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Items: 1 to 50 of 93

1.

NCAM1/FGF module serves as a putative pleuropulmonary blastoma therapeutic target.

Shukrun R, Golan H, Caspi R, Pode-Shakked N, Pleniceanu O, Vax E, Bar-Lev DD, Pri-Chen S, Jacob-Hirsch J, Schiby G, Harari-Steinberg O, Mark-Danieli M, Dekel B, Toren A.

Oncogenesis. 2019 Sep 2;8(9):48. doi: 10.1038/s41389-019-0156-9.

2.

Corrigendum to: A new cis-acting regulatory element driving gene expression in the zebrafish pineal gland.

Alon S, Eisenberg E, Jacob-Hirsch J, Rechavi G, Vatine G, Toyama R, Coon SL, Klein DC, Gothilf Y.

Bioinformatics. 2019 May 18. pii: btz410. doi: 10.1093/bioinformatics/btz410. [Epub ahead of print] No abstract available.

PMID:
31102508
3.

Unilesional mycosis fungoides is associated with increased expression of microRNA-17~92 and T helper 1 skewing.

Moyal L, Gorovitz-Haris B, Yehezkel S, Jacob-Hirsch J, Bershtein V, Barzilai A, Rotem C, Sherman S, Amitay-Laish I, Feinmesser M, Hodak E.

Br J Dermatol. 2019 May;180(5):1123-1134. doi: 10.1111/bjd.17425. Epub 2019 Jan 24.

PMID:
30431147
4.

In Vivo Expansion of Cancer Stemness Affords Novel Cancer Stem Cell Targets: Malignant Rhabdoid Tumor as an Example.

Golan H, Shukrun R, Caspi R, Vax E, Pode-Shakked N, Goldberg S, Pleniceanu O, Bar-Lev DD, Mark-Danieli M, Pri-Chen S, Jacob-Hirsch J, Kanter I, Trink A, Schiby G, Bilik R, Kalisky T, Harari-Steinberg O, Toren A, Dekel B.

Stem Cell Reports. 2018 Sep 11;11(3):795-810. doi: 10.1016/j.stemcr.2018.07.010. Epub 2018 Aug 16.

5.

Whole-genome sequencing reveals principles of brain retrotransposition in neurodevelopmental disorders.

Jacob-Hirsch J, Eyal E, Knisbacher BA, Roth J, Cesarkas K, Dor C, Farage-Barhom S, Kunik V, Simon AJ, Gal M, Yalon M, Moshitch-Moshkovitz S, Tearle R, Constantini S, Levanon EY, Amariglio N, Rechavi G.

Cell Res. 2018 Feb;28(2):187-203. doi: 10.1038/cr.2018.8. Epub 2018 Jan 12.

6.

Alterations of microRNAs throughout the malignant evolution of cutaneous squamous cell carcinoma: the role of miR-497 in epithelial to mesenchymal transition of keratinocytes.

Mizrahi A, Barzilai A, Gur-Wahnon D, Ben-Dov IZ, Glassberg S, Meningher T, Elharar E, Masalha M, Jacob-Hirsch J, Tabibian-Keissar H, Barshack I, Roszik J, Leibowitz-Amit R, Sidi Y, Avni D.

Oncogene. 2018 Jan 11;37(2):218-230. doi: 10.1038/onc.2017.315. Epub 2017 Sep 18.

PMID:
28925390
7.

Ras Signaling Inhibitors Attenuate Disease in Adjuvant-Induced Arthritis via Targeting Pathogenic Antigen-Specific Th17-Type Cells.

Zayoud M, Marcu-Malina V, Vax E, Jacob-Hirsch J, Elad-Sfadia G, Barshack I, Kloog Y, Goldstein I.

Front Immunol. 2017 Jul 7;8:799. doi: 10.3389/fimmu.2017.00799. eCollection 2017.

8.

ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.

Ben-Shoshan SO, Kagan P, Sultan M, Barabash Z, Dor C, Jacob-Hirsch J, Harmelin A, Pappo O, Marcu-Malina V, Ben-Ari Z, Amariglio N, Rechavi G, Goldstein I, Safran M.

RNA Biol. 2017 May 4;14(5):587-602. doi: 10.1080/15476286.2016.1203501. Epub 2016 Jun 30.

