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Different Original and Biosimilar TNF Inhibitors Similarly Reduce Joint Destruction in Rheumatoid Arthritis-A Network Meta-Analysis of 36 Randomized Controlled Trials.

Graudal N, Kaas-Hansen BS, Guski L, Hubeck-Graudal T, Welton NJ, Jürgens G.

Int J Mol Sci. 2019 Sep 5;20(18). pii: E4350. doi: 10.3390/ijms20184350. Review.


Dose-response relation between dietary sodium and blood pressure: a meta-regression analysis of 133 randomized controlled trials.

Graudal N, Hubeck-Graudal T, Jürgens G, Taylor RS.

Am J Clin Nutr. 2019 May 1;109(5):1273-1278. doi: 10.1093/ajcn/nqy384.


The impact of human CES1 genetic variation on enzyme activity assessed by ritalinic acid/methylphenidate ratios.

Stage C, Dalhoff K, Rasmussen HB, Schow Guski L, Thomsen R, Bjerre D, Ferrero-Miliani L, Busk Madsen M, Jürgens G.

Basic Clin Pharmacol Toxicol. 2019 Jul;125(1):54-61. doi: 10.1111/bcpt.13212. Epub 2019 Apr 24.


Emergencies related to recreational drug abuse in Spain compared to emergencies attended in 3 European areas.

Miró Ò, Yates C, Dines AM, Wood DM, Dargan PI, Galán I, Jerez A, Puiguriguer J, Waring WS, Moughty A, O'Connor N, Heyerdahl F, Hovda KE, Vallersnes OM, Paasma R, Põld K, Jürgens G, Megarbane B, Anand JS, Liakoni E, Liechti M, Eyer F, Zacharov S, Caganova B, Giraudon I, Galicia M.

Emergencias. 2018 Dic;30(6):385-394. English, Spanish.


Poor Identification of Emergency Department Acute Recreational Drug Toxicity Presentations Using Routine Hospital Coding Systems: the Experience in Denmark, Switzerland and the UK.

Wood DM, De La Rue L, Hosin AA, Jurgens G, Liakoni E, Heyerdahl F, Hovda KE, Dines A, Giraudon I, Liechti ME, Dargan PI.

J Med Toxicol. 2019 Apr;15(2):112-120. doi: 10.1007/s13181-018-0687-z. Epub 2019 Jan 2.


The impact of Bacillus subtilis DSM 32315 on the pathology, performance, and intestinal microbiome of broiler chickens in a necrotic enteritis challenge.

Whelan RA, Doranalli K, Rinttilä T, Vienola K, Jurgens G, Apajalahti J.

Poult Sci. 2019 Sep 1;98(9):3450-3463. doi: 10.3382/ps/pey500.


A single class of ARF GTPase activated by several pathway-specific ARF-GEFs regulates essential membrane traffic in Arabidopsis.

Singh MK, Richter S, Beckmann H, Kientz M, Stierhof YD, Anders N, Fäßler F, Nielsen M, Knöll C, Thomann A, Franz-Wachtel M, Macek B, Skriver K, Pimpl P, Jürgens G.

PLoS Genet. 2018 Nov 15;14(11):e1007795. doi: 10.1371/journal.pgen.1007795. eCollection 2018 Nov.


Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate.

Kaddurah-Daouk R, Hankemeier T, Scholl EH, Baillie R, Harms A, Stage C, Dalhoff KP, Jűrgens G, Taboureau O, Nzabonimpa GS, Motsinger-Reif AA, Thomsen R, Linnet K, Rasmussen HB; INDICES Consortium; Pharmacometabolomics Research Network.

CPT Pharmacometrics Syst Pharmacol. 2018 Aug;7(8):525-533. doi: 10.1002/psp4.12309.


Sodium Excretion in Population Subgroups.

Jürgens G.

JAMA. 2018 Aug 21;320(7):719-720. doi: 10.1001/jama.2018.8012. No abstract available.


Functional diversification of Arabidopsis SEC1-related SM proteins in cytokinetic and secretory membrane fusion.

Karnahl M, Park M, Krause C, Hiller U, Mayer U, Stierhof YD, Jürgens G.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6309-6314. doi: 10.1073/pnas.1722611115. Epub 2018 May 29.


Conflicting Evidence on Health Effects Associated with Salt Reduction Calls for a Redesign of the Salt Dietary Guidelines.

Graudal N, Jürgens G.

Prog Cardiovasc Dis. 2018 May - Jun;61(1):20-26. doi: 10.1016/j.pcad.2018.04.008. Epub 2018 May 2. Review.


