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Items: 1 to 50 of 209

1.

LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs).

Zhou P, Polovitskaya MM, Jentsch TJ.

J Biol Chem. 2018 Aug 31;293(35):13440-13451. doi: 10.1074/jbc.RA118.002853. Epub 2018 Jun 20.

2.

LRRC8/VRAC anion channels are required for late stages of spermatid development in mice.

Lück JC, Puchkov D, Ullrich F, Jentsch TJ.

J Biol Chem. 2018 Jul 27;293(30):11796-11808. doi: 10.1074/jbc.RA118.003853. Epub 2018 Jun 7.

3.

CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease.

Jentsch TJ, Pusch M.

Physiol Rev. 2018 Jul 1;98(3):1493-1590. doi: 10.1152/physrev.00047.2017. Review.

PMID:
29845874
4.

LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.

Stuhlmann T, Planells-Cases R, Jentsch TJ.

Nat Commun. 2018 May 17;9(1):1974. doi: 10.1038/s41467-018-04353-y.

5.

Ca2+-activated Cl- currents in the murine vomeronasal organ enhance neuronal spiking but are dispensable for male-male aggression.

Münch J, Billig G, Hübner CA, Leinders-Zufall T, Zufall F, Jentsch TJ.

J Biol Chem. 2018 Jun 29;293(26):10392-10403. doi: 10.1074/jbc.RA118.003153. Epub 2018 May 16.

PMID:
29769308
6.

Reply from L. P. Cid, T. J. Jentsch and F. V. Sepúlveda: intestinal electrolyte and fluid secretion - a model in trouble?

Cid LP, Jentsch TJ, Sepúlveda FV.

J Physiol. 2018 Jun;596(12):2465-2466. doi: 10.1113/JP276139. Epub 2018 Apr 16. No abstract available.

7.

A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism.

Fernandes-Rosa FL, Daniil G, Orozco IJ, Göppner C, El Zein R, Jain V, Boulkroun S, Jeunemaitre X, Amar L, Lefebvre H, Schwarzmayr T, Strom TM, Jentsch TJ, Zennaro MC.

Nat Genet. 2018 Mar;50(3):355-361. doi: 10.1038/s41588-018-0053-8. Epub 2018 Feb 5.

8.

K2P TASK-2 and KCNQ1-KCNE3 K+ channels are major players contributing to intestinal anion and fluid secretion.

Julio-Kalajzić F, Villanueva S, Burgos J, Ojeda M, Cid LP, Jentsch TJ, Sepúlveda FV.

J Physiol. 2018 Feb 1;596(3):393-407. doi: 10.1113/JP275178. Epub 2017 Dec 18.

9.

Loss of the Na+/H+ exchanger NHE8 causes male infertility in mice by disrupting acrosome formation.

Oberheide K, Puchkov D, Jentsch TJ.

J Biol Chem. 2017 Jun 30;292(26):10845-10854. doi: 10.1074/jbc.M117.784108. Epub 2017 May 5.

10.

Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.

Lutter D, Ullrich F, Lueck JC, Kempa S, Jentsch TJ.

J Cell Sci. 2017 Mar 15;130(6):1122-1133. doi: 10.1242/jcs.196253. Epub 2017 Feb 13.

11.

De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females.

Palmer EE, Stuhlmann T, Weinert S, Haan E, Van Esch H, Holvoet M, Boyle J, Leffler M, Raynaud M, Moraine C, van Bokhoven H, Kleefstra T, Kahrizi K, Najmabadi H, Ropers HH, Delgado MR, Sirsi D, Golla S, Sommer A, Pietryga MP, Chung WK, Wynn J, Rohena L, Bernardo E, Hamlin D, Faux BM, Grange DK, Manwaring L, Tolmie J, Joss S; DDD Study, Cobben JM, Duijkers FAM, Goehringer JM, Challman TD, Hennig F, Fischer U, Grimme A, Suckow V, Musante L, Nicholl J, Shaw M, Lodh SP, Niu Z, Rosenfeld JA, Stankiewicz P, Jentsch TJ, Gecz J, Field M, Kalscheuer VM.

