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Items: 1 to 50 of 90

1.

Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction.

Zhang FP, Malinen M, Mehmood A, Lehtiniemi T, Jääskeläinen T, Niskanen EA, Korhonen H, Laiho A, Elo LL, Ohlsson C, Kotaja N, Poutanen M, Sipilä P, Palvimo JJ.

Nat Commun. 2019 Feb 15;10(1):777. doi: 10.1038/s41467-019-08730-z.

2.

Dampness and mold hypersensitivity syndrome and vaccination as risk factors for chronic fatigue syndrome.

Tuuminen T, Jääskeläinen T, Vaali K, Polo O.

Autoimmun Rev. 2019 Jan;18(1):107-108. doi: 10.1016/j.autrev.2018.08.004. Epub 2018 Nov 5. No abstract available.

PMID:
30408578
3.

A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants.

Jääskeläinen T, Kärkkäinen O, Jokkala J, Litonius K, Heinonen S, Auriola S, Lehtonen M, Hanhineva K, Laivuori H; FINNPEC.

Sci Rep. 2018 Oct 2;8(1):14616. doi: 10.1038/s41598-018-32804-5.

4.

Impact of obesity on angiogenic and inflammatory markers in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort.

Jääskeläinen T, Heinonen S, Hämäläinen E, Pulkki K, Romppanen J, Laivuori H; FINNPEC.

Int J Obes (Lond). 2019 May;43(5):1070-1081. doi: 10.1038/s41366-018-0217-8. Epub 2018 Sep 25.

PMID:
30254363
5.

Airway obstruction, serum vitamin D and mortality in a 33-year follow-up study.

Mattila T, Vasankari T, Rissanen H, Knekt P, Sares-Jäske L, Jääskeläinen T, Heliövaara M.

Eur J Clin Nutr. 2019 Jul;73(7):1024-1032. doi: 10.1038/s41430-018-0299-3. Epub 2018 Sep 13.

PMID:
30214033
6.

Angiogenic profile in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort.

Jääskeläinen T, Heinonen S, Hämäläinen E, Pulkki K, Romppanen J, Laivuori H; FINNPEC.

Pregnancy Hypertens. 2018 Oct;14:252-259. doi: 10.1016/j.preghy.2018.03.004. Epub 2018 Mar 10.

PMID:
29803331
7.

Reasons for non-participation and ways to enhance participation in health examination surveys-the Health 2011 Survey.

Tolonen H, Lundqvist A, Jääskeläinen T, Koskinen S, Koponen P.

Eur J Public Health. 2017 Oct 1;27(5):909-911. doi: 10.1093/eurpub/ckx098.

PMID:
28957480
8.

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

McGinnis R, Steinthorsdottir V, Williams NO, Thorleifsson G, Shooter S, Hjartardottir S, Bumpstead S, Stefansdottir L, Hildyard L, Sigurdsson JK, Kemp JP, Silva GB, Thomsen LCV, Jääskeläinen T, Kajantie E, Chappell S, Kalsheker N, Moffett A, Hiby S, Lee WK, Padmanabhan S, Simpson NAB, Dolby VA, Staines-Urias E, Engel SM, Haugan A, Trogstad L, Svyatova G, Zakhidova N, Najmutdinova D; FINNPEC Consortium; GOPEC Consortium, Dominiczak AF, Gjessing HK, Casas JP, Dudbridge F, Walker JJ, Pipkin FB, Thorsteinsdottir U, Geirsson RT, Lawlor DA, Iversen AC, Magnus P, Laivuori H, Stefansson K, Morgan L.

Nat Genet. 2017 Aug;49(8):1255-1260. doi: 10.1038/ng.3895. Epub 2017 Jun 19.

9.

Angiogenic profile and smoking in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort.

Jääskeläinen T, Suomalainen-König S, Hämäläinen E, Pulkki K, Romppanen J, Heinonen S, Laivuori H; FINNPEC.

