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[11C]JNJ54173717, a novel P2X7 receptor radioligand as marker for neuroinflammation: human biodistribution, dosimetry, brain kinetic modelling and quantification of brain P2X7 receptors in patients with Parkinson's disease and healthy volunteers.

Van Weehaeghe D, Koole M, Schmidt ME, Deman S, Jacobs AH, Souche E, Serdons K, Sunaert S, Bormans G, Vandenberghe W, Van Laere K.

Eur J Nucl Med Mol Imaging. 2019 Sep;46(10):2051-2064. doi: 10.1007/s00259-019-04369-6. Epub 2019 Jun 26.


A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies.

Perani D, Iaccarino L, Lammertsma AA, Windhorst AD, Edison P, Boellaard R, Hansson O, Nordberg A, Jacobs AH; IMBI Project.

Alzheimers Dement. 2019 Aug;15(8):1081-1103. doi: 10.1016/j.jalz.2019.02.004. Epub 2019 Jun 21.


Diagnosis and treatment of cognitive impairment.

von Arnim CAF, Bartsch T, Jacobs AH, Holbrook J, Bergmann P, Zieschang T, Polidori MC, Dodel R.

Z Gerontol Geriatr. 2019 Jul;52(4):309-315. doi: 10.1007/s00391-019-01560-0. Epub 2019 Jun 3. Review.


Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies.

Perani D, Iaccarino L, Jacobs AH; IMBI Brain Imaging Working Group.

Alzheimers Dement (Amst). 2019 Apr 16;11:327-332. doi: 10.1016/j.dadm.2019.02.004. eCollection 2019 Dec.


Molecular Imaging of Immune Cell Dynamics During De- and Remyelination in the Cuprizone Model of Multiple Sclerosis by [18F]DPA-714 PET and MRI.

Zinnhardt B, Belloy M, Fricke IB, Orije J, Guglielmetti C, Hermann S, Wagner S, Schäfers M, Van der Linden A, Jacobs AH.

Theranostics. 2019 Feb 20;9(6):1523-1537. doi: 10.7150/thno.32461. eCollection 2019.


Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure.

Freundt JK, Frommeyer G, Spieker T, Wötzel F, Grotthoff JS, Stypmann J, Hempel G, Schäfers M, Jacobs AH, Eckardt L, Lange PS.

BMC Pharmacol Toxicol. 2019 Mar 6;20(1):16. doi: 10.1186/s40360-019-0294-x.


TSPO-PET and diffusion-weighted MRI for imaging a mouse model of infiltrative human glioma.

Pigeon H, Pérès EA, Truillet C, Jego B, Boumezbeur F, Caillé F, Zinnhardt B, Jacobs AH, Le Bihan D, Winkeler A.

Neuro Oncol. 2019 Jun 10;21(6):755-764. doi: 10.1093/neuonc/noz029.


[Simvastatin-Induced Myopathy after Dose Increase].

Kandzia I, Kowar M, Frackowiak M, Jacobs AH.

Dtsch Med Wochenschr. 2018 Dec;143(24):1791-1794. doi: 10.1055/a-0759-2544. Epub 2018 Dec 3. German.


In vivo imaging biomarkers of neuroinflammation in the development and assessment of stroke therapies - towards clinical translation.

Zinnhardt B, Wiesmann M, Honold L, Barca C, Schäfers M, Kiliaan AJ, Jacobs AH.

Theranostics. 2018 Apr 3;8(10):2603-2620. doi: 10.7150/thno.24128. eCollection 2018. Review.


Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-18F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model.

Schelhaas S, Wachsmuth L, Hermann S, Rieder N, Heller A, Heinzmann K, Honess DJ, Smith DM, Fricke IB, Just N, Doblas S, Sinkus R, Döring C, Schäfers KP, Griffiths JR, Faber C, Schneider R, Aboagye EO, Jacobs AH.

