tigerfish Hydrocynus vittatus for the design of freshwater protected areas.

Jacobs FJ, Naesje TF, Ulvan EM, Weyl OLF, Tiyeho D, Hay CJ, O'Brien GC, Downs CT.

J Fish Biol. 2019 Oct 15. doi: 10.1111/jfb.14158. [Epub ahead of print]


Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells.

Ayala-Nunez NV, Follain G, Delalande F, Hirschler A, Partiot E, Hale GL, Bollweg BC, Roels J, Chazal M, Bakoa F, Carocci M, Bourdoulous S, Faklaris O, Zaki SR, Eckly A, Uring-Lambert B, Doussau F, Cianferani S, Carapito C, Jacobs FMJ, Jouvenet N, Goetz JG, Gaudin R.

Nat Commun. 2019 Sep 27;10(1):4430. doi: 10.1038/s41467-019-12408-x.


P120 and E-cadherin: Double-edged swords in tumor metastasis.

Venhuizen JH, Jacobs FJC, Span PN, Zegers MM.

Semin Cancer Biol. 2019 Jul 29. pii: S1044-579X(19)30106-3. doi: 10.1016/j.semcancer.2019.07.020. [Epub ahead of print] Review.


Detection of Aedes flavopictus (Yamada, 1921), Netherlands, June 2019.

Ibáñez-Justicia A, van de Vossenberg B, van den Biggelaar R, Voogd J, Metz E, Jacobs F, Dik M, Stroo A.

Euro Surveill. 2019 Jul;24(30). doi: 10.2807/1560-7917.ES.2019.24.30.1900433.


Language Matters: Development of an Objective Structured Language Test for Foreign Physicians - Results of a Pilot Study in Germany.

Lenz H, Opitz A, Huber D, Jacobs F, Paik WG, Roche J, Fischer MR.

GMS J Med Educ. 2019 Feb 15;36(1):Doc2. doi: 10.3205/zma001210. eCollection 2019.


Temporal-Spatial Variation in Questing Tick Activity in the Netherlands: The Effect of Climatic and Habitat Factors.

Hartemink N, van Vliet A, Sprong H, Jacobs F, Garcia-Martí I, Zurita-Milla R, Takken W.

Vector Borne Zoonotic Dis. 2019 Jul;19(7):494-505. doi: 10.1089/vbz.2018.2369. Epub 2019 Feb 27.


Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes.

de Vries R, Jacobs F, Mannens G, Snoeys J, Cuyckens F, Chien C, Ward P.

Drug Metab Dispos. 2019 May;47(5):453-464. doi: 10.1124/dmd.118.084517. Epub 2019 Feb 20.


Structurally Conserved Primate LncRNAs Are Transiently Expressed during Human Cortical Differentiation and Influence Cell-Type-Specific Genes.

Field AR, Jacobs FMJ, Fiddes IT, Phillips APR, Reyes-Ortiz AM, LaMontagne E, Whitehead L, Meng V, Rosenkrantz JL, Olsen M, Hauessler M, Katzman S, Salama SR, Haussler D.

Stem Cell Reports. 2019 Feb 12;12(2):245-257. doi: 10.1016/j.stemcr.2018.12.006. Epub 2019 Jan 10.


An equal opportunity for everyone?! Supporting international students of medicine at the Ludwig-Maximilians-University in Munich.

Lenz H, Paik WG, Jacobs F.

GMS J Med Educ. 2018 Nov 30;35(5):Doc55. doi: 10.3205/zma001201. eCollection 2018.


Isolation and Characterization of Different Mesenchymal Stem Cell Populations from Rat Femur.

Jacobs FA, van de Vyver M, Ferris WF.

Methods Mol Biol. 2019;1916:133-147. doi: 10.1007/978-1-4939-8994-2_13.


Host-pathogen interactions and prognosis of critically ill immunocompetent patients with pneumococcal pneumonia: the nationwide prospective observational STREPTOGENE study.

