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Prophylactic supplementation of 20-HETE ameliorates hypoxia/reoxygenation injury in pulmonary vascular endothelial cells by inhibiting apoptosis.

Sugumaran P, Narayanan V, Zhu D, Medhora M, Jacobs ER, Chandramohan Y, Selvaraj V, Dhanasekaran A.

Acta Histochem. 2019 Nov 6:151461. doi: 10.1016/j.acthis.2019.151461. [Epub ahead of print]


Pharmacokinetics of 99mTc-HMPAO in isolated perfused rat lungs.

Clough AV, Barry K, Rizzo BM, Jacobs ER, Audi SH.

J Appl Physiol (1985). 2019 Nov 1;127(5):1317-1327. doi: 10.1152/japplphysiol.00717.2018. Epub 2019 Aug 15.


Integrated Computational Model of Lung Tissue Bioenergetics.

Zhang X, Dash RK, Clough AV, Xie D, Jacobs ER, Audi SH.

Front Physiol. 2019 Mar 8;10:191. doi: 10.3389/fphys.2019.00191. eCollection 2019.


Delayed Effects of Acute Radiation Exposure (Deare) in Juvenile and Old Rats: Mitigation by Lisinopril.

Medhora M, Gao F, Gasperetti T, Narayanan J, Khan AH, Jacobs ER, Fish BL.

Health Phys. 2019 Apr;116(4):529-545. doi: 10.1097/HP.0000000000000920.


Cardiac Remodeling and Reversible Pulmonary Hypertension During Pneumonitis in Rats after 13-Gy Partial-Body Irradiation with Minimal Bone Marrow Sparing: Effect of Lisinopril.

Jacobs ER, Narayanan J, Fish BL, Gao F, Harmann LM, Bergom C, Gasperetti T, Strande JL, Medhora M.

Health Phys. 2019 Apr;116(4):558-565. doi: 10.1097/HP.0000000000000919.


Detection of hydrogen peroxide production in the isolated rat lung using Amplex red.

Audi SH, Friedly N, Dash RK, Beyer AM, Clough AV, Jacobs ER.

Free Radic Res. 2018 Sep;52(9):1052-1062. doi: 10.1080/10715762.2018.1511051. Epub 2018 Sep 28.


Integrated computational model of the bioenergetics of isolated lung mitochondria.

Zhang X, Dash RK, Jacobs ER, Camara AKS, Clough AV, Audi SH.

PLoS One. 2018 Jun 11;13(6):e0197921. doi: 10.1371/journal.pone.0197921. eCollection 2018.


Hyperoxia Causes Mitochondrial Fragmentation in Pulmonary Endothelial Cells by Increasing Expression of Pro-Fission Proteins.

Ma C, Beyer AM, Durand M, Clough AV, Zhu D, Norwood Toro L, Terashvili M, Ebben JD, Hill RB, Audi SH, Medhora M, Jacobs ER.

Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):622-635. doi: 10.1161/ATVBAHA.117.310605. Epub 2018 Feb 1.


Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging.

Audi SH, Jacobs ER, Zhang X, Camara AKS, Zhao M, Medhora MM, Rizzo B, Clough AV.

Shock. 2017 Oct;48(4):467-476. doi: 10.1097/SHK.0000000000000872.


Impact of duration of hypotension prior to norepinephrine initiation in medical intensive care unit patients with septic shock: A prospective observational study.

Patel JJ, Kurman JS, Biesboer A, Taha H, Katz M, Szabo A, Simpson SQ, Jacobs ER.

J Crit Care. 2017 Aug;40:178-183. doi: 10.1016/j.jcrc.2017.04.013. Epub 2017 Apr 9.


Changes in miRNA in the lung and whole blood after whole thorax irradiation in rats.

Gao F, Liu P, Narayanan J, Yang M, Fish BL, Liu Y, Liang M, Jacobs ER, Medhora M.

Sci Rep. 2017 Mar 17;7:44132. doi: 10.1038/srep44132.


Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia.

Densmore JC, Schaid TR, Jeziorczak PM, Medhora M, Audi S, Nayak S, Auchampach J, Dwinell MR, Geurts AM, Jacobs ER.

Exp Lung Res. 2017 Feb;43(1):38-48. doi: 10.1080/01902148.2017.1286697. Epub 2017 Mar 7.


