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Evaluating the impact of intravenous fluid resuscitation on survival for the management of patients with Ebola Virus Disease.

Jacob ST, Brown CS.

Clin Infect Dis. 2019 May 6. pii: ciz349. doi: 10.1093/cid/ciz349. [Epub ahead of print] No abstract available.


Biomarkers of endothelial activation/dysfunction distinguish sub-groups of Ugandan patients with sepsis and differing mortality risks.

Clark DV, Banura P, Bandeen-Roche K, Liles WC, Kain KC, Scheld WM, Moss WJ, Jacob ST.

JCI Insight. 2019 Apr 23;5. pii: 127623. doi: 10.1172/jci.insight.127623.


Shifting the Paradigm - Applying Universal Standards of Care to Ebola Virus Disease.

Fischer WA 2nd, Crozier I, Bausch DG, Muyembe JJ, Mulangu S, Diaz JV, Kojan R, Wohl DA, Jacob ST.

N Engl J Med. 2019 Apr 11;380(15):1389-1391. doi: 10.1056/NEJMp1817070. No abstract available.


New filovirus disease classification and nomenclature.

Kuhn JH, Adachi T, Adhikari NKJ, Arribas JR, Bah IE, Bausch DG, Bhadelia N, Borchert M, Brantsæter AB, Brett-Major DM, Burgess TH, Chertow DS, Chute CG, Cieslak TJ, Colebunders R, Crozier I, Davey RT, de Clerck H, Delgado R, Evans L, Fallah M, Fischer WA 2nd, Fletcher TE, Fowler RA, Grünewald T, Hall A, Hewlett A, Hoepelman AIM, Houlihan CF, Ippolito G, Jacob ST, Jacobs M, Jakob R, Jacquerioz FA, Kaiser L, Kalil AC, Kamara RF, Kapetshi J, Klenk HD, Kobinger G, Kortepeter MG, Kraft CS, Kratz T, Bosa HSK, Lado M, Lamontagne F, Lane HC, Lobel L, Lutwama J, Lyon GM 3rd, Massaquoi MBF, Massaquoi TA, Mehta AK, Makuma VM, Murthy S, Musoke TS, Muyembe-Tamfum JJ, Nakyeyune P, Nanclares C, Nanyunja M, Nsio-Mbeta J, O'Dempsey T, Pawęska JT, Peters CJ, Piot P, Rapp C, Renaud B, Ribner B, Sabeti PC, Schieffelin JS, Slenczka W, Soka MJ, Sprecher A, Strong J, Swanepoel R, Uyeki TM, van Herp M, Vetter P, Wohl DA, Wolf T, Wolz A, Wurie AH, Yoti Z.

Nat Rev Microbiol. 2019 May;17(5):261-263. doi: 10.1038/s41579-019-0187-4. No abstract available.


Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma.

Majumder S, Ghoshal K, Datta J, Bai S, Dong X, Quan N, Plass C, Jacob ST.

J Biol Chem. 2018 Aug 17;293(33):12948. doi: 10.1074/jbc.W118.004970. No abstract available.


Mitochondrial transcription factor A and its downstream targets are up-regulated in a rat hepatoma.

Dong X, Ghoshal K, Majumder S, Yadav SP, Jacob ST.

J Biol Chem. 2018 Aug 17;293(33):12947. doi: 10.1074/jbc.W118.004969. No abstract available.


Identification of a novel cyclic AMP-response element (CRE-II) and the role of CREB-1 in the cAMP-induced expression of the survival motor neuron (SMN) gene.

Majumder S, Varadharaj S, Ghoshal K, Monani U, Burghes AHM, Jacob ST.

J Biol Chem. 2018 Aug 17;293(33):12946. doi: 10.1074/jbc.W118.004968. No abstract available.


Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1.

Nasser MW, Datta J, Nuovo G, Kutay H, Motiwala T, Majumder S, Wang B, Suster S, Jacob ST, Ghoshal K.

J Biol Chem. 2018 Aug 17;293(33):12945. doi: 10.1074/jbc.W118.004967. No abstract available.


The African Sepsis Alliance: making a difference in the fight against sepsis in Africa.

Rylance J, Nsutebu E, Mergani KO, Grobusch MP, Jacob ST; African Sepsis Alliance.

Infection. 2018 Oct;46(5):733-734. doi: 10.1007/s15010-018-1184-7. Epub 2018 Aug 15. No abstract available.


The role of miR-122 in the dysregulation of glucose-6-phosphate dehydrogenase (G6PD) expression in hepatocellular cancer.

