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Items: 1 to 50 of 102

1.

Synthesis and Biological Evaluation of 8-Quinolinamines and Their Amino Acid Conjugates as Broad-Spectrum Anti-infectives.

Jain M, Reddy CVRP, Halder M, Singh S, Kumar R, Wasudeo SG, Singh PP, Khan SI, Jacob MR, Tekwani BL, Jain R.

ACS Omega. 2018 Mar 31;3(3):3060-3075. doi: 10.1021/acsomega.7b02047. Epub 2018 Mar 14.

2.

Chloramphenicol Derivatives with Antibacterial Activity Identified by Functional Metagenomics.

Nasrin S, Ganji S, Kakirde KS, Jacob MR, Wang M, Ravu RR, Cobine PA, Khan IA, Wu CC, Mead DA, Li XC, Liles MR.

J Nat Prod. 2018 Jun 22;81(6):1321-1332. doi: 10.1021/acs.jnatprod.7b00903. Epub 2018 Jun 13.

PMID:
29897754
3.

Synthesis and Antimicrobial Evaluation of Fire Ant Venom Alkaloid Based 2-Methyl-6-alkyl-Δ1,6-piperideines.

Yan Y, An Y, Wang X, Chen Y, Jacob MR, Tekwani BL, Dai L, Li XC.

J Nat Prod. 2017 Oct 27;80(10):2795-2798. doi: 10.1021/acs.jnatprod.7b00625. Epub 2017 Oct 12.

PMID:
29023124
4.

Antimycobacterial and antimalarial activities of endophytic fungi associated with the ancient and narrowly endemic neotropical plant Vellozia gigantea from Brazil.

Ferreira MC, Cantrell CL, Wedge DE, Gonçalves VN, Jacob MR, Khan S, Rosa CA, Rosa LH.

Mem Inst Oswaldo Cruz. 2017 Oct;112(10):692-697. doi: 10.1590/0074-02760170144.

5.

Protocol for Identifying Natural Agents That Selectively Affect Adhesion, Thickness, Architecture, Cellular Phenotypes, Extracellular Matrix, and Human White Blood Cell Impenetrability of Candida albicans Biofilms.

Park YN, Srikantha T, Daniels KJ, Jacob MR, Agarwal AK, Li XC, Soll DR.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01319-17. doi: 10.1128/AAC.01319-17. Print 2017 Nov.

6.

Two plant-derived aporphinoid alkaloids exert their antifungal activity by disrupting mitochondrial iron-sulfur cluster biosynthesis.

Tripathi SK, Xu T, Feng Q, Avula B, Shi X, Pan X, Mask MM, Baerson SR, Jacob MR, Ravu RR, Khan SI, Li XC, Khan IA, Clark AM, Agarwal AK.

J Biol Chem. 2017 Oct 6;292(40):16578-16593. doi: 10.1074/jbc.M117.781773. Epub 2017 Aug 18.

7.

Discovery of a Membrane-Active, Ring-Modified Histidine Containing Ultrashort Amphiphilic Peptide That Exhibits Potent Inhibition of Cryptococcus neoformans.

Sharma KK, Maurya IK, Khan SI, Jacob MR, Kumar V, Tikoo K, Jain R.

J Med Chem. 2017 Aug 10;60(15):6607-6621. doi: 10.1021/acs.jmedchem.7b00481. Epub 2017 Jul 25.

PMID:
28697301
8.

Synthesis, stability and mechanistic studies of potent anticryptococcal hexapeptides.

Shenmar K, Sharma KK, Wangoo N, Maurya IK, Kumar V, Khan SI, Jacob MR, Tikoo K, Jain R.

Eur J Med Chem. 2017 May 26;132:192-203. doi: 10.1016/j.ejmech.2017.03.046. Epub 2017 Mar 24.

9.

Biological evaluation of phytoconstituents from Polygonum hydropiper.

Xiao H, Rao Ravu R, Tekwani BL, Li W, Liu WB, Jacob MR, Khan SI, Cai X, Peng CY, Khan IA, Li XC, Wang W.

