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Items: 1 to 50 of 267

1.

Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.

Cerrada-Gimenez M, Pietilä M, Loimas S, Pirinen E, Hyvönen MT, Keinänen TA, Jänne J, Alhonen L.

Transgenic Res. 2011 Apr;20(2):387-96. doi: 10.1007/s11248-010-9422-5. Epub 2010 Jun 25.

PMID:
20577801
2.

The role of spermidine/spermine N1-acetyltransferase in endotoxin-induced acute kidney injury.

Zahedi K, Barone S, Kramer DL, Amlal H, Alhonen L, Jänne J, Porter CW, Soleimani M.

Am J Physiol Cell Physiol. 2010 Jul;299(1):C164-74. doi: 10.1152/ajpcell.00512.2009. Epub 2010 Apr 14.

3.

Proteomic analysis of livers from a transgenic mouse line with activated polyamine catabolism.

Cerrada-Gimenez M, Häyrinen J, Juutinen S, Reponen T, Jänne J, Alhonen L.

Amino Acids. 2010 Feb;38(2):613-22. doi: 10.1007/s00726-009-0420-y. Epub 2009 Dec 10.

PMID:
20012117
4.

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis.

Pirinen E, Gylling H, Itkonen P, Yaluri N, Heikkinen S, Pietilä M, Kuulasmaa T, Tusa M, Cerrada-Gimenez M, Pihlajamäki J, Alhonen L, Jänne J, Miettinen TA, Laakso M.

Amino Acids. 2010 Feb;38(2):549-60. doi: 10.1007/s00726-009-0416-7. Epub 2009 Dec 3.

PMID:
19956992
5.

Cutaneous application of alpha-methylspermidine activates the growth of resting hair follicles in mice.

Fashe TM, Keinänen TA, Grigorenko NA, Khomutov AR, Jänne J, Alhonen L, Pietilä M.

Amino Acids. 2010 Feb;38(2):583-90. doi: 10.1007/s00726-009-0421-x. Epub 2009 Dec 3.

PMID:
19956989
6.

Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.

Vuohelainen S, Pirinen E, Cerrada-Gimenez M, Keinänen TA, Uimari A, Pietilä M, Khomutov AR, Jänne J, Alhonen L.

J Cell Mol Med. 2010 Jun;14(6B):1683-92. doi: 10.1111/j.1582-4934.2009.00808.x. Epub 2009 Jun 16.

7.

Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues.

Hyvönen MT, Howard MT, Anderson CB, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J, Keinänen TA.

Biochem J. 2009 Aug 13;422(2):321-8. doi: 10.1042/BJ20090737.

PMID:
19522702
8.

Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts.

Uimari A, Keinänen TA, Karppinen A, Woster P, Uimari P, Jänne J, Alhonen L.

Biochem J. 2009 Jul 29;422(1):101-9. doi: 10.1042/BJ20090411.

9.

[Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism].

Khomutov AR, Keinanen TA, Grigorenko NA, Hyvonen MT, Uimari A, Pietila M, Cerrada-Gimenez M, Simonian AR, Khomutov MA, Verspalainen J, Alhonen L, Janne J.

Mol Biol (Mosk). 2009 Mar-Apr;43(2):274-85. Russian.

PMID:
19425496
10.

Spermidine/spermine-N1-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice.

Zahedi K, Lentsch AB, Okaya T, Barone S, Sakai N, Witte DP, Arend LJ, Alhonen L, Jell J, Jänne J, Porter CW, Soleimani M.

Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G899-909. doi: 10.1152/ajpgi.90507.2008. Epub 2009 Jan 22.

11.

Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS.

Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S.

J Pharm Biomed Anal. 2008 Sep 29;48(2):414-21. doi: 10.1016/j.jpba.2008.02.019. Epub 2008 Feb 26.

PMID:
18394842
12.

Effect of medium- and long-chain fatty acid diets on PPAR and SREBP-1 expression and glucose homeostasis in ACBP-overexpressing transgenic rats.