Ann Med. 2017 Nov;49(7):593-602. doi: 10.1080/07853890.2017.1335427. Epub 2017 Jun 9.

PMID:
28537456
10.

The positive impact of general vitamin D food fortification policy on vitamin D status in a representative adult Finnish population: evidence from an 11-y follow-up based on standardized 25-hydroxyvitamin D data.

Jääskeläinen T, Itkonen ST, Lundqvist A, Erkkola M, Koskela T, Lakkala K, Dowling KG, Hull GL, Kröger H, Karppinen J, Kyllönen E, Härkänen T, Cashman KD, Männistö S, Lamberg-Allardt C.

Am J Clin Nutr. 2017 Jun;105(6):1512-1520. doi: 10.3945/ajcn.116.151415. Epub 2017 May 10.

PMID:
28490516
11.

ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss.

Anttonen AK, Laari A, Kousi M, Yang YJ, Jääskeläinen T, Somer M, Siintola E, Jakkula E, Muona M, Tegelberg S, Lönnqvist T, Pihko H, Valanne L, Paetau A, Lun MP, Hästbacka J, Kopra O, Joensuu T, Katsanis N, Lehtinen MK, Palvimo JJ, Lehesjoki AE.

Brain. 2017 May 1;140(5):1267-1279. doi: 10.1093/brain/awx040.

PMID:
28335020
12.

Cohort profile: the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC).

Jääskeläinen T, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Laivuori H; FINNPEC Study Group.

BMJ Open. 2016 Nov 10;6(11):e013148. doi: 10.1136/bmjopen-2016-013148.

13.

Effects of Scheduled Waiting for Psychotherapy in Patients With Major Depression.

Ahola P, Joensuu M, Knekt P, Lindfors O, Saarinen P, Tolmunen T, Valkonen-Korhonen M, Jääskeläinen T, Virtala E, Tiihonen J, Lehtonen J.

J Nerv Ment Dis. 2017 Aug;205(8):611-617. doi: 10.1097/NMD.0000000000000616.

PMID:
27861459
14.

FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.

Livingstone KM, Celis-Morales C, Papandonatos GD, Erar B, Florez JC, Jablonski KA, Razquin C, Marti A, Heianza Y, Huang T, Sacks FM, Svendstrup M, Sui X, Church TS, Jääskeläinen T, Lindström J, Tuomilehto J, Uusitupa M, Rankinen T, Saris WH, Hansen T, Pedersen O, Astrup A, Sørensen TI, Qi L, Bray GA, Martinez-Gonzalez MA, Martinez JA, Franks PW, McCaffery JM, Lara J, Mathers JC.

BMJ. 2016 Sep 20;354:i4707. doi: 10.1136/bmj.i4707. Review. Erratum in: BMJ. 2017 Jan 17;356:j263.

15.

Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene.

Känsäkoski J, Jääskeläinen J, Jääskeläinen T, Tommiska J, Saarinen L, Lehtonen R, Hautaniemi S, Frilander MJ, Palvimo JJ, Toppari J, Raivio T.

Sci Rep. 2016 Sep 9;6:32819. doi: 10.1038/srep32819.

16.

Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human α/β-hydrolase domain containing 11 (ABHD11).

Navia-Paldanius D, Patel JZ, López Navarro M, Jakupović H, Goffart S, Pasonen-Seppänen S, Nevalainen TJ, Jääskeläinen T, Laitinen T, Laitinen JT, Savinainen JR.

Eur J Pharm Sci. 2016 Oct 10;93:253-63. doi: 10.1016/j.ejps.2016.08.031. Epub 2016 Aug 17.

PMID:
27544863
17.

The diagnosis of pre-eclampsia using two revised classifications in the Finnish Pre-eclampsia Consortium (FINNPEC) cohort.

Kallela J, Jääskeläinen T, Kortelainen E, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Laivuori H.

