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Cyp1 inhibition prevents doxorubicin-induced cardiomyopathy in a zebrafish heart failure model.

Lam PY, Kutchukian P, Anand R, Imbriglio J, Andrews C, Padilla H, Vohra A, Lane S, Parker DL Jr, Taracido IC, Johns DG, Beerens M, MacRae CA, Caldwell J, Sorota S, Asnani A, Peterson RT.

Chembiochem. 2020 Jan 30. doi: 10.1002/cbic.201900741. [Epub ahead of print]


Impact of drug distribution into adipose on tissue function: The cholesteryl ester transfer protein (CETP) inhibitor anacetrapib as a test case.

Johns DG, Wang SP, Rosa R, Hubert J, Xu S, Chen Y, Bateman T, Blaustein RO.

Pharmacol Res Perspect. 2019 Nov 15;7(6):e00543. doi: 10.1002/prp2.543. eCollection 2019 Dec.


The rise in ocean plastics evidenced from a 60-year time series.

Ostle C, Thompson RC, Broughton D, Gregory L, Wootton M, Johns DG.

Nat Commun. 2019 Apr 16;10(1):1622. doi: 10.1038/s41467-019-09506-1.


Characterization of Anacetrapib Distribution into the Lipid Droplet of Adipose Tissue in Mice and Human Cultured Adipocytes.

Johns DG, LeVoci L, Krsmanovic M, Lu M, Hartmann G, Xu S, Wang SP, Chen Y, Bateman T, Blaustein RO.

Drug Metab Dispos. 2019 Mar;47(3):227-233. doi: 10.1124/dmd.118.084525. Epub 2018 Dec 19.


Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity.

Asnani A, Zheng B, Liu Y, Wang Y, Chen HH, Vohra A, Chi A, Cornella-Taracido I, Wang H, Johns DG, Sosnovik DE, Peterson RT.

JCI Insight. 2018 Jan 11;3(1). pii: 96753. doi: 10.1172/jci.insight.96753. eCollection 2018 Jan 11.


Assessing the mechanisms of cholesteryl ester transfer protein inhibitors.

Zhang M, Lei D, Peng B, Yang M, Zhang L, Charles MA, Rye KA, Krauss RM, Johns DG, Ren G.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Dec;1862(12):1606-1617. doi: 10.1016/j.bbalip.2017.09.004. Epub 2017 Sep 12.


Use of Microcomputed Tomography to Measure the Relaxin-induced Expansion of Intrapubic Ligaments in Mice.

Zimmerman HA, Kennan RP, Zhang C, Shah K, Johns DG, Lynch JJ, Dajee M.

Comp Med. 2017 Aug 1;67(4):330-334.


Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers.

Daurio NA, Wang SP, Chen Y, Zhou H, McLaren DG, Roddy TP, Johns DG, Milot D, Kasumov T, Erion MD, Kelley DE, Previs SF.

J Pharmacol Exp Ther. 2017 Oct;363(1):80-91. doi: 10.1124/jpet.117.241091. Epub 2017 Jul 19. Review.


Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms.

Howatt DA, Dajee M, Xie X, Moorleghen J, Rateri DL, Balakrishnan A, Da Cunha V, Johns DG, Gutstein DE, Daugherty A, Lu H.

Circ J. 2017 May 25;81(6):888-890. doi: 10.1253/circj.CJ-17-0229. Epub 2017 Apr 18.


Phenological sensitivity to climate across taxa and trophic levels.

Thackeray SJ, Henrys PA, Hemming D, Bell JR, Botham MS, Burthe S, Helaouet P, Johns DG, Jones ID, Leech DI, Mackay EB, Massimino D, Atkinson S, Bacon PJ, Brereton TM, Carvalho L, Clutton-Brock TH, Duck C, Edwards M, Elliott JM, Hall SJ, Harrington R, Pearce-Higgins JW, Høye TT, Kruuk LE, Pemberton JM, Sparks TH, Thompson PM, White I, Winfield IJ, Wanless S.

Nature. 2016 Jul 14;535(7611):241-5. doi: 10.1038/nature18608. Epub 2016 Jun 29.


Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided Approach.

Wilson JE, Kurukulasuriya R, Reibarkh M, Reiter M, Zwicker A, Zhao K, Zhang F, Anand R, Colandrea VJ, Cumiskey AM, Crespo A, Duffy RA, Murphy BA, Mitra K, Johns DG, Duffy JL, Vachal P.

ACS Med Chem Lett. 2016 Jan 4;7(3):261-5. doi: 10.1021/acsmedchemlett.5b00404. eCollection 2016 Mar 10.


Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux.

