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Items: 47

1.

Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice.

Jabara HH, Lee JJ, Janssen E, Ullas S, Liadaki K, Garibyan L, Benson H, Sannikova T, Bram R, Hammarstrom L, Cruz AC, Siegel R, Manis J, Malley R, Geha RS.

J Allergy Clin Immunol. 2017 Apr;139(4):1293-1301.e4. doi: 10.1016/j.jaci.2016.07.028. Epub 2016 Sep 5.

2.

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.

Jabara HH, Boyden SE, Chou J, Ramesh N, Massaad MJ, Benson H, Bainter W, Fraulino D, Rahimov F, Sieff C, Liu ZJ, Alshemmari SH, Al-Ramadi BK, Al-Dhekri H, Arnaout R, Abu-Shukair M, Vatsayan A, Silver E, Ahuja S, Davies EG, Sola-Visner M, Ohsumi TK, Andrews NC, Notarangelo LD, Fleming MD, Al-Herz W, Kunkel LM, Geha RS.

Nat Genet. 2016 Jan;48(1):74-8. doi: 10.1038/ng.3465. Epub 2015 Dec 7.

3.

Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-α 2b therapy.

Keles S, Jabara HH, Reisli I, McDonald DR, Barlan I, Hanna-Wakim R, Dbaibo G, Lefranc G, Al-Herz W, Geha RS, Chatila TA.

J Allergy Clin Immunol. 2014 Jun;133(6):1753-5.e3. doi: 10.1016/j.jaci.2014.03.032. Epub 2014 Apr 24. No abstract available.

4.

Successful interferon-alpha 2b therapy for unremitting warts in a patient with DOCK8 deficiency.

Al-Zahrani D, Raddadi A, Massaad M, Keles S, Jabara HH, Chatila TA, Geha R.

Clin Immunol. 2014 Jul;153(1):104-108. doi: 10.1016/j.clim.2014.04.005. Epub 2014 Apr 15.

5.

Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency.

Pai SY, de Boer H, Massaad MJ, Chatila TA, Keles S, Jabara HH, Janssen E, Lehmann LE, Hanna-Wakim R, Dbaibo G, McDonald DR, Al-Herz W, Geha RS.

J Allergy Clin Immunol. 2014 Jul;134(1):221-3. doi: 10.1016/j.jaci.2014.02.023. Epub 2014 Apr 1. No abstract available.

PMID:
24698323
6.

TRIF signaling is essential for TLR4-driven IgE class switching.

Janssen E, Ozcan E, Liadaki K, Jabara HH, Manis J, Ullas S, Akira S, Fitzgerald KA, Golenbock DT, Geha RS.

J Immunol. 2014 Mar 15;192(6):2651-8. doi: 10.4049/jimmunol.1300909. Epub 2014 Feb 14.

7.

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.

Jabara HH, Ohsumi T, Chou J, Massaad MJ, Benson H, Megarbane A, Chouery E, Mikhael R, Gorka O, Gewies A, Portales P, Nakayama T, Hosokawa H, Revy P, Herrod H, Le Deist F, Lefranc G, Ruland J, Geha RS.

J Allergy Clin Immunol. 2013 Jul;132(1):151-8. doi: 10.1016/j.jaci.2013.04.047. Epub 2013 May 31. Erratum in: J Allergy Clin Immunol. 2013 Sep;132(3):773. J Allergy Clin Immunol. 2013 Sep;132(3):773.

8.

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.

Jabara HH, McDonald DR, Janssen E, Massaad MJ, Ramesh N, Borzutzky A, Rauter I, Benson H, Schneider L, Baxi S, Recher M, Notarangelo LD, Wakim R, Dbaibo G, Dasouki M, Al-Herz W, Barlan I, Baris S, Kutukculer N, Ochs HD, Plebani A, Kanariou M, Lefranc G, Reisli I, Fitzgerald KA, Golenbock D, Manis J, Keles S, Ceja R, Chatila TA, Geha RS.

