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Items: 1 to 50 of 440

1.

Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis.

Xu XR, Wang Y, Adili R, Ju L, Spring CM, Jin JW, Yang H, Neves MAD, Chen P, Yang Y, Lei X, Chen Y, Gallant RC, Xu M, Zhang H, Song J, Ke P, Zhang D, Carrim N, Yu SY, Zhu G, She YM, Cyr T, Fu W, Liu G, Connelly PW, Rand ML, Adeli K, Freedman J, Lee JE, Tso P, Marchese P, Davidson WS, Jackson SP, Zhu C, Ruggeri ZM, Ni H.

Nat Commun. 2018 Sep 6;9(1):3608. doi: 10.1038/s41467-018-05806-0.

2.

Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticles.

Chen C, Wang F, Wen S, Su QP, Wu MCL, Liu Y, Wang B, Li D, Shan X, Kianinia M, Aharonovich I, Toth M, Jackson SP, Xi P, Jin D.

Nat Commun. 2018 Aug 17;9(1):3290. doi: 10.1038/s41467-018-05842-w.

3.

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.

Dev H, Chiang TW, Lescale C, de Krijger I, Martin AG, Pilger D, Coates J, Sczaniecka-Clift M, Wei W, Ostermaier M, Herzog M, Lam J, Shea A, Demir M, Wu Q, Yang F, Fu B, Lai Z, Balmus G, Belotserkovskaya R, Serra V, O'Connor MJ, Bruna A, Beli P, Pellegrini L, Caldas C, Deriano L, Jacobs JJL, Galanty Y, Jackson SP.

Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18.

PMID:
30022119
4.

Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway.

Larrieu D, Viré E, Robson S, Breusegem SY, Kouzarides T, Jackson SP.

Sci Signal. 2018 Jul 3;11(537). pii: eaar5401. doi: 10.1126/scisignal.aar5401.

PMID:
29970603
5.

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.

Velimezi G, Robinson-Garcia L, Muñoz-Martínez F, Wiegant WW, Ferreira da Silva J, Owusu M, Moder M, Wiedner M, Rosenthal SB, Fisch KM, Moffat J, Menche J, van Attikum H, Jackson SP, Loizou JI.

Nat Commun. 2018 Jun 11;9(1):2280. doi: 10.1038/s41467-018-04649-z.

6.

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion.

Pleines I, Lebois M, Gangatirkar P, Au AE, Lane RM, Henley KJ, Kauppi M, Corbin J, Cannon P, Bernardini J, Alwis I, Jarman KE, Ellis S, Metcalf D, Jackson SP, Schoenwaelder SM, Kile BT, Josefsson EC.

Blood. 2018 Jul 12;132(2):197-209. doi: 10.1182/blood-2017-11-816355. Epub 2018 May 21.

PMID:
29784641
7.

Validating the concept of mutational signatures with isogenic cell models.

Zou X, Owusu M, Harris R, Jackson SP, Loizou JI, Nik-Zainal S.

Nat Commun. 2018 May 1;9(1):1744. doi: 10.1038/s41467-018-04052-8.

8.

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.

Balmus G, Larrieu D, Barros AC, Collins C, Abrudan M, Demir M, Geisler NJ, Lelliott CJ, White JK, Karp NA, Atkinson J, Kirton A, Jacobsen M, Clift D, Rodriguez R; Sanger Mouse Genetics Project, Adams DJ, Jackson SP.

Nat Commun. 2018 Apr 27;9(1):1700. doi: 10.1038/s41467-018-03770-3.

9.

Detection of functional protein domains by unbiased genome-wide forward genetic screening.

Herzog M, Puddu F, Coates J, Geisler N, Forment JV, Jackson SP.

Sci Rep. 2018 Apr 18;8(1):6161. doi: 10.1038/s41598-018-24400-4.

10.

Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets.

Ju L, McFadyen JD, Al-Daher S, Alwis I, Chen Y, Tønnesen LL, Maiocchi S, Coulter B, Calkin AC, Felner EI, Cohen N, Yuan Y, Schoenwaelder SM, Cooper ME, Zhu C, Jackson SP.

Nat Commun. 2018 Mar 14;9(1):1087. doi: 10.1038/s41467-018-03430-6.

11.

Thromboinflammatory Functions of Platelets in Ischemia-Reperfusion Injury and Its Dysregulation in Diabetes.

Maiocchi S, Alwis I, Wu MCL, Yuan Y, Jackson SP.

Semin Thromb Hemost. 2018 Mar;44(2):102-113. doi: 10.1055/s-0037-1613694. Epub 2018 Jan 2. Review.

PMID:
29294493
12.

Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia.

Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, Robinson-Garcia L, Schischlik F, Slavkovsky R, Kralovics R, Schuster M, Bock C, Ideker T, Jackson SP, Menche J, Loizou JI.