BMC Pregnancy Childbirth. 2016 Aug 12;16:221. doi: 10.1186/s12884-016-1010-0.

18.

Dietary carbohydrate quantity and quality in relation to obesity: A pooled analysis of three Finnish population-based studies.

Kaartinen NE, Knekt P, Kanerva N, Valsta LM, Eriksson JG, Rissanen H, Jääskeläinen T, Männistö S.

Scand J Public Health. 2016 Jun;44(4):385-93. doi: 10.1177/1403494815622860. Epub 2016 Jan 19.

PMID:
26787554
19.

Baseline symptom severity predicts serotonin transporter change during psychotherapy in patients with major depression.

Joensuu M, Ahola P, Knekt P, Lindfors O, Saarinen P, Tolmunen T, Valkonen-Korhonen M, Vanninen R, Jääskeläinen T, Virtala E, Kuikka J, Tiihonen J, Lehtonen J.

Psychiatry Clin Neurosci. 2016 Jan;70(1):34-41. doi: 10.1111/pcn.12335. Epub 2015 Sep 22.

20.

Androgen receptor- and PIAS1-regulated gene programs in molecular apocrine breast cancer cells.

Malinen M, Toropainen S, Jääskeläinen T, Sahu B, Jänne OA, Palvimo JJ.

Mol Cell Endocrinol. 2015 Oct 15;414:91-8. doi: 10.1016/j.mce.2015.07.024. Epub 2015 Jul 26.

PMID:
26219822
21.

Higher serum 25-hydroxyvitamin D concentrations are related to a reduced risk of depression.

Jääskeläinen T, Knekt P, Suvisaari J, Männistö S, Partonen T, Sääksjärvi K, Kaartinen NE, Kanerva N, Lindfors O.

Br J Nutr. 2015 May 14;113(9):1418-26. doi: 10.1017/S0007114515000689.

PMID:
25989997
22.

Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.

Zimmermann E, Ängquist LH, Mirza SS, Zhao JH, Chasman DI, Fischer K, Qi Q, Smith AV, Thinggaard M, Jarczok MN, Nalls MA, Trompet S, Timpson NJ, Schmidt B, Jackson AU, Lyytikäinen LP, Verweij N, Mueller-Nurasyid M, Vikström M, Marques-Vidal P, Wong A, Meidtner K, Middelberg RP, Strawbridge RJ, Christiansen L; FTO-Mortality Collaborating Group, Kyvik KO, Hamsten A, Jääskeläinen T, Tjønneland A, Eriksson JG, Whitfield JB, Boeing H, Hardy R, Vollenweider P, Leander K, Peters A, van der Harst P, Kumari M, Lehtimäki T, Meirhaeghe A, Tuomilehto J, Jöckel KH, Ben-Shlomo Y, Sattar N, Baumeister SE, Smith GD, Casas JP, Houston DK, März W, Christensen K, Gudnason V, Hu FB, Metspalu A, Ridker PM, Wareham NJ, Loos RJF, Tiemeier H, Sonestedt E, Sørensen TIA.

Obes Rev. 2015 Apr;16(4):327-340. doi: 10.1111/obr.12263. Epub 2015 Mar 5.

23.

Synthesis and biological evaluation of second-generation tropanol-based androgen receptor modulators.

Sundén H, Holland MC, Poutiainen PK, Jääskeläinen T, Pulkkinen JT, Palvimo JJ, Olsson R.

J Med Chem. 2015 Feb 12;58(3):1569-74. doi: 10.1021/jm501995n. Epub 2015 Feb 3.

PMID:
25646649
24.

SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin.

Toropainen S, Malinen M, Kaikkonen S, Rytinki M, Jääskeläinen T, Sahu B, Jänne OA, Palvimo JJ.

Nucleic Acids Res. 2015 Jan;43(2):848-61. doi: 10.1093/nar/gku1375. Epub 2014 Dec 30.