Bedos JP, Varon E, Porcher R, Asfar P, Le Tulzo Y, Megarbane B, Mathonnet A, Dugard A, Veinstein A, Ouchenir K, Siami S, Reignier J, Galbois A, Cousson J, Preau S, Baldesi O, Rigaud JP, Souweine B, Misset B, Jacobs F, Dewavrin F, Mira JP.

Intensive Care Med. 2018 Dec;44(12):2162-2173. doi: 10.1007/s00134-018-5444-x. Epub 2018 Nov 19.


Effect of Noninvasive Ventilation After Unplanned Extubation.

Kudela A, Millereux M, Gouezel C, Prat D, Jacobs F, Hamzaoui O, Demars N, Moneger G, Dumenil AS, Trouiller P, Sztrymf B.

Respir Care. 2019 Mar;64(3):248-254. doi: 10.4187/respcare.06328. Epub 2018 Nov 6.


Investigation of unbound colistin A and B in clinical samples using a mass spectrometry method.

Fage D, Deprez G, Wolff F, Hites M, Jacobs F, Van Bambeke F, Cotton F.

Int J Antimicrob Agents. 2019 Mar;53(3):330-336. doi: 10.1016/j.ijantimicag.2018.10.017. Epub 2018 Nov 2.


Host and microbial factors in kidney transplant recipients with Escherichia coli acute pyelonephritis or asymptomatic bacteriuria: a prospective study using whole-genome sequencing.

Coussement J, Argudín MA, Heinrichs A, Racapé J, de Mendonça R, Nienhaus L, Le Moine A, Roisin S, Dodémont M, Jacobs F, Abramowicz D, Johnston BD, Johnson JR, Denis O.

Nephrol Dial Transplant. 2019 May 1;34(5):878-885. doi: 10.1093/ndt/gfy292.


The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles.

Coulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ, Gaudin R, Walsh CA.

Cell Rep. 2018 Jul 24;24(4):973-986.e8. doi: 10.1016/j.celrep.2018.06.100.


β-Lactam Dosage Regimens in Septic Patients with Augmented Renal Clearance.

Jacobs A, Taccone FS, Roberts JA, Jacobs F, Cotton F, Wolff F, Creteur J, Vincent JL, Hites M.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e02534-17. doi: 10.1128/AAC.02534-17. Print 2018 Sep.


Nebulized Versus IV Amikacin: Systemic Antibiotics Treatment Modalities May Hamper Results.

Jacobs FM.

Crit Care Med. 2018 Jul;46(7):e732. doi: 10.1097/CCM.0000000000003120. No abstract available.


Caspofungin dosage adjustments are not required for patients with Child-Pugh B or C cirrhosis.

Gustot T, Ter Heine R, Brauns E, Cotton F, Jacobs F, Brüggemann RJ.

J Antimicrob Chemother. 2018 Sep 1;73(9):2493-2496. doi: 10.1093/jac/dky189.


Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.

Fiddes IT, Lodewijk GA, Mooring M, Bosworth CM, Ewing AD, Mantalas GL, Novak AM, van den Bout A, Bishara A, Rosenkrantz JL, Lorig-Roach R, Field AR, Haeussler M, Russo L, Bhaduri A, Nowakowski TJ, Pollen AA, Dougherty ML, Nuttle X, Addor MC, Zwolinski S, Katzman S, Kriegstein A, Eichler EE, Salama SR, Jacobs FMJ, Haussler D.

Cell. 2018 May 31;173(6):1356-1369.e22. doi: 10.1016/j.cell.2018.03.051. Epub 2018 May 31.


Constipation in critical care patients: both timing and duration matter.

Prat D, Messika J, Millereux M, Gouezel C, Hamzaoui O, Demars N, Jacobs F, Trouiller P, Ricard JD, Sztrymf B.

