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Eur J Nutr. 2018 Jun 5. doi: 10.1007/s00394-018-1738-6. [Epub ahead of print]

Interesterified palm olein lowers postprandial glucose-dependent insulinotropic polypeptide response in type 2 diabetes.

Author information

1
Product Development and Advisory Services, Malaysian Palm Oil Board, Kajang, Selangor, Malaysia.
2
Department of Bioprocess Engineering, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM Serdang, Serdang, Selangor, Malaysia.
3
Institute of Bioscience, Universiti Putra Malaysia, UPM Serdang, Serdang, Selangor, Malaysia.
4
Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Serdang, Selangor, Malaysia.
5
Sepang District Health Office, Selangor State Health Department, Sepang, Selangor, Malaysia.
6
Hulu Langat District Health Office, Selangor State Health Department, Kajang, Selangor, Malaysia.
7
Non-communicable Diseases Unit, Selangor State Health Department, Shah Alam, Selangor, Malaysia.
8
Product Development and Advisory Services, Malaysian Palm Oil Board, Kajang, Selangor, Malaysia. kt.teng@gmail.com.

Abstract

PURPOSE:

We aim to investigate the postprandial effects of palm olein (PO) and chemically interesterified palm olein (IPO) with different proportions of palmitic acid at the sn-2 position using high oleic sunflower oil (HOS) as control fat on concentrations of gut hormones, glucose homeostasis, satiety, lipid and inflammatory parameters in type 2 diabetic (T2D) subjects.

METHODS:

Using a randomised double-blind crossover design, 21 (men = 6, women = 15) T2D subjects consumed test meals (3.65 MJ) consisting of a high fat muffin (containing 50 g test fats provided as PO, IPO or HOS) and a milkshake. Postprandial changes in gut hormones, glucose homeostasis, satiety, lipid and inflammatory parameters after meals were analysed. Some of the solid fractions of the IPO were removed and thus the fatty acid composition of the PO and IPO was not entirely equal (PO vs IPO: palmitate 39.8 vs 38.7; oleate 43.6 vs 45.1). PO, IPO and HOS contained 9.7, 38.9 and 0.2 g/100 g total fatty acids of palmitic acid at the sn-2 position, respectively. At 37 °C, IPO contained 4.2% SFC whereas PO and HOS were completely melted.

RESULTS:

Our novel observation shows that the incremental area under curve (iAUC) 0-6 h of plasma GIP concentration was on average 16% lower following IPO meal compared with PO and HOS (P < 0.05) meals. Serum C-peptide concentrations exhibited a significant meal × gender interaction (P = 0.009). No differences between test meals were noted for other measurements.

CONCLUSIONS:

This study shows no adverse effect of interesterification on hormones associated with glucose homeostasis notably GLP-1 in T2D subjects.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01906359. https://clinicaltrials.gov/ct2/show/NCT01906359.

KEYWORDS:

Glucose metabolism; Glucose-dependent insulinotropic polypeptide; Gut hormones; Interesterified palm olein; Type 2 diabetes

PMID:
29872922
DOI:
10.1007/s00394-018-1738-6

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