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Proposed Therapies for Pantothenate-Kinase-Associated Neurodegeneration.

Jackowski S.

J Exp Neurosci. 2019 May 23;13:1179069519851118. doi: 10.1177/1179069519851118. eCollection 2019.


Human pantothenate kinase 4 is a pseudo-pantothenate kinase.

Yao J, Subramanian C, Rock CO, Jackowski S.

Protein Sci. 2019 Jun;28(6):1031-1047. doi: 10.1002/pro.3611. Epub 2019 Apr 17.


A therapeutic approach to pantothenate kinase associated neurodegeneration.

Sharma LK, Subramanian C, Yun MK, Frank MW, White SW, Rock CO, Lee RE, Jackowski S.

Nat Commun. 2018 Oct 23;9(1):4399. doi: 10.1038/s41467-018-06703-2.


Adolescent Trajectories of Aerobic Fitness and Adiposity as Markers of Cardiometabolic Risk in Adulthood.

Jackowski SA, Eisenmann JC, Sherar LB, Bailey DA, Baxter-Jones ADG.

J Obes. 2017;2017:6471938. doi: 10.1155/2017/6471938. Epub 2017 Nov 27.


Structural Strength Benefits Observed at the Hip of Premenarcheal Gymnasts Are Maintained Into Young Adulthood 10 Years After Retirement From the Sport.

Erlandson MC, Runalls SB, Jackowski SA, Faulkner RA, Baxter-Jones ADG.

Pediatr Exerc Sci. 2017 Nov 1;29(4):476-485. doi: 10.1123/pes.2017-0039. Epub 2017 Oct 11.


Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2.

Corbin DR, Rehg JE, Shepherd DL, Stoilov P, Percifield RJ, Horner L, Frase S, Zhang YM, Rock CO, Hollander JM, Jackowski S, Leonardi R.

Mol Genet Metab. 2017 Apr;120(4):350-362. doi: 10.1016/j.ymgme.2017.02.001. Epub 2017 Feb 3.


T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions.

Van de Velde LA, Subramanian C, Smith AM, Barron L, Qualls JE, Neale G, Alfonso-Pecchio A, Jackowski S, Rock CO, Wynn TA, Murray PJ.

J Biol Chem. 2017 Jan 6;292(1):15-30. doi: 10.1074/jbc.M116.766238. Epub 2016 Nov 30.


Allosteric Regulation of Mammalian Pantothenate Kinase.

Subramanian C, Yun MK, Yao J, Sharma LK, Lee RE, White SW, Jackowski S, Rock CO.

J Biol Chem. 2016 Oct 14;291(42):22302-22314. Epub 2016 Aug 23.


Oxidation levels of North American over-the-counter n-3 (omega-3) supplements and the influence of supplement formulation and delivery form on evaluating oxidative safety.

Jackowski SA, Alvi AZ, Mirajkar A, Imani Z, Gamalevych Y, Shaikh NA, Jackowski G.

J Nutr Sci. 2015 Nov 4;4:e30. doi: 10.1017/jns.2015.21. eCollection 2015.


Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy.

Zano SP, Pate C, Frank M, Rock CO, Jackowski S.

Mol Genet Metab. 2015 Dec;116(4):281-8. doi: 10.1016/j.ymgme.2015.10.011. Epub 2015 Oct 29.


The associations of exposure to combined hormonal contraceptive use on bone mineral content and areal bone mineral density accrual from adolescence to young adulthood: A longitudinal study.

Jackowski SA, Baxter-Jones ADG, McLardy AJ, Pierson RA, Rodgers CD.

Bone Rep. 2015 Jun 12;5:e333-e341. doi: 10.1016/j.bonr.2015.06.001. eCollection 2016 Dec.


Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice.

Shumar SA, Fagone P, Alfonso-Pecchio A, Gray JT, Rehg JE, Jackowski S, Leonardi R.

PLoS One. 2015 Jun 8;10(6):e0130013. doi: 10.1371/journal.pone.0130013. eCollection 2015.


The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

Selathurai A, Kowalski GM, Burch ML, Sepulveda P, Risis S, Lee-Young RS, Lamon S, Meikle PJ, Genders AJ, McGee SL, Watt MJ, Russell AP, Frank M, Jackowski S, Febbraio MA, Bruce CR.

Cell Metab. 2015 May 5;21(5):718-30. doi: 10.1016/j.cmet.2015.04.001.


A longitudinal study of bone area, content, density, and strength development at the radius and tibia in children 4-12 years of age exposed to recreational gymnastics.

Jackowski SA, Baxter-Jones AD, Gruodyte-Raciene R, Kontulainen SA, Erlandson MC.

Osteoporos Int. 2015 Jun;26(6):1677-90. doi: 10.1007/s00198-015-3041-1. Epub 2015 Mar 5.


A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.

Sharma LK, Leonardi R, Lin W, Boyd VA, Goktug A, Shelat AA, Chen T, Jackowski S, Rock CO.

J Med Chem. 2015 Feb 12;58(3):1563-8. doi: 10.1021/jm501585q. Epub 2015 Jan 21.