9.

Profiling of Discrete Gynecological Cancers Reveals Novel Transcriptional Modules and Common Features Shared by Other Cancer Types and Embryonic Stem Cells.

Pappa KI, Polyzos A, Jacob-Hirsch J, Amariglio N, Vlachos GD, Loutradis D, Anagnou NP.

PLoS One. 2015 Nov 11;10(11):e0142229. doi: 10.1371/journal.pone.0142229. eCollection 2015.

10.

MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma.

Zehavi L, Schayek H, Jacob-Hirsch J, Sidi Y, Leibowitz-Amit R, Avni D.

Mol Cancer. 2015 Mar 26;14:68. doi: 10.1186/s12943-015-0338-9.

11.

Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.

Edri R, Yaffe Y, Ziller MJ, Mutukula N, Volkman R, David E, Jacob-Hirsch J, Malcov H, Levy C, Rechavi G, Gat-Viks I, Meissner A, Elkabetz Y.

Nat Commun. 2015 Mar 23;6:6500. doi: 10.1038/ncomms7500.

12.

Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway.

Makovski V, Jacob-Hirsch J, Gefen-Dor C, Shai B, Ehrlich M, Rechavi G, Kloog Y.

Cell Death Dis. 2014 Dec 4;5:e1557. doi: 10.1038/cddis.2014.502.

13.

Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex.

Greenberg E, Hajdu S, Nemlich Y, Cohen R, Itzhaki O, Jacob-Hirsch J, Besser MJ, Schachter J, Markel G.

Open Biol. 2014 Jun;4(6):140030. doi: 10.1098/rsob.140030.

14.

Blastocyst implantation failure relates to impaired translational machinery gene expression.

Plaks V, Gershon E, Zeisel A, Jacob-Hirsch J, Neeman M, Winterhager E, Rechavi G, Domany E, Dekel N.

Reproduction. 2014 Jul;148(1):87-98. doi: 10.1530/REP-13-0395. Epub 2014 Apr 3.

PMID:
24700326
15.

Induction of polyploidy by nuclear fusion mechanism upon decreased expression of the nuclear envelope protein LAP2β in the human osteosarcoma cell line U2OS.

Ben-Shoshan SO, Simon AJ, Jacob-Hirsch J, Shaklai S, Paz-Yaacov N, Amariglio N, Rechavi G, Trakhtenbrot L.

Mol Cytogenet. 2014 Jan 28;7(1):9. doi: 10.1186/1755-8166-7-9.

16.

Exposure of fallopian tube epithelium to follicular fluid mimics carcinogenic changes in precursor lesions of serous papillary carcinoma.

Bahar-Shany K, Brand H, Sapoznik S, Jacob-Hirsch J, Yung Y, Korach J, Perri T, Cohen Y, Hourvitz A, Levanon K.

Gynecol Oncol. 2014 Feb;132(2):322-7. doi: 10.1016/j.ygyno.2013.12.015. Epub 2013 Dec 17.

PMID:
24355484
17.

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes.

Bazak L, Haviv A, Barak M, Jacob-Hirsch J, Deng P, Zhang R, Isaacs FJ, Rechavi G, Li JB, Eisenberg E, Levanon EY.

Genome Res. 2014 Mar;24(3):365-76. doi: 10.1101/gr.164749.113. Epub 2013 Dec 17.

18.

Epidermal growth-factor-induced transcript isoform variation drives mammary cell migration.

Köstler WJ, Zeisel A, Körner C, Tsai JM, Jacob-Hirsch J, Ben-Chetrit N, Sharma K, Cohen-Dvashi H, Yitzhaky A, Lader E, Tschulena U, Rechavi G, Domany E, Wiemann S, Yarden Y.

PLoS One. 2013 Dec 6;8(12):e80566. doi: 10.1371/journal.pone.0080566. eCollection 2013.

19.

ADAR1 is involved in the regulation of reprogramming human fibroblasts to induced pluripotent stem cells.

Germanguz I, Shtrichman R, Osenberg S, Ziskind A, Novak A, Domev H, Laevsky I, Jacob-Hirsch J, Feiler Y, Rechavi G, Itskovitz-Eldor J.