J Nucl Med. 2018 Jul;59(7):1063-1069. doi: 10.2967/jnumed.117.206250. Epub 2018 Feb 23.


Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models.

Heinzmann K, Honess DJ, Lewis DY, Smith DM, Cawthorne C, Keen H, Heskamp S, Schelhaas S, Witney TH, Soloviev D, Williams KJ, Jacobs AH, Aboagye EO, Griffiths JR, Brindle KM.

EJNMMI Res. 2017 Dec 15;7(1):99. doi: 10.1186/s13550-017-0349-1.


3'-Deoxy-3'-[18F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models.

Schelhaas S, Heinzmann K, Honess DJ, Smith DM, Keen H, Heskamp S, Witney TH, Besret L, Doblas S, Griffiths JR, Aboagye EO, Jacobs AH.

Mol Imaging Biol. 2018 Apr;20(2):194-199. doi: 10.1007/s11307-017-1125-3.


Effect of a multinutrient intervention after ischemic stroke in female C57Bl/6 mice.

Wiesmann M, Timmer NM, Zinnhardt B, Reinhard D, Eligehausen S, Königs A, Ben Jeddi H, Dederen PJ, Jacobs AH, Kiliaan AJ.

J Neurochem. 2018 Mar;144(5):549-564. doi: 10.1111/jnc.14213. Epub 2017 Oct 10.


Multimodal Imaging of Patients With Gliomas Confirms 11C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy.

Laukamp KR, Lindemann F, Weckesser M, Hesselmann V, Ligges S, Wölfer J, Jeibmann A, Zinnhardt B, Viel T, Schäfers M, Paulus W, Stummer W, Schober O, Jacobs AH.

Mol Imaging. 2017 Jan 1;16:1536012116687651. doi: 10.1177/1536012116687651.


[Altered orientation and aggressiveness in an 89-year-old woman].

Kowar M, Jacobs AH.

Internist (Berl). 2018 Jan;59(1):97-101. doi: 10.1007/s00108-017-0270-8. German.


A specific dietary intervention to restore brain structure and function after ischemic stroke.

Wiesmann M, Zinnhardt B, Reinhardt D, Eligehausen S, Wachsmuth L, Hermann S, Dederen PJ, Hellwich M, Kuhlmann MT, Broersen LM, Heerschap A, Jacobs AH, Kiliaan AJ.

Theranostics. 2017 Jan 6;7(2):493-512. doi: 10.7150/thno.17559. eCollection 2017.


Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G.

Kailayangiri S, Altvater B, Spurny C, Jamitzky S, Schelhaas S, Jacobs AH, Wiek C, Roellecke K, Hanenberg H, Hartmann W, Wiendl H, Pankratz S, Meltzer J, Farwick N, Greune L, Fluegge M, Rossig C.

Oncoimmunology. 2016 Oct 28;6(1):e1250050. doi: 10.1080/2162402X.2016.1250050. eCollection 2017.


In vivo bioluminescence imaging of neurogenesis - the role of the blood brain barrier in an experimental model of Parkinson's disease.

Fricke IB, Schelhaas S, Zinnhardt B, Viel T, Hermann S, Couillard-Després S, Jacobs AH.

Eur J Neurosci. 2017 Apr;45(7):975-986. doi: 10.1111/ejn.13540. Epub 2017 Mar 7.


Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake.

Zinnhardt B, Pigeon H, Thézé B, Viel T, Wachsmuth L, Fricke IB, Schelhaas S, Honold L, Schwegmann K, Wagner S, Faust A, Faber C, Kuhlmann MT, Hermann S, Schäfers M, Winkeler A, Jacobs AH.

Cancer Res. 2017 Apr 15;77(8):1831-1841. doi: 10.1158/0008-5472.CAN-16-2628. Epub 2017 Jan 30.


Preclinical Applications of 3'-Deoxy-3'-[18F]Fluorothymidine in Oncology - A Systematic Review.