Barajas JM, Reyes R, Guerrero MJ, Jacob ST, Motiwala T, Ghoshal K.

Sci Rep. 2018 Jun 14;8(1):9105. doi: 10.1038/s41598-018-27358-5.


CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128.

Badawi M, Kim J, Dauki A, Sutaria D, Motiwala T, Reyes R, Wani N, Kolli S, Jiang J, Coss CC, Jacob ST, Phelps MA, Schmittgen TD.

Oncotarget. 2018 May 25;9(40):26032-26045. doi: 10.18632/oncotarget.25430. eCollection 2018 May 25.


Etiology of Sepsis in Uganda Using a Quantitative Polymerase Chain Reaction-based TaqMan Array Card.

Moore CC, Jacob ST, Banura P, Zhang J, Stroup S, Boulware DR, Scheld WM, Houpt ER, Liu J.

Clin Infect Dis. 2019 Jan 7;68(2):266-272. doi: 10.1093/cid/ciy472.


Correction for Ghoshal et al., "5-Aza-Deoxycytidine Induces Selective Degradation of DNA Methyltransferase 1 by a Proteasomal Pathway That Requires the KEN Box, Bromo-Adjacent Homology Domain, and Nuclear Localization Signal".

Ghoshal K, Datta J, Majumder S, Bai S, Kutay H, Motiwala T, Jacob ST.

Mol Cell Biol. 2018 Apr 30;38(10). pii: e00539-17. doi: 10.1128/MCB.00539-17. Print 2018 May 15. No abstract available.


Considerations for Randomized Controlled Trials During Future Filovirus Outbreaks.

Jacob ST, Colebunders R.

Clin Infect Dis. 2018 Aug 31;67(6):984-985. doi: 10.1093/cid/ciy247. No abstract available.


The sixth vital sign: HIV status assessment and severe illness triage in Uganda.

Cummings MJ, Goldberg E, Mwaka S, Kabajaasi O, Vittinghoff E, Katamba A, Cattamanchi A, Kenya-Mugisha N, Davis JL, Jacob ST.

Public Health Action. 2017 Dec 21;7(4):245-250. doi: 10.5588/pha.17.0045. Epub 2017 Nov 13.


Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription.

Majumder S, Ghoshal K, Datta J, Smith DS, Bai S, Jacob ST.

J Biol Chem. 2018 Mar 9;293(10):3591. doi: 10.1074/jbc.W118.002433. No abstract available.


Treatment of PC12 cells with nerve growth factor induces proteasomal degradation of T-cadherin that requires tyrosine phosphorylation of its cadherin domain.

Bai S, Datta J, Jacob ST, Ghoshal K.

J Biol Chem. 2018 Mar 9;293(10):3590. doi: 10.1074/jbc.W118.002432. No abstract available.


PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells.

Motiwala T, Majumder S, Ghoshal K, Kutay H, Datta J, Roy S, Lucas DM, Jacob ST.

J Biol Chem. 2018 Mar 9;293(10):3589. doi: 10.1074/jbc.W118.002431. No abstract available.


Anti-microRNA-222 (anti-miR-222) and -181B suppresses growth of tamoxifen-resistant xenografts in mouse by targeting TIMP3 protein and modulating mitogenic signal.

Lu Y, Roy S, Nuovo G, Ramaswamy B, Miller T, Shapiro C, Jacob ST, Majumder S.

J Biol Chem. 2018 Mar 9;293(10):3588. doi: 10.1074/jbc.W118.002430. No abstract available.


Reprograming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis.

Wani NA, Zhang B, Teng KY, Barajas JM, Motiwala T, Hu P, Yu L, Brüschweiler R, Ghoshal K, Jacob ST.

Mol Cancer Res. 2018 Feb;16(2):256-268. doi: 10.1158/1541-7786.MCR-17-0304. Epub 2017 Nov 29.


A complex intervention to improve implementation of World Health Organization guidelines for diagnosis of severe illness in low-income settings: a quasi-experimental study from Uganda.

Cummings MJ, Goldberg E, Mwaka S, Kabajaasi O, Vittinghoff E, Cattamanchi A, Katamba A, Kenya-Mugisha N, Jacob ST, Davis JL.

Implement Sci. 2017 Nov 6;12(1):126. doi: 10.1186/s13012-017-0654-0.


Dietary fat/cholesterol-sensitive PKCβ-RB signaling: Potential role in NASH/HCC axis.

Huang W, Mehta D, Sif S, Kent LN, Jacob ST, Ghoshal K, Mehta KD.