Combined Hydration and Antibiotics with Lisinopril to Mitigate Acute and Delayed High-dose Radiation Injuries to Multiple Organs.

Fish BL, Gao F, Narayanan J, Bergom C, Jacobs ER, Cohen EP, Moulder JE, Orschell CM, Medhora M.

Health Phys. 2016 Nov;111(5):410-9. doi: 10.1097/HP.0000000000000554.


Biomarkers for Radiation Pneumonitis Using Noninvasive Molecular Imaging.

Medhora M, Haworth S, Liu Y, Narayanan J, Gao F, Zhao M, Audi S, Jacobs ER, Fish BL, Clough AV.

J Nucl Med. 2016 Aug;57(8):1296-301. doi: 10.2967/jnumed.115.160291. Epub 2016 Mar 31.


99MTc-Hexamethylpropyleneamine Oxime Imaging for Early Detection of Acute Lung Injury in Rats Exposed to Hyperoxia or Lipopolysaccharide Treatment.

Audi SH, Clough AV, Haworth ST, Medhora M, Ranji M, Densmore JC, Jacobs ER.

Shock. 2016 Oct;46(4):420-30. doi: 10.1097/SHK.0000000000000605.


Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE.

Kizub IV, Lakhkar A, Dhagia V, Joshi SR, Jiang H, Wolin MS, Falck JR, Koduru SR, Errabelli R, Jacobs ER, Schwartzman ML, Gupte SA.

Am J Physiol Lung Cell Mol Physiol. 2016 Apr 15;310(8):L772-83. doi: 10.1152/ajplung.00377.2015. Epub 2016 Feb 19.


Novel Flurometric Tool to Assess Mitochondrial Redox State of Isolated Perfused Rat Lungs after Exposure to Hyperoxia.

Sepehr R, Audi SH, Staniszewski KS, Haworth ST, Jacobs ER, Ranji M.

IEEE J Transl Eng Health Med. 2013 Oct 16;1. pii: 1500210.


Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling.

Medhora M, Gao F, Glisch C, Narayanan J, Sharma A, Harmann LM, Lawlor MW, Snyder LA, Fish BL, Down JD, Moulder JE, Strande JL, Jacobs ER.

J Radiat Res. 2015 Mar;56(2):248-60. doi: 10.1093/jrr/rru095. Epub 2014 Nov 3.


Model development and use of ACE inhibitors for preclinical mitigation of radiation-induced injury to multiple organs.

Medhora M, Gao F, Wu Q, Molthen RC, Jacobs ER, Moulder JE, Fish BL.

Radiat Res. 2014 Nov;182(5):545-55. doi: 10.1667/RR13425.1. Epub 2014 Oct 31.


Early Trophic Enteral Nutrition Is Associated With Improved Outcomes in Mechanically Ventilated Patients With Septic Shock: A Retrospective Review.

Patel JJ, Kozeniecki M, Biesboer A, Peppard W, Ray AS, Thomas S, Jacobs ER, Nanchal R, Kumar G.

J Intensive Care Med. 2016 Aug;31(7):471-7. doi: 10.1177/0885066614554887. Epub 2014 Oct 14.


In vivo detection of hyperoxia-induced pulmonary endothelial cell death using (99m)Tc-duramycin.

Audi SH, Jacobs ER, Zhao M, Roerig DL, Haworth ST, Clough AV.

Nucl Med Biol. 2015 Jan;42(1):46-52. doi: 10.1016/j.nucmedbio.2014.08.010. Epub 2014 Aug 19.


Enhanced survival from radiation pneumonitis by combined irradiation to the skin.

Gao F, Fish BL, Szabo A, Schock A, Narayanan J, Jacobs ER, Moulder JE, Lazarova Z, Medhora M.

Int J Radiat Biol. 2014 Sep;90(9):753-61. doi: 10.3109/09553002.2014.922722. Epub 2014 Jun 25.


Hypoxia preconditioning increases survival and decreases expression of Toll-like receptor 4 in pulmonary artery endothelial cells exposed to lipopolysaccharide.

Ali I, Nanchal R, Husnain F, Audi S, Konduri GG, Densmore JC, Medhora M, Jacobs ER.

Pulm Circ. 2013 Sep;3(3):578-88. doi: 10.1086/674337. Epub 2013 Dec 4.


Clinical CVVH model removes endothelium-derived microparticles from circulation.