Deregulated coenzyme A, loss of metabolic flexibility and diabetes.

Jackowski S, Leonardi R.

Biochem Soc Trans. 2014 Aug;42(4):1118-22. doi: 10.1042/BST20140156. Review.


Physiological roles of the pantothenate kinases.

Dansie LE, Reeves S, Miller K, Zano SP, Frank M, Pate C, Wang J, Jackowski S.

Biochem Soc Trans. 2014 Aug;42(4):1033-6. doi: 10.1042/BST20140096. Review.


Coenzyme A and its derivatives: renaissance of a textbook classic.

Theodoulou FL, Sibon OC, Jackowski S, Gout I.

Biochem Soc Trans. 2014 Aug;42(4):1025-32. doi: 10.1042/BST20140176. Review.


Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance.

Leonardi R, Rock CO, Jackowski S.

Diabetologia. 2014 Jul;57(7):1466-75. doi: 10.1007/s00125-014-3245-5. Epub 2014 Apr 30.


Does lean tissue mass accrual during adolescence influence bone structural strength at the proximal femur in young adulthood?

Jackowski SA, Lanovaz JL, Van Oort C, Baxter-Jones AD.

Osteoporos Int. 2014 Apr;25(4):1297-304. doi: 10.1007/s00198-013-2592-2. Epub 2013 Dec 11.


Tracking of aerobic fitness from adolescence to mid-adulthood.

Van Oort C, Jackowski SA, Eisenmann JC, Sherar LB, Bailey DA, Mirwald R, Baxter-Jones AD.

Ann Hum Biol. 2013 Nov-Dec;40(6):547-53. doi: 10.3109/03014460.2013.817606. Epub 2013 Jul 26.


Adolescent physical activity and bone strength at the proximal femur in adulthood.

Jackowski SA, Kontulainen SA, Cooper DM, Lanovaz JL, Beck TJ, Baxter-Jones AD.

Med Sci Sports Exerc. 2014 Apr;46(4):736-44. doi: 10.1249/MSS.0000000000000154.


Structural strength development at the proximal femur in 4- to 10-year-old precompetitive gymnasts: a 4-year longitudinal hip structural analysis study.

Gruodyte-Raciene R, Erlandson MC, Jackowski SA, Baxter-Jones AD.

J Bone Miner Res. 2013 Dec;28(12):2592-600. doi: 10.1002/jbmr.1986.


Influence of nutrition provision during the first two weeks of life in premature infants on adolescent body composition and blood pressure.

Ludwig-Auser H, Sherar LB, Erlandson MC, Baxter-Jones AD, Jackowski SA, Arnold C, Sankaran K.

Zhongguo Dang Dai Er Ke Za Zhi. 2013 Mar;15(3):161-70.


Preface: phospholipids and phospholipid metabolism.

Jackowski S, Rock CO.

Biochim Biophys Acta. 2013 Mar;1831(3):469-70. doi: 10.1016/j.bbalip.2013.01.001. No abstract available.


Compartmentalization of mammalian pantothenate kinases.

Alfonso-Pecchio A, Garcia M, Leonardi R, Jackowski S.

PLoS One. 2012;7(11):e49509. doi: 10.1371/journal.pone.0049509. Epub 2012 Nov 13.


Phosphatidylcholine and the CDP-choline cycle.

Fagone P, Jackowski S.

Biochim Biophys Acta. 2013 Mar;1831(3):523-32. doi: 10.1016/j.bbalip.2012.09.009. Epub 2012 Sep 23. Review.


Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism.

Garcia M, Leonardi R, Zhang YM, Rehg JE, Jackowski S.

PLoS One. 2012;7(7):e40871. doi: 10.1371/journal.pone.0040871. Epub 2012 Jul 17.


The specialized unfolded protein response of B lymphocytes: ATF6α-independent development of antibody-secreting B cells.

Aragon IV, Barrington RA, Jackowski S, Mori K, Brewer JW.

Mol Immunol. 2012 Jul;51(3-4):347-55. doi: 10.1016/j.molimm.2012.04.001. Epub 2012 May 1.


Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation.

Leonardi R, Subramanian C, Jackowski S, Rock CO.

J Biol Chem. 2012 Apr 27;287(18):14615-20. doi: 10.1074/jbc.C112.353946. Epub 2012 Mar 22.


UPR-Mediated Membrane Biogenesis in B Cells.

Brewer JW, Jackowski S.

Biochem Res Int. 2012;2012:738471. doi: 10.1155/2012/738471. Epub 2011 Nov 1.


Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration.

Siudeja K, Srinivasan B, Xu L, Rana A, de Jong J, Nollen EA, Jackowski S, Sanford L, Hayflick S, Sibon OC.

EMBO Mol Med. 2011 Dec;3(12):755-66. doi: 10.1002/emmm.201100180. Epub 2011 Oct 14.


Maturational timing does not predict HSA estimated adult bone geometry at the proximal femur.

Jackowski SA, Kontulainen SA, Cooper DM, Lanovaz JL, Baxter-Jones AD.

Bone. 2011 Dec;49(6):1270-8. doi: 10.1016/j.bone.2011.08.030. Epub 2011 Sep 5.


