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Biallelic variants in EFEMP1 in a man with a pronounced connective tissue phenotype.

Driver SGW, Jackson MR, Richter K, Tomlinson P, Brockway B, Halliday BJ, Markie DM, Robertson SP, Wade EM.

Eur J Hum Genet. 2019 Dec 2. doi: 10.1038/s41431-019-0546-7. [Epub ahead of print]


Mesothelioma Cells Depend on the Antiapoptotic Protein Bcl-xL for Survival and Are Sensitized to Ionizing Radiation by BH3-Mimetics.

Jackson MR, Ashton M, Koessinger AL, Dick C, Verheij M, Chalmers AJ.

Int J Radiat Oncol Biol Phys. 2020 Mar 15;106(4):867-877. doi: 10.1016/j.ijrobp.2019.11.029. Epub 2019 Nov 28.


Radiation Responses of 2D and 3D Glioblastoma Cells: A Novel, 3D-specific Radioprotective Role of VEGF/Akt Signaling through Functional Activation of NHEJ.

Gomez-Roman N, Chong MY, Chahal SK, Caragher SP, Jackson MR, Stevenson KH, Dongre SA, Chalmers AJ.

Mol Cancer Ther. 2020 Feb;19(2):575-589. doi: 10.1158/1535-7163.MCT-18-1320. Epub 2019 Oct 31.


Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading.

Gilbert HTJ, Mallikarjun V, Dobre O, Jackson MR, Pedley R, Gilmore AP, Richardson SM, Swift J.

Nat Commun. 2019 Sep 12;10(1):4149. doi: 10.1038/s41467-019-11923-1.


Heterozygous loss of function of IQSEC2/Iqsec2 leads to increased activated Arf6 and severe neurocognitive seizure phenotype in females.

Jackson MR, Loring KE, Homan CC, Thai MH, Määttänen L, Arvio M, Jarvela I, Shaw M, Gardner A, Gecz J, Shoubridge C.

Life Sci Alliance. 2019 Aug 22;2(4). pii: e201900386. doi: 10.26508/lsa.201900386. Print 2019 Aug.


Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.

Pinkerton AB, Peddibhotla S, Yamamoto F, Slosky LM, Bai Y, Maloney P, Hershberger P, Hedrick MP, Falter B, Ardecky RJ, Smith LH, Chung TDY, Jackson MR, Caron MG, Barak LS.

J Med Chem. 2019 Sep 12;62(17):8357-8363. doi: 10.1021/acs.jmedchem.9b00340. Epub 2019 Aug 20.


Radiolabeled Oligonucleotides Targeting the RNA Subunit of Telomerase Inhibit Telomerase and Induce DNA Damage in Telomerase-Positive Cancer Cells.

Jackson MR, Bavelaar BM, Waghorn PA, Gill MR, El-Sagheer AH, Brown T, Tarsounas M, Vallis KA.

Cancer Res. 2019 Sep 15;79(18):4627-4637. doi: 10.1158/0008-5472.CAN-18-3594. Epub 2019 Jul 16.


X-Ray Structure of Human Sulfide:Quinone Oxidoreductase: Insights into the Mechanism of Mitochondrial Hydrogen Sulfide Oxidation.

Jackson MR, Loll PJ, Jorns MS.

Structure. 2019 May 7;27(5):794-805.e4. doi: 10.1016/j.str.2019.03.002. Epub 2019 Mar 21.


Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells.

Feng Y, Sessions EH, Zhang F, Ban F, Placencio-Hickok V, Ma CT, Zeng FY, Pass I, Terry DB, Cadwell G, Bankston LA, Liddington RC, Chung TDY, Pinkerton AB, Sergienko E, Gleave M, Bhowmick NA, Jackson MR, Cherkasov A, Ronai ZA.

Cancer Lett. 2019 May 1;449:145-162. doi: 10.1016/j.canlet.2019.02.012. Epub 2019 Feb 14.


Fecal coliform concentrations in effluent from ultraviolet disinfection units installed in onsite wastewater treatment systems.

Jackson MR, Meschke JS, Simmons J, Isaksen TB.

J Water Health. 2019 Feb;17(1):113-123. doi: 10.2166/wh.2018.256.


Delayed development of ossification centers in the tibia of prenatal and early postnatal MPS VII mice.