Auxin and Vesicle Traffic.

Robinson DG, Hawes C, Hillmer S, Jürgens G, Schwechheimer C, Stierhof YD, Viotti C.

Plant Physiol. 2018 Mar;176(3):1884-1888. doi: 10.1104/pp.17.01510. Epub 2018 Mar 6. No abstract available.


Tall oil fatty acid inclusion in the diet improves performance and increases ileal density of lactobacilli in broiler chickens.

Vienola K, Jurgens G, Vuorenmaa J, Apajalahti J.

Br Poult Sci. 2018 Jun;59(3):349-355. doi: 10.1080/00071668.2018.1455965. Epub 2018 Apr 20.


Concerted Action of Evolutionarily Ancient and Novel SNARE Complexes in Flowering-Plant Cytokinesis.

Park M, Krause C, Karnahl M, Reichardt I, El Kasmi F, Mayer U, Stierhof YD, Hiller U, Strompen G, Bayer M, Kientz M, Sato MH, Nishimura MT, Dangl JL, Sanderfoot AA, Jürgens G.

Dev Cell. 2018 Feb 26;44(4):500-511.e4. doi: 10.1016/j.devcel.2017.12.027. Epub 2018 Jan 27.


Plant membrane trafficking is coming of age.

Jürgens G, Pimpl P.

Semin Cell Dev Biol. 2018 Aug;80:83-84. doi: 10.1016/j.semcdb.2018.01.006. Epub 2018 Feb 6. No abstract available.


Specificity of plant membrane trafficking - ARFs, regulators and coat proteins.

Singh MK, Jürgens G.

Semin Cell Dev Biol. 2018 Aug;80:85-93. doi: 10.1016/j.semcdb.2017.10.005. Epub 2017 Oct 13. Review.


The prognosis following amphetamine poisoning.

Horwitz H, Dalhoff KP, Klemp M, Horwitz A, Andersen JT, Jürgens G.

Scand J Public Health. 2017 Dec;45(8):773-781. doi: 10.1177/1403494817707634. Epub 2017 Aug 21.


VPS9a Activates the Rab5 GTPase ARA7 to Confer Distinct Pre- and Postinvasive Plant Innate Immunity.

Nielsen ME, Jürgens G, Thordal-Christensen H.

Plant Cell. 2017 Aug;29(8):1927-1937. doi: 10.1105/tpc.16.00859. Epub 2017 Aug 14.


Evolutionarily diverse SYP1 Qa-SNAREs jointly sustain pollen tube growth in Arabidopsis.

Slane D, Reichardt I, El Kasmi F, Bayer M, Jürgens G.

Plant J. 2017 Nov;92(3):375-385. doi: 10.1111/tpj.13659. Epub 2017 Sep 17.


Reappraisal of the genetic diversity and pharmacogenetic assessment of CES1.

Ferrero-Miliani L, Bjerre D, Stage C, Madsen MB, Jűrgens G, Dalhoff KP, Rasmussen HB.

Pharmacogenomics. 2017 Aug;18(13):1241-1257. doi: 10.2217/pgs-2017-0052. Epub 2017 Aug 8.


The Pharmacokinetics of Enalapril in Relation to CES1 Genotype in Healthy Danish Volunteers.

Stage C, Jürgens G, Guski LS, Thomsen R, Bjerre D, Ferrero-Miliani L, Lyauk YK, Rasmussen HB, Dalhoff K; INDICES Consortium (for members of this consortium-see Supplementum).

Basic Clin Pharmacol Toxicol. 2017 Dec;121(6):487-492. doi: 10.1111/bcpt.12835. Epub 2017 Jul 25.


Intoxication by gamma hydroxybutyrate and related analogues: Clinical characteristics and comparison between pure intoxication and that combined with other substances of abuse.

Miró Ò, Galicia M, Dargan P, Dines AM, Giraudon I, Heyerdahl F, Hovda KE, Yates C, Wood DM, Liakoni E, Liechti M, Jürgens G, Pedersen CB, O'Connor N, Markey G, Moughty A, Lee C, O'Donohoe P, Sein Anand J, Puiguriguer J, Homar C, Eyer F, Vallersnes OM, Persett PS, Chevillard L, Mégarbane B, Paasma R, Waring WS, Põld K, Rabe C, Kabata PM.

Toxicol Lett. 2017 Aug 5;277:84-91. doi: 10.1016/j.toxlet.2017.05.030. Epub 2017 Jun 1.