Nat Prod Res. 2017 Sep;31(17):2053-2057. doi: 10.1080/14786419.2016.1269094. Epub 2016 Dec 21.

PMID:
28000515
10.

Bioactive Formylated Flavonoids from Eugenia rigida: Isolation, Synthesis, and X-ray Crystallography.

Zaki MA, Nanayakkara NP, Hetta MH, Jacob MR, Khan SI, Mohammed R, Ibrahim MA, Samoylenko V, Coleman C, Fronczek FR, Ferreira D, Muhammad I.

J Nat Prod. 2016 Sep 23;79(9):2341-9. doi: 10.1021/acs.jnatprod.6b00474. Epub 2016 Sep 12.

PMID:
27618204
11.

Synthesis of Natural Acylphloroglucinol-Based Antifungal Compounds against Cryptococcus Species.

Yu Q, Ravu RR, Jacob MR, Khan SI, Agarwal AK, Yu BY, Li XC.

J Nat Prod. 2016 Sep 23;79(9):2195-201. doi: 10.1021/acs.jnatprod.6b00224. Epub 2016 Sep 1.

PMID:
27584935
12.

Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum.

Shi YN, Liu FF, Jacob MR, Li XC, Zhu HT, Wang D, Cheng RR, Yang CR, Xu M, Zhang YJ.

Planta Med. 2017 Jan;83(1-02):143-150. doi: 10.1055/s-0042-109778. Epub 2016 Jul 12.

PMID:
27405106
13.

New ent-Clerodane and Abietane Diterpenoids from the Roots of Kenyan Croton megalocarpoides Friis & M. G. Gilbert.

Ndunda B, Langat MK, Mulholland DA, Eastman H, Jacob MR, Khan SI, Walker LA, Muhammad I, Kerubo LO, Midiwo JO.

Planta Med. 2016 Jul;82(11-12):1079-86. doi: 10.1055/s-0042-108857. Epub 2016 Jun 10.

PMID:
27286332
14.

Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum.

Zhang J, Bowling JJ, Smithson D, Clark J, Jacob MR, Khan SI, Tekwani BL, Connelly M, Samoylenko V, Ibrahim MA, Zaki MA, Wang M, Hester JP, Tu Y, Jeffries C, Twarog N, Shelat AA, Walker LA, Muhammad I, Guy RK.

Malar J. 2016 May 10;15(1):270. doi: 10.1186/s12936-016-1313-7.

15.

Antibacterial Prenylated Acylphloroglucinols from Psorothamnus fremontii.

Yu Q, Ravu RR, Xu QM, Ganji S, Jacob MR, Khan SI, Yu BY, Li XC.

J Nat Prod. 2015 Nov 25;78(11):2748-53. doi: 10.1021/acs.jnatprod.5b00721. Epub 2015 Oct 15.

PMID:
26469557
16.

LC-MS- and (1)H NMR Spectroscopy-Guided Identification of Antifungal Diterpenoids from Sagittaria latifolia.

Ravu RR, Jacob MR, Jeffries C, Tu Y, Khan SI, Agarwal AK, Guy RK, Walker LA, Clark AM, Li XC.

J Nat Prod. 2015 Sep 25;78(9):2255-9. doi: 10.1021/acs.jnatprod.5b00470. Epub 2015 Sep 15.

PMID:
26371504
17.

Antimicrobial and Antileishmanial Activities of Diterpenoids Isolated from the Roots of Salvia deserta.

Búfalo J, Cantrell CL, Jacob MR, Schrader KK, Tekwani BL, Kustova TS, Ali A, Boaro CS.

Planta Med. 2016 Jan;82(1-2):131-7. doi: 10.1055/s-0035-1557875. Epub 2015 Aug 26.

PMID:
26308356
18.

Fungi associated with rocks of the Atacama Desert: taxonomy, distribution, diversity, ecology and bioprospection for bioactive compounds.

Gonçalves VN, Cantrell CL, Wedge DE, Ferreira MC, Soares MA, Jacob MR, Oliveira FS, Galante D, Rodrigues F, Alves TM, Zani CL, Junior PA, Murta S, Romanha AJ, Barbosa EC, Kroon EG, Oliveira JG, Gomez-Silva B, Galetovic A, Rosa CA, Rosa LH.