Eur J Gastroenterol Hepatol. 2018 Sep;30(9):1003-1008. doi: 10.1097/MEG.0000000000001165.


Long Non-Coding RNAs in Neuronal Aging.

Pereira Fernandes D, Bitar M, Jacobs FMJ, Barry G.

Noncoding RNA. 2018 Apr 18;4(2). pii: E12. doi: 10.3390/ncrna4020012. Review.


Norepinephrine exerts an inotropic effect during the early phase of human septic shock.

Hamzaoui O, Jozwiak M, Geffriaud T, Sztrymf B, Prat D, Jacobs F, Monnet X, Trouiller P, Richard C, Teboul JL.

Br J Anaesth. 2018 Mar;120(3):517-524. doi: 10.1016/j.bja.2017.11.065. Epub 2017 Nov 21.


The Effectiveness of Asian Bush Mosquito (Aedes japonicus japonicus) Control Actions in Colonised Peri-urban Areas in the Netherlands.

Ibañez-Justicia A, Teekema S, den Hartog W, Jacobs F, Dik M, Stroo A.

J Med Entomol. 2018 May 4;55(3):673-680. doi: 10.1093/jme/tjy002.


Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.

Bell CC, Dankers ACA, Lauschke VM, Sison-Young R, Jenkins R, Rowe C, Goldring CE, Park K, Regan SL, Walker T, Schofield C, Baze A, Foster AJ, Williams DP, van de Ven AWM, Jacobs F, Houdt JV, Lähteenmäki T, Snoeys J, Juhila S, Richert L, Ingelman-Sundberg M.

Toxicol Sci. 2018 Apr 1;162(2):655-666. doi: 10.1093/toxsci/kfx289.


The first detected airline introductions of yellow fever mosquitoes (Aedes aegypti) to Europe, at Schiphol International airport, the Netherlands.

Ibañez-Justicia A, Gloria-Soria A, den Hartog W, Dik M, Jacobs F, Stroo A.

Parasit Vectors. 2017 Dec 8;10(1):603. doi: 10.1186/s13071-017-2555-0.


False-positive galactomannan assay in broncho-alveolar lavage after enteral nutrition solution inhalation: a case report.

Lheureux O, Montesinos I, Taton O, Antoine M, Preiser JC, Nortier J, Creteur J, Jacobs F, Grimaldi D.

JMM Case Rep. 2017 Sep 18;4(9):e005116. doi: 10.1099/jmmcr.0.005116. eCollection 2017 Sep.


[Lower respiratory tract infections in immunocompetent adult].

Jacobs F.

Rev Med Brux. 2017;38(4):313-319. French.


Selective HDL-Raising Human Apo A-I Gene Therapy Counteracts Cardiac Hypertrophy, Reduces Myocardial Fibrosis, and Improves Cardiac Function in Mice with Chronic Pressure Overload.

Amin R, Muthuramu I, Aboumsallem JP, Mishra M, Jacobs F, De Geest B.

Int J Mol Sci. 2017 Sep 20;18(9). pii: E2012. doi: 10.3390/ijms18092012.


Cholesterol-Lowering Gene Therapy Counteracts the Development of Non-ischemic Cardiomyopathy in Mice.

Muthuramu I, Amin R, Postnov A, Mishra M, Aboumsallem JP, Dresselaers T, Himmelreich U, Van Veldhoven PP, Gheysens O, Jacobs F, De Geest B.

Mol Ther. 2017 Nov 1;25(11):2513-2525. doi: 10.1016/j.ymthe.2017.07.017. Epub 2017 Aug 1.


Effects of Co-Culture Media on Hepatic Differentiation of hiPSC with or without HUVEC Co-Culture.

Freyer N, Greuel S, Knöspel F, Strahl N, Amini L, Jacobs F, Monshouwer M, Zeilinger K.

Int J Mol Sci. 2017 Aug 7;18(8). pii: E1724. doi: 10.3390/ijms18081724.