Nat Immunol. 2012 May 13;13(6):612-20. doi: 10.1038/ni.2305.

9.

Functional analysis of transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) mutations associated with common variable immunodeficiency.

Fried AJ, Rauter I, Dillon SR, Jabara HH, Geha RS.

J Allergy Clin Immunol. 2011 Jul;128(1):226-228.e1. doi: 10.1016/j.jaci.2011.01.048. Epub 2011 Mar 21. No abstract available.

10.

Ligation of CD46 to CD40 inhibits CD40 signaling in B cells.

Jabara HH, Angelini F, Brodeur SR, Geha RS.

Int Immunol. 2011 Mar;23(3):215-21. doi: 10.1093/intimm/dxq474.

11.

The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency.

Lee JJ, Jabara HH, Garibyan L, Rauter I, Sannikova T, Dillon SR, Bram R, Geha RS.

J Allergy Clin Immunol. 2010 Dec;126(6):1234-41.e2. doi: 10.1016/j.jaci.2010.08.017.

12.

TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.

Jabara HH, Weng Y, Sannikova T, Geha RS.

Int Immunol. 2009 Apr;21(4):477-88. doi: 10.1093/intimm/dxp013. Epub 2009 Feb 19.

13.

Analysis of in vitro lymphocyte proliferation as a screening tool for cellular immunodeficiency.

Stone KD, Feldman HA, Huisman C, Howlett C, Jabara HH, Bonilla FA.

Clin Immunol. 2009 Apr;131(1):41-9. doi: 10.1016/j.clim.2008.11.003. Epub 2009 Jan 1.

PMID:
19121607
14.

Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency.

Pai SY, Levy O, Jabara HH, Glickman JN, Stoler-Barak L, Sachs J, Nurko S, Orange JS, Geha RS.

J Allergy Clin Immunol. 2008 Dec;122(6):1113-1118.e1. doi: 10.1016/j.jaci.2008.08.026. Epub 2008 Oct 11.

15.

B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE.

Jabara HH, Chaudhuri J, Dutt S, Dedeoglu F, Weng Y, Murphy MM, Franco S, Alt FW, Manis J, Geha RS.

J Allergy Clin Immunol. 2008 Jan;121(1):191-196.e2. Epub 2007 Sep 27.

PMID:
17900678
16.

Jun N-terminal kinase is essential for CD40-mediated IgE class switching in B cells.

Jabara HH, Geha RS.

J Allergy Clin Immunol. 2005 Apr;115(4):856-63.

PMID:
15806010
17.

The regulation of immunoglobulin E class-switch recombination.

Geha RS, Jabara HH, Brodeur SR.

Nat Rev Immunol. 2003 Sep;3(9):721-32. Review.

PMID:
12949496
18.
19.

Role of JAK3 in CD40-mediated signaling.

Jabara HH, Buckley RH, Roberts JL, Lefranc G, Loiselet J, Khalil G, Geha RS.

Blood. 1998 Oct 1;92(7):2435-40.

20.
21.
22.

Interleukin-4 receptor expression by human B cells: functional analysis with a human interleukin-4 toxin, DAB389IL-4.

Jabara HH, Vercelli D, Schneider LC, Williams DP, Genbauffe FS, Poisson LR, Waters CA, Geha RS.

J Allergy Clin Immunol. 1995 Apr;95(4):893-900.

PMID:
7722171
23.
24.

Role of protein tyrosine kinases in CD40/interleukin-4-mediated isotype switching to IgE.

Loh RK, Jabara HH, Ren CL, Fu SM, Geha RS.

J Allergy Clin Immunol. 1994 Oct;94(4):784-92.

PMID:
7523475
25.
26.

Engagement of CD14 on monocytes inhibits the synthesis of human Igs, including IgE.

Jabara HH, Vercelli D.

J Immunol. 1994 Aug 1;153(3):972-8.

PMID:
7517978
27.

Sequential switching from mu to epsilon via gamma 4 in human B cells stimulated with IL-4 and hydrocortisone.