The timing of BMD and geometric adaptation at the proximal femur from childhood to early adulthood in males and females: a longitudinal study.

Jackowski SA, Kontulainen SA, Cooper DM, Lanovaz JL, Baxter-Jones AD.

J Bone Miner Res. 2011 Nov;26(11):2753-61. doi: 10.1002/jbmr.468.


The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis.

Zhang K, Wang S, Malhotra J, Hassler JR, Back SH, Wang G, Chang L, Xu W, Miao H, Leonardi R, Chen YE, Jackowski S, Kaufman RJ.

EMBO J. 2011 Apr 6;30(7):1357-75. doi: 10.1038/emboj.2011.52. Epub 2011 Mar 15.


Effect of maturational timing on bone mineral content accrual from childhood to adulthood: evidence from 15 years of longitudinal data.

Jackowski SA, Erlandson MC, Mirwald RL, Faulkner RA, Bailey DA, Kontulainen SA, Cooper DM, Baxter-Jones AD.

Bone. 2011 May 1;48(5):1178-85. doi: 10.1016/j.bone.2011.02.010. Epub 2011 Feb 19.


Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.

Leonardi R, Zhang YM, Yun MK, Zhou R, Zeng FY, Lin W, Cui J, Chen T, Rock CO, White SW, Jackowski S.

Chem Biol. 2010 Aug 27;17(8):892-902. doi: 10.1016/j.chembiol.2010.06.006.


Preterm birth and adolescent bone mineral content.

Erlandson MC, Sherar LB, Baxter-Jones AD, Jackowski SA, Ludwig-Auser H, Arnold C, Sankaran K.

Am J Perinatol. 2011 Feb;28(2):157-63. doi: 10.1055/s-0030-1263299. Epub 2010 Aug 6.


Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state.

Leonardi R, Rehg JE, Rock CO, Jackowski S.

PLoS One. 2010 Jun 14;5(6):e11107. doi: 10.1371/journal.pone.0011107.


Phosphatidylcholine biosynthesis during neuronal differentiation and its role in cell fate determination.

Marcucci H, Paoletti L, Jackowski S, Banchio C.

J Biol Chem. 2010 Aug 13;285(33):25382-93. doi: 10.1074/jbc.M110.139477. Epub 2010 Jun 5.


Pantothenate kinase from the thermoacidophilic archaeon Picrophilus torridus.

Takagi M, Tamaki H, Miyamoto Y, Leonardi R, Hanada S, Jackowski S, Chohnan S.

J Bacteriol. 2010 Jan;192(1):233-41. doi: 10.1128/JB.01021-09.


Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis.

Leonardi R, Frank MW, Jackson PD, Rock CO, Jackowski S.

J Biol Chem. 2009 Oct 2;284(40):27077-89. doi: 10.1074/jbc.M109.031336. Epub 2009 Aug 7.


ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum.

Bommiasamy H, Back SH, Fagone P, Lee K, Meshinchi S, Vink E, Sriburi R, Frank M, Jackowski S, Kaufman RJ, Brewer JW.

J Cell Sci. 2009 May 15;122(Pt 10):1626-36. doi: 10.1242/jcs.045625.


Peak lean tissue mass accrual precedes changes in bone strength indices at the proximal femur during the pubertal growth spurt.

Jackowski SA, Faulkner RA, Farthing JP, Kontulainen SA, Beck TJ, Baxter-Jones AD.

Bone. 2009 Jun;44(6):1186-90. doi: 10.1016/j.bone.2009.02.008. Epub 2009 Feb 21.


CTP:phosphocholine cytidylyltransferase alpha is required for B-cell proliferation and class switch recombination.

Fagone P, Gunter C, Sage CR, Gunn KE, Brewer JW, Jackowski S.

J Biol Chem. 2009 Mar 13;284(11):6847-54. doi: 10.1074/jbc.M807338200. Epub 2009 Jan 12.


Membrane phospholipid synthesis and endoplasmic reticulum function.

Fagone P, Jackowski S.

J Lipid Res. 2009 Apr;50 Suppl:S311-6. doi: 10.1194/jlr.R800049-JLR200. Epub 2008 Oct 23. Review.


Cytokine secretion requires phosphatidylcholine synthesis.

Tian Y, Pate C, Andreolotti A, Wang L, Tuomanen E, Boyd K, Claro E, Jackowski S.

J Cell Biol. 2008 Jun 16;181(6):945-57. doi: 10.1083/jcb.200706152.


Localization and regulation of mouse pantothenate kinase 2.

Leonardi R, Zhang YM, Lykidis A, Rock CO, Jackowski S.

FEBS Lett. 2007 Oct 2;581(24):4639-44. Epub 2007 Sep 7.


Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.

Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW.

J Biol Chem. 2007 Sep 21;282(38):27984-93. Epub 2007 Jul 13.


Radiogenic lymphangiogenesis in the skin.

Jackowski S, Janusch M, Fiedler E, Marsch WC, Ulbrich EJ, Gaisbauer G, Dunst J, Kerjaschki D, Helmbold P.

Am J Pathol. 2007 Jul;171(1):338-48.

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