Oncotarget. 2017 May 15;8(43):73757-73765. doi: 10.18632/oncotarget.17890. eCollection 2017 Sep 26.


Derivation and validation of a universal vital assessment (UVA) score: a tool for predicting mortality in adult hospitalised patients in sub-Saharan Africa.

Moore CC, Hazard R, Saulters KJ, Ainsworth J, Adakun SA, Amir A, Andrews B, Auma M, Baker T, Banura P, Crump JA, Grobusch MP, Huson MAM, Jacob ST, Jarrett OD, Kellett J, Lakhi S, Majwala A, Opio M, Rubach MP, Rylance J, Michael Scheld W, Schieffelin J, Ssekitoleko R, Wheeler I, Barnes LE.

BMJ Glob Health. 2017 Jul 28;2(2):e000344. doi: 10.1136/bmjgh-2017-000344. eCollection 2017.


Evidence-based guidelines for supportive care of patients with Ebola virus disease.

Lamontagne F, Fowler RA, Adhikari NK, Murthy S, Brett-Major DM, Jacobs M, Uyeki TM, Vallenas C, Norris SL, Fischer WA 2nd, Fletcher TE, Levine AC, Reed P, Bausch DG, Gove S, Hall A, Shepherd S, Siemieniuk RA, Lamah MC, Kamara R, Nakyeyune P, Soka MJ, Edwin A, Hazzan AA, Jacob ST, Elkarsany MM, Adachi T, Benhadj L, Clément C, Crozier I, Garcia A, Hoffman SJ, Guyatt GH.

Lancet. 2018 Feb 17;391(10121):700-708. doi: 10.1016/S0140-6736(17)31795-6. Epub 2017 Oct 17.


High mortality in non-Ebola virus disease cases: need to provide timely and effective care.

Colebunders R, Jacob ST, Ariën KK, Weggheleire A, Decroo T.

Lancet Infect Dis. 2017 Oct;17(10):1021-1022. doi: 10.1016/S1473-3099(17)30523-6. No abstract available.


The predicament of patients with suspected Ebola.

Colebunders R, Jacob ST, van Griensven J.

Lancet Glob Health. 2017 Jul;5(7):e658. doi: 10.1016/S2214-109X(17)30214-0. No abstract available.


Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future.

Schultz MJ, Dunser MW, Dondorp AM, Adhikari NK, Iyer S, Kwizera A, Lubell Y, Papali A, Pisani L, Riviello BD, Angus DC, Azevedo LC, Baker T, Diaz JV, Festic E, Haniffa R, Jawa R, Jacob ST, Kissoon N, Lodha R, Martin-Loeches I, Lundeg G, Misango D, Mer M, Mohanty S, Murthy S, Musa N, Nakibuuka J, Serpa Neto A, Nguyen Thi Hoang M, Nguyen Thien B, Pattnaik R, Phua J, Preller J, Povoa P, Ranjit S, Talmor D, Thevanayagam J, Thwaites CL; Global Intensive Care Working Group of the European Society of Intensive Care Medicine.

Intensive Care Med. 2017 May;43(5):612-624. doi: 10.1007/s00134-017-4750-z. Epub 2017 Mar 27. Review.


The Malaria TaqMan Array Card Includes 87 Assays for Plasmodium falciparum Drug Resistance, Identification of Species, and Genotyping in a Single Reaction.

Pholwat S, Liu J, Stroup S, Jacob ST, Banura P, Moore CC, Huang F, Laufer MK, Houpt E, Guler JL.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e00110-17. doi: 10.1128/AAC.00110-17. Print 2017 May.


Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model.

Teng KY, Han J, Zhang X, Hsu SH, He S, Wani NA, Barajas JM, Snyder LA, Frankel WL, Caligiuri MA, Jacob ST, Yu J, Ghoshal K.

Mol Cancer Ther. 2017 Feb;16(2):312-322. doi: 10.1158/1535-7163.MCT-16-0124. Epub 2016 Dec 15.


Sorafenib and 2-Deoxyglucose Synergistically Inhibit Proliferation of Both Sorafenib-Sensitive and -Resistant HCC Cells by Inhibiting ATP Production.

Reyes R, Wani NA, Ghoshal K, Jacob ST, Motiwala T.

Gene Expr. 2017 Feb 10;17(2):129-140. doi: 10.3727/105221616X693855. Epub 2016 Nov 16.


Nodding syndrome, other forms of epilepsy, and the Nakalanga syndrome most likely directly or indirectly caused by Onchocerca volvulus.