Oikari S, Ahtialansaari T, Huotari A, Kiehne K, Fölsch UR, Wolffram S, Jänne J, Alhonen L, Herzig KH.

Acta Physiol (Oxf). 2008 Sep;194(1):57-65. doi: 10.1111/j.1748-1716.2008.01860.x. Epub 2008 Apr 3.

PMID:
18394026
13.

Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats.

Oikari S, Ahtialansaari T, Heinonen MV, Mauriala T, Auriola S, Kiehne K, Fölsch UR, Jänne J, Alhonen L, Herzig KH.

Pflugers Arch. 2008 May;456(2):369-77. Epub 2007 Dec 22.

PMID:
18157544
14.

Novel CoA-polyamine conjugates for effective inhibition of spermine/spermidine-N1-acetyltransferase.

Simonian A, Khomutov A, Hyvonen T, Grigorenko N, Keinanen T, Vepsalainen J, Alhonen L, Janne J.

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1245-8.

PMID:
18066761
15.

Analysis of underivatized polyamines by reversed phase liquid chromatography with electrospray tandem mass spectrometry.

Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S.

J Pharm Biomed Anal. 2007 Nov 30;45(4):625-34. Epub 2007 Sep 7.

PMID:
17945452
16.

Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.

Hyvönen MT, Keinänen TA, Cerrada-Gimenez M, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J.

J Biol Chem. 2007 Nov 30;282(48):34700-6. Epub 2007 Sep 27.

17.

Alpha-methylated polyamines as potential drugs and experimental tools in enzymology.

Keinänen TA, Järvinen A, Uimari A, Vepsäläinen J, Khomutov AR, Grigorenko NA, Hyvönen MT, Cerrada-Gimenez M, Alhonen L, Jänne J.

Mini Rev Med Chem. 2007 Aug;7(8):813-20. Review.

PMID:
17692042
18.

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.

Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen AL, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J, Laakso M.

Mol Cell Biol. 2007 Jul;27(13):4953-67. Epub 2007 May 7.

19.

Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis.

Merentie M, Uimari A, Pietilä M, Sinervirta R, Keinänen TA, Vepsäläinen J, Khomutov A, Grigorenko N, Herzig KH, Jänne J, Alhonen L.

Amino Acids. 2007 Aug;33(2):323-30. Epub 2007 Apr 6.

PMID:
17410333
20.

Mechanisms of polyamine catabolism-induced acute pancreatitis.

Hyvönen MT, Merentie M, Uimari A, Keinänen TA, Jänne J, Alhonen L.

Biochem Soc Trans. 2007 Apr;35(Pt 2):326-30.

PMID:
17371271
21.

Short and long-term effects of hVEGF-A(165) in Cre-activated transgenic mice.

Leppänen P, Kholová I, Mähönen AJ, Airenne K, Koota S, Mansukoski H, Närväinen J, Wirzenius M, Alhonen L, Jänne J, Alitalo K, Ylä-Herttuala S.

PLoS One. 2006 Dec 20;1:e13.

22.

Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocampus-dependent learning.

Siiskonen H, Oikari S, Korhonen VP, Pitkänen A, Voikar V, Kettunen M, Hakumäki J, Wahlfors T, Pussinen R, Penttonen M, Kiehne K, Kaasinen SK, Alhonen L, Jänne J, Herzig KH.

Mol Cell Neurosci. 2007 Feb;34(2):199-208. Epub 2006 Dec 4.

PMID:
17150371
23.

Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.

Niiranen K, Keinänen TA, Pirinen E, Heikkinen S, Tusa M, Fatrai S, Suppola S, Pietilä M, Uimari A, Laakso M, Alhonen L, Jänne J.

J Cell Mol Med. 2006 Oct-Dec;10(4):933-45.

24.

Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1-acetyltransferase.

Hyvönen MT, Uimari A, Keinänen TA, Heikkinen S, Pellinen R, Wahlfors T, Korhonen A, Närvänen A, Wahlfors J, Alhonen L, Jänne J.