Abdelhafeez AH, Jeziorczak PM, Schaid TR, Hoefs SL, Kaul S, Nanchal R, Jacobs ER, Densmore JC.

J Extracell Vesicles. 2014 Feb 27;3. doi: 10.3402/jev.v3.23498. eCollection 2014.


The association of lacking insurance with outcomes of severe sepsis: retrospective analysis of an administrative database*.

Kumar G, Taneja A, Majumdar T, Jacobs ER, Whittle J, Nanchal R; Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators.

Crit Care Med. 2014 Mar;42(3):583-91. doi: 10.1097/01.ccm.0000435667.15070.9c.


Enalapril mitigates radiation-induced pneumonitis and pulmonary fibrosis if started 35 days after whole-thorax irradiation.

Gao F, Fish BL, Moulder JE, Jacobs ER, Medhora M.

Radiat Res. 2013 Nov;180(5):546-52. doi: 10.1667/RR13350.1. Epub 2013 Oct 18.


Utilization of mechanical ventilation for asthma exacerbations: analysis of a national database.

Nanchal R, Kumar G, Majumdar T, Taneja A, Patel J, Dagar G, Jacobs ER, Whittle J.

Respir Care. 2014 May;59(5):644-53. doi: 10.4187/respcare.02505. Epub 2013 Oct 8.


Enalapril mitigates focal alveolar lesions, a histological marker of late pulmonary injury by radiation to the lung.

Gao F, Narayanan J, Joneikis C, Fish BL, Szabo A, Moulder JE, Molthen RC, Jacobs ER, Rao RN, Medhora M.

Radiat Res. 2013 Apr;179(4):465-74. doi: 10.1667/RR3127.1. Epub 2013 Mar 12.


Rattus model utilizing selective pulmonary ischemia induces bronchiolitis obliterans organizing pneumonia.

Densmore JC, Jeziorczak PM, Clough AV, Pritchard KA Jr, Cummens B, Medhora M, Rao A, Jacobs ER.

Shock. 2013 Mar;39(3):271-7. doi: 10.1097/SHK.0b013e318281a58c.


Outcomes of morbidly obese patients receiving invasive mechanical ventilation: a nationwide analysis.

Kumar G, Majumdar T, Jacobs ER, Danesh V, Dagar G, Deshmukh A, Taneja A, Nanchal R; from the Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators.

Chest. 2013 Jul;144(1):48-54. doi: 10.1378/chest.12-2310.


Surface fluorescence studies of tissue mitochondrial redox state in isolated perfused rat lungs.

Staniszewski K, Audi SH, Sepehr R, Jacobs ER, Ranji M.

Ann Biomed Eng. 2013 Apr;41(4):827-36. doi: 10.1007/s10439-012-0716-z. Epub 2012 Dec 13.


Short-term treatment with a SOD/catalase mimetic, EUK-207, mitigates pneumonitis and fibrosis after single-dose total-body or whole-thoracic irradiation.

Gao F, Fish BL, Szabo A, Doctrow SR, Kma L, Molthen RC, Moulder JE, Jacobs ER, Medhora M.

Radiat Res. 2012 Nov;178(5):468-80. doi: 10.1667/RR2953.1. Epub 2012 Sep 28.


Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril.

Molthen RC, Wu Q, Fish BL, Moulder JE, Jacobs ER, Medhora MM.

Respirology. 2012 Nov;17(8):1261-8. doi: 10.1111/j.1440-1843.2012.02247.x.


Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane.

Harland DR, Lorenz LD, Fay K, Dunn BE, Gruenloh SK, Narayanan J, Jacobs ER, Medhora M.

Prostaglandins Leukot Essent Fatty Acids. 2012 Aug-Sep;87(2-3):79-89. doi: 10.1016/j.plefa.2012.07.002. Epub 2012 Aug 2.


Dose-modifying factor for captopril for mitigation of radiation injury to normal lung.

Medhora M, Gao F, Fish BL, Jacobs ER, Moulder JE, Szabo A.

J Radiat Res. 2012 Jul;53(4):633-40. doi: 10.1093/jrr/rrs004. Epub 2012 Jun 6.


Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices.

Jacobs ER, Bodiga S, Ali I, Falck AM, Falck JR, Medhora M, Dhanasekaran A.

Exp Cell Res. 2012 Oct 1;318(16):2143-52. doi: 10.1016/j.yexcr.2012.06.005. Epub 2012 Jun 9.