Mol Psychiatry. 2018 Feb;23(2):222-230. doi: 10.1038/mp.2016.135. Epub 2016 Aug 23.

12.

Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination.

Gödde K, Gschwend O, Puchkov D, Pfeffer CK, Carleton A, Jentsch TJ.

Nat Commun. 2016 Jul 8;7:12043. doi: 10.1038/ncomms12043.

13.

The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.

Hennings JC, Andrini O, Picard N, Paulais M, Huebner AK, Cayuqueo IK, Bignon Y, Keck M, Cornière N, Böhm D, Jentsch TJ, Chambrey R, Teulon J, Hübner CA, Eladari D.

J Am Soc Nephrol. 2017 Jan;28(1):209-217. doi: 10.1681/ASN.2016010085. Epub 2016 Jun 22.

14.

Inactivation and Anion Selectivity of Volume-regulated Anion Channels (VRACs) Depend on C-terminal Residues of the First Extracellular Loop.

Ullrich F, Reincke SM, Voss FK, Stauber T, Jentsch TJ.

J Biol Chem. 2016 Aug 12;291(33):17040-8. doi: 10.1074/jbc.M116.739342. Epub 2016 Jun 20.

15.

VRACs and other ion channels and transporters in the regulation of cell volume and beyond.

Jentsch TJ.

Nat Rev Mol Cell Biol. 2016 May;17(5):293-307. doi: 10.1038/nrm.2016.29. Epub 2016 Apr 1. Review.

PMID:
27033257
16.

KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors.

Schütze S, Orozco IJ, Jentsch TJ.

J Biol Chem. 2016 Mar 11;291(11):5566-75. doi: 10.1074/jbc.M115.681098. Epub 2016 Jan 5.

17.

VRAC: molecular identification as LRRC8 heteromers with differential functions.

Jentsch TJ, Lutter D, Planells-Cases R, Ullrich F, Voss FK.

Pflugers Arch. 2016 Mar;468(3):385-93. doi: 10.1007/s00424-015-1766-5. Epub 2015 Dec 3. Review.

PMID:
26635246
18.

Optogenetic acidification of synaptic vesicles and lysosomes.

Rost BR, Schneider F, Grauel MK, Wozny C, Bentz C, Blessing A, Rosenmund T, Jentsch TJ, Schmitz D, Hegemann P, Rosenmund C.

Nat Neurosci. 2015 Dec;18(12):1845-1852. doi: 10.1038/nn.4161. Epub 2015 Nov 9.

19.

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.

Planells-Cases R, Lutter D, Guyader C, Gerhards NM, Ullrich F, Elger DA, Kucukosmanoglu A, Xu G, Voss FK, Reincke SM, Stauber T, Blomen VA, Vis DJ, Wessels LF, Brummelkamp TR, Borst P, Rottenberg S, Jentsch TJ.

EMBO J. 2015 Dec 14;34(24):2993-3008. doi: 10.15252/embj.201592409. Epub 2015 Nov 3.

20.

In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11.

Varga RE, Khundadze M, Damme M, Nietzsche S, Hoffmann B, Stauber T, Koch N, Hennings JC, Franzka P, Huebner AK, Kessels MM, Biskup C, Jentsch TJ, Qualmann B, Braulke T, Kurth I, Beetz C, Hübner CA.

PLoS Genet. 2015 Aug 18;11(8):e1005454. doi: 10.1371/journal.pgen.1005454. eCollection 2015 Aug.

21.

Departure gate of acidic Ca²⁺ confirmed.

Jentsch TJ, Hoegg-Beiler MB, Vogt J.

EMBO J. 2015 Jul 2;34(13):1737-9. doi: 10.15252/embj.201591884. Epub 2015 May 28. No abstract available.