RNA. 2006 Aug;12(8):1569-82. Epub 2006 Jun 29.

25.

Polyamine depletion and cell cycle manipulation in combination with HSV thymidine kinase/ganciclovir cancer gene therapy.

Wahlfors T, Karppinen A, Jänne J, Alhonen L, Wahlfors J.

Int J Oncol. 2006 Jun;28(6):1515-22.

PMID:
16685452
26.

Genetic manipulation of polyamine catabolism in rodents.

Jänne J, Alhonen L, Pietilä M, Keinänen TA, Uimari A, Hyvönen MT, Pirinen E, Järvinen A.

J Biochem. 2006 Feb;139(2):155-60. Review.

PMID:
16452302
27.

activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality.

Hyvönen MT, Herzig KH, Sinervirta R, Albrecht E, Nordback I, Sand J, Keinänen TA, Vepsäläinen J, Grigorenko N, Khomutov AR, Krüger B, Jänne J, Alhonen L.

Am J Pathol. 2006 Jan;168(1):115-22.

28.

Alpha-methyl polyamines: efficient synthesis and tolerance studies in vivo and in vitro. First evidence for dormant stereospecificity of polyamine oxidase.

Järvinen AJ, Cerrada-Gimenez M, Grigorenko NA, Khomutov AR, Vepsäläinen JJ, Sinervirta RM, Keinänen TA, Alhonen LI, Jänne JE.

J Med Chem. 2006 Jan 12;49(1):399-406.

PMID:
16392825
29.

In vivo enhancement of herpes simplex virus thymidine kinase/ganciclovir cancer gene therapy with polyamine biosynthesis inhibition.

Wahlfors T, Hakkarainen T, Jänne J, Alhonen L, Wahlfors J.

Int J Cancer. 2006 Jun 1;118(11):2907-10.

30.

Animal disease models generated by genetic engineering of polyamine metabolism.

Jänne J, Alhonen L, Keinänen TA, Pietilä M, Uimari A, Pirinen E, Hyvönen MT, Järvinen A.

J Cell Mol Med. 2005 Oct-Dec;9(4):865-82. Review.

31.

Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase.

Järvinen A, Keinänen TA, Grigorenko NA, Khomutov AR, Uimari A, Vepsäläinen J, Närvänen A, Alhonen L, Jänne J.

J Biol Chem. 2006 Feb 24;281(8):4589-95. Epub 2005 Dec 14.

32.

Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase.

Tucker JM, Murphy JT, Kisiel N, Diegelman P, Barbour KW, Davis C, Medda M, Alhonen L, Jänne J, Kramer DL, Porter CW, Berger FG.

Cancer Res. 2005 Jun 15;65(12):5390-8.

33.

[New oxaanalogues of spermine].

Khomutov AR, Simonian AR, Vespalainen J, Keinanen TA, Alhonen L, Janne J.

Bioorg Khim. 2005 Mar-Apr;31(2):206-12. Russian.

PMID:
15889796
34.

[New syntheses of alpha-methyl- and alpha,alpha'-dimethylspermine].

Grigorenko NA, Vepsalainen J, Jarvinen A, Keinanen TA, Alhonen L, Janne J, Khomutov AR.

Bioorg Khim. 2005 Mar-Apr;31(2):200-5. Russian.

PMID:
15889795
35.

Acute pancreatitis induced by activation of the polyamine catabolism in gene-modified mice and rats overexpressing spermidine/spermine N1-acetyltransferase.

Herzig KH, Jänne J, Alhonen L.

Scand J Gastroenterol. 2005 Jan;40(1):120-1. No abstract available.

PMID:
15841726
36.

Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N-acetyltransferase overexpression.

Pietilä M, Pirinen E, Keskitalo S, Juutinen S, Pasonen-Seppänen S, Keinänen T, Alhonen L, Jänne J.

J Invest Dermatol. 2005 Mar;124(3):596-601.

37.

Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines.