Environ Microbiol. 2016 Jan;18(1):232-45. doi: 10.1111/1462-2920.13005. Epub 2015 Sep 28.

PMID:
26235221
19.

Anti-vancomycin-resistant Enterococcus faecium and E. faecalis activities of (-)-gossypol and derivatives from Thespesia garckeana.

Masila VM, Midiwo JO, Zhang J, Gisacho BM, Munayi R, Omosa LK, Wiggers FT, Jacob MR, Walker LA, Muhammad I.

Nat Prod Commun. 2015 Apr;10(4):613-6.

PMID:
25973489
20.

Bacillusin A, an Antibacterial Macrodiolide from Bacillus amyloliquefaciens AP183.

Ravu RR, Jacob MR, Chen X, Wang M, Nasrin S, Kloepper JW, Liles MR, Mead DA, Khan IA, Li XC.

J Nat Prod. 2015 Apr 24;78(4):924-8. doi: 10.1021/np500911k. Epub 2015 Mar 10.

PMID:
25756620
21.

Evaluation of three medicinal plant extracts against Plasmodium falciparum and selected microganisms.

Falodun A, Imieje V, Erharuyi O, Ahomafor J, Jacob MR, Khan SI, Hamann MT.

Afr J Tradit Complement Altern Med. 2014 Jun 4;11(4):142-6. eCollection 2014.

22.

Development of an antifungal denture adhesive film for oral candidiasis utilizing hot melt extrusion technology.

Park JB, Prodduturi S, Morott J, Kulkarni VI, Jacob MR, Khan SI, Stodghill SP, Repka MA.

Expert Opin Drug Deliv. 2015 Jan;12(1):1-13. doi: 10.1517/17425247.2014.949235. Epub 2014 Aug 29.

23.

Synthesis and Antimicrobial Activities of His(2-aryl)-Arg and Trp-His(2-aryl) Classes of Dipeptidomimetics.

Mahindra A, Sharma KK, Rathore D, Khan SI, Jacob MR, Jain R.

Medchemcomm. 2014 May 1;5(5):671-676.

24.

Discovery of Short Peptides Exhibiting High Potency against Cryptococcus neoformans.

Mahindra A, Bagra N, Wangoo N, Khan SI, Jacob MR, Jain R.

ACS Med Chem Lett. 2014 Jan 15;5(4):315-20. doi: 10.1021/ml500011v. eCollection 2014 Apr 10.

25.

Synthetically modified L-histidine-rich peptidomimetics exhibit potent activity against Cryptococcus neoformans.

Mahindra A, Bagra N, Wangoo N, Jain R, Khan SI, Jacob MR, Jain R.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3150-4. doi: 10.1016/j.bmcl.2014.04.120. Epub 2014 May 10.

26.
27.

UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries.

Yang J, Liang Q, Wang M, Jeffries C, Smithson D, Tu Y, Boulos N, Jacob MR, Shelat AA, Wu Y, Ravu RR, Gilbertson R, Avery MA, Khan IA, Walker LA, Guy RK, Li XC.

J Nat Prod. 2014 Apr 25;77(4):902-9. doi: 10.1021/np4009706. Epub 2014 Mar 11.

28.

Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents.

Bolden S Jr, Zhu XY, Etukala JR, Boateng C, Mazu T, Flores-Rozas H, Jacob MR, Khan SI, Walker LA, Ablordeppey SY.

Eur J Med Chem. 2013;70:130-42. doi: 10.1016/j.ejmech.2013.09.044. Epub 2013 Oct 5.

29.

CoMFA studies and in vitro evaluation of some 3-substituted benzylthio quinolinium salts as anticryptococcal agents.

Bolden S, Boateng CA, Zhu XY, Etukala JR, Eyunni SK, Jacob MR, Khan SI, Ablordeppey SY.

Bioorg Med Chem. 2013 Nov 15;21(22):7194-201. doi: 10.1016/j.bmc.2013.08.043. Epub 2013 Sep 3.