22.

KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.

Fidzinski P, Korotkova T, Heidenreich M, Maier N, Schuetze S, Kobler O, Zuschratter W, Schmitz D, Ponomarenko A, Jentsch TJ.

Nat Commun. 2015 Feb 4;6:6254. doi: 10.1038/ncomms7254.

PMID:
25649132
23.

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.

Hu H, Haas SA, Chelly J, Van Esch H, Raynaud M, de Brouwer AP, Weinert S, Froyen G, Frints SG, Laumonnier F, Zemojtel T, Love MI, Richard H, Emde AK, Bienek M, Jensen C, Hambrock M, Fischer U, Langnick C, Feldkamp M, Wissink-Lindhout W, Lebrun N, Castelnau L, Rucci J, Montjean R, Dorseuil O, Billuart P, Stuhlmann T, Shaw M, Corbett MA, Gardner A, Willis-Owen S, Tan C, Friend KL, Belet S, van Roozendaal KE, Jimenez-Pocquet M, Moizard MP, Ronce N, Sun R, O'Keeffe S, Chenna R, van Bömmel A, Göke J, Hackett A, Field M, Christie L, Boyle J, Haan E, Nelson J, Turner G, Baynam G, Gillessen-Kaesbach G, Müller U, Steinberger D, Budny B, Badura-Stronka M, Latos-Bieleńska A, Ousager LB, Wieacker P, Rodríguez Criado G, Bondeson ML, Annerén G, Dufke A, Cohen M, Van Maldergem L, Vincent-Delorme C, Echenne B, Simon-Bouy B, Kleefstra T, Willemsen M, Fryns JP, Devriendt K, Ullmann R, Vingron M, Wrogemann K, Wienker TF, Tzschach A, van Bokhoven H, Gecz J, Jentsch TJ, Chen W, Ropers HH, Kalscheuer VM.

Mol Psychiatry. 2016 Jan;21(1):133-48. doi: 10.1038/mp.2014.193. Epub 2015 Feb 3.

24.

Discovery of CLC transport proteins: cloning, structure, function and pathophysiology.

Jentsch TJ.

J Physiol. 2015 Sep 15;593(18):4091-109. doi: 10.1113/JP270043. Epub 2015 Aug 24. Review.

25.

Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries.

Schleifenbaum J, Kassmann M, Szijártó IA, Hercule HC, Tano JY, Weinert S, Heidenreich M, Pathan AR, Anistan YM, Alenina N, Rusch NJ, Bader M, Jentsch TJ, Gollasch M.

Circ Res. 2014 Jul 7;115(2):263-72. doi: 10.1161/CIRCRESAHA.115.302882. Epub 2014 May 16.

PMID:
24838176
26.

Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions.

Weinert S, Jabs S, Hohensee S, Chan WL, Kornak U, Jentsch TJ.

EMBO Rep. 2014 Jul;15(7):784-91. doi: 10.15252/embr.201438553. Epub 2014 May 12.

27.

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.

Voss FK, Ullrich F, Münch J, Lazarow K, Lutter D, Mah N, Andrade-Navarro MA, von Kries JP, Stauber T, Jentsch TJ.

Science. 2014 May 9;344(6184):634-8. doi: 10.1126/science.1252826. Epub 2014 Apr 10.

28.

Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction.

Hoegg-Beiler MB, Sirisi S, Orozco IJ, Ferrer I, Hohensee S, Auberson M, Gödde K, Vilches C, de Heredia ML, Nunes V, Estévez R, Jentsch TJ.

Nat Commun. 2014 Mar 19;5:3475. doi: 10.1038/ncomms4475.

29.

A missense mutation accelerating the gating of the lysosomal Cl-/H+-exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle.

Sartelet A, Stauber T, Coppieters W, Ludwig CF, Fasquelle C, Druet T, Zhang Z, Ahariz N, Cambisano N, Jentsch TJ, Charlier C.