25.

FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals.

Qi Q, Kilpeläinen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY, Renström F, Lin X, Ängquist LH, Huang J, Liu Z, Li Y, Asif Ali M, Xu M, Ahluwalia TS, Boer JM, Chen P, Daimon M, Eriksson J, Perola M, Friedlander Y, Gao YT, Heppe DH, Holloway JW, Houston DK, Kanoni S, Kim YM, Laaksonen MA, Jääskeläinen T, Lee NR, Lehtimäki T, Lemaitre RN, Lu W, Luben RN, Manichaikul A, Männistö S, Marques-Vidal P, Monda KL, Ngwa JS, Perusse L, van Rooij FJ, Xiang YB, Wen W, Wojczynski MK, Zhu J, Borecki IB, Bouchard C, Cai Q, Cooper C, Dedoussis GV, Deloukas P, Ferrucci L, Forouhi NG, Hansen T, Christiansen L, Hofman A, Johansson I, Jørgensen T, Karasawa S, Khaw KT, Kim MK, Kristiansson K, Li H, Lin X, Liu Y, Lohman KK, Long J, Mikkilä V, Mozaffarian D, North K, Pedersen O, Raitakari O, Rissanen H, Tuomilehto J, van der Schouw YT, Uitterlinden AG, Zillikens MC, Franco OH, Shyong Tai E, Ou Shu X, Siscovick DS, Toft U, Verschuren WM, Vollenweider P, Wareham NJ, Witteman JC, Zheng W, Ridker PM, Kang JH, Liang L, Jensen MK, Curhan GC, Pasquale LR, Hunter DJ, Mohlke KL, Uusitupa M, Cupples LA, Rankinen T, Orho-Melander M, Wang T, Chasman DI, Franks PW, Sørensen TI, Hu FB, Loos RJ, Nettleton JA, Qi L.

Hum Mol Genet. 2014 Dec 20;23(25):6961-72. doi: 10.1093/hmg/ddu411. Epub 2014 Aug 7.

26.

Serum 25-hydroxyvitamin D and the risk of knee and hip osteoarthritis leading to hospitalization: a cohort study of 5274 Finns.

Konstari S, Kaila-Kangas L, Jääskeläinen T, Heliövaara M, Rissanen H, Marniemi J, Knekt P, Arokoski J, Karppinen J.

Rheumatology (Oxford). 2014 Oct;53(10):1778-82. doi: 10.1093/rheumatology/keu178. Epub 2014 May 9.

PMID:
24817700
27.

Reduced risk of Parkinson's disease associated with lower body mass index and heavy leisure-time physical activity.

Sääksjärvi K, Knekt P, Männistö S, Lyytinen J, Jääskeläinen T, Kanerva N, Heliövaara M.

Eur J Epidemiol. 2014 Apr;29(4):285-92. doi: 10.1007/s10654-014-9887-2. Epub 2014 Mar 16.

PMID:
24633681
28.

Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet).

Lankinen M, Kolehmainen M, Jääskeläinen T, Paananen J, Joukamo L, Kangas AJ, Soininen P, Poutanen K, Mykkänen H, Gylling H, Orešič M, Jauhiainen M, Ala-Korpela M, Uusitupa M, Schwab U.

PLoS One. 2014 Feb 28;9(2):e90352. doi: 10.1371/journal.pone.0090352. eCollection 2014.

29.

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator.

Poutiainen PK, Huhtala T, Jääskeläinen T, Petsalo A, Küblbeck J, Kaikkonen S, Palvimo JJ, Raunio H, Närvänen A, Peräkylä M, Juvonen RO, Honkakoski P, Laatikainen R, Pulkkinen JT.

Mol Cell Endocrinol. 2014 Apr 25;387(1-2):8-18. doi: 10.1016/j.mce.2014.02.008. Epub 2014 Feb 22.