Colebunders R, Suykerbuyk P, Jacob ST, van Oijen M.

J Neurol Sci. 2017 Jan 15;372:439-440. doi: 10.1016/j.jns.2016.10.008. Epub 2016 Oct 8. No abstract available.


Ebola virus disease and critical illness.

Leligdowicz A, Fischer WA 2nd, Uyeki TM, Fletcher TE, Adhikari NK, Portella G, Lamontagne F, Clement C, Jacob ST, Rubinson L, Vanderschuren A, Hajek J, Murthy S, Ferri M, Crozier I, Ibrahima E, Lamah MC, Schieffelin JS, Brett-Major D, Bausch DG, Shindo N, Chan AK, O'Dempsey T, Mishra S, Jacobs M, Dickson S, Lyon GM 3rd, Fowler RA.

Crit Care. 2016 Jul 29;20(1):217. doi: 10.1186/s13054-016-1325-2. Review.


An Outbreak of Ebola Virus Disease in the Lassa Fever Zone.

Goba A, Khan SH, Fonnie M, Fullah M, Moigboi A, Kovoma A, Sinnah V, Yoko N, Rogers H, Safai S, Momoh M, Koroma V, Kamara FK, Konowu E, Yillah M, French I, Mustapha I, Kanneh F, Foday M, McCarthy H, Kallon T, Kallon M, Naiebu J, Sellu J, Jalloh AA, Gbakie M, Kanneh L, Massaly JL, Kargbo D, Kargbo B, Vandi M, Gbetuwa M, Gevao SM, Sandi JD, Jalloh SC, Grant DS, Blyden SO, Crozier I, Schieffelin JS, McLellan SL, Jacob ST, Boisen ML, Hartnett JN, Cross RW, Branco LM, Andersen KG, Yozwiak NL, Gire SK, Tariyal R, Park DJ, Haislip AM, Bishop CM, Melnik LI, Gallaher WR, Wimley WC, He J, Shaffer JG, Sullivan BM, Grillo S, Oman S, Garry CE, Edwards DR, McCormick SJ, Elliott DH, Rouelle JA, Kannadka CB, Reyna AA, Bradley BT, Yu H, Yenni RE, Hastie KM, Geisbert JB, Kulakosky PC, Wilson RB, Oldstone MB, Pitts KR, Henderson LA, Robinson JE, Geisbert TW, Saphire EO, Happi CT, Asogun DA, Sabeti PC, Garry RF; Viral Hemorrhagic Fever Consortium.

J Infect Dis. 2016 Oct 15;214(suppl 3):S110-S121. Epub 2016 Jul 11.


Corrigendum to "Design of a multi-arm randomized clinical trial with no control arm" [Contemporary Clinical Trials 46 (2016) 12-17].

Magaret A, Angus DC, Adhikari NK, Banura P, Kissoon N, Lawler JV, Jacob ST.

Contemp Clin Trials. 2016 Jul;49:190. doi: 10.1016/j.cct.2016.06.011. Epub 2016 Jun 29. No abstract available.


Convalescent Plasma for Ebola Virus Disease.

Fletcher TE, Fischer WA 2nd, Jacob ST.

N Engl J Med. 2016 Jun 23;374(25):2499-500. doi: 10.1056/NEJMc1602284. No abstract available.


Design of a multi-arm randomized clinical trial with no control arm.

Magaret A, Angus DC, Adhikari NKJ, Banura P, Kissoon N, Lawler JV, Jacob ST.

Contemp Clin Trials. 2016 Jan;46:12-17. doi: 10.1016/j.cct.2015.11.003. Epub 2015 Nov 3.


Development of a TaqMan Array Card for Acute-Febrile-Illness Outbreak Investigation and Surveillance of Emerging Pathogens, Including Ebola Virus.

Liu J, Ochieng C, Wiersma S, Ströher U, Towner JS, Whitmer S, Nichol ST, Moore CC, Kersh GJ, Kato C, Sexton C, Petersen J, Massung R, Hercik C, Crump JA, Kibiki G, Maro A, Mujaga B, Gratz J, Jacob ST, Banura P, Scheld WM, Juma B, Onyango CO, Montgomery JM, Houpt E, Fields B.

J Clin Microbiol. 2016 Jan;54(1):49-58. doi: 10.1128/JCM.02257-15. Epub 2015 Oct 21.


Raising the standard for clinical care of patients with Ebola virus disease.

Schieffelin JS, Jacob ST.