30.

Synthesis and antifungal activities of miltefosine analogs.

Ravu RR, Chen YL, Jacob MR, Pan X, Agarwal AK, Khan SI, Heitman J, Clark AM, Li XC.

Bioorg Med Chem Lett. 2013 Sep 1;23(17):4828-31. doi: 10.1016/j.bmcl.2013.06.096. Epub 2013 Jul 6.

31.

Phytochemical, Antimicrobial and Antiplasmodial Investigations of Terminalia brownii.

Machumi F, Midiwo JO, Jacob MR, Khan SI, Tekwani BL, Zhang J, Walker LA, Muhammad I.

Nat Prod Commun. 2013 Jul 1;8(6):761-764.

32.

Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.

Bharate SB, Bharate JB, Khan SI, Tekwani BL, Jacob MR, Mudududdla R, Yadav RR, Singh B, Sharma PR, Maity S, Singh B, Khan IA, Vishwakarma RA.

Eur J Med Chem. 2013 May;63:435-43. doi: 10.1016/j.ejmech.2013.02.024. Epub 2013 Feb 28.

33.

Antimicrobial and antiprotozoal activities of secondary metabolites from the fungus Eurotium repens.

Gao J, Radwan MM, León F, Wang X, Jacob MR, Tekwani BL, Khan SI, Lupien S, Hill RA, Dugan FM, Cutler HG, Cutler SJ.

Med Chem Res. 2012 Oct;21(10):3080-3086. Epub 2011 Nov 11.

34.

Pentacyclic ingamine alkaloids, a new antiplasmodial pharmacophore from the marine sponge Petrosid Ng5 Sp5.

Ilias M, Ibrahim MA, Khan SI, Jacob MR, Tekwani BL, Walker LA, Samoylenko V.

Planta Med. 2012 Oct;78(15):1690-7. doi: 10.1055/s-0032-1315213. Epub 2012 Aug 17.

PMID:
22903383
35.

Antifungal cyclic peptides from the marine sponge Microscleroderma herdmani.

Zhang X, Jacob MR, Rao RR, Wang YH, Agarwal AK, Newman DJ, Khan IA, Clark AM, Li XC.

Res Rep Med Chem. 2012 May 22;2:7-14.

36.

Amino acid, dipeptide and pseudodipeptide conjugates of ring-substituted 8-aminoquinolines: synthesis and evaluation of anti-infective, β-haematin inhibition and cytotoxic activities.

Kaur K, Jain M, Khan SI, Jacob MR, Tekwani BL, Singh S, Singh PP, Jain R.

Eur J Med Chem. 2012 Jun;52:230-41. doi: 10.1016/j.ejmech.2012.03.019. Epub 2012 Mar 21.

PMID:
22483965
37.

Exploring the molecular basis of antifungal synergies using genome-wide approaches.

Agarwal AK, Tripathi SK, Xu T, Jacob MR, Li XC, Clark AM.

Front Microbiol. 2012 Mar 27;3:115. doi: 10.3389/fmicb.2012.00115. eCollection 2012.

38.

A potent plant-derived antifungal acetylenic acid mediates its activity by interfering with fatty acid homeostasis.

Xu T, Tripathi SK, Feng Q, Lorenz MC, Wright MA, Jacob MR, Mask MM, Baerson SR, Li XC, Clark AM, Agarwal AK.

Antimicrob Agents Chemother. 2012 Jun;56(6):2894-907. doi: 10.1128/AAC.05663-11. Epub 2012 Mar 19.

39.

Antiparasitic and antimicrobial isoflavanquinones from Abrus schimperi.

Rahman AA, Samoylenko V, Jain SK, Tekwani BL, Khan SI, Jacob MR, Midiwo JO, Hester JP, Walker LA, Muhammad I.

Nat Prod Commun. 2011 Nov;6(11):1645-50.

40.

Synthesis and antifungal activity of natural product-based 6-alkyl-2,3,4,5-tetrahydropyridines.

Dai L, Jacob MR, Khan SI, Khan IA, Clark AM, Li XC.