PMID:
24565895
30.

Serum androgen bioactivity is low in children with premature adrenarche.

Liimatta J, Laakso S, Utriainen P, Voutilainen R, Palvimo JJ, Jääskeläinen T, Jääskeläinen J.

Pediatr Res. 2014 May;75(5):645-50. doi: 10.1038/pr.2014.21. Epub 2014 Feb 12.

PMID:
24522103
31.

Social support as a predictor of the outcome of depressive and anxiety disorder in short-term and long-term psychotherapy.

Lindfors O, Ojanen S, Jääskeläinen T, Knekt P.

Psychiatry Res. 2014 Apr 30;216(1):44-51. doi: 10.1016/j.psychres.2013.12.050. Epub 2014 Jan 9.

PMID:
24508367
32.

Genetic risk score does not predict the outcome of obesity surgery.

Käkelä P, Jääskeläinen T, Torpström J, Ilves I, Venesmaa S, Pääkkönen M, Gylling H, Paajanen H, Uusitupa M, Pihlajamäki J.

Obes Surg. 2014 Jan;24(1):128-33. doi: 10.1007/s11695-013-1080-2.

PMID:
24065439
33.

Therapists' professional and personal characteristics as predictors of outcome in long-term psychodynamic psychotherapy and psychoanalysis.

Heinonen E, Knekt P, Jääskeläinen T, Lindfors O.

Eur Psychiatry. 2014 Jun;29(5):265-74. doi: 10.1016/j.eurpsy.2013.07.002. Epub 2013 Sep 21.

PMID:
24060629
34.

Therapists' professional and personal characteristics as predictors of working alliance in short-term and long-term psychotherapies.

Heinonen E, Lindfors O, Härkänen T, Virtala E, Jääskeläinen T, Knekt P.

Clin Psychol Psychother. 2014 Nov-Dec;21(6):475-94. doi: 10.1002/cpp.1852. Epub 2013 Jun 28.

PMID:
23813617
35.

Genetic predisposition to obesity and lifestyle factors--the combined analyses of twenty-six known BMI- and fourteen known waist:hip ratio (WHR)-associated variants in the Finnish Diabetes Prevention Study.

Jääskeläinen T, Paananen J, Lindström J, Eriksson JG, Tuomilehto J, Uusitupa M; Finnish Diabetes Prevention Study Group.

Br J Nutr. 2013 Nov;110(10):1856-65. doi: 10.1017/S0007114513001116. Epub 2013 May 14.

PMID:
23668671
36.

Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors.

Malinen M, Jääskeläinen T, Pelkonen M, Heikkinen S, Väisänen S, Kosma VM, Nieminen K, Mannermaa A, Palvimo JJ.

Mol Cell Endocrinol. 2013 Jan 30;365(2):270-6. doi: 10.1016/j.mce.2012.10.028. Epub 2012 Nov 6.

PMID:
23142699
37.

FoxA1 corrupts the antiandrogenic effect of bicalutamide but only weakly attenuates the effect of MDV3100 (Enzalutamide™).

Belikov S, Öberg C, Jääskeläinen T, Rahkama V, Palvimo JJ, Wrange Ö.

Mol Cell Endocrinol. 2013 Jan 5;365(1):95-107. doi: 10.1016/j.mce.2012.10.002. Epub 2012 Oct 11.

PMID:
23063623
38.

Adrenocortical hormonal activity in 20-year-old subjects born small or appropriate for gestational age.

Todorova B, Salonen M, Jääskeläinen J, Tapio A, Jääskeläinen T, Palvimo J, Turpeinen U, Hämäläinen E, Räsänen M, Tenhola S, Voutilainen R.

Horm Res Paediatr. 2012;77(5):298-304. doi: 10.1159/000338344. Epub 2012 May 31.

PMID:
22652900
39.

Vitamin D status is associated with sociodemographic factors, lifestyle and metabolic health.

