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Items: 31

1.

Parvalbumin Interneuron Dysfunction in a Thalamo-Prefrontal Cortical Circuit in Disc1 Locus Impairment Mice.

Delevich K, Jaaro-Peled H, Penzo M, Sawa A, Li B.

eNeuro. 2020 Mar 3;7(2). pii: ENEURO.0496-19.2020. doi: 10.1523/ENEURO.0496-19.2020. Print 2020 Mar/Apr.

2.

The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthood.

Yang K, Kondo MA, Jaaro-Peled H, Cash-Padgett T, Kano SI, Ishizuka K, Pevsner J, Tomoda T, Sawa A, Niwa M.

Schizophr Res. 2019 Aug;210:149-156. doi: 10.1016/j.schres.2019.05.032. Epub 2019 Jun 13.

PMID:
31204062
3.

Aripiprazole and haloperidol protect neurite lesions via reducing excessive D2R-DISC1 complex formation.

Zheng P, Hu M, Xie Y, Yu Y, Jaaro-Peled H, Huang XF.

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8;92:59-69. doi: 10.1016/j.pnpbp.2018.12.007. Epub 2018 Dec 28.

PMID:
30597182
4.

Dominant-Negative DISC1 Alters the Dopaminergic Modulation of Inhibitory Interneurons in the Mouse Prefrontal Cortex.

Cardarelli RA, Martin R, Jaaro-Peled H, Sawa A, Powell EM, O'Donnell P.

Mol Neuropsychiatry. 2018 Jun;4(1):20-29. doi: 10.1159/000488030. Epub 2018 May 7.

5.

[11C](R)-Rolipram positron emission tomography detects DISC1 inhibition of phosphodiesterase type 4 in live Disc1 locus-impaired mice.

Ooms M, Tsujikawa T, Lohith TG, Mabins SN, Zoghbi SS, Sumitomo A, Jaaro-Peled H, Kimura Y, Telu S, Pike VW, Tomoda T, Innis RB, Sawa A, Fujita M.

J Cereb Blood Flow Metab. 2019 Jul;39(7):1306-1313. doi: 10.1177/0271678X18758997. Epub 2018 Feb 12.

PMID:
29430995
6.

Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1.

Jaaro-Peled H, Altimus C, LeGates T, Cash-Padgett T, Zoubovsky S, Hikida T, Ishizuka K, Hattar S, Mongrain V, Sawa A.

Neurosci Res. 2016 Nov;112:63-69. doi: 10.1016/j.neures.2016.06.006. Epub 2016 Jun 26.

7.

DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia 1.

Niwa M, Cash-Padgett T, Kubo KI, Saito A, Ishii K, Sumitomo A, Taniguchi Y, Ishizuka K, Jaaro-Peled H, Tomoda T, Nakajima K, Sawa A, Kamiya A.

Mol Psychiatry. 2016 Nov;21(11):1488-1489. doi: 10.1038/mp.2016.154. Epub 2016 Sep 6. No abstract available.

8.

Cell Type-Specific Effects of Mutant DISC1: A Proteomics Study.

Xia M, Broek JA, Jouroukhin Y, Schoenfelder J, Abazyan S, Jaaro-Peled H, Sawa A, Bahn S, Pletnikov M.

Mol Neuropsychiatry. 2016 May;2(1):28-36. doi: 10.1159/000444587. Epub 2016 Apr 1.

9.

Utility and validity of DISC1 mouse models in biological psychiatry.

Tomoda T, Sumitomo A, Jaaro-Peled H, Sawa A.

Neuroscience. 2016 May 3;321:99-107. doi: 10.1016/j.neuroscience.2015.12.061. Epub 2016 Jan 6. Review.

10.

Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex.

Seshadri S, Faust T, Ishizuka K, Delevich K, Chung Y, Kim SH, Cowles M, Niwa M, Jaaro-Peled H, Tomoda T, Lai C, Anton ES, Li B, Sawa A.

Nat Commun. 2015 Dec 11;6:10118. doi: 10.1038/ncomms10118.

11.

Increased stereotypy in conditional Cxcr4 knockout mice.

Cash-Padgett T, Sawa A, Jaaro-Peled H.

Neurosci Res. 2016 Apr;105:75-9. doi: 10.1016/j.neures.2015.10.001. Epub 2015 Oct 13.

12.

Disordered ripples are a common feature of genetically distinct mouse models relevant to schizophrenia.

Altimus C, Harrold J, Jaaro-Peled H, Sawa A, Foster DJ.

Mol Neuropsychiatry. 2015 May;1(1):52-59.

13.

Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory.

Ballinger MD, Saito A, Abazyan B, Taniguchi Y, Huang CH, Ito K, Zhu X, Segal H, Jaaro-Peled H, Sawa A, Mackie K, Pletnikov MV, Kamiya A.

Neurobiol Dis. 2015 Oct;82:176-184. doi: 10.1016/j.nbd.2015.06.006. Epub 2015 Jun 18.

14.

Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice.

Nomura J, Jaaro-Peled H, Lewis E, Nuñez-Abades P, Huppe-Gourgues F, Cash-Padgett T, Emiliani F, Kondo MA, Furuya A, Landek-Salgado MA, Ayhan Y, Kamiya A, Takumi T, Huganir R, Pletnikov M, O'Donnell P, Sawa A.

Mol Psychiatry. 2016 Mar;21(3):386-93. doi: 10.1038/mp.2015.61. Epub 2015 May 26.

15.

Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1).

Zoubovsky S, Oh EC, Cash-Padgett T, Johnson AW, Hou Z, Mori S, Gallagher M, Katsanis N, Sawa A, Jaaro-Peled H.