Nat Commun. 2017 Nov 1;8(1):1238. doi: 10.1038/s41467-017-01439-x.

13.

Dual Biomembrane Force Probe enables single-cell mechanical analysis of signal crosstalk between multiple molecular species.

Ju L, Chen Y, Li K, Yuan Z, Liu B, Jackson SP, Zhu C.

Sci Rep. 2017 Oct 27;7(1):14185. doi: 10.1038/s41598-017-13793-3.

14.

Endogenous fibrinolysis facilitates clot retraction in vivo.

Samson AL, Alwis I, Maclean JAA, Priyananda P, Hawkett B, Schoenwaelder SM, Jackson SP.

Blood. 2017 Dec 7;130(23):2453-2462. doi: 10.1182/blood-2017-06-789032. Epub 2017 Oct 26.

PMID:
29074499
15.

Deubiquitylating enzymes and drug discovery: emerging opportunities.

Harrigan JA, Jacq X, Martin NM, Jackson SP.

Nat Rev Drug Discov. 2018 Jan;17(1):57-78. doi: 10.1038/nrd.2017.152. Epub 2017 Sep 29. Review.

PMID:
28959952
16.

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia.

Yuan Y, Alwis I, Wu MCL, Kaplan Z, Ashworth K, Bark D Jr, Pham A, Mcfadyen J, Schoenwaelder SM, Josefsson EC, Kile BT, Jackson SP.

Sci Transl Med. 2017 Sep 27;9(409). pii: eaam5861. doi: 10.1126/scitranslmed.aam5861.

PMID:
28954929
17.

Erratum: PGBD5 promotes site-specific oncogenic mutations in human tumors.

Henssen AG, Koche R, Zhuang J, Jiang E, Reed C, Eisenberg A, Still E, MacArthur IC, Rodríguez-Fos E, Gonzalez S, Puiggròs M, Blackford AN, Mason CE, de Stanchina E, Gönen M, Emde AK, Shah M, Arora K, Reeves C, Socci ND, Perlman E, Antonescu CR, Roberts CWM, Steen H, Mullen E, Jackson SP, Torrents D, Weng Z, Armstrong SA, Kentsis A.

Nat Genet. 2017 Sep 27;49(10):1558. doi: 10.1038/ng1017-1558b. No abstract available.

PMID:
28951624
18.

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

Schoenwaelder SM, Darbousset R, Cranmer SL, Ramshaw HS, Orive SL, Sturgeon S, Yuan Y, Yao Y, Krycer JR, Woodcock J, Maclean J, Pitson S, Zheng Z, Henstridge DC, van der Wal D, Gardiner EE, Berndt MC, Andrews RK, James DE, Lopez AF, Jackson SP.

Nat Commun. 2017 Aug 30;8:16125. doi: 10.1038/ncomms16125.

19.

Application of a strain rate gradient microfluidic device to von Willebrand's disease screening.

Brazilek RJ, Tovar-Lopez FJ, Wong AKT, Tran H, Davis AS, McFadyen JD, Kaplan Z, Chunilal S, Jackson SP, Nandurkar H, Mitchell A, Nesbitt WS.

Lab Chip. 2017 Jul 25;17(15):2595-2608. doi: 10.1039/c7lc00498b.

PMID:
28660968
20.

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.

Blackford AN, Jackson SP.

Mol Cell. 2017 Jun 15;66(6):801-817. doi: 10.1016/j.molcel.2017.05.015. Review.

21.

Corrigendum: Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks.

Chanut P, Britton S, Coates J, Jackson SP, Calsou P.

Nat Commun. 2017 Jun 13;8:15917. doi: 10.1038/ncomms15917.

22.

PGBD5 promotes site-specific oncogenic mutations in human tumors.

Henssen AG, Koche R, Zhuang J, Jiang E, Reed C, Eisenberg A, Still E, MacArthur IC, Rodríguez-Fos E, Gonzalez S, Puiggròs M, Blackford AN, Mason CE, de Stanchina E, Gönen M, Emde AK, Shah M, Arora K, Reeves C, Socci ND, Perlman E, Antonescu CR, Roberts CWM, Steen H, Mullen E, Jackson SP, Torrents D, Weng Z, Armstrong SA, Kentsis A.

Nat Genet. 2017 Jul;49(7):1005-1014. doi: 10.1038/ng.3866. Epub 2017 May 15. Erratum in: Nat Genet. 2017 Sep 27;49(10 ):1558.

23.

Chromatin determinants impart camptothecin sensitivity.

Puddu F, Salguero I, Herzog M, Geisler NJ, Costanzo V, Jackson SP.

EMBO Rep. 2017 Jun;18(6):1000-1012. doi: 10.15252/embr.201643560. Epub 2017 Apr 7.