McLaren DG, Previs SF, Phair RD, Stout SJ, Xie D, Chen Y, Salituro GM, Xu SS, Castro-Perez JM, Opiteck GJ, Akinsanya KO, Cleary MA, Dansky HM, Johns DG, Roddy TP.

J Lipid Res. 2016 Mar;57(3):398-409. doi: 10.1194/jlr.M063842. Epub 2015 Dec 9.


Quantitative profiling of oxylipins in plasma and atherosclerotic plaques of hypercholesterolemic rabbits.

Bojic LA, McLaren DG, Harms AC, Hankemeier T, Dane A, Wang SP, Rosa R, Previs SF, Johns DG, Castro-Perez JM.

Anal Bioanal Chem. 2016 Jan;408(1):97-105. doi: 10.1007/s00216-015-9105-4. Epub 2015 Oct 28.


Effect of Error Propagation in Stable Isotope Tracer Studies: An Approach for Estimating Impact on Apparent Biochemical Flux.

Previs SF, Herath K, Castro-Perez J, Mahsut A, Zhou H, McLaren DG, Shah V, Rohm RJ, Stout SJ, Zhong W, Wang SP, Johns DG, Hubbard BK, Cleary MA, Roddy TP.

Methods Enzymol. 2015;561:331-58. doi: 10.1016/bs.mie.2015.06.021. Epub 2015 Aug 19. Review.


Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor.

Hirano K, Chen WS, Chueng AL, Dunne AA, Seredenina T, Filippova A, Ramachandran S, Bridges A, Chaudry L, Pettman G, Allan C, Duncan S, Lee KC, Lim J, Ma MT, Ong AB, Ye NY, Nasir S, Mulyanidewi S, Aw CC, Oon PP, Liao S, Li D, Johns DG, Miller ND, Davies CH, Browne ER, Matsuoka Y, Chen DW, Jaquet V, Rutter AR.

Antioxid Redox Signal. 2015 Aug 10;23(5):358-74. doi: 10.1089/ars.2014.6202.


Inhibition of cholesteryl ester transfer protein increases cholesteryl ester content of large HDL independently of HDL-to-HDL homotypic transfer: in vitro vs in vivo comparison using anacetrapib and dalcetrapib.

Johns DG, Chen Y, Wang SP, Castro-Perez J, Previs SF, Roddy TP.

Eur J Pharmacol. 2015 Sep 5;762:256-62. doi: 10.1016/j.ejphar.2015.05.061. Epub 2015 Jun 3.


HDL surface lipids mediate CETP binding as revealed by electron microscopy and molecular dynamics simulation.

Zhang M, Charles R, Tong H, Zhang L, Patel M, Wang F, Rames MJ, Ren A, Rye KA, Qiu X, Johns DG, Charles MA, Ren G.

Sci Rep. 2015 Mar 4;5:8741. doi: 10.1038/srep08741.


Development of lipoprotein(a) siRNAs for mechanism of action studies in non-human primate models of atherosclerosis.

Tadin-Strapps M, Robinson M, Le Voci L, Andrews L, Yendluri S, Williams S, Bartz S, Johns DG.

J Cardiovasc Transl Res. 2015 Feb;8(1):44-53. doi: 10.1007/s12265-014-9605-1. Epub 2015 Jan 21.


Lipidome of atherosclerotic plaques from hypercholesterolemic rabbits.

Bojic LA, McLaren DG, Shah V, Previs SF, Johns DG, Castro-Perez JM.

Int J Mol Sci. 2014 Dec 15;15(12):23283-93. doi: 10.3390/ijms151223283.


In vivo isotopically labeled atherosclerotic aorta plaques in ApoE KO mice and molecular profiling by matrix-assisted laser desorption/ionization mass spectrometric imaging.

Castro-Perez J, Hatcher N, Kofi Karikari N, Wang SP, Mendoza V, Shion H, Millar A, Shockcor J, Towers M, McLaren D, Shah V, Previs S, Akinsanya K, Cleary M, Roddy TP, Johns DG.

Rapid Commun Mass Spectrom. 2014 Nov 30;28(22):2471-9. doi: 10.1002/rcm.7039.


Anacetrapib and dalcetrapib differentially alters HDL metabolism and macrophage-to-feces reverse cholesterol transport at similar levels of CETP inhibition in hamsters.

Briand F, Thieblemont Q, Muzotte E, Burr N, Urbain I, Sulpice T, Johns DG.

Eur J Pharmacol. 2014 Oct 5;740:135-43. doi: 10.1016/j.ejphar.2014.06.022. Epub 2014 Jul 5.


Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques.

