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Items: 1 to 50 of 128

1.

EZH2 Inactivates Primary Cilia to Activate Wnt and Drive Melanoma.

Jackson PK.

Cancer Cell. 2018 Jul 9;34(1):3-5. doi: 10.1016/j.ccell.2018.06.011.

PMID:
29990499
2.

Guanine Nucleotide Exchange Assay Using Fluorescent MANT-GDP.

Kanie T, Jackson PK.

Bio Protoc. 2018 Apr 5;8(7). pii: e2795. doi: 10.21769/BioProtoc.2795.

3.

Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma.

Qin EY, Cooper DD, Abbott KL, Lennon J, Nagaraja S, Mackay A, Jones C, Vogel H, Jackson PK, Monje M.

Cell. 2017 Aug 24;170(5):845-859.e19. doi: 10.1016/j.cell.2017.07.016. Epub 2017 Aug 17.

4.

The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.

Kanie T, Abbott KL, Mooney NA, Plowey ED, Demeter J, Jackson PK.

Dev Cell. 2017 Jul 10;42(1):22-36.e12. doi: 10.1016/j.devcel.2017.05.016. Epub 2017 Jun 15.

5.

Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis.

Li B, Ding S, Feng N, Mooney N, Ooi YS, Ren L, Diep J, Kelly MR, Yasukawa LL, Patton JT, Yamazaki H, Shirao T, Jackson PK, Greenberg HB.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3642-E3651. doi: 10.1073/pnas.1619266114. Epub 2017 Apr 17.

6.

Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex.

Ding S, Mooney N, Li B, Kelly MR, Feng N, Loktev AV, Sen A, Patton JT, Jackson PK, Greenberg HB.

PLoS Pathog. 2016 Oct 5;12(10):e1005929. doi: 10.1371/journal.ppat.1005929. eCollection 2016 Oct.

7.

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.

Boudreau A, Purkey HE, Hitz A, Robarge K, Peterson D, Labadie S, Kwong M, Hong R, Gao M, Del Nagro C, Pusapati R, Ma S, Salphati L, Pang J, Zhou A, Lai T, Li Y, Chen Z, Wei B, Yen I, Sideris S, McCleland M, Firestein R, Corson L, Vanderbilt A, Williams S, Daemen A, Belvin M, Eigenbrot C, Jackson PK, Malek S, Hatzivassiliou G, Sampath D, Evangelista M, O'Brien T.

Nat Chem Biol. 2016 Oct;12(10):779-86. doi: 10.1038/nchembio.2143. Epub 2016 Aug 1.

PMID:
27479743
8.

Corrigendum: The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery.

Toriyama M, Lee C, Taylor SP, Duran I, Cohn DH, Bruel AL, Tabler JM, Drew K, Kelly MR, Kim S, Park TJ, Braun DA, Pierquin G, Biver A, Wagner K, Malfroot A, Panigrahi I, Franco B, Al-Lami HA, Yeung Y, Choi YJ; University of Washington Center for Mendelian Genomics, Duffourd Y, Faivre L, Rivière JB, Chen J, Liu KJ, Marcotte EM, Hildebrandt F, Thauvin-Robinet C, Krakow D, Jackson PK, Wallingford JB.

Nat Genet. 2016 Jul 27;48(8):970. doi: 10.1038/ng0816-970b. No abstract available.

PMID:
27463398
9.

The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery.

Toriyama M, Lee C, Taylor SP, Duran I, Cohn DH, Bruel AL, Tabler JM, Drew K, Kelly MR, Kim S, Park TJ, Braun DA, Pierquin G, Biver A, Wagner K, Malfroot A, Panigrahi I, Franco B, Al-Lami HA, Yeung Y, Choi YJ; University of Washington Center for Mendelian Genomics, Duffourd Y, Faivre L, Rivière JB, Chen J, Liu KJ, Marcotte EM, Hildebrandt F, Thauvin-Robinet C, Krakow D, Jackson PK, Wallingford JB.

