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The therapeutic potential of targeting CD40-TRAF6 pathway in cardiovascular Diseases.

Bosch L, de Haan JJ, Seijkens TTP, van Tiel CM, Brans MAD, Pasterkamp G, Lutgens E, de Jager SCA.

Int J Cardiol. 2020 Feb 1;300:220. doi: 10.1016/j.ijcard.2019.09.013. No abstract available.


Potential of mesenchymal- and cardiac progenitor cells for therapeutic targeting of B-cells and antibody responses in end-stage heart failure.

van den Hoogen P, de Jager SCA, Mol EA, Schoneveld AS, Huibers MMH, Vink A, Doevendans PA, Laman JD, Sluijter JPG.

PLoS One. 2019 Dec 31;14(12):e0227283. doi: 10.1371/journal.pone.0227283. eCollection 2019.


Multi-dimensional computational pipeline for large-scale deep screening of compound effect assessment: an in silico case study on ageing-related compounds.

Gupta V, Crudu A, Matsuoka Y, Ghosh S, Rozot R, Marat X, Jäger S, Kitano H, Breton L.

NPJ Syst Biol Appl. 2019 Nov 26;5:42. doi: 10.1038/s41540-019-0119-y. eCollection 2019.


Platelet RNA modules point to coronary calcification in asymptomatic women with former preeclampsia.

Hartman RJG, Korporaal SJA, Mokry M, de Jager SCA, Meeuwsen JAL, van der Laan SW, Lansu NR, Zoet GA, Pasterkamp G, Urbanus RT, Hoefer IE, Franx A, Velthuis BK, van Rijn BB, den Ruijter HM; Queen of Hearts and CREW consortia.

Atherosclerosis. 2019 Dec;291:114-121. doi: 10.1016/j.atherosclerosis.2019.10.009. Epub 2019 Oct 11.


Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells.

Frodermann V, Rohde D, Courties G, Severe N, Schloss MJ, Amatullah H, McAlpine CS, Cremer S, Hoyer FF, Ji F, van Koeverden ID, Herisson F, Honold L, Masson GS, Zhang S, Grune J, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Lee IH, Gustafsson K, Pasterkamp G, de Jager SCA, Sadreyev RI, MacFadyen J, Libby P, Ridker P, Scadden DT, Naxerova K, Jeffrey KL, Swirski FK, Nahrendorf M.

Nat Med. 2019 Nov;25(11):1761-1771. doi: 10.1038/s41591-019-0633-x. Epub 2019 Nov 7.


Isolation of Anti-Hapten Antibodies by Fluorescence-Activated Cell Sorting of Yeast-Displayed B-Cell Receptor Gene Repertoires.

Jäger S, Krah S, Könning D, Rosskopf J, Dickgiesser S, Rasche N, Kolmar H, Hecht S, Schröter C.

Methods Mol Biol. 2020;2070:267-287. doi: 10.1007/978-1-4939-9853-1_15.


Isolation of Tailor-Made Antibody Fragments from Yeast-Displayed B-Cell Receptor Repertoires by Multiparameter Fluorescence-Activated Cell Sorting.

Kaempffe A, Jäger S, Könning D, Kolmar H, Schröter C.

Methods Mol Biol. 2020;2070:249-266. doi: 10.1007/978-1-4939-9853-1_14.


Selection and Characterization of Anti-idiotypic Shark Antibody Domains.

Könning D, Zielonka S, Kaempffe A, Jäger S, Kolmar H, Schröter C.

Methods Mol Biol. 2020;2070:191-209. doi: 10.1007/978-1-4939-9853-1_11.


Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells.

Fontaine MAC, Westra MM, Bot I, Jin H, Franssen AJPM, Bot M, de Jager SCA, Dzhagalov I, He YW, van Vlijmen BJM, Gijbels MJJ, Reutelingsperger CP, van Berkel TJC, Sluimer JC, Temmerman L, Biessen EAL.