Neurosci Res. 2015 Sep;98:45-9. doi: 10.1016/j.neures.2015.02.002. Epub 2015 Feb 16.

16.

DISC1 regulates trafficking and processing of APP and Aβ generation.

Shahani N, Seshadri S, Jaaro-Peled H, Ishizuka K, Hirota-Tsuyada Y, Wang Q, Koga M, Sedlak TW, Korth C, Brandon NJ, Kamiya A, Subramaniam S, Tomoda T, Sawa A.

Mol Psychiatry. 2015 Jul;20(7):874-9. doi: 10.1038/mp.2014.100. Epub 2014 Sep 16.

17.

DISC1 mouse models as a tool to decipher gene-environment interactions in psychiatric disorders.

Cash-Padgett T, Jaaro-Peled H.

Front Behav Neurosci. 2013 Sep 3;7:113. doi: 10.3389/fnbeh.2013.00113. Review.

18.

Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness.

Johnson AW, Jaaro-Peled H, Shahani N, Sedlak TW, Zoubovsky S, Burruss D, Emiliani F, Sawa A, Gallagher M.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12462-7. doi: 10.1073/pnas.1307925110. Epub 2013 Jul 9.

19.

Unique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control.

Kondo MA, Tajinda K, Colantuoni C, Hiyama H, Seshadri S, Huang B, Pou S, Furukori K, Hookway C, Jaaro-Peled H, Kano SI, Matsuoka N, Harada K, Ni K, Pevsner J, Sawa A.

Transl Psychiatry. 2013 Apr 2;3:e243. doi: 10.1038/tp.2013.19.

20.

Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids.

Niwa M, Jaaro-Peled H, Tankou S, Seshadri S, Hikida T, Matsumoto Y, Cascella NG, Kano S, Ozaki N, Nabeshima T, Sawa A.

Science. 2013 Jan 18;339(6117):335-9. doi: 10.1126/science.1226931.

21.

Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging.

Jaaro-Peled H, Niwa M, Foss CA, Murai R, de Los Reyes S, Kamiya A, Mateo Y, O'Donnell P, Cascella NG, Nabeshima T, Guilarte TR, Pomper MG, Sawa A.

Hum Mol Genet. 2013 Apr 15;22(8):1574-80. doi: 10.1093/hmg/ddt007. Epub 2013 Jan 11.

22.

Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice.

Rais R, Thomas AG, Wozniak K, Wu Y, Jaaro-Peled H, Sawa A, Strick CA, Engle SJ, Brandon NJ, Rojas C, Slusher BS, Tsukamoto T.

Drug Metab Dispos. 2012 Nov;40(11):2067-73. doi: 10.1124/dmd.112.046482. Epub 2012 Jul 26.

23.

Better understanding of mechanisms of schizophrenia and bipolar disorder: from human gene expression profiles to mouse models.

Lin CY, Sawa A, Jaaro-Peled H.

Neurobiol Dis. 2012 Jan;45(1):48-56. doi: 10.1016/j.nbd.2011.08.025. Epub 2011 Sep 3. Review.

24.

Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia.

Lipina TV, Niwa M, Jaaro-Peled H, Fletcher PJ, Seeman P, Sawa A, Roder JC.

Genes Brain Behav. 2010 Oct;9(7):777-89. doi: 10.1111/j.1601-183X.2010.00615.x. Epub 2010 Aug 12.

25.

Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits.

Niwa M, Kamiya A, Murai R, Kubo K, Gruber AJ, Tomita K, Lu L, Tomisato S, Jaaro-Peled H, Seshadri S, Hiyama H, Huang B, Kohda K, Noda Y, O'Donnell P, Nakajima K, Sawa A, Nabeshima T.

Neuron. 2010 Feb 25;65(4):480-9. doi: 10.1016/j.neuron.2010.01.019.

26.

Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models.

Jaaro-Peled H, Ayhan Y, Pletnikov MV, Sawa A.

Schizophr Bull. 2010 Mar;36(2):301-13. doi: 10.1093/schbul/sbp133. Epub 2009 Nov 10. Review.

27.

Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood.

Ibi D, Nagai T, Koike H, Kitahara Y, Mizoguchi H, Niwa M, Jaaro-Peled H, Nitta A, Yoneda Y, Nabeshima T, Sawa A, Yamada K.

Behav Brain Res. 2010 Jan 5;206(1):32-7. doi: 10.1016/j.bbr.2009.08.027. Epub 2009 Aug 28.

28.

Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1.

Jaaro-Peled H, Hayashi-Takagi A, Seshadri S, Kamiya A, Brandon NJ, Sawa A.

Trends Neurosci. 2009 Sep;32(9):485-95. doi: 10.1016/j.tins.2009.05.007. Epub 2009 Aug 26. Review.

29.

Gene models of schizophrenia: DISC1 mouse models.

Jaaro-Peled H.

Prog Brain Res. 2009;179:75-86. doi: 10.1016/S0079-6123(09)17909-8. Epub 2009 Nov 20. Review.

PMID:
20302820
30.

How has DISC1 enabled drug discovery?

Wang Q, Jaaro-Peled H, Sawa A, Brandon NJ.

Mol Cell Neurosci. 2008 Feb;37(2):187-95. Epub 2007 Oct 23. Review.

PMID:
18055216
31.

Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.

Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, Wu D, Xue R, Andradé M, Tankou S, Mori S, Gallagher M, Ishizuka K, Pletnikov M, Kida S, Sawa A.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14501-6. Epub 2007 Aug 3.

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