Jääskeläinen T, Knekt P, Marniemi J, Sares-Jäske L, Männistö S, Heliövaara M, Järvinen R.

Eur J Nutr. 2013 Mar;52(2):513-25. doi: 10.1007/s00394-012-0354-0. Epub 2012 Apr 27.

PMID:
22538929
40.

Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.

Jääskeläinen T, Makkonen H, Visakorpi T, Kim J, Roeder RG, Palvimo JJ.

Mol Cell Endocrinol. 2012 Mar 5;350(1):87-98. doi: 10.1016/j.mce.2011.11.025. Epub 2011 Dec 2.

PMID:
22155569
41.

Analysis of androgen receptor activity by reporter gene assays.

Makkonen H, Jääskeläinen T, Rytinki MM, Palvimo JJ.

Methods Mol Biol. 2011;776:71-80. doi: 10.1007/978-1-61779-243-4_5.

PMID:
21796521
42.

Interleukins 1α and 1β as regulators of steroidogenesis in human NCI-H295R adrenocortical cells.

Tkachenko IV, Jääskeläinen T, Jääskeläinen J, Palvimo JJ, Voutilainen R.

Steroids. 2011 Sep-Oct;76(10-11):1103-15. doi: 10.1016/j.steroids.2011.04.018. Epub 2011 May 8.

PMID:
21600230
43.

Steroid up-regulation of FKBP51 and its role in hormone signaling.

Jääskeläinen T, Makkonen H, Palvimo JJ.

Curr Opin Pharmacol. 2011 Aug;11(4):326-31. doi: 10.1016/j.coph.2011.04.006. Epub 2011 Apr 29. Review.

PMID:
21531172
44.

Androgen receptor amplification is reflected in the transcriptional responses of Vertebral-Cancer of the Prostate cells.

Makkonen H, Kauhanen M, Jääskeläinen T, Palvimo JJ.

Mol Cell Endocrinol. 2011 Jan 1;331(1):57-65. doi: 10.1016/j.mce.2010.08.008. Epub 2010 Aug 20.

PMID:
20728506
45.

Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions.

Paakinaho V, Makkonen H, Jääskeläinen T, Palvimo JJ.

Mol Endocrinol. 2010 Mar;24(3):511-25. doi: 10.1210/me.2009-0443. Epub 2010 Jan 21.

46.

PIAS proteins: pleiotropic interactors associated with SUMO.

Rytinki MM, Kaikkonen S, Pehkonen P, Jääskeläinen T, Palvimo JJ.

Cell Mol Life Sci. 2009 Sep;66(18):3029-41. doi: 10.1007/s00018-009-0061-z. Epub 2009 Jun 13. Review.

PMID:
19526197
47.

Long-range activation of FKBP51 transcription by the androgen receptor via distal intronic enhancers.

Makkonen H, Kauhanen M, Paakinaho V, Jääskeläinen T, Palvimo JJ.

Nucleic Acids Res. 2009 Jul;37(12):4135-48. doi: 10.1093/nar/gkp352. Epub 2009 May 11.

48.

SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells.

Kaikkonen S, Jääskeläinen T, Karvonen U, Rytinki MM, Makkonen H, Gioeli D, Paschal BM, Palvimo JJ.

Mol Endocrinol. 2009 Mar;23(3):292-307. doi: 10.1210/me.2008-0219. Epub 2008 Dec 30.

49.

Diffractive parameric colors.

Orava J, Heikkila N, Jaaskelainen T, Parkkinen J.

J Opt Soc Am A Opt Image Sci Vis. 2008 Dec;25(12):2901-7.

PMID:
19037379
50.

Kernel-based spectral color image segmentation.

Li H, Bochko V, Jaaskelainen T, Parkkinen J, Shen IF.

J Opt Soc Am A Opt Image Sci Vis. 2008 Nov;25(11):2805-16.

PMID:
18978860

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