Stem Cells Dev. 2014 Mar 1;23(5):443-56. doi: 10.1089/scd.2013.0206. Epub 2013 Dec 14.

PMID:
24192045
20.

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia.

Goldberg L, Tijssen MR, Birger Y, Hannah RL, Kinston SJ, Schütte J, Beck D, Knezevic K, Schiby G, Jacob-Hirsch J, Biran A, Kloog Y, Marcucci G, Bloomfield CD, Aplan PD, Pimanda JE, Göttgens B, Izraeli S.

Blood. 2013 Oct 10;122(15):2694-703. doi: 10.1182/blood-2013-01-477133. Epub 2013 Aug 23.

21.

A role for APETALA1/fruitfull transcription factors in tomato leaf development.

Burko Y, Shleizer-Burko S, Yanai O, Shwartz I, Zelnik ID, Jacob-Hirsch J, Kela I, Eshed-Williams L, Ori N.

Plant Cell. 2013 Jun;25(6):2070-83. doi: 10.1105/tpc.113.113035. Epub 2013 Jun 14.

22.

MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.

Nemlich Y, Greenberg E, Ortenberg R, Besser MJ, Barshack I, Jacob-Hirsch J, Jacoby E, Eyal E, Rivkin L, Prieto VG, Chakravarti N, Duncan LM, Kallenberg DM, Galun E, Bennett DC, Amariglio N, Bar-Eli M, Schachter J, Rechavi G, Markel G.

J Clin Invest. 2013 Jun;123(6):2703-18.

23.

Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder.

Birger Y, Goldberg L, Chlon TM, Goldenson B, Muler I, Schiby G, Jacob-Hirsch J, Rechavi G, Crispino JD, Izraeli S.

Blood. 2013 Aug 8;122(6):988-98. doi: 10.1182/blood-2012-10-460998. Epub 2013 May 29.

24.

miR-155 is involved in tumor progression of mycosis fungoides.

Moyal L, Barzilai A, Gorovitz B, Hirshberg A, Amariglio N, Jacob-Hirsch J, Maron L, Feinmesser M, Hodak E.

Exp Dermatol. 2013 Jun;22(6):431-3. doi: 10.1111/exd.12161.

PMID:
23711069
25.

Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR).

Solomon O, Oren S, Safran M, Deshet-Unger N, Akiva P, Jacob-Hirsch J, Cesarkas K, Kabesa R, Amariglio N, Unger R, Rechavi G, Eyal E.

RNA. 2013 May;19(5):591-604. doi: 10.1261/rna.038042.112. Epub 2013 Mar 8.

26.

Determination of molecular markers for BRCA1 and BRCA2 heterozygosity using gene expression profiling.

Salmon AY, Salmon-Divon M, Zahavi T, Barash Y, Levy-Drummer RS, Jacob-Hirsch J, Peretz T.

Cancer Prev Res (Phila). 2013 Feb;6(2):82-90. doi: 10.1158/1940-6207.CAPR-12-0105. Epub 2013 Jan 22.

27.

Systematic identification of rhythmic genes reveals camk1gb as a new element in the circadian clockwork.

Tovin A, Alon S, Ben-Moshe Z, Mracek P, Vatine G, Foulkes NS, Jacob-Hirsch J, Rechavi G, Toyama R, Coon SL, Klein DC, Eisenberg E, Gothilf Y.

PLoS Genet. 2012;8(12):e1003116. doi: 10.1371/journal.pgen.1003116. Epub 2012 Dec 20.

28.

Detection of BCR-ABL1 mutations in chronic myeloid leukaemia by massive parallel sequencing.

Eyal E, Tohami T, Amir A, Cesarkas K, Jacob-Hirsch J, Volchek Y, Nagler A, Rechavi G, Amariglio N.

Br J Haematol. 2013 Feb;160(4):477-86. doi: 10.1111/bjh.12171. Epub 2012 Dec 17.

PMID:
23252482
29.

Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis.

Harel I, Maezawa Y, Avraham R, Rinon A, Ma HY, Cross JW, Leviatan N, Hegesh J, Roy A, Jacob-Hirsch J, Rechavi G, Carvajal J, Tole S, Kioussi C, Quaggin S, Tzahor E.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18839-44. doi: 10.1073/pnas.1208690109. Epub 2012 Oct 29.