Nat Genet. 2016 Jun;48(6):648-56. doi: 10.1038/ng.3558. Epub 2016 May 9. Erratum in: Nat Genet. 2016 Jul 27;48(8):970.

10.

Cell biology: Calcium contradictions in cilia.

Norris DP, Jackson PK.

Nature. 2016 Mar 31;531(7596):582-3. doi: 10.1038/nature17313. Epub 2016 Mar 23. No abstract available.

PMID:
27007852
11.

Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.

Pal K, Hwang SH, Somatilaka B, Badgandi H, Jackson PK, DeFea K, Mukhopadhyay S.

J Cell Biol. 2016 Mar 28;212(7):861-75. doi: 10.1083/jcb.201506132. Epub 2016 Mar 21.

12.

p73 and FoxJ1: Programming Multiciliated Epithelia.

Jackson PK, Attardi LD.

Trends Cell Biol. 2016 Apr;26(4):239-240. doi: 10.1016/j.tcb.2016.03.001. Epub 2016 Mar 14.

13.

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling.

Hilgendorf KI, Johnson CT, Jackson PK.

Curr Opin Cell Biol. 2016 Apr;39:84-92. doi: 10.1016/j.ceb.2016.02.008. Epub 2016 Feb 27. Review.

14.

Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.

Gholkar AA, Senese S, Lo YC, Capri J, Deardorff WJ, Dharmarajan H, Contreras E, Hodara E, Whitelegge JP, Jackson PK, Torres JZ.

Cell Cycle. 2015;14(7):1116-25. doi: 10.4161/15384101.2014.985066.

15.

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.

Lu Q, Insinna C, Ott C, Stauffer J, Pintado PA, Rahajeng J, Baxa U, Walia V, Cuenca A, Hwang YS, Daar IO, Lopes S, Lippincott-Schwartz J, Jackson PK, Caplan S, Westlake CJ.

Nat Cell Biol. 2015 Apr;17(4):531. doi: 10.1038/ncb3155. No abstract available.

PMID:
25812525
16.

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.

Lu Q, Insinna C, Ott C, Stauffer J, Pintado PA, Rahajeng J, Baxa U, Walia V, Cuenca A, Hwang YS, Daar IO, Lopes S, Lippincott-Schwartz J, Jackson PK, Caplan S, Westlake CJ.

Nat Cell Biol. 2015 Mar;17(3):228-240. doi: 10.1038/ncb3109. Epub 2015 Feb 16. Erratum in: Nat Cell Biol. 2015 Apr;17(4):531.

17.

3D spheroid model of mIMCD3 cells for studying ciliopathies and renal epithelial disorders.

Giles RH, Ajzenberg H, Jackson PK.

Nat Protoc. 2014 Dec;9(12):2725-31. doi: 10.1038/nprot.2014.181. Epub 2014 Oct 30.

PMID:
25356583
18.

Regulating microtubules and genome stability via the CUL7/3M syndrome complex and CUL9.

Jackson PK.

Mol Cell. 2014 Jun 5;54(5):713-5. doi: 10.1016/j.molcel.2014.05.024.

19.

Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia.

Loktev AV, Jackson PK.

Cell Rep. 2013 Dec 12;5(5):1316-29. doi: 10.1016/j.celrep.2013.11.011. Epub 2013 Dec 5.

20.

Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death.

Del Nagro CJ, Choi J, Xiao Y, Rangell L, Mohan S, Pandita A, Zha J, Jackson PK, O'Brien T.

Cell Cycle. 2014;13(2):303-14. doi: 10.4161/cc.27055. Epub 2013 Feb 1.

21.

Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618.

Xiao Y, Elkins K, Durieux JK, Lee L, Oeh J, Yang LX, Liang X, DelNagro C, Tremayne J, Kwong M, Liederer BM, Jackson PK, Belmont LD, Sampath D, O'Brien T.

Neoplasia. 2013 Oct;15(10):1151-60.

22.

A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium.