Jiang Z, Derrick-Roberts ALK, Jackson MR, Rossouw C, Pyragius CE, Xian C, Fletcher J, Byers S.

Mol Genet Metab. 2018 Jun;124(2):135-142. doi: 10.1016/j.ymgme.2018.04.014. Epub 2018 May 3.


Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.

Pinkerton AB, Sergienko E, Bravo Y, Dahl R, Ma CT, Sun Q, Jackson MR, Cosford NDP, Millán JL.

Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34. doi: 10.1016/j.bmcl.2017.11.024. Epub 2017 Nov 11.


Substrate Deprivation Therapy to Reduce Glycosaminoglycan Synthesis Improves Aspects of Neurological and Skeletal Pathology in MPS I Mice.

Derrick-Roberts ALK, Jackson MR, Pyragius CE, Byers S.

Diseases. 2017 Feb 23;5(1). pii: E5. doi: 10.3390/diseases5010005.


Actions of the Biceps Brachii at the Shoulder: A Review.

Landin D, Thompson M, Jackson MR.

J Clin Med Res. 2017 Aug;9(8):667-670. doi: 10.14740/jocmr2901w. Epub 2017 Jul 1. Review.


Extensive phenotyping of two ARX polyalanine expansion mutation mouse models that span clinical spectrum of intellectual disability and epilepsy.

Jackson MR, Lee K, Mattiske T, Jaehne EJ, Ozturk E, Baune BT, O'Brien TJ, Jones N, Shoubridge C.

Neurobiol Dis. 2017 Sep;105:245-256. doi: 10.1016/j.nbd.2017.05.012. Epub 2017 Jun 8.


Unified clinical science, or paradigm diversity? Comment on Melchert (2016).

Jackson MR.

Am Psychol. 2017 May-Jun;72(4):395-396. doi: 10.1037/amp0000125.


Incorrect dosage of IQSEC2, a known intellectual disability and epilepsy gene, disrupts dendritic spine morphogenesis.

Hinze SJ, Jackson MR, Lie S, Jolly L, Field M, Barry SC, Harvey RJ, Shoubridge C.

Transl Psychiatry. 2017 May 2;7(5):e1110. doi: 10.1038/tp.2017.81.


Gonadal mosaicism of a novel IQSEC2 variant causing female limited intellectual disability and epilepsy.

Ewans LJ, Field M, Zhu Y, Turner G, Leffler M, Dinger ME, Cowley MJ, Buckley MF, Scheffer IE, Jackson MR, Roscioli T, Shoubridge C.

Eur J Hum Genet. 2017 Jun;25(6):763-767. doi: 10.1038/ejhg.2017.29. Epub 2017 Mar 15.


Use of Tissue Metabolite Analysis and Enzyme Kinetics To Discriminate between Alternate Pathways for Hydrogen Sulfide Metabolism.

Augustyn KD, Jackson MR, Jorns MS.

Biochemistry. 2017 Feb 21;56(7):986-996. doi: 10.1021/acs.biochem.6b01093. Epub 2017 Feb 7.


Targeting telomerase with radiolabeled inhibitors.

Waghorn PA, Jackson MR, Gouverneur V, Vallis KA.

Eur J Med Chem. 2017 Jan 5;125:117-129. doi: 10.1016/j.ejmech.2016.09.028. Epub 2016 Sep 10.


Roles of Cross-Membrane Transport and Signaling in the Maintenance of Cellular Homeostasis.

Cho I, Jackson MR, Swift J.

Cell Mol Bioeng. 2016;9:234-246. Epub 2016 Apr 28.


Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1.

Rong J, Pass I, Diaz PW, Ngo TA, Sauer M, Magnuson G, Zeng FY, Hassig CA, Jackson MR, Cosford ND, Matsuzawa S, Reed JC.

J Biomol Screen. 2015 Dec;20(10):1232-45. doi: 10.1177/1087057115600414. Epub 2015 Aug 11.


Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.

Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, Palmer M, Shamji AF, Wawer MJ, McManus O, Wu M, Zou B, Yu H, Golden JE, Schoenen FJ, Simeonov A, Jadhav A, Jackson MR, Pinkerton AB, Chung TD, Griffin PR, Cravatt BF, Hodder PS, Roush WR, Roberts E, Chung DH, Jonsson CB, Noah JW, Severson WE, Ananthan S, Edwards B, Oprea TI, Conn PJ, Hopkins CR, Wood MR, Stauffer SR, Emmitte KA; NIH Molecular Libraries Project Team.