ER assembly of SNARE complexes mediating formation of partitioning membrane in Arabidopsis cytokinesis.

Karnahl M, Park M, Mayer U, Hiller U, Jürgens G.

Elife. 2017 May 19;6. pii: e25327. doi: 10.7554/eLife.25327.


[Haloperidol and promethazine in psychotic aggression].

Jürgens G, Bauer JØ.

Ugeskr Laeger. 2017 Apr 17;179(16). pii: V69167. Danish. No abstract available.


Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride.

Graudal NA, Hubeck-Graudal T, Jurgens G.

Cochrane Database Syst Rev. 2017 Apr 9;4:CD004022. doi: 10.1002/14651858.CD004022.pub4. Review.


Dynamic PIN-FORMED auxin efflux carrier phosphorylation at the plasma membrane controls auxin efflux-dependent growth.

Weller B, Zourelidou M, Frank L, Barbosa IC, Fastner A, Richter S, Jürgens G, Hammes UZ, Schwechheimer C.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E887-E896. doi: 10.1073/pnas.1614380114. Epub 2017 Jan 17.


The impact of CES1 genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects.

Stage C, Jürgens G, Guski LS, Thomsen R, Bjerre D, Ferrero-Miliani L, Lyauk YK, Rasmussen HB, Dalhoff K; INDICES Consortium.

Br J Clin Pharmacol. 2017 Jul;83(7):1506-1514. doi: 10.1111/bcp.13237. Epub 2017 Feb 24.


Screening for novel genes of Saccharomyces cerevisiae involved in recombinant antibody production.

de Ruijter JC, Jurgens G, Frey AD.

FEMS Yeast Res. 2017 Jan;17(1). pii: fow104. doi: 10.1093/femsyr/fow104. Epub 2016 Dec 11.


Early plant embryogenesis-dark ages or dark matter?

Bayer M, Slane D, Jürgens G.

Curr Opin Plant Biol. 2017 Feb;35:30-36. doi: 10.1016/j.pbi.2016.10.004. Epub 2016 Oct 31. Review.


Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 (CES1) Variants.

Lyauk YK, Stage C, Bergmann TK, Ferrero-Milliani L, Bjerre D, Thomsen R, Dalhoff KP, Rasmussen HB, Jürgens G.

Clin Transl Sci. 2016 Dec;9(6):337-345. doi: 10.1111/cts.12423. Epub 2016 Oct 18.


Clinical Pharmacology in Denmark in 2016 - 40 Years with the Danish Society of Clinical Pharmacology and 20 Years as a Medical Speciality.

Brøsen K, Andersen SE, Borregaard J, Christensen HR, Christensen PM, Dalhoff KP, Damkier P, Hallas J, Heisterberg J, Jessen N, Jürgens G, Kampmann JP, Laursen BE, Laursen T, Nielsen LP, Poulsen BK, Poulsen HE, Andersen LV, Senderovitz T, Sonne J.

Basic Clin Pharmacol Toxicol. 2016 Dec;119(6):523-532. doi: 10.1111/bcpt.12681. Epub 2016 Oct 23. Review.


Reduced Dietary Sodium Intake Increases Heart Rate. A Meta-Analysis of 63 Randomized Controlled Trials Including 72 Study Populations.

Graudal NA, Hubeck-Graudal T, Jürgens G.

Front Physiol. 2016 Mar 24;7:111. doi: 10.3389/fphys.2016.00111. eCollection 2016.


Simvastatin Efficiently Lowers Small LDL-IgG Immune Complex Levels: A Therapeutic Quality beyond the Lipid-Lowering Effect.

Hörl G, Froehlich H, Ferstl U, Ledinski G, Binder J, Cvirn G, Stojakovic T, Trauner M, Koidl C, Tafeit E, Amrein K, Scharnagl H, Jürgens G, Hallström S.

PLoS One. 2016 Feb 3;11(2):e0148210. doi: 10.1371/journal.pone.0148210. eCollection 2016.


Plant cytokinesis-No ring, no constriction but centrifugal construction of the partitioning membrane.

Müller S, Jürgens G.

Semin Cell Dev Biol. 2016 May;53:10-8. doi: 10.1016/j.semcdb.2015.10.037. Epub 2015 Oct 31. Review.


An S-Acylation Switch of Conserved G Domain Cysteines Is Required for Polarity Signaling by ROP GTPases.

Sorek N, Segev O, Gutman O, Bar E, Richter S, Poraty L, Hirsch JA, Henis YI, Lewinsohn E, Jürgens G, Yalovsky S.