Thomas S, Wright KJ, Le Corre S, Micalizzi A, Romani M, Abhyankar A, Saada J, Perrault I, Amiel J, Litzler J, Filhol E, Elkhartoufi N, Kwong M, Casanova JL, Boddaert N, Baehr W, Lyonnet S, Munnich A, Burglen L, Chassaing N, Encha-Ravazi F, Vekemans M, Gleeson JG, Valente EM, Jackson PK, Drummond IA, Saunier S, Attié-Bitach T.

Hum Mutat. 2014 Jan;35(1):137-46.

23.

Identification of preferred chemotherapeutics for combining with a CHK1 inhibitor.

Xiao Y, Ramiscal J, Kowanetz K, Del Nagro C, Malek S, Evangelista M, Blackwood E, Jackson PK, O'Brien T.

Mol Cancer Ther. 2013 Nov;12(11):2285-95. doi: 10.1158/1535-7163.MCT-13-0404. Epub 2013 Sep 13.

24.

Nek8 couples renal ciliopathies to DNA damage and checkpoint control.

Jackson PK.

Mol Cell. 2013 Aug 22;51(4):407-8. doi: 10.1016/j.molcel.2013.08.013.

25.

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.

Magnaghi P, D'Alessio R, Valsasina B, Avanzi N, Rizzi S, Asa D, Gasparri F, Cozzi L, Cucchi U, Orrenius C, Polucci P, Ballinari D, Perrera C, Leone A, Cervi G, Casale E, Xiao Y, Wong C, Anderson DJ, Galvani A, Donati D, O'Brien T, Jackson PK, Isacchi A.

Nat Chem Biol. 2013 Sep;9(9):548-56. doi: 10.1038/nchembio.1313. Epub 2013 Jul 28.

PMID:
23892893
26.

Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900.

Blackwood E, Epler J, Yen I, Flagella M, O'Brien T, Evangelista M, Schmidt S, Xiao Y, Choi J, Kowanetz K, Ramiscal J, Wong K, Jakubiak D, Yee S, Cain G, Gazzard L, Williams K, Halladay J, Jackson PK, Malek S.

Mol Cancer Ther. 2013 Oct;12(10):1968-80. doi: 10.1158/1535-7163.MCT-12-1218. Epub 2013 Jul 19.

27.

Cilia - the prodigal organelle.

Beales P, Jackson PK.

Cilia. 2012 Apr 25;1(1):1. doi: 10.1186/2046-2530-1-1. No abstract available.

28.

Cilia develop long-lasting contacts, with other cilia.

Jackson PK.

Cilia. 2012 May 4;1(1):5. doi: 10.1186/2046-2530-1-5. No abstract available.

29.

Cilia, tubby mice, and obesity.

Mukhopadhyay S, Jackson PK.

Cilia. 2013 Jan 3;2:1. doi: 10.1186/2046-2530-2-1. eCollection 2013.

30.

The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.

Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, Jackson PK.

Cell. 2013 Jan 17;152(1-2):210-23. doi: 10.1016/j.cell.2012.12.026.

31.

A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3.

Lahtela J, Corson LB, Hemmes A, Brauer MJ, Koopal S, Lee J, Hunsaker TL, Jackson PK, Verschuren EW.

Cell Cycle. 2013 Feb 15;12(4):625-34. doi: 10.4161/cc.23515. Epub 2013 Jan 16.

32.

Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships.

Polucci P, Magnaghi P, Angiolini M, Asa D, Avanzi N, Badari A, Bertrand J, Casale E, Cauteruccio S, Cirla A, Cozzi L, Galvani A, Jackson PK, Liu Y, Magnuson S, Malgesini B, Nuvoloni S, Orrenius C, Sirtori FR, Riceputi L, Rizzi S, Trucchi B, O'Brien T, Isacchi A, Donati D, D'Alessio R.

J Med Chem. 2013 Jan 24;56(2):437-50. doi: 10.1021/jm3013213. Epub 2013 Jan 4.

PMID:
23245311
33.