Jabara HH, Loh R, Ramesh N, Vercelli D, Geha RS.

J Immunol. 1993 Nov 1;151(9):4528-33.

PMID:
8409416
28.
29.

Deletional switch recombination occurs in interleukin-4-induced isotype switching to IgE expression by human B cells.

Shapira SK, Jabara HH, Thienes CP, Ahern DJ, Vercelli D, Gould HJ, Geha RS.

Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7528-32.

30.

Hydrocortisone and IL-4 induce IgE isotype switching in human B cells.

Jabara HH, Ahern DJ, Vercelli D, Geha RS.

J Immunol. 1991 Sep 1;147(5):1557-60.

PMID:
1715363
32.

Induction of germ-line and mature C epsilon transcripts in human B cells stimulated with rIL-4 and EBV.

Jabara HH, Schneider LC, Shapira SK, Alfieri C, Moody CT, Kieff E, Geha RS, Vercelli D.

J Immunol. 1990 Nov 15;145(10):3468-73.

PMID:
2172384
33.

Regulation of immunoglobulin (Ig)E synthesis in the hyper-IgE syndrome.

Vercelli D, Jabara HH, Cunningham-Rundles C, Abrams JS, Lewis DB, Meyer J, Schneider LC, Leung DY, Geha RS.

J Clin Invest. 1990 May;85(5):1666-71.

34.

IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures.

Vercelli D, Jabara HH, Lauener RP, Geha RS.

J Immunol. 1990 Jan 15;144(2):570-3.

PMID:
2136895
35.

Endogenous interleukin 6 plays an obligatory role in interleukin 4-dependent human IgE synthesis.

Vercelli D, Jabara HH, Arai K, Yokota T, Geha RS.

Eur J Immunol. 1989 Aug;19(8):1419-24.

PMID:
2789139
37.

Regulation of human IgE synthesis.

Vercelli D, Jabara HH, Geha RS.

Int Rev Immunol. 1989;5(2):111-5. Review.

PMID:
8691043
38.

Interleukin 4 dependent induction of IgE synthesis and CD23 expression by the supernatants of a human helper T cell clone.

Vercelli D, Leung DY, Jabara HH, Geha RS.

Int Arch Allergy Appl Immunol. 1989;88(1-2):119-21.

PMID:
2523353
39.

Induction of interleukin-4-dependent IgE synthesis and interleukin-5-dependent eosinophil differentiation by supernatants of a human helper T-cell clone.

Jabara HH, Ackerman SJ, Vercelli D, Yokota T, Arai K, Abrams J, Dvorak AM, Lavigne MC, Banchereau J, De Vries J, et al.

J Clin Immunol. 1988 Nov;8(6):437-46.

PMID:
2975669
40.

Functional heterogeneity among human inducer T cell clones.

Umetsu DT, Jabara HH, DeKruyff RH, Abbas AK, Abrams JS, Geha RS.

J Immunol. 1988 Jun 15;140(12):4211-6.

PMID:
2967331
41.
42.

Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes.

Vercelli D, Jabara HH, Lee BW, Woodland N, Geha RS, Leung DY.

J Exp Med. 1988 Apr 1;167(4):1406-16.

43.

Requirements for activation of human peripheral blood T cells by mouse monoclonal antibodies to CD3.

Umetsu DT, Katzen D, Chatila T, Miller R, Jabara HH, Maher M, Oettgen H, Terhorst C, Geha RS.

Clin Immunol Immunopathol. 1987 Apr;43(1):48-64.

PMID:
3103959
44.

Antigen presentation by human dermal fibroblasts: activation of resting T lymphocytes.

Umetsu DT, Katzen D, Jabara HH, Geha RS.

J Immunol. 1986 Jan;136(2):440-5.

PMID:
3484491
45.
46.

Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones.

Umetsu DT, Pober JS, Jabara HH, Fiers W, Yunis EJ, Burakoff SJ, Reiss CS, Geha RS.

J Clin Invest. 1985 Jul;76(1):254-60.

47.

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