Cell. 2015 Jun 4;161(6):1252-65. doi: 10.1016/j.cell.2015.05.023. Review.


Small Molecules Targeting the Mitochondrial Permeability Transition.

Sileikyte J, Roy S, Porubsky P, Neuenswander B, Wang J, Hedrick M, Pinkerton AB, Salaniwal S, Kung P, Mangravita-Novo A, Smith LH, Bourdette DN, Jackson MR, Aubé J, Chung TDY, Schoenen FJ, Forte MA, Bernardi P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2014 Apr 15 [updated 2015 Jan 16].


Functional Antagonists of EBI-2.

Ardecky R, Sergienko E, Zou J, Ganji S, Brown B, Sun Q, Ma CT, Hood B, Nguyen K, Vasile S, Suyama E, Mangravita-Novo A, Salaniwal S, Kung P, Smith LH, Chung TDY, Jackson MR, Pinkerton AB, Rickert R.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2014 Apr 15 [updated 2015 Jan 16].


Role of human sulfide: quinone oxidoreductase in H2S metabolism.

Jackson MR, Melideo SL, Jorns MS.

Methods Enzymol. 2015;554:255-70. doi: 10.1016/bs.mie.2014.11.037. Epub 2015 Jan 10.


Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification.

Sheen CR, Kuss P, Narisawa S, Yadav MC, Nigro J, Wang W, Chhea TN, Sergienko EA, Kapoor K, Jackson MR, Hoylaerts MF, Pinkerton AB, O'Neill WC, Millán JL.

J Bone Miner Res. 2015 May;30(5):824-36. doi: 10.1002/jbmr.2420.


Engaging African American Faith-Based Organizations in Adolescent HIV Prevention.

Woods-Jaeger BA, Carlson M, Taggart T, Riggins L, Lightfoot AF, Jackson MR.

J Relig Health. 2015 Aug;54(4):1358-74. doi: 10.1007/s10943-014-9932-1.


Lentiviral-mediated gene therapy results in sustained expression of β-glucuronidase for up to 12 months in the gus(mps/mps) and up to 18 months in the gus(tm(L175F)Sly) mouse models of mucopolysaccharidosis type VII.

Derrick-Roberts AL, Pyragius CE, Kaidonis XM, Jackson MR, Anson DS, Byers S.

Hum Gene Ther. 2014 Sep;25(9):798-810. doi: 10.1089/hum.2013.141. Epub 2014 Aug 14.


Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast ortholog.

Melideo SL, Jackson MR, Jorns MS.

Biochemistry. 2014 Jul 22;53(28):4739-53. doi: 10.1021/bi500650h. Epub 2014 Jul 10.


Where is the faith? Using a CBPR approach to propose adaptations to an evidence-based HIV prevention intervention for adolescents in African American faith settings.

Lightfoot AF, Taggart T, Woods-Jaeger BA, Riggins L, Jackson MR, Eng E.

J Relig Health. 2014 Aug;53(4):1223-35. doi: 10.1007/s10943-014-9846-y.


Engaging underserved populations in Affordable Care Act-required needs assessments.

Lightfoot AF, De Marco MM, Dendas RC, Jackson MR, Meehan EF.

J Health Care Poor Underserved. 2014 Feb;25(1 Suppl):11-8. doi: 10.1353/hpu.2014.0060.


Advances in anticancer radiopharmaceuticals.

Jackson MR, Falzone N, Vallis KA.

Clin Oncol (R Coll Radiol). 2013 Oct;25(10):604-9. doi: 10.1016/j.clon.2013.06.004. Epub 2013 Jul 17. Review.


Chemical probe development versus drug development.

Jackson MR.

Methods Mol Biol. 2013;1053:1-6. doi: 10.1007/978-1-62703-562-0_1.


In vivo microdialysis sampling of cytokines from rat hippocampus: comparison of cannula implantation procedures.

Vasicek TW, Jackson MR, Poseno TM, Stenken JA.

ACS Chem Neurosci. 2013 May 15;4(5):737-46. doi: 10.1021/cn400025m. Epub 2013 Apr 2.