Sci Rep. 2019 Oct 10;9(1):14547. doi: 10.1038/s41598-019-51020-3.


Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure.

van den Hoogen P, de Jager SCA, Huibers MMH, Schoneveld AH, Puspitasari YM, Valstar GB, Oerlemans MIFJ, de Weger RA, Doevendans PA, den Ruijter HM, Laman JD, Vink A, Sluijter JPG.

J Cell Mol Med. 2019 Nov;23(11):7505-7516. doi: 10.1111/jcmm.14619. Epub 2019 Sep 26.


Dynamical Phase Transitions to Optomechanical Superradiance.

Jäger SB, Cooper J, Holland MJ, Morigi G.

Phys Rev Lett. 2019 Aug 2;123(5):053601. doi: 10.1103/PhysRevLett.123.053601.


Femoral Cementation in Knee Arthroplasty-A Comparison of Three Cementing Techniques in a Sawbone Model Using the ATTUNE Knee.

Schwarze M, Schonhoff M, Beckmann NA, Eckert JA, Bitsch RG, Jäger S.

J Knee Surg. 2019 Aug 21. doi: 10.1055/s-0039-1694795. [Epub ahead of print]


CRISPR/Cas9-mediated Knockout of the Neuropsychiatric Risk Gene KCTD13 Causes Developmental Deficits in Human Cortical Neurons Derived from Induced Pluripotent Stem Cells.

Kizner V, Naujock M, Fischer S, Jäger S, Reich S, Schlotthauer I, Zuckschwerdt K, Geiger T, Hildebrandt T, Lawless N, Macartney T, Dorner-Ciossek C, Gillardon F.

Mol Neurobiol. 2019 Aug 11. doi: 10.1007/s12035-019-01727-1. [Epub ahead of print]


[Workshop report: Listening to stories: Using podcasts and storytelling to communicate science and evidence].

Jäger S, Hinneburg I.

Z Evid Fortbild Qual Gesundhwes. 2019 Aug;144-145:84-89. doi: 10.1016/j.zefq.2019.07.004. Epub 2019 Jul 28. German.


Local inflammatory responses take their toll on the heart.

de Jager SCA, Hoefer IE.

Int J Cardiol. 2019 Oct 15;293:254-255. doi: 10.1016/j.ijcard.2019.07.055. Epub 2019 Jul 22. No abstract available.


A Pro-Inflammatory Biomarker-Profile Predicts Amputation-Free Survival in Patients with Severe Limb Ischemia.

Gremmels H, Teraa M, de Jager SCA, Pasterkamp G, de Borst GJ, Verhaar MC.

Sci Rep. 2019 Jul 24;9(1):10740. doi: 10.1038/s41598-019-47217-1.


Corrigendum to 'Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure' [Int. J. Cardiol., Volume 279, 15 March 2019, Pages 141-144].

Bosch L, de Haan JJ, Seijkens TTP, van Tiel CM, Brans MAD, Pasterkamp G, Lutgens E, de Jager SCA.

Int J Cardiol. 2019 Oct 15;293:297. doi: 10.1016/j.ijcard.2019.07.044. Epub 2019 Jul 18. No abstract available.


SICOR: Subgraph Isomorphism Comparison of RNA Secondary Structures.

Schmidt M, Hamacher K, Reinhardt F, Lotz T, Groher F, Suess B, Jager S.

IEEE/ACM Trans Comput Biol Bioinform. 2019 Jul 10. doi: 10.1109/TCBB.2019.2926711. [Epub ahead of print]


Sex hormones and number processing. Progesterone and testosterone relate to hemispheric asymmetries during number comparison.

Pletzer B, Jäger S, Hawelka S.

Horm Behav. 2019 Sep;115:104553. doi: 10.1016/j.yhbeh.2019.07.001. Epub 2019 Jul 20.


Circulating CD14+CD16- classical monocytes do not associate with a vulnerable plaque phenotype, and do not predict secondary events in severe atherosclerotic patients.