Acute Kidney Injury in Patients with Cancer.

Dreyfus A, Jacobs FM.

N Engl J Med. 2017 Aug 3;377(5):499-500. doi: 10.1056/NEJMc1707248. No abstract available.


Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis.

Muthuramu I, Amin R, Postnov A, Mishra M, Jacobs F, Gheysens O, Van Veldhoven PP, De Geest B.

Int J Mol Sci. 2017 Jul 18;18(7). pii: E1565. doi: 10.3390/ijms18071565.


Optimizing β-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: are first conventional doses effective?

Delattre IK, Taccone FS, Jacobs F, Hites M, Dugernier T, Spapen H, Laterre PF, Wallemacq PE, Van Bambeke F, Tulkens PM.

Expert Rev Anti Infect Ther. 2017 Jul;15(7):677-688. doi: 10.1080/14787210.2017.1338139. Epub 2017 Jun 19.


Culture-Based Methods and Molecular Tools for Azole-Resistant Aspergillus fumigatus Detection in a Belgian University Hospital.

Montesinos I, Argudín MA, Hites M, Ahajjam F, Dodémont M, Dagyaran C, Bakkali M, Etienne I, Jacobs F, Knoop C, Patteet S, Lagrou K.

J Clin Microbiol. 2017 Aug;55(8):2391-2399. doi: 10.1128/JCM.00520-17. Epub 2017 May 17.


Acute bacterial meningitis in adults.

Phan AD, Benchetrit L, Jacobs FM.

Lancet. 2017 Apr 22;389(10079):1609-1610. doi: 10.1016/S0140-6736(17)31020-6. No abstract available.


Urgent Chemotherapy for Life-Threatening Complications Related to Solid Neoplasms.

Zerbib Y, Rabbat A, Fartoukh M, Bigé N, Andréjak C, Mayaux J, De Prost N, Misset B, Lemiale V, Bruneel F, Maizel J, Ricome S, Jacobs F, Bornstain C, Dupont H, Baudin F, Azoulay E, Pène F; Groupe de Recherche sur la Réanimation Respiratoire en Onco-Hématologie (GRRR-OH).

Crit Care Med. 2017 Jul;45(7):e640-e648. doi: 10.1097/CCM.0000000000002331.


Comprehensive analysis of the in vitro and ex ovo hemocompatibility of surface engineered iron oxide nanoparticles for biomedical applications.

Schlenk F, Werner S, Rabel M, Jacobs F, Bergemann C, Clement JH, Fischer D.

Arch Toxicol. 2017 Oct;91(10):3271-3286. doi: 10.1007/s00204-017-1968-z. Epub 2017 Apr 4.


Performance evaluation of direct fluorescent antibody, Focus Diagnostics Simplexa™ Flu A/B & RSV and multi-parameter customized respiratory Taqman® array card in immunocompromised patients.

Steensels D, Reynders M, Descheemaeker P, Curran MD, Jacobs F, Denis O, Delforge ML, Montesinos I.

J Virol Methods. 2017 Jul;245:61-65. doi: 10.1016/j.jviromet.2017.03.013. Epub 2017 Mar 30.


Outcome and Treatment of Nocardiosis After Solid Organ Transplantation: New Insights From a European Study.

Lebeaux D, Freund R, van Delden C, Guillot H, Marbus SD, Matignon M, Van Wijngaerden E, Douvry B, De Greef J, Vuotto F, Tricot L, Fernández-Ruiz M, Dantal J, Hirzel C, Jais JP, Rodriguez-Nava V, Jacobs F, Lortholary O, Coussement J; European Study Group for Nocardia in Solid Organ Transplantation ; European Study Group for Nocardia in Solid Organ Transplantation .

Clin Infect Dis. 2017 May 15;64(10):1396-1405. doi: 10.1093/cid/cix124. Erratum in: Clin Infect Dis. 2017 Oct 15;65(8):1431-1433.