24.

Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility.

Wright DJ, Day FR, Kerrison ND, Zink F, Cardona A, Sulem P, Thompson DJ, Sigurjonsdottir S, Gudbjartsson DF, Helgason A, Chapman JR, Jackson SP, Langenberg C, Wareham NJ, Scott RA, Thorsteindottir U, Ong KK, Stefansson K, Perry JRB.

Nat Genet. 2017 May;49(5):674-679. doi: 10.1038/ng.3821. Epub 2017 Mar 27.

25.

Targeting DNA Repair in Cancer: Beyond PARP Inhibitors.

Brown JS, O'Carrigan B, Jackson SP, Yap TA.

Cancer Discov. 2017 Jan;7(1):20-37. doi: 10.1158/2159-8290.CD-16-0860. Epub 2016 Dec 21. Review.

26.

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome.

Bar DZ, Arlt MF, Brazier JF, Norris WE, Campbell SE, Chines P, Larrieu D, Jackson SP, Collins FS, Glover TW, Gordon LB.

J Med Genet. 2017 Mar;54(3):212-216. doi: 10.1136/jmedgenet-2016-104295. Epub 2016 Dec 5.

27.

Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells.

Forment JV, Herzog M, Coates J, Konopka T, Gapp BV, Nijman SM, Adams DJ, Keane TM, Jackson SP.

Nat Chem Biol. 2017 Jan;13(1):12-14. doi: 10.1038/nchembio.2226. Epub 2016 Oct 31.

28.

Synthetic lethality between PAXX and XLF in mammalian development.

Balmus G, Barros AC, Wijnhoven PW, Lescale C, Hasse HL, Boroviak K, le Sage C, Doe B, Speak AO, Galli A, Jacobsen M, Deriano L, Adams DJ, Blackford AN, Jackson SP.

Genes Dev. 2016 Oct 1;30(19):2152-2157.

29.

Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency.

Chang HH, Watanabe G, Gerodimos CA, Ochi T, Blundell TL, Jackson SP, Lieber MR.

J Biol Chem. 2016 Nov 18;291(47):24377-24389. Epub 2016 Oct 4.

30.

Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse.

Larsson P, Alwis I, Niego B, Sashindranath M, Fogelstrand P, Wu MC, Glise L, Magnusson M, Daglas M, Bergh N, Jackson SP, Medcalf RL, Jern S.

J Thromb Haemost. 2016 Dec;14(12):2496-2508. doi: 10.1111/jth.13527. Epub 2016 Nov 23.

PMID:
27706906
31.

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

Schoenwaelder SM, Darbousset R, Cranmer SL, Ramshaw HS, Orive SL, Sturgeon S, Yuan Y, Yao Y, Krycer JR, Woodcock J, Maclean J, Pitson S, Zheng Z, Henstridge DC, van der Wal D, Gardiner EE, Berndt MC, Andrews RK, James DE, Lopez AF, Jackson SP.

Nat Commun. 2016 Sep 27;7:12862. doi: 10.1038/ncomms12862. Erratum in: Nat Commun. 2017 Aug 30;8:16125.

32.

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks.

Chanut P, Britton S, Coates J, Jackson SP, Calsou P.

Nat Commun. 2016 Sep 19;7:12889. doi: 10.1038/ncomms12889. Erratum in: Nat Commun. 2017 Jun 13;8:15917.

33.

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.

Lescale C, Lenden Hasse H, Blackford AN, Balmus G, Bianchi JJ, Yu W, Bacoccina L, Jarade A, Clouin C, Sivapalan R, Reina-San-Martin B, Jackson SP, Deriano L.

Cell Rep. 2016 Sep 13;16(11):2967-2979. doi: 10.1016/j.celrep.2016.08.069. Epub 2016 Sep 2.

34.

Global genome nucleotide excision repair is organized into domains that promote efficient DNA repair in chromatin.

Yu S, Evans K, van Eijk P, Bennett M, Webster RM, Leadbitter M, Teng Y, Waters R, Jackson SP, Reed SH.

Genome Res. 2016 Oct;26(10):1376-1387. Epub 2016 Jul 28.

35.

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient.

Cobb AM, Larrieu D, Warren DT, Liu Y, Srivastava S, Smith AJO, Bowater RP, Jackson SP, Shanahan CM.

Aging Cell. 2016 Dec;15(6):1039-1050. doi: 10.1111/acel.12506. Epub 2016 Jul 27.

36.

G9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status.

Agarwal P, Jackson SP.

Cancer Lett. 2016 Oct 1;380(2):467-75. doi: 10.1016/j.canlet.2016.07.009. Epub 2016 Jul 16.

37.

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922).