Järvinen A, Grigorenko N, Khomutov AR, Hyvönen MT, Uimari A, Vepsäläinen J, Sinervirta R, Keinänen TA, Vujcic S, Alhonen L, Porter CW, Jänne J.

J Biol Chem. 2005 Feb 25;280(8):6595-601. Epub 2004 Dec 16.

38.

Early dysregulation of hippocampal proteins in transgenic rats with Alzheimer's disease-linked mutations in amyloid precursor protein and presenilin 1.

Vercauteren FG, Clerens S, Roy L, Hamel N, Arckens L, Vandesande F, Alhonen L, Janne J, Szyf M, Cuello AC.

Brain Res Mol Brain Res. 2004 Dec 20;132(2):241-59.

PMID:
15582162
39.

Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons.

Echeverria V, Ducatenzeiler A, Dowd E, Jänne J, Grant SM, Szyf M, Wandosell F, Avila J, Grimm H, Dunnett SB, Hartmann T, Alhonen L, Cuello AC.

Neuroscience. 2004;129(3):583-92.

PMID:
15541880
40.

[A new synthesis of alpha-methylspermidine].

Grigorenko NA, Vepsalainen J, Jarvinen A, Keinanen TA, Alhonen L, Janne J, Kritsyn AM, Khomutov AR.

Bioorg Khim. 2004 Jul-Aug;30(4):441-5. Russian.

PMID:
15469020
41.

Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex.

Echeverria V, Ducatenzeiler A, Alhonen L, Janne J, Grant SM, Wandosell F, Muro A, Baralle F, Li H, Duff K, Szyf M, Cuello AC.

J Alzheimers Dis. 2004 Jun;6(3):209-19.

PMID:
15201476
42.

Spermidine/spermine N1-acetyltransferase overexpression in mice induces hypoactivity and spatial learning impairment.

Kaasinen SK, Oksman M, Alhonen L, Tanila H, Jänne J.

Pharmacol Biochem Behav. 2004 May;78(1):35-45.

PMID:
15159132
43.

Genetic approaches to the cellular functions of polyamines in mammals.

Jänne J, Alhonen L, Pietilä M, Keinänen TA.

Eur J Biochem. 2004 Mar;271(5):877-94. Review.

PMID:
15009201
44.

Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb.

Pirinen E, Heikkinen S, Malkki M, Deeb SS, Jänne J, Laakso M.

Biochim Biophys Acta. 2004 Jan 20;1676(2):149-54.

PMID:
14746909
45.

Tissue-specific expression of the prostatic acid phosphatase promoter constructs.

Shan J, Porvari K, Kivinen A, Patrikainen L, Halmekytö M, Jänne J, Vihko P.

Biochem Biophys Res Commun. 2003 Nov 28;311(4):864-9.

PMID:
14623260
46.

Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice.

Kaasinen SK, Gröhn OH, Keinänen TA, Alhonen L, Jänne J.

Exp Neurol. 2003 Oct;183(2):645-52.

PMID:
14552906
47.

Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase.

Räsänen TL, Alhonen L, Sinervirta R, Uimari A, Kaasinen K, Keinänen T, Herzig KH, Jänne J.

Scand J Gastroenterol. 2003 Jul;38(7):787-93.

PMID:
12889567
48.

Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells.

Pasanen T, Karppinen A, Alhonen L, Jänne J, Wahlfors J.

Int J Cancer. 2003 Apr 10;104(3):380-8.

49.

p53-independent apoptosis in UV-irradiated mouse skin: possible inhibition by 50 Hz magnetic fields.

Kumlin T, Heikkinen P, Kosma VM, Alhonen L, Jänne J, Juutilainen J.

Radiat Environ Biophys. 2002 Jun;41(2):155-8.

PMID:
12201060
50.

A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism.

Rasanen TL, Alhonen L, Sinervirta R, Keinanen T, Herzig KH, Suppola S, Khomutov AR, Vepsalainen J, Janne J.

J Biol Chem. 2002 Oct 18;277(42):39867-72. Epub 2002 Aug 13.

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