Lancet Infect Dis. 2015 Nov;15(11):1247-8. doi: 10.1016/S1473-3099(15)00221-2. Epub 2015 Aug 10. No abstract available.


Being ready to treat Ebola virus disease patients.

Brett-Major DM, Jacob ST, Jacquerioz FA, Risi GF, Fischer WA, Kato Y, Houlihan CF, Crozier I, Bosa HK, Lawler JV, Adachi T, Hurley SK, Berry LE, Carlson JC, Button TC, McLellan SL, Shea BJ, Kuniyoshi GG, Ferri M, Murthy SG, Petrosillo N, Lamontagne F, Porembka DT, Schieffelin JS, Rubinson L, O'Dempsey T, Donovan SM, Bausch DG, Fowler RA, Fletcher TE.

Am J Trop Med Hyg. 2015 Feb;92(2):233-237. doi: 10.4269/ajtmh.14-0746. Epub 2014 Dec 15.


PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model.

Motiwala T, Kutay H, Zanesi N, Frissora FW, Mo X, Muthusamy N, Jacob ST.

Leukemia. 2015 Jun;29(6):1350-9. doi: 10.1038/leu.2014.341. Epub 2014 Dec 8.


Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog.

Wang X, He H, Lu Y, Ren W, Teng KY, Chiang CL, Yang Z, Yu B, Hsu S, Jacob ST, Ghoshal K, Lee LJ.

Biochim Biophys Acta. 2015 Jan;1853(1):244-53. doi: 10.1016/j.bbamcr.2014.10.017. Epub 2014 Oct 25.


Clinical presentation of patients with Ebola virus disease in Conakry, Guinea.

Bah EI, Lamah MC, Fletcher T, Jacob ST, Brett-Major DM, Sall AA, Shindo N, Fischer WA 2nd, Lamontagne F, Saliou SM, Bausch DG, Moumié B, Jagatic T, Sprecher A, Lawler JV, Mayet T, Jacquerioz FA, Méndez Baggi MF, Vallenas C, Clement C, Mardel S, Faye O, Faye O, Soropogui B, Magassouba N, Koivogui L, Pinto R, Fowler RA.

N Engl J Med. 2015 Jan 1;372(1):40-7. doi: 10.1056/NEJMoa1411249. Epub 2014 Nov 5.


Priorities for Ebola virus disease response in west Africa.

Jacob ST, Crozier I, Schieffelin JS, Colebunders R.

Lancet. 2014 Nov 22;384(9957):1843. doi: 10.1016/S0140-6736(14)61609-3. Epub 2014 Sep 25. No abstract available.


Doing today's work superbly well--treating Ebola with current tools.

Lamontagne F, Clément C, Fletcher T, Jacob ST, Fischer WA 2nd, Fowler RA.

N Engl J Med. 2014 Oct 23;371(17):1565-6. doi: 10.1056/NEJMp1411310. Epub 2014 Sep 24. No abstract available.


Regulation of glucose metabolism in hepatocarcinogenesis by microRNAs.

Reyes RK, Motiwala T, Jacob ST.

Gene Expr. 2014;16(2):85-92. doi: 10.3727/105221614X13919976902093. Review.


Introduction. Special issue of Gene Expression.

Jacob ST, Reddy JK.

Gene Expr. 2014;16(2):49. doi: 10.3727/105221614X13959522308830. No abstract available.


Access to urban acute care services in high- vs. middle-income countries: an analysis of seven cities.

Austin S, Murthy S, Wunsch H, Adhikari NK, Karir V, Rowan K, Jacob ST, Salluh J, Bozza FA, Du B, An Y, Lee B, Wu F, Nguyen YL, Oppong C, Venkataraman R, Velayutham V, Dueñas C, Angus DC; International Forum of Acute Care Trialists.

Intensive Care Med. 2014 Mar;40(3):342-52. doi: 10.1007/s00134-013-3174-7. Epub 2013 Dec 13.


Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations.

Wang X, Yu B, Ren W, Mo X, Zhou C, He H, Jia H, Wang L, Jacob ST, Lee RJ, Ghoshal K, Lee LJ.

J Control Release. 2013 Dec 28;172(3):690-8. doi: 10.1016/j.jconrel.2013.09.027. Epub 2013 Oct 8.


Clinical care for severe influenza and other severe illness in resource-limited settings: the need for evidence and guidelines.

Ortiz JR, Jacob ST, West TE.

Influenza Other Respir Viruses. 2013 Sep;7 Suppl 2:87-92. doi: 10.1111/irv.12086. Review.

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