Crystallization, optimization and preliminary X-ray characterization of a metal-dependent PI-PLC from Streptomyces antibioticus.

Jackson MR, Selby TL.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1378-86. doi: 10.1107/S1744309112041371. Epub 2012 Oct 30.


Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite.

Jackson MR, Melideo SL, Jorns MS.

Biochemistry. 2012 Aug 28;51(34):6804-15. Epub 2012 Aug 20.


An αß T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science. 1996. 274: 209-219.

Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA.

J Immunol. 2010 Dec 1;185(11):6402-12. No abstract available.


Mechanotransduction by endothelial cells is locally generated, direction-dependent, and ligand-specific.

Chrétien ML, Zhang M, Jackson MR, Kapus A, Langille BL.

J Cell Physiol. 2010 Aug;224(2):352-61. doi: 10.1002/jcp.22125.


Interrogation: hard for psychologists to act as whistleblowers.

Jackson MR.

Nature. 2009 Jun 25;459(7250):1052. doi: 10.1038/4591052a. No abstract available.


Commentary: Everett BM, et al. Prevalence of heparin/platelet factor 4 antibodies before and after cardiac surgery. Ann Thorac Surg. 2007;83:592-597.

Jackson MR.

Perspect Vasc Surg Endovasc Ther. 2008 Mar;20(1):102-3. doi: 10.1177/1531003507310836. No abstract available.


Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.

Krahn JM, Jackson MR, DeRose EF, Howell EE, London RE.

Biochemistry. 2007 Dec 25;46(51):14878-88. Epub 2007 Dec 4.


Attitudes of respiratory therapists and nurses about measures to prevent ventilator-associated pneumonia: a multicenter, cross-sectional survey study.

Kaynar AM, Mathew JJ, Hudlin MM, Gingras DJ, Ritz RH, Jackson MR, Kacmarek RM, Kollef MH.

Respir Care. 2007 Dec;52(12):1687-94.


Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice.

Joo JH, Lee YJ, Munguba GC, Park S, Taxter TJ, Elsagga MY, Jackson MR, Oh SP, Sugrue SP.

Dev Dyn. 2007 Aug;236(8):2147-58.


A preference for edgewise interactions between aromatic rings and carboxylate anions: the biological relevance of anion-quadrupole interactions.

Jackson MR, Beahm R, Duvvuru S, Narasimhan C, Wu J, Wang HN, Philip VM, Hinde RJ, Howell EE.

J Phys Chem B. 2007 Jul 19;111(28):8242-9. Epub 2007 Jun 20.


Shear stress regulates forward and reverse planar cell polarity of vascular endothelium in vivo and in vitro.

McCue S, Dajnowiec D, Xu F, Zhang M, Jackson MR, Langille BL.

Circ Res. 2006 Apr 14;98(7):939-46. Epub 2006 Mar 9.


Delayed-onset heparin-induced thrombocytopenia and thrombosis after intraoperative heparin anticoagulation-four case reports.

Jackson MR, Neilson WJ, Lary M, Baay P, Web K, Clagett GP.

Vasc Endovascular Surg. 2006 Jan-Feb;40(1):67-70.


Postoperative outcomes according to preoperative medical and functional status after infrainguinal revascularization for critical limb ischemia in patients 80 years and older.

Taylor SM, Kalbaugh CA, Blackhurst DW, Langan EM 3rd, Cull DL, Snyder BA, Carsten CG 3rd, Jackson MR, York JW, Youkey JR.

Am Surg. 2005 Aug;71(8):640-5; discussion 645-6.


Preoperative clinical factors predict postoperative functional outcomes after major lower limb amputation: an analysis of 553 consecutive patients.

Taylor SM, Kalbaugh CA, Blackhurst DW, Hamontree SE, Cull DL, Messich HS, Robertson RT, Langan EM 3rd, York JW, Carsten CG 3rd, Snyder BA, Jackson MR, Youkey JR.

J Vasc Surg. 2005 Aug;42(2):227-35.


Reduction of Pnn by RNAi induces loss of cell-cell adhesion between human corneal epithelial cells.

Joo JH, Alpatov R, Munguba GC, Jackson MR, Hunt ME, Sugrue SP.

Mol Vis. 2005 Feb 18;11:133-42.

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