Optical imaging of tissue mitochondrial redox state in intact rat lungs in two models of pulmonary oxidative stress.

Sepehr R, Staniszewski K, Maleki S, Jacobs ER, Audi S, Ranji M.

J Biomed Opt. 2012 Apr;17(4):046010. doi: 10.1117/1.JBO.17.4.046010.


Pulmonary embolism: the weekend effect.

Nanchal R, Kumar G, Taneja A, Patel J, Deshmukh A, Tarima S, Jacobs ER, Whittle J; from the Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators.

Chest. 2012 Sep;142(3):690-696. doi: 10.1378/chest.11-2663.


A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels.

Liu Y, Zhang J, Yu L, Cao F, Rao J, Li J, Jiang C, Falck JR, Jacobs ER, Zhu D.

Pulm Pharmacol Ther. 2012 Feb;25(1):69-76. doi: 10.1016/j.pupt.2011.11.005. Epub 2011 Dec 3.


Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats.

Ali I, Gruenloh S, Gao Y, Clough A, Falck JR, Medhora M, Jacobs ER.

Ann Thorac Surg. 2012 Jan;93(1):282-8. doi: 10.1016/j.athoracsur.2011.08.074. Epub 2011 Nov 23.


Radiation damage to the lung: mitigation by angiotensin-converting enzyme (ACE) inhibitors.

Medhora M, Gao F, Jacobs ER, Moulder JE.

Respirology. 2012 Jan;17(1):66-71. doi: 10.1111/j.1440-1843.2011.02092.x. Review.


Stable EET urea agonist and soluble epoxide hydrolase inhibitor regulate rat pulmonary arteries through TRPCs.

Liu Y, Wang R, Li J, Rao J, Li W, Falck JR, Manthati VL, Medhora M, Jacobs ER, Zhu D.

Hypertens Res. 2011 May;34(5):630-9. doi: 10.1038/hr.2011.5. Epub 2011 Feb 10.


Effects of a localized high-flow anastomosis between the aorta and left lower lobe pulmonary artery on great vessel flow and pulmonary arterial reactivity in the contralateral lung.

Somberg L, Nirula R, Bousamra M 2nd, Friesema J, Zhu D, Medhora M, Jacobs ER.

J Thorac Cardiovasc Surg. 2011 Feb;141(2):407-12. doi: 10.1016/j.jtcvs.2010.06.020. Epub 2010 Nov 13.


Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis.

Pfister S, Somberg L, Lowry T, Gao Y, Medhora M, Jacobs ER.

J Thorac Cardiovasc Surg. 2011 Feb;141(2):425-31. doi: 10.1016/j.jtcvs.2010.07.007. Epub 2010 Nov 13.


8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway.

Ma J, Zhang L, Li S, Liu S, Ma C, Li W, Falck JR, Manthati VL, Reddy DS, Medhora M, Jacobs ER, Zhu D.

Exp Cell Res. 2010 Aug 15;316(14):2340-53. doi: 10.1016/j.yexcr.2010.05.013. Epub 2010 May 21.


Cellular inflammatory infiltrate in pneumonitis induced by a single moderate dose of thoracic x radiation in rats.

Szabo S, Ghosh SN, Fish BL, Bodiga S, Tomic R, Kumar G, Morrow NV, Moulder JE, Jacobs ER, Medhora M.

Radiat Res. 2010 Apr;173(4):545-56. doi: 10.1667/RR1753.1.


20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt.

Bodiga S, Gruenloh SK, Gao Y, Manthati VL, Dubasi N, Falck JR, Medhora M, Jacobs ER.

Am J Physiol Lung Cell Mol Physiol. 2010 Apr;298(4):L564-74. doi: 10.1152/ajplung.00298.2009. Epub 2010 Jan 8.


Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis.

Ghosh SN, Zhang R, Fish BL, Semenenko VA, Li XA, Moulder JE, Jacobs ER, Medhora M.

Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1528-36. doi: 10.1016/j.ijrobp.2009.07.1743.


Prolonged hypothermia as a bridge to recovery for cerebral edema and intracranial hypertension associated with fulminant hepatic failure.

Jacob S, Khan A, Jacobs ER, Kandiah P, Nanchal R.

Neurocrit Care. 2009;11(2):242-6. doi: 10.1007/s12028-009-9266-0.


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