Dis Model Mech. 2014 Jan;7(1):119-28. doi: 10.1242/dmm.012500. Epub 2013 Oct 23.

30.

CLCN7 and TCIRG1 mutations differentially affect bone matrix mineralization in osteopetrotic individuals.

Barvencik F, Kurth I, Koehne T, Stauber T, Zustin J, Tsiakas K, Ludwig CF, Beil FT, Pestka JM, Hahn M, Santer R, Supanchart C, Kornak U, Del Fattore A, Jentsch TJ, Teti A, Schulz A, Schinke T, Amling M.

J Bone Miner Res. 2014 Apr;29(4):982-91. doi: 10.1002/jbmr.2100.

31.

ClC-7 expression levels critically regulate bone turnover, but not gastric acid secretion.

Supanchart C, Wartosch L, Schlack C, Kühnisch J, Felsenberg D, Fuhrmann JC, de Vernejoul MC, Jentsch TJ, Kornak U.

Bone. 2014 Jan;58:92-102. doi: 10.1016/j.bone.2013.09.022. Epub 2013 Oct 5.

PMID:
24103576
32.

Common gating of both CLC transporter subunits underlies voltage-dependent activation of the 2Cl-/1H+ exchanger ClC-7/Ostm1.

Ludwig CF, Ullrich F, Leisle L, Stauber T, Jentsch TJ.

J Biol Chem. 2013 Oct 4;288(40):28611-9. doi: 10.1074/jbc.M113.509364. Epub 2013 Aug 27.

33.

Cell biology and physiology of CLC chloride channels and transporters.

Stauber T, Weinert S, Jentsch TJ.

Compr Physiol. 2012 Jul;2(3):1701-44. doi: 10.1002/cphy.c110038. Review.

PMID:
23723021
34.

From mice to man: chloride transport in leukoencephalopathy.

Jentsch TJ.

Lancet Neurol. 2013 Jul;12(7):626-8. doi: 10.1016/S1474-4422(13)70068-1. Epub 2013 May 22. No abstract available.

PMID:
23707148
35.

Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.

Veeramah KR, Johnstone L, Karafet TM, Wolf D, Sprissler R, Salogiannis J, Barth-Maron A, Greenberg ME, Stuhlmann T, Weinert S, Jentsch TJ, Pazzi M, Restifo LL, Talwar D, Erickson RP, Hammer MF.

Epilepsia. 2013 Jul;54(7):1270-81. doi: 10.1111/epi.12201. Epub 2013 May 3.

36.

Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.

Spitzmaul G, Tolosa L, Winkelman BH, Heidenreich M, Frens MA, Chabbert C, de Zeeuw CI, Jentsch TJ.

J Biol Chem. 2013 Mar 29;288(13):9334-44. doi: 10.1074/jbc.M112.433383. Epub 2013 Feb 13.

37.

Chloride in vesicular trafficking and function.

Stauber T, Jentsch TJ.

Annu Rev Physiol. 2013;75:453-77. doi: 10.1146/annurev-physiol-030212-183702. Epub 2012 Oct 17. Review.

PMID:
23092411
38.

A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.

Hennings JC, Picard N, Huebner AK, Stauber T, Maier H, Brown D, Jentsch TJ, Vargas-Poussou R, Eladari D, Hübner CA.

EMBO Mol Med. 2012 Oct;4(10):1057-71. doi: 10.1002/emmm.201201527. Epub 2012 Aug 30.

39.

GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit.

Jeworutzki E, López-Hernández T, Capdevila-Nortes X, Sirisi S, Bengtsson L, Montolio M, Zifarelli G, Arnedo T, Müller CS, Schulte U, Nunes V, Martínez A, Jentsch TJ, Gasull X, Pusch M, Estévez R.

Neuron. 2012 Mar 8;73(5):951-61. doi: 10.1016/j.neuron.2011.12.039.