TTBK2 kinase: linking primary cilia and cerebellar ataxias.

Jackson PK.

Cell. 2012 Nov 9;151(4):697-699. doi: 10.1016/j.cell.2012.10.027.

34.

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.

Maurer T, Garrenton LS, Oh A, Pitts K, Anderson DJ, Skelton NJ, Fauber BP, Pan B, Malek S, Stokoe D, Ludlam MJ, Bowman KK, Wu J, Giannetti AM, Starovasnik MA, Mellman I, Jackson PK, Rudolph J, Wang W, Fang G.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5299-304. doi: 10.1073/pnas.1116510109. Epub 2012 Mar 19.

35.

The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly.

Torres JZ, Summers MK, Peterson D, Brauer MJ, Lee J, Senese S, Gholkar AA, Lo YC, Lei X, Jung K, Anderson DC, Davis DP, Belmont L, Jackson PK.

Cell. 2011 Dec 9;147(6):1309-23. doi: 10.1016/j.cell.2011.11.020.

36.

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.

Wright KJ, Baye LM, Olivier-Mason A, Mukhopadhyay S, Sang L, Kwong M, Wang W, Pretorius PR, Sheffield VC, Sengupta P, Slusarski DC, Jackson PK.

Genes Dev. 2011 Nov 15;25(22):2347-60. doi: 10.1101/gad.173443.111.

37.

Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics.

Anderson DJ, Durieux JK, Song K, Alvarado R, Jackson PK, Hatzivassiliou G, Ludlam MJ.

PLoS One. 2011;6(8):e22607. doi: 10.1371/journal.pone.0022607. Epub 2011 Aug 4.

38.

The tubby family proteins.

Mukhopadhyay S, Jackson PK.

Genome Biol. 2011 Jun 28;12(6):225. doi: 10.1186/gb-2011-12-6-225. Review.

39.

Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.

Huang X, Summers MK, Pham V, Lill JR, Liu J, Lee G, Kirkpatrick DS, Jackson PK, Fang G, Dixit VM.

Mol Cell. 2011 May 20;42(4):511-23. doi: 10.1016/j.molcel.2011.03.027.

40.

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, Otto EA, Baye LM, Wen X, Scales SJ, Kwong M, Huntzicker EG, Sfakianos MK, Sandoval W, Bazan JF, Kulkarni P, Garcia-Gonzalo FR, Seol AD, O'Toole JF, Held S, Reutter HM, Lane WS, Rafiq MA, Noor A, Ansar M, Devi AR, Sheffield VC, Slusarski DC, Vincent JB, Doherty DA, Hildebrandt F, Reiter JF, Jackson PK.

Cell. 2011 May 13;145(4):513-28. doi: 10.1016/j.cell.2011.04.019.

41.

Do cilia put brakes on the cell cycle?

Jackson PK.

Nat Cell Biol. 2011 Apr;13(4):340-2. doi: 10.1038/ncb0411-340.

PMID:
21460803
42.

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

Wertz IE, Kusam S, Lam C, Okamoto T, Sandoval W, Anderson DJ, Helgason E, Ernst JA, Eby M, Liu J, Belmont LD, Kaminker JS, O'Rourke KM, Pujara K, Kohli PB, Johnson AR, Chiu ML, Lill JR, Jackson PK, Fairbrother WJ, Seshagiri S, Ludlam MJ, Leong KG, Dueber EC, Maecker H, Huang DC, Dixit VM.

Nature. 2011 Mar 3;471(7336):110-4. doi: 10.1038/nature09779. Erratum in: Nature. 2011 Jul 7;475(7354):122.

PMID:
21368834
43.

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.

Westlake CJ, Baye LM, Nachury MV, Wright KJ, Ervin KE, Phu L, Chalouni C, Beck JS, Kirkpatrick DS, Slusarski DC, Sheffield VC, Scheller RH, Jackson PK.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2759-64. doi: 10.1073/pnas.1018823108. Epub 2011 Jan 27.

44.

A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation.