Zheng Z, Pinson JA, Mountford SJ, Orive S, Schoenwaelder SM, Shackleford D, Powell A, Nelson EM, Hamilton JR, Jackson SP, Jennings IG, Thompson PE.

Eur J Med Chem. 2016 Oct 21;122:339-351. doi: 10.1016/j.ejmech.2016.06.010. Epub 2016 Jun 10.

PMID:
27387421
38.

Molecular Insights into Division of Single Human Cancer Cells in On-Chip Transparent Microtubes.

Xi W, Schmidt CK, Sanchez S, Gracias DH, Carazo-Salas RE, Butler R, Lawrence N, Jackson SP, Schmidt OG.

ACS Nano. 2016 Jun 28;10(6):5835-46. doi: 10.1021/acsnano.6b00461. Epub 2016 Jun 15.

39.

DNA REPAIR. Drugging DNA repair.

Jackson SP, Helleday T.

Science. 2016 Jun 3;352(6290):1178-9. doi: 10.1126/science.aab0958. No abstract available.

PMID:
27257245
40.

CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing.

Chiang TW, le Sage C, Larrieu D, Demir M, Jackson SP.

Sci Rep. 2016 Apr 15;6:24356. doi: 10.1038/srep24356.

41.

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Zimmer J, Tacconi EMC, Folio C, Badie S, Porru M, Klare K, Tumiati M, Markkanen E, Halder S, Ryan A, Jackson SP, Ramadan K, Kuznetsov SG, Biroccio A, Sale JE, Tarsounas M.

Mol Cell. 2016 Feb 4;61(3):449-460. doi: 10.1016/j.molcel.2015.12.004. Epub 2015 Dec 31.

42.

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.

Harley ME, Murina O, Leitch A, Higgs MR, Bicknell LS, Yigit G, Blackford AN, Zlatanou A, Mackenzie KJ, Reddy K, Halachev M, McGlasson S, Reijns MAM, Fluteau A, Martin CA, Sabbioneda S, Elcioglu NH, Altmüller J, Thiele H, Greenhalgh L, Chessa L, Maghnie M, Salim M, Bober MB, Nürnberg P, Jackson SP, Hurles ME, Wollnik B, Stewart GS, Jackson AP.

Nat Genet. 2016 Jan;48(1):36-43. doi: 10.1038/ng.3451. Epub 2015 Nov 23.

43.

The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose).

Silva AP, Ryan DP, Galanty Y, Low JK, Vandevenne M, Jackson SP, Mackay JP.

J Biol Chem. 2016 Jan 8;291(2):924-38. doi: 10.1074/jbc.M115.683227. Epub 2015 Nov 12.

44.

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents.

Samson AL, Ju L, Ah Kim H, Zhang SR, Lee JA, Sturgeon SA, Sobey CG, Jackson SP, Schoenwaelder SM.

Sci Rep. 2015 Nov 4;5:16171. doi: 10.1038/srep16171.

45.

Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma.

Gill SJ, Travers J, Pshenichnaya I, Kogera FA, Barthorpe S, Mironenko T, Richardson L, Benes CH, Stratton MR, McDermott U, Jackson SP, Garnett MJ.

PLoS One. 2015 Oct 27;10(10):e0140988. doi: 10.1371/journal.pone.0140988. eCollection 2015.

46.

Ferric chloride thrombosis model: unraveling the vascular effects of a highly corrosive oxidant.

Schoenwaelder SM, Jackson SP.

Blood. 2015 Dec 10;126(24):2652-3. doi: 10.1182/blood-2015-09-668384. Epub 2015 Oct 26. No abstract available.

47.

Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.

Schmidt CK, Galanty Y, Sczaniecka-Clift M, Coates J, Jhujh S, Demir M, Cornwell M, Beli P, Jackson SP.

Nat Cell Biol. 2015 Nov;17(11):1458-1470. doi: 10.1038/ncb3260. Epub 2015 Oct 26.

48.

USP4 Auto-Deubiquitylation Promotes Homologous Recombination.

Wijnhoven P, Konietzny R, Blackford AN, Travers J, Kessler BM, Nishi R, Jackson SP.

Mol Cell. 2015 Nov 5;60(3):362-73. doi: 10.1016/j.molcel.2015.09.019. Epub 2015 Oct 8.

49.

Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein.

Yuan Y, Britton S, Delteil C, Coates J, Jackson SP, Barboule N, Frit P, Calsou P.

Nucleic Acids Res. 2015 Dec 2;43(21):10264-76. doi: 10.1093/nar/gkv894. Epub 2015 Sep 8.

50.

When two is not enough: a CtIP tetramer is required for DNA repair by Homologous Recombination.

Forment JV, Jackson SP, Pellegrini L.

Nucleus. 2015;6(5):344-8. doi: 10.1080/19491034.2015.1086050.

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