40.

Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning.

Seja P, Schonewille M, Spitzmaul G, Badura A, Klein I, Rudhard Y, Wisden W, Hübner CA, De Zeeuw CI, Jentsch TJ.

EMBO J. 2012 Mar 7;31(5):1217-30. doi: 10.1038/emboj.2011.488. Epub 2012 Jan 17.

41.

KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man.

Heidenreich M, Lechner SG, Vardanyan V, Wetzel C, Cremers CW, De Leenheer EM, Aránguez G, Moreno-Pelayo MÁ, Jentsch TJ, Lewin GR.

Nat Neurosci. 2011 Nov 20;15(1):138-45. doi: 10.1038/nn.2985.

PMID:
22101641
42.

Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus.

Khalilov I, Chazal G, Chudotvorova I, Pellegrino C, Corby S, Ferrand N, Gubkina O, Nardou R, Tyzio R, Yamamoto S, Jentsch TJ, Hübner CA, Gaiarsa JL, Ben-Ari Y, Medina I.

Front Cell Neurosci. 2011 Nov 1;5:23. doi: 10.3389/fncel.2011.00023. eCollection 2011.

43.

Generation and analyses of R8L barttin knockin mouse.

Nomura N, Tajima M, Sugawara N, Morimoto T, Kondo Y, Ohno M, Uchida K, Mutig K, Bachmann S, Soleimani M, Ohta E, Ohta A, Sohara E, Okado T, Rai T, Jentsch TJ, Sasaki S, Uchida S.

Am J Physiol Renal Physiol. 2011 Aug;301(2):F297-307. doi: 10.1152/ajprenal.00604.2010. Epub 2011 May 18.

44.

ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity.

Leisle L, Ludwig CF, Wagner FA, Jentsch TJ, Stauber T.

EMBO J. 2011 Jun 1;30(11):2140-52. doi: 10.1038/emboj.2011.137. Epub 2011 Apr 28.

45.

Ca2+-activated Cl− currents are dispensable for olfaction.

Billig GM, Pál B, Fidzinski P, Jentsch TJ.

Nat Neurosci. 2011 Jun;14(6):763-9. doi: 10.1038/nn.2821. Epub 2011 Apr 24.

PMID:
21516098
46.

Distinct neuropathologic phenotypes after disrupting the chloride transport proteins ClC-6 or ClC-7/Ostm1.

Pressey SN, O'Donnell KJ, Stauber T, Fuhrmann JC, Tyynelä J, Jentsch TJ, Cooper JD.

J Neuropathol Exp Neurol. 2010 Dec;69(12):1228-46. doi: 10.1097/NEN.0b013e3181ffe742.

PMID:
21107136
47.

ClC-3--a granular anion transporter involved in insulin secretion?

Jentsch TJ, Maritzen T, Keating DJ, Zdebik AA, Thévenod F.

Cell Metab. 2010 Oct 6;12(4):307-308. doi: 10.1016/j.cmet.2010.08.014. No abstract available.

48.

Sorting motifs of the endosomal/lysosomal CLC chloride transporters.

Stauber T, Jentsch TJ.

J Biol Chem. 2010 Nov 5;285(45):34537-48. doi: 10.1074/jbc.M110.162545. Epub 2010 Sep 3.

49.

A cation counterflux supports lysosomal acidification.

Steinberg BE, Huynh KK, Brodovitch A, Jabs S, Stauber T, Jentsch TJ, Grinstein S.

J Cell Biol. 2010 Jun 28;189(7):1171-86. doi: 10.1083/jcb.200911083. Epub 2010 Jun 21.

50.

The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.

Tzingounis AV, Heidenreich M, Kharkovets T, Spitzmaul G, Jensen HS, Nicoll RA, Jentsch TJ.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10232-7. doi: 10.1073/pnas.1004644107. Epub 2010 May 13.

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