The buzz about bees and poverty alleviation: Identifying drivers and barriers of beekeeping in sub-Saharan Africa.

Amulen DR, D'Haese M, Ahikiriza E, Agea JG, Jacobs FJ, de Graaf DC, Smagghe G, Cross P.

PLoS One. 2017 Feb 24;12(2):e0172820. doi: 10.1371/journal.pone.0172820. eCollection 2017.


Deployment of Analytics into the Healthcare Safety Net: Lessons Learned.

Hartzband D, Jacobs F.

Online J Public Health Inform. 2016 Dec 28;8(3):e203. doi: 10.5210/ojphi.v8i3.7000. eCollection 2016.


Evaluation of total body weight and body mass index cut-offs for increased cefazolin dose for surgical prophylaxis.

Hites M, Deprez G, Wolff F, Ickx B, Verleije A, Closset J, Loi P, Prévost J, Taccone FS, Racapé J, Cotton F, Jacobs F.

Int J Antimicrob Agents. 2016 Dec;48(6):633-640. doi: 10.1016/j.ijantimicag.2016.08.019. Epub 2016 Oct 5.


In vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Göttingen Minipigs.

Van Peer E, Jacobs F, Snoeys J, Van Houdt J, Pijpers I, Casteleyn C, Van Ginneken C, Van Cruchten S.

Pharm Res. 2017 Apr;34(4):750-764. doi: 10.1007/s11095-017-2101-y. Epub 2017 Jan 17.


Intravenous zanamivir or oral oseltamivir for hospitalised patients with influenza: an international, randomised, double-blind, double-dummy, phase 3 trial.

Marty FM, Vidal-Puigserver J, Clark C, Gupta SK, Merino E, Garot D, Chapman MJ, Jacobs F, Rodriguez-Noriega E, Husa P, Shortino D, Watson HA, Yates PJ, Peppercorn AF.

Lancet Respir Med. 2017 Feb;5(2):135-146. doi: 10.1016/S2213-2600(16)30435-0. Epub 2017 Jan 14.


Acarological Risk of Borrelia burgdorferi Sensu Lato Infections Across Space and Time in The Netherlands.

Takken W, van Vliet AJ, Verhulst NO, Jacobs FH, Gassner F, Hartemink N, Mulder S, Sprong H.

Vector Borne Zoonotic Dis. 2017 Feb;17(2):99-107. doi: 10.1089/vbz.2015.1933. Epub 2016 Nov 28.


Evaluation of a new commercial real-time PCR assay for diagnosis of Pneumocystis jirovecii pneumonia and identification of dihydropteroate synthase (DHPS) mutations.

Montesinos I, Delforge ML, Ajjaham F, Brancart F, Hites M, Jacobs F, Denis O.

Diagn Microbiol Infect Dis. 2017 Jan;87(1):32-36. doi: 10.1016/j.diagmicrobio.2016.10.005. Epub 2016 Oct 7.


Don't Overlook the Role of Intraabdominal Pressure.

Taleb-Bendiab T, Jacobs FM.

Am J Med. 2016 Oct;129(10):e261. doi: 10.1016/j.amjmed.2016.05.040. No abstract available.


Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor.

Freyer N, Knöspel F, Strahl N, Amini L, Schrade P, Bachmann S, Damm G, Seehofer D, Jacobs F, Monshouwer M, Zeilinger K.

Biores Open Access. 2016 Aug 1;5(1):235-48. doi: 10.1089/biores.2016.0027. eCollection 2016.


Vanadate Impedes Adipogenesis in Mesenchymal Stem Cells Derived from Different Depots within Bone.

Jacobs FA, Sadie-Van Gijsen H, van de Vyver M, Ferris WF.

Front Endocrinol (Lausanne). 2016 Aug 3;7:108. doi: 10.3389/fendo.2016.00108. eCollection 2016.

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