30.

Radiotherapy-induced basal cell carcinomas of the scalp: are they genetically different?

Tessone A, Amariglio N, Weissman O, Jacob-Hirsch J, Liran A, Stavrou D, Haik J, Orenstein A, Winkler E.

Aesthetic Plast Surg. 2012 Dec;36(6):1387-92. doi: 10.1007/s00266-012-9969-z. Epub 2012 Oct 10.

PMID:
23052377
31.

Genome-wide activation of latent donor splice sites in stress and disease.

Nevo Y, Kamhi E, Jacob-Hirsch J, Amariglio N, Rechavi G, Sperling J, Sperling R.

Nucleic Acids Res. 2012 Nov;40(21):10980-94. doi: 10.1093/nar/gks834. Epub 2012 Sep 23.

32.

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, Rechavi G.

Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.

PMID:
22575960
33.

Global methylation analysis identifies PITX2 as an upstream regulator of the androgen receptor and IGF-I receptor genes in prostate cancer.

Schayek H, Bentov I, Jacob-Hirsch J, Yeung C, Khanna C, Helman LJ, Plymate SR, Werner H.

Horm Metab Res. 2012 Jun;44(7):511-9. doi: 10.1055/s-0032-1311566. Epub 2012 Apr 11.

PMID:
22495974
34.

HIPK2 downregulates vimentin and inhibits breast cancer cell invasion.

Nodale C, Sheffer M, Jacob-Hirsch J, Folgiero V, Falcioni R, Aiello A, Garufi A, Rechavi G, Givol D, D'Orazi G.

Cancer Biol Ther. 2012 Feb 15;13(4):198-205. doi: 10.4161/cbt.13.4.18694. Epub 2012 Feb 15.

PMID:
22236966
35.

Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation.

Sheffer M, Simon AJ, Jacob-Hirsch J, Rechavi G, Domany E, Givol D, D'Orazi G.

Oncotarget. 2011 Dec;2(12):1191-202.

36.

EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF.

Tarcic G, Avraham R, Pines G, Amit I, Shay T, Lu Y, Zwang Y, Katz M, Ben-Chetrit N, Jacob-Hirsch J, Virgilio L, Rechavi G, Mavrothalassitis G, Mills GB, Domany E, Yarden Y.

FASEB J. 2012 Apr;26(4):1582-92. doi: 10.1096/fj.11-194654. Epub 2011 Dec 23.

37.

Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions.

Pradeep CR, Zeisel A, Köstler WJ, Lauriola M, Jacob-Hirsch J, Haibe-Kains B, Amariglio N, Ben-Chetrit N, Emde A, Solomonov I, Neufeld G, Piccart M, Sagi I, Sotiriou C, Rechavi G, Domany E, Desmedt C, Yarden Y.

Oncogene. 2012 Aug 2;31(31):3569-83. doi: 10.1038/onc.2011.547. Epub 2011 Dec 5.

38.

Expression profiling of vulvar carcinoma: clues for deranged extracellular matrix remodeling and effects on multiple signaling pathways combined with discrete patient subsets.

Pappa KI, Jacob-Hirsch J, Vlachos GD, Christodoulou I, Partsinevelos G, Amariglio N, Markaki S, Antsaklis A, Anagnou NP.

Transl Oncol. 2011 Oct;4(5):301-13. Epub 2011 Oct 1.

39.

Zinc supplementation augments in vivo antitumor effect of chemotherapy by restoring p53 function.

Margalit O, Simon AJ, Yakubov E, Puca R, Yosepovich A, Avivi C, Jacob-Hirsch J, Gelernter I, Harmelin A, Barshack I, Rechavi G, D'Orazi G, Givol D, Amariglio N.

Int J Cancer. 2012 Aug 15;131(4):E562-8. doi: 10.1002/ijc.26441. Epub 2011 Nov 30.

40.

Coupled pre-mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli.

Zeisel A, Köstler WJ, Molotski N, Tsai JM, Krauthgamer R, Jacob-Hirsch J, Rechavi G, Soen Y, Jung S, Yarden Y, Domany E.

Mol Syst Biol. 2011 Sep 13;7:529. doi: 10.1038/msb.2011.62.

41.

TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.

Leshem O, Madar S, Kogan-Sakin I, Kamer I, Goldstein I, Brosh R, Cohen Y, Jacob-Hirsch J, Ehrlich M, Ben-Sasson S, Goldfinger N, Loewenthal R, Gazit E, Rotter V, Berger R.

PLoS One. 2011;6(7):e21650. doi: 10.1371/journal.pone.0021650. Epub 2011 Jul 1.

42.

Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.

Pradeep CR, Köstler WJ, Lauriola M, Granit RZ, Zhang F, Jacob-Hirsch J, Rechavi G, Nair HB, Hennessy BT, Gonzalez-Angulo AM, Tekmal RR, Ben-Porath I, Mills GB, Domany E, Yarden Y.

Oncogene. 2012 Feb 16;31(7):907-17. doi: 10.1038/onc.2011.279. Epub 2011 Jul 11.

43.

Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals.

Zwang Y, Sas-Chen A, Drier Y, Shay T, Avraham R, Lauriola M, Shema E, Lidor-Nili E, Jacob-Hirsch J, Amariglio N, Lu Y, Mills GB, Rechavi G, Oren M, Domany E, Yarden Y.

Mol Cell. 2011 May 20;42(4):524-35. doi: 10.1016/j.molcel.2011.04.017.

44.

Kidney spheroids recapitulate tubular organoids leading to enhanced tubulogenic potency of human kidney-derived cells.

Buzhor E, Harari-Steinberg O, Omer D, Metsuyanim S, Jacob-Hirsch J, Noiman T, Dotan Z, Goldstein RS, Dekel B.

Tissue Eng Part A. 2011 Sep;17(17-18):2305-19. doi: 10.1089/ten.TEA.2010.0595. Epub 2011 Jun 14.

PMID:
21542667
45.

Resistance or sensitivity of Wilms' tumor to anti-FZD7 antibody highlights the Wnt pathway as a possible therapeutic target.

Pode-Shakked N, Harari-Steinberg O, Haberman-Ziv Y, Rom-Gross E, Bahar S, Omer D, Metsuyanim S, Buzhor E, Jacob-Hirsch J, Goldstein RS, Mark-Danieli M, Dekel B.

Oncogene. 2011 Apr 7;30(14):1664-80. doi: 10.1038/onc.2010.549. Epub 2011 Jan 17.

PMID:
21472018
46.

Microbial alcohol-conferred hemolysis is a late response to alcohol stress.

Shuster A, Korem M, Jacob-Hirsch J, Amariglio N, Rechavi G, Rosenberg M.

FEMS Yeast Res. 2011 Jun;11(4):315-23. doi: 10.1111/j.1567-1364.2011.00722.x. Epub 2011 Feb 21.

47.

Bid regulates the immunological profile of murine microglia and macrophages.

Mayo L, Levy A, Jacob-Hirsch J, Amariglio N, Rechavi G, Stein R.

Glia. 2011 Mar;59(3):397-412. doi: 10.1002/glia.21109. Epub 2010 Dec 6.

PMID:
21264947
48.

Trans-SILAC: sorting out the non-cell-autonomous proteome.

Rechavi O, Kalman M, Fang Y, Vernitsky H, Jacob-Hirsch J, Foster LJ, Kloog Y, Goldstein I.

Nat Methods. 2010 Nov;7(11):923-7. doi: 10.1038/nmeth.1513. Epub 2010 Oct 10.

PMID:
20935649
49.

Serum free cultured bone marrow mesenchymal stem cells as a platform to characterize the effects of specific molecules.

Solmesky L, Lefler S, Jacob-Hirsch J, Bulvik S, Rechavi G, Weil M.

PLoS One. 2010 Sep 10;5(9). pii: e12689. doi: 10.1371/journal.pone.0012689.

50.

Alu sequences in undifferentiated human embryonic stem cells display high levels of A-to-I RNA editing.

Osenberg S, Paz Yaacov N, Safran M, Moshkovitz S, Shtrichman R, Sherf O, Jacob-Hirsch J, Keshet G, Amariglio N, Itskovitz-Eldor J, Rechavi G.

PLoS One. 2010 Jun 21;5(6):e11173. doi: 10.1371/journal.pone.0011173.

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