Roddy TP, McLaren DG, Chen Y, Xie D, Dunn K, Kulick A, Szeto D, Forrest G, Albanese K, Donnelly M, Gai C, Gewain A, Lederman H, Jensen KK, Ai X, Vachal P, Akinsanya KO, Cleary MA, Previs SF, Dansky HM, Johns DG.

Eur J Pharmacol. 2014 Oct 5;740:410-6. doi: 10.1016/j.ejphar.2014.04.015. Epub 2014 Apr 21.


Understanding the distribution of marine megafauna in the English channel region: identifying key habitats for conservation within the busiest seaway on earth.

McClellan CM, Brereton T, Dell'Amico F, Johns DG, Cucknell AC, Patrick SC, Penrose R, Ridoux V, Solandt JL, Stephan E, Votier SC, Williams R, Godley BJ.

PLoS One. 2014 Feb 28;9(2):e89720. doi: 10.1371/journal.pone.0089720. eCollection 2014.


Determination of low levels of 2H-labeling using high-resolution mass spectrometry: application in studies of lipid flux and beyond.

Herath KB, Zhong W, Yang J, Mahsut A, Rohm RJ, Shah V, Castro-Perez J, Zhou H, Attygalle AB, Kang L, Singh S, Johns DG, Cleary MA, Hubbard BK, Previs SF, Roddy TP.

Rapid Commun Mass Spectrom. 2014 Feb 15;28(3):239-44. doi: 10.1002/rcm.6776.


Inverse relationship between LDL cholesterol and PCSK9 plasma levels in dyslipidemic cynomolgus monkeys: effects of LDL lowering by ezetimibe in the absence of statins.

Hentze H, Jensen KK, Chia SM, Johns DG, Shaw RJ, Davis HR Jr, Shih SJ, Wong KK.

Atherosclerosis. 2013 Nov;231(1):84-90. doi: 10.1016/j.atherosclerosis.2013.08.028. Epub 2013 Sep 5.


In vivo effects of anacetrapib on preβ HDL: improvement in HDL remodeling without effects on cholesterol absorption.

Wang SP, Daniels E, Chen Y, Castro-Perez J, Zhou H, Akinsanya KO, Previs SF, Roddy TP, Johns DG.

J Lipid Res. 2013 Oct;54(10):2858-65. doi: 10.1194/jlr.M041541. Epub 2013 Jul 29.


New methodologies for studying lipid synthesis and turnover: looking backwards to enable moving forwards.

Previs SF, McLaren DG, Wang SP, Stout SJ, Zhou H, Herath K, Shah V, Miller PL, Wilsie L, Castro-Perez J, Johns DG, Cleary MA, Roddy TP.

Biochim Biophys Acta. 2014 Mar;1842(3):402-13. doi: 10.1016/j.bbadis.2013.05.019. Epub 2013 May 22. Review.


Use of [13C18] oleic acid and mass isotopomer distribution analysis to study synthesis of plasma triglycerides in vivo: analytical and experimental considerations.

McLaren DG, Cardasis HL, Stout SJ, Wang SP, Mendoza V, Castro-Perez JM, Miller PL, Murphy BA, Cumiskey AM, Cleary MA, Johns DG, Previs SF, Roddy TP.

Anal Chem. 2013 Jul 2;85(13):6287-94. doi: 10.1021/ac400363k. Epub 2013 Jun 10.


Inhibition of cholesteryl ester transfer protein by anacetrapib does not impair the anti-inflammatory properties of high density lipoprotein.

Han S, Levoci L, Fischer P, Wang SP, Gagen K, Chen Y, Xie D, Fisher T, Ehrhardt AG, Peier AM, Johns DG.

Biochim Biophys Acta. 2013 Apr;1831(4):825-33. doi: 10.1016/j.bbalip.2012.12.008. Epub 2012 Dec 23.


Tracking fatty acid kinetics in distinct lipoprotein fractions in vivo: a novel high-throughput approach for studying dyslipidemia in rodent models.

McLaren DG, Wang SP, Stout SJ, Xie D, Miller PL, Mendoza V, Rosa R, Castro-Perez J, Previs SF, Johns DG, Roddy TP.

J Lipid Res. 2013 Jan;54(1):276-81. doi: 10.1194/jlr.D030791. Epub 2012 Oct 5.


Quantifying apoprotein synthesis in rodents: coupling LC-MS/MS analyses with the administration of labeled water.

Zhou H, Li W, Wang SP, Mendoza V, Rosa R, Hubert J, Herath K, McLaughlin T, Rohm RJ, Lassman ME, Wong KK, Johns DG, Previs SF, Hubbard BK, Roddy TP.