Schelhaas S, Heinzmann K, Bollineni VR, Kramer GM, Liu Y, Waterton JC, Aboagye EO, Shields AF, Soloviev D, Jacobs AH.

Theranostics. 2017 Jan 1;7(1):40-50. doi: 10.7150/thno.16676. eCollection 2017. Review.


Preclinical Evidence That 3'-Deoxy-3'-[18F]Fluorothymidine PET Can Visualize Recovery of Hematopoiesis after Gemcitabine Chemotherapy.

Schelhaas S, Held A, Bäumer N, Viel T, Hermann S, Müller-Tidow C, Jacobs AH.

Cancer Res. 2016 Dec 15;76(24):7089-7095. Epub 2016 Oct 20.


Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3'-Deoxy-3'-[18F]Fluorothymidine in Preclinical Models of Lung Cancer.

Schelhaas S, Held A, Wachsmuth L, Hermann S, Honess DJ, Heinzmann K, Smith DM, Griffiths JR, Faber C, Jacobs AH.

Cancer Res. 2016 Dec 15;76(24):7096-7105. Epub 2016 Oct 26.


[In process].

Jacobs AH.

Med Monatsschr Pharm. 2016 Oct;39(10):403. German. No abstract available.


The relationship between endogenous thymidine concentrations and [(18)F]FLT uptake in a range of preclinical tumour models.

Heinzmann K, Honess DJ, Lewis DY, Smith DM, Cawthorne C, Keen H, Heskamp S, Schelhaas S, Witney TH, Soloviev D, Williams KJ, Jacobs AH, Aboagye EO, Griffiths JR, Brindle KM.

EJNMMI Res. 2016 Dec;6(1):63. doi: 10.1186/s13550-016-0218-3. Epub 2016 Aug 11. Erratum in: EJNMMI Res. 2017 Dec 15;7(1):99.


[In process].

Jacobs AH.

Med Monatsschr Pharm. 2016 Jul;39(7):273. German. No abstract available.


Mechanistic interrogation of combination bevacizumab/dual PI3K/mTOR inhibitor response in glioblastoma implementing novel MR and PET imaging biomarkers.

O'Halloran PJ, Viel T, Murray DW, Wachsmuth L, Schwegmann K, Wagner S, Kopka K, Jarzabek MA, Dicker P, Hermann S, Faber C, Klasen T, Schäfers M, O'Brien D, Prehn JH, Jacobs AH, Byrne AT.

Eur J Nucl Med Mol Imaging. 2016 Aug;43(9):1673-83. doi: 10.1007/s00259-016-3343-3. Epub 2016 Mar 15.


6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis.

Fricke IB, Viel T, Worlitzer MM, Collmann FM, Vrachimis A, Faust A, Wachsmuth L, Faber C, Dollé F, Kuhlmann MT, Schäfers K, Hermann S, Schwamborn JC, Jacobs AH.

Eur J Neurosci. 2016 May;43(10):1352-65. doi: 10.1111/ejn.13232. Epub 2016 Apr 5.


[Pregabalin as a rare cause of liver disease].

Kowar M, Friedrich C, Jacobs AH.

Dtsch Med Wochenschr. 2015 Nov;140(23):1759-60. doi: 10.1055/s-0041-105987. Epub 2015 Nov 19. German.


Pericytes are progenitors for coronary artery smooth muscle.

Volz KS, Jacobs AH, Chen HI, Poduri A, McKay AS, Riordan DP, Kofler N, Kitajewski J, Weissman I, Red-Horse K.

Elife. 2015 Oct 19;4. pii: e10036. doi: 10.7554/eLife.10036.


FDG μPET Fails to Detect a Disease-Specific Phenotype in Rats Transgenic for Huntington's Disease – A 15 Months Follow-up Study.

Reilmann R, Lippross V, Hölzner E, Gigengack F, Bohlen S, Kugel H, Deppe M, Osada N, Lücke M, Riess O, Nguyen HP, Von Hörsten S, Schäfers K, Schäfers M, Jacobs AH, Hermann S.