Chu CW, Hou F, Zhang J, Phu L, Loktev AV, Kirkpatrick DS, Jackson PK, Zhao Y, Zou H.

Mol Biol Cell. 2011 Feb 15;22(4):448-56. doi: 10.1091/mbc.E10-03-0203. Epub 2010 Dec 22.

45.

APC/C(Cdc20) targets E2F1 for degradation in prometaphase.

Peart MJ, Poyurovsky MV, Kass EM, Urist M, Verschuren EW, Summers MK, Jackson PK, Prives C.

Cell Cycle. 2010 Oct 1;9(19):3956-64. Epub 2010 Oct 26.

46.

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.

Mukhopadhyay S, Wen X, Chih B, Nelson CD, Lane WS, Scales SJ, Jackson PK.

Genes Dev. 2010 Oct 1;24(19):2180-93. doi: 10.1101/gad.1966210.

47.

Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy.

Otto EA, Hurd TW, Airik R, Chaki M, Zhou W, Stoetzel C, Patil SB, Levy S, Ghosh AK, Murga-Zamalloa CA, van Reeuwijk J, Letteboer SJ, Sang L, Giles RH, Liu Q, Coene KL, Estrada-Cuzcano A, Collin RW, McLaughlin HM, Held S, Kasanuki JM, Ramaswami G, Conte J, Lopez I, Washburn J, Macdonald J, Hu J, Yamashita Y, Maher ER, Guay-Woodford LM, Neumann HP, Obermüller N, Koenekoop RK, Bergmann C, Bei X, Lewis RA, Katsanis N, Lopes V, Williams DS, Lyons RH, Dang CV, Brito DA, Dias MB, Zhang X, Cavalcoli JD, Nürnberg G, Nürnberg P, Pierce EA, Jackson PK, Antignac C, Saunier S, Roepman R, Dollfus H, Khanna H, Hildebrandt F.

Nat Genet. 2010 Oct;42(10):840-50. doi: 10.1038/ng.662. Epub 2010 Sep 12.

48.

A chemosensitization screen identifies TP53RK, a kinase that restrains apoptosis after mitotic stress.

Peterson D, Lee J, Lei XC, Forrest WF, Davis DP, Jackson PK, Belmont LD.

Cancer Res. 2010 Aug 1;70(15):6325-35. doi: 10.1158/0008-5472.CAN-10-0015. Epub 2010 Jul 20.

49.

Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.

O'Toole JF, Liu Y, Davis EE, Westlake CJ, Attanasio M, Otto EA, Seelow D, Nurnberg G, Becker C, Nuutinen M, Kärppä M, Ignatius J, Uusimaa J, Pakanen S, Jaakkola E, van den Heuvel LP, Fehrenbach H, Wiggins R, Goyal M, Zhou W, Wolf MT, Wise E, Helou J, Allen SJ, Murga-Zamalloa CA, Ashraf S, Chaki M, Heeringa S, Chernin G, Hoskins BE, Chaib H, Gleeson J, Kusakabe T, Suzuki T, Isaac RE, Quarmby LM, Tennant B, Fujioka H, Tuominen H, Hassinen I, Lohi H, van Houten JL, Rotig A, Sayer JA, Rolinski B, Freisinger P, Madhavan SM, Herzer M, Madignier F, Prokisch H, Nurnberg P, Jackson PK, Khanna H, Katsanis N, Hildebrandt F.

J Clin Invest. 2010 Mar;120(3):791-802. doi: 10.1172/JCI40076. Epub 2010 Feb 22. Erratum in: J Clin Invest. 2010 Apr;120(4):1362. Jackson, Peter [corrected to Jackson, Peter K].

50.

A specific form of phospho protein phosphatase 2 regulates anaphase-promoting complex/cyclosome association with spindle poles.

Torres JZ, Ban KH, Jackson PK.

Mol Biol Cell. 2010 Mar 15;21(6):897-904. doi: 10.1091/mbc.E09-07-0598. Epub 2010 Jan 20.

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