Curr Biol. 2015 Nov 2;25(21):2875-2877. doi: 10.1016/j.cub.2015.10.029. Epub 2015 Nov 2. No abstract available.


Profiling of embryonic nuclear vs. cellular RNA in Arabidopsis thaliana.

Slane D, Kong J, Schmid M, Jürgens G, Bayer M.

Genom Data. 2015 Apr 8;4:96-8. doi: 10.1016/j.gdata.2015.03.015. eCollection 2015 Jun.


The Pleiotropic Effects of Atorvastatin on Stable Angina Patients: Evidence by Analysis of High-Density Lipoprotein Size and Subclasses, and Plasma mRNA.

Mirjanić-Azarić B, Jelić-Ivanović Z, Zeljković A, Vekić J, Jürgens G, Milivojac T, Avram S, Ćorić J, Marc J, Černe D.

J Med Biochem. 2015 Jul;34(3):314-322. doi: 10.2478/jomb-2014-0058. Epub 2015 Jul 14.


Adverse Events Associated with Flumazenil Treatment for the Management of Suspected Benzodiazepine Intoxication--A Systematic Review with Meta-Analyses of Randomised Trials.

Penninga EI, Graudal N, Ladekarl MB, Jürgens G.

Basic Clin Pharmacol Toxicol. 2016 Jan;118(1):37-44. doi: 10.1111/bcpt.12434. Epub 2015 Jul 28. Review.


The blood pressure sensitivity to changes in sodium intake is similar in Asians, Blacks and Whites. An analysis of 92 randomized controlled trials.

Graudal N, Jürgens G.

Front Physiol. 2015 May 21;6:157. doi: 10.3389/fphys.2015.00157. eCollection 2015.


Combination Therapy With and Without Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis: A Meta-Analysis of Randomized Trials.

Graudal N, Hubeck-Graudal T, Faurschou M, Baslund B, Jürgens G.

Arthritis Care Res (Hoboken). 2015 Nov;67(11):1487-95. doi: 10.1002/acr.22618.


Atorvastatin treatment increases plasma bilirubin but not HMOX1 expression in stable angina patients.

Mirjanic-Azaric B, Rizzo M, Jürgens G, Hallstroem S, Srdic S, Marc J, Cerne D.

Scand J Clin Lab Invest. 2015 Sep;75(5):382-9. doi: 10.3109/00365513.2015.1031691. Epub 2015 Apr 29.


Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics.

Rasmussen HB, Bjerre D, Linnet K, Jürgens G, Dalhoff K, Stefansson H, Hankemeier T, Kaddurah-Daouk R, Taboureau O, Brunak S, Houmann T, Jeppesen P, Pagsberg AK, Plessen K, Dyrborg J, Hansen PR, Hansen PE, Hughes T, Werge T; INDICES Consortium.

Pharmacogenomics. 2015;16(6):649-65. doi: 10.2217/pgs.15.7. Epub 2015 Apr 21. Review.


Levothyroxine Poisoning - Symptoms and Clinical Outcome.

Nygaard B, Saedder EA, Dalhoff K, Wikkelsoe M, Jürgens G.

Basic Clin Pharmacol Toxicol. 2015 Oct;117(4):280-5. doi: 10.1111/bcpt.12401. Epub 2015 Apr 20. Review.


The significance of duration and amount of sodium reduction intervention in normotensive and hypertensive individuals: a meta-analysis.

Graudal N, Hubeck-Graudal T, Jürgens G, McCarron DA.

Adv Nutr. 2015 Mar 13;6(2):169-77. doi: 10.3945/an.114.007708. Print 2015 Mar. Review. Erratum in: Adv Nutr. 2015 May;6(3):285.


[Cannabis--abuse and consequences].

Wøien VA, Horwitz H, Høgberg LC, Askaa B, Jürgens G.

Ugeskr Laeger. 2015 Feb 2;177(6). pii: V04140228. Review. Danish.


Etanercept tapering in rheumatoid arthritis.

Graudal N, Jürgens G.

N Engl J Med. 2015 Jan 29;372(5):489. doi: 10.1056/NEJMc1414787. No abstract available.


Plant cytokinesis: a tale of membrane traffic and fusion.

Jürgens G, Park M, Richter S, Touihri S, Krause C, El Kasmi F, Mayer U.

Biochem Soc Trans. 2015 Feb;43(1):73-8. doi: 10.1042/BST20140246. Review.


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