J Huntingtons Dis. 2015;4(1):37-47.


Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study.

Ehlert A, Schmidt C, Wölfer J, Manthei G, Jacobs AH, Brüning R, Heindel W, Ringelstein EB, Stummer W, Pluta RM, Hesselmann V.

J Neurosurg. 2016 Jan;124(1):51-8. doi: 10.3171/2014.12.JNS13846. Epub 2015 Jul 10.


Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke.

Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz HJ, Faust A, Hermann S, Kopka K, Faber C, Dollé F, Pappata S, Planas AM, Tavitian B, Schäfers M, Sorokin LM, Kuhlmann MT, Jacobs AH.

J Cereb Blood Flow Metab. 2015 Nov;35(11):1711-21. doi: 10.1038/jcbfm.2015.149. Epub 2015 Jul 1.


Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven-center multivendor study.

Doblas S, Almeida GS, Blé FX, Garteiser P, Hoff BA, McIntyre DJ, Wachsmuth L, Chenevert TL, Faber C, Griffiths JR, Jacobs AH, Morris DM, O'Connor JP, Robinson SP, Van Beers BE, Waterton JC.

J Magn Reson Imaging. 2015 Dec;42(6):1759-64. doi: 10.1002/jmri.24955. Epub 2015 May 26.


Neuroinflammation in Alzheimer's disease.

Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP.

Lancet Neurol. 2015 Apr;14(4):388-405. doi: 10.1016/S1474-4422(15)70016-5. Review.


PEGylated human serum albumin (HSA) nanoparticles: preparation, characterization and quantification of the PEGylation extent.

Fahrländer E, Schelhaas S, Jacobs AH, Langer K.

Nanotechnology. 2015 Apr 10;26(14):145103. doi: 10.1088/0957-4484/26/14/145103. Epub 2015 Mar 19.


[Sarcopenia and frailty in neurology].

Maetzler W, Drey M, Jacobs AH.

Nervenarzt. 2015 Apr;86(4):420-30. doi: 10.1007/s00115-014-4181-9. German.


Epigenetic dysregulation of KCa 3.1 channels induces poor prognosis in lung cancer.

Bulk E, Ay AS, Hammadi M, Ouadid-Ahidouch H, Schelhaas S, Hascher A, Rohde C, Thoennissen NH, Wiewrodt R, Schmidt E, Marra A, Hillejan L, Jacobs AH, Klein HU, Dugas M, Berdel WE, Müller-Tidow C, Schwab A.

Int J Cancer. 2015 Sep 15;137(6):1306-17. doi: 10.1002/ijc.29490. Epub 2015 May 29.


Multiple sclerosis: myeloperoxidase immunoradiology improves detection of acute and chronic disease in experimental model.

Pulli B, Bure L, Wojtkiewicz GR, Iwamoto Y, Ali M, Li D, Schob S, Hsieh KL, Jacobs AH, Chen JW.

Radiology. 2015 May;275(2):480-9. doi: 10.1148/radiol.14141495. Epub 2014 Dec 10.


The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis.

Chen HI, Sharma B, Akerberg BN, Numi HJ, Kivelä R, Saharinen P, Aghajanian H, McKay AS, Bogard PE, Chang AH, Jacobs AH, Epstein JA, Stankunas K, Alitalo K, Red-Horse K.

Development. 2014 Dec;141(23):4500-12. doi: 10.1242/dev.113639. Epub 2014 Nov 5.


[Sensory aphasia during therapy with metronidazole--an important differential diagnosis of acute cerebral ischemia].

Kowar M, Frackowiak M, Friedrich C, Wilhelm K, Walger P, Jacobs AH.

Dtsch Med Wochenschr. 2014 Nov;139(46):2341-3. doi: 10.1055/s-0034-1387341. Epub 2014 Nov 4. German.


Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3'-Deoxy-3'-¹⁸F-Fluorothymidine PET and Diffusion-Weighted MR Imaging.

Schelhaas S, Wachsmuth L, Viel T, Honess DJ, Heinzmann K, Smith DM, Hermann S, Wagner S, Kuhlmann MT, Müller-Tidow C, Kopka K, Schober O, Schäfers M, Schneider R, Aboagye EO, Griffiths J, Faber C, Jacobs AH.

J Nucl Med. 2014 Jun;55(6):983-8. doi: 10.2967/jnumed.113.133348. Epub 2014 Apr 28.


An intra-individual comparison of MRI, [18F]-FET and [18F]-FLT PET in patients with high-grade gliomas.

Nowosielski M, DiFranco MD, Putzer D, Seiz M, Recheis W, Jacobs AH, Stockhammer G, Hutterer M.

PLoS One. 2014 Apr 23;9(4):e95830. doi: 10.1371/journal.pone.0095830. eCollection 2014.


Serial F-18-FDG PET/CT distinguishes inflamed from stable plaque phenotypes in shear-stress induced murine atherosclerosis.

Wenning C, Kloth C, Kuhlmann MT, Jacobs AH, Schober O, Hermann S, Schäfers MA.

Atherosclerosis. 2014 Jun;234(2):276-82. doi: 10.1016/j.atherosclerosis.2014.03.008. Epub 2014 Mar 19.


The translocator protein radioligand 18F-DPA-714 monitors antitumor effect of erufosine in a rat 9L intracranial glioma model.

Awde AR, Boisgard R, Thézé B, Dubois A, Zheng J, Dollé F, Jacobs AH, Tavitian B, Winkeler A.

J Nucl Med. 2013 Dec;54(12):2125-31. doi: 10.2967/jnumed.112.118794. Epub 2013 Nov 8.


Molecular imaging reveals time course of matrix metalloproteinase activity in acute cutaneous vasculitis in vivo.

Steingräber AK, Schelhaas S, Faust A, Jacobs AH, Schäfers M, Goerge T.

Exp Dermatol. 2013 Nov;22(11):730-5. doi: 10.1111/exd.12253.


Early assessment of the efficacy of temozolomide chemotherapy in experimental glioblastoma using [18F]FLT-PET imaging.

Viel T, Schelhaas S, Wagner S, Wachsmuth L, Schwegmann K, Kuhlmann M, Faber C, Kopka K, Schäfers M, Jacobs AH.

PLoS One. 2013 Jul 4;8(7):e67911. doi: 10.1371/journal.pone.0067911. Print 2013.


Molecular imaging in the development of a novel treatment paradigm for glioblastoma (GBM): an integrated multidisciplinary commentary.

Jarzabek MA, Sweeney KJ, Evans RL, Jacobs AH, Stupp R, O'Brien D, Berger MS, Prehn JH, Byrne AT.

Drug Discov Today. 2013 Nov;18(21-22):1052-66. doi: 10.1016/j.drudis.2013.06.004. Epub 2013 Jun 20. Review.


Response to "reply to [18F]-fluoro-ethyl-L-tyrosine PET: a valuable diagnostic tool in neuro-oncology, but not all that glitters is glioma" by Hutterer et al.

Hutterer M, Nowosielski M, Putzer D, Fougère Cl, Virgolini IJ, Jacobs AH, Stockhammer G.

Neuro Oncol. 2013 Jul;15(7):814-5. doi: 10.1093/neuonc/not081. Epub 2013 Jun 19. No abstract available.


Non-invasive imaging of glioma vessel size and densities in correlation with tumour cell proliferation by small animal PET and MRI.

Viel T, Boehm-Sturm P, Rapic S, Monfared P, Neumaier B, Hoehn M, Jacobs AH.

Eur J Nucl Med Mol Imaging. 2013 Oct;40(10):1595-606. doi: 10.1007/s00259-013-2464-1. Epub 2013 Jun 11.


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