J Lipid Res. 2012 Jun;53(6):1223-31. doi: 10.1194/jlr.D021295. Epub 2012 Mar 3.


An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes.

Zhang L, McCabe T, Condra JH, Ni YG, Peterson LB, Wang W, Strack AM, Wang F, Pandit S, Hammond H, Wood D, Lewis D, Rosa R, Mendoza V, Cumiskey AM, Johns DG, Hansen BC, Shen X, Geoghagen N, Jensen K, Zhu L, Wietecha K, Wisniewski D, Huang L, Zhao JZ, Ernst R, Hampton R, Haytko P, Ansbro F, Chilewski S, Chin J, Mitnaul LJ, Pellacani A, Sparrow CP, An Z, Strohl W, Hubbard B, Plump AS, Blom D, Sitlani A.

Int J Biol Sci. 2012;8(3):310-27. doi: 10.7150/ijbs.3524. Epub 2012 Feb 9.


Measuring H(2)(18)O tracer incorporation on a QQQ-MS platform provides a rapid, transferable screening tool for relative protein synthesis.

Conway JP, Johns DG, Wang SP, Walker ND, McAvoy TA, Zhou H, Zhao X, Previs SF, Roddy TP, Hubbard BK, Yates NA, Hendrickson RC.

J Proteome Res. 2012 Mar 2;11(3):1591-7. doi: 10.1021/pr2007494. Epub 2012 Feb 10.


Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin.

Owens AP 3rd, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton JA, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N.

J Clin Invest. 2012 Feb;122(2):558-68. doi: 10.1172/JCI58969. Epub 2012 Jan 3.


NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation.

Gatto GJ Jr, Ao Z, Kearse MG, Zhou M, Morales CR, Daniels E, Bradley BT, Goserud MT, Goodman KB, Douglas SA, Harpel MR, Johns DG.

J Enzyme Inhib Med Chem. 2013 Feb;28(1):95-104. doi: 10.3109/14756366.2011.636360. Epub 2011 Dec 3.


Reconstituted HDL elicits marked changes in plasma lipids following single-dose injection in C57Bl/6 mice.

Chen Z, O'Neill EA, Meurer RD, Gagen K, Luell S, Wang SP, Ichetovkin M, Frantz-Wattley B, Eveland S, Strack AM, Fisher TS, Johns DG, Sparrow CP, Wright SD, Hubbard BK, Carballo-Jane E.

J Cardiovasc Pharmacol Ther. 2012 Sep;17(3):315-23. doi: 10.1177/1074248411426144. Epub 2011 Nov 8.


Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and 2H2O quantification.

Jensen KK, Previs SF, Zhu L, Herath K, Wang SP, Bhat G, Hu G, Miller PL, McLaren DG, Shin MK, Vogt TF, Wang L, Wong KK, Roddy TP, Johns DG, Hubbard BK.

Am J Physiol Endocrinol Metab. 2012 Jan 15;302(2):E209-17. doi: 10.1152/ajpendo.00436.2011. Epub 2011 Nov 1.


A gene expression signature that classifies human atherosclerotic plaque by relative inflammation status.

Puig O, Yuan J, Stepaniants S, Zieba R, Zycband E, Morris M, Coulter S, Yu X, Menke J, Woods J, Chen F, Ramey DR, He X, O'Neill EA, Hailman E, Johns DG, Hubbard BK, Yee Lum P, Wright SD, Desouza MM, Plump A, Reiser V.

Circ Cardiovasc Genet. 2011 Dec;4(6):595-604. doi: 10.1161/CIRCGENETICS.111.960773. Epub 2011 Oct 18.


Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters.

Chen Z, Wang SP, Krsmanovic ML, Castro-Perez J, Gagen K, Mendoza V, Rosa R, Shah V, He T, Stout SJ, Geoghagen NS, Lee SH, McLaren DG, Wang L, Roddy TP, Plump AS, Hubbard BK, Sinz CJ, Johns DG.

Metabolism. 2012 Apr;61(4):470-81. doi: 10.1016/j.metabol.2011.08.006. Epub 2011 Oct 14.


Localization of fatty acyl and double bond positions in phosphatidylcholines using a dual stage CID fragmentation coupled with ion mobility mass spectrometry.

Castro-Perez J, Roddy TP, Nibbering NM, Shah V, McLaren DG, Previs S, Attygalle AB, Herath K, Chen Z, Wang SP, Mitnaul L, Hubbard BK, Vreeken RJ, Johns DG, Hankemeier T.