J Nat Prod. 2011 Sep 23;74(9):2023-6. doi: 10.1021/np200644s. Epub 2011 Sep 9.

41.

Natural Product Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium Scaffold as A New Antifungal Template.

Li XC, Babu KS, Jacob MR, Khan SI, Agarwal AK, Clark AM.

ACS Med Chem Lett. 2011 May 12;2(5):391-395.

42.

An entry to curcuphenol/elvirol core structures via a retro-Aldol reaction.

Plano MF, Labadie GR, Jacob MR, Tekwani BL, Cravero RM.

Chem Biodivers. 2011 Jun;8(6):1098-111. doi: 10.1002/cbdv.201000160.

43.

Health is wealth: methods to improve attendance in a lifestyle intervention for a largely immigrant Filipino-American sample.

Leake AR, Bermudo VC, Jacob J, Jacob MR, Inouye J.

J Immigr Minor Health. 2012 Jun;14(3):475-80. doi: 10.1007/s10903-011-9487-0.

PMID:
21647623
44.

δ-Carbolines and their ring-opened analogs: synthesis and evaluation against fungal and bacterial opportunistic pathogens.

Mazu TK, Etukala JR, Jacob MR, Khan SI, Walker LA, Ablordeppey SY.

Eur J Med Chem. 2011 Jun;46(6):2378-85. doi: 10.1016/j.ejmech.2011.03.021. Epub 2011 Mar 17.

45.

Optimization of 3-(phenylthio)quinolinium compounds against opportunistic fungal pathogens.

Boateng CA, Zhu XY, Jacob MR, Khan SI, Walker LA, Ablordeppey SY.

Eur J Med Chem. 2011 May;46(5):1789-97. doi: 10.1016/j.ejmech.2011.02.034. Epub 2011 Feb 23.

46.

Antiparasitic and antimicrobial indolizidines from the leaves of Prosopis glandulosa var. glandulosa.

Rahman AA, Samoylenko V, Jacob MR, Sahu R, Jain SK, Khan SI, Tekwani BL, Muhammad I.

Planta Med. 2011 Sep;77(14):1639-43. doi: 10.1055/s-0030-1270906. Epub 2011 Mar 7.

47.

The marine sponge-derived polyketide endoperoxide plakortide F acid mediates its antifungal activity by interfering with calcium homeostasis.

Xu T, Feng Q, Jacob MR, Avula B, Mask MM, Baerson SR, Tripathi SK, Mohammed R, Hamann MT, Khan IA, Walker LA, Clark AM, Agarwal AK.

Antimicrob Agents Chemother. 2011 Apr;55(4):1611-21. doi: 10.1128/AAC.01022-10. Epub 2011 Feb 7.

48.

Synthesis, antiprotozoal, antimicrobial, β-hematin inhibition, cytotoxicity and methemoglobin (MetHb) formation activities of bis(8-aminoquinolines).

Kaur K, Jain M, Khan SI, Jacob MR, Tekwani BL, Singh S, Singh PP, Jain R.

Bioorg Med Chem. 2011 Jan 1;19(1):197-210. doi: 10.1016/j.bmc.2010.11.036. Epub 2010 Nov 25.

49.

Benzothieno[3,2-b]quinolinium and 3-(phenylthio)quinolinium compounds: Synthesis and evaluation against opportunistic fungal pathogens.

Boateng CA, Eyunni SV, Zhu XY, Etukala JR, Bricker BA, Ashfaq MK, Jacob MR, Khan SI, Walker LA, Ablordeppey SY.

Bioorg Med Chem. 2011 Jan 1;19(1):458-70. doi: 10.1016/j.bmc.2010.11.008. Epub 2010 Nov 10.

50.

Identification of 3-phenylaminoquinolinium and 3-phenylaminopyridinium salts as new agents against opportunistic fungal pathogens.

Mazu TK, Etukala JR, Zhu XY, Jacob MR, Khan SI, Walker LA, Ablordeppey SY.

Bioorg Med Chem. 2011 Jan 1;19(1):524-33. doi: 10.1016/j.bmc.2010.10.065. Epub 2010 Nov 5.

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