J Am Soc Mass Spectrom. 2011 Sep;22(9):1552-67. doi: 10.1007/s13361-011-0172-2. Epub 2011 Jun 24. Erratum in: J Am Soc Mass Spectrom. 2011 Sep;22(9):1568-9.


Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters.

Castro-Perez J, Briand F, Gagen K, Wang SP, Chen Y, McLaren DG, Shah V, Vreeken RJ, Hankemeier T, Sulpice T, Roddy TP, Hubbard BK, Johns DG.

J Lipid Res. 2011 Nov;52(11):1965-73. doi: 10.1194/jlr.M016410. Epub 2011 Aug 14.


Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy.

Castro-Perez JM, Roddy TP, Shah V, Wang SP, Ouyang X, Ogawa A, McLaren DG, Tadin-Strapps M, Robinson MJ, Bartz SR, Ason B, Chen Y, Previs SF, Wong KK, Vreeken RJ, Johns DG, Hubbard BK, Hankemeier T, Mitnaul L.

J Proteome Res. 2011 Oct 7;10(10):4683-91. doi: 10.1021/pr200475g. Epub 2011 Aug 26.


Identifying static and kinetic lipid phenotypes by high resolution UPLC-MS: unraveling diet-induced changes in lipid homeostasis by coupling metabolomics and fluxomics.

Castro-Perez JM, Roddy TP, Shah V, McLaren DG, Wang SP, Jensen K, Vreeken RJ, Hankemeier T, Johns DG, Previs SF, Hubbard BK.

J Proteome Res. 2011 Sep 2;10(9):4281-90. doi: 10.1021/pr200480g. Epub 2011 Aug 4.


Equilibration of (2)H labeling between body water and free amino acids: enabling studies of proteome synthesis.

Herath K, Bhat G, Miller PL, Wang SP, Kulick A, Andrews-Kelly G, Johnson C, Rohm RJ, Lassman ME, Previs SF, Johns DG, Hubbard BK, Roddy TP.

Anal Biochem. 2011 Aug 15;415(2):197-9. doi: 10.1016/j.ab.2011.04.031. Epub 2011 Apr 27.


Quantifying cholesterol synthesis in vivo using (2)H(2)O: enabling back-to-back studies in the same subject.

Previs SF, Mahsut A, Kulick A, Dunn K, Andrews-Kelly G, Johnson C, Bhat G, Herath K, Miller PL, Wang SP, Azer K, Xu J, Johns DG, Hubbard BK, Roddy TP.

J Lipid Res. 2011 Jul;52(7):1420-8. doi: 10.1194/jlr.D014993. Epub 2011 Apr 17.


The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species.

McLaren DG, He T, Wang SP, Mendoza V, Rosa R, Gagen K, Bhat G, Herath K, Miller PL, Stribling S, Taggart A, Imbriglio J, Liu J, Chen D, Pinto S, Balkovec JM, Devita RJ, Marsh DJ, Castro-Perez JM, Strack A, Johns DG, Previs SF, Hubbard BK, Roddy TP.

J Lipid Res. 2011 Jun;52(6):1150-61. doi: 10.1194/jlr.M011049. Epub 2011 Mar 17.


A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo.

Ni YG, Di Marco S, Condra JH, Peterson LB, Wang W, Wang F, Pandit S, Hammond HA, Rosa R, Cummings RT, Wood DD, Liu X, Bottomley MJ, Shen X, Cubbon RM, Wang SP, Johns DG, Volpari C, Hamuro L, Chin J, Huang L, Zhao JZ, Vitelli S, Haytko P, Wisniewski D, Mitnaul LJ, Sparrow CP, Hubbard B, Carfí A, Sitlani A.

J Lipid Res. 2011 Jan;52(1):78-86. doi: 10.1194/jlr.M011445. Epub 2010 Oct 19.


In vivo D2O labeling to quantify static and dynamic changes in cholesterol and cholesterol esters by high resolution LC/MS.

Castro-Perez J, Previs SF, McLaren DG, Shah V, Herath K, Bhat G, Johns DG, Wang SP, Mitnaul L, Jensen K, Vreeken R, Hankemeier T, Roddy TP, Hubbard BK.

J Lipid Res. 2011 Jan;52(1):159-69. doi: 10.1194/jlr.D009787. Epub 2010 Sep 30.


Headspace analyses of ²H labeling of acetone: enabling studies of fatty acid oxidation in vivo.

Mahsut A, Wang SP, McLaren DG, Bhat G, Herath K, Miller PL, Hubbard BK, Johns DG, Previs SF, Roddy TP.

Anal Biochem. 2011 Jan 15;408(2):351-3. doi: 10.1016/j.ab.2010.09.016. Epub 2010 Sep 17.


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