Meeuwsen JAL, de Vries JJ, van Duijvenvoorde A, van der Velden S, van der Laan SW, van Koeverden ID, van de Weg SM, de Borst GJ, de Winther MPJ, Kuiper J, Pasterkamp G, Hoefer IE, de Jager SCA; Queen of Hearts Consortium.

J Mol Cell Cardiol. 2019 Feb;127:260-269. doi: 10.1016/j.yjmcc.2019.01.002. Epub 2019 Jan 7.


Facial Adiposity, Attractiveness, and Health: A Review.

de Jager S, Coetzee N, Coetzee V.

Front Psychol. 2018 Dec 21;9:2562. doi: 10.3389/fpsyg.2018.02562. eCollection 2018. Review.


Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure.

Bosch L, de Haan J, Seijkens T, van Tiel C, Brans M, Pasterkamp G, Lutgens E, de Jager S.

Int J Cardiol. 2019 Mar 15;279:141-144. doi: 10.1016/j.ijcard.2018.12.076. Epub 2018 Dec 28. Erratum in: Int J Cardiol. 2019 Oct 15;293:297.


Tuning the Performance of Synthetic Riboswitches using Machine Learning.

Groher AC, Jager S, Schneider C, Groher F, Hamacher K, Suess B.

ACS Synth Biol. 2019 Jan 18;8(1):34-44. doi: 10.1021/acssynbio.8b00207. Epub 2019 Jan 8.


Convenient synthesis of the immunogenic glycolipid BbGL1.

Jäger SN, Porta EOJ, Labadie GR.

Steroids. 2019 Jan;141:41-45. doi: 10.1016/j.steroids.2018.11.012. Epub 2018 Nov 22.


Cation-dependent changes in the thylakoid membrane appression of the diatom Thalassiosira pseudonana.

Jäger S, Büchel C.

Biochim Biophys Acta Bioenerg. 2019 Jan;1860(1):41-51. doi: 10.1016/j.bbabio.2018.11.003. Epub 2018 Nov 15.


Smoking is Associated to DNA Methylation in Atherosclerotic Carotid Lesions.

Siemelink MA, van der Laan SW, Haitjema S, van Koeverden ID, Schaap J, Wesseling M, de Jager SCA, Mokry M, van Iterson M, Dekkers KF, Luijk R, Foroughi Asl H, Michoel T, Björkegren JLM, Aavik E, Ylä-Herttuala S, de Borst GJ, Asselbergs FW, El Azzouzi H, den Ruijter HM, Heijmans BT, Pasterkamp G.

Circ Genom Precis Med. 2018 Sep;11(9):e002030. doi: 10.1161/CIRCGEN.117.002030.


Corrigendum: Improvement in the Thermostability of a β-Amino Acid Converting ω-Transaminase by Using FoldX.

Buß O, Muller D, Jager S, Rudat J, Rabe KS.

Chembiochem. 2018 Oct 18;19(20):2241. doi: 10.1002/cbic.201700465. No abstract available.


4,5-Diazafluorene N-glycopyranosyl hydrazones as scaffolds for potential bioactive metallo-organic compounds: Synthesis, structural study and cytotoxic activity.

Jäger S, Gude L, Arias-Pérez MS.

Bioorg Chem. 2018 Dec;81:405-413. doi: 10.1016/j.bioorg.2018.08.019. Epub 2018 Sep 1.


A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response.

Shamalnasab M, Gravel SP, St-Pierre J, Breton L, Jäger S, Aguilaniu H.

Aging Cell. 2018 Dec;17(6):e12830. doi: 10.1111/acel.12830. Epub 2018 Sep 7. Erratum in: Aging Cell. 2019 Apr;18(2):e12917.


An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses.

Penn BH, Netter Z, Johnson JR, Von Dollen J, Jang GM, Johnson T, Ohol YM, Maher C, Bell SL, Geiger K, Golovkine G, Du X, Choi A, Parry T, Mohapatra BC, Storck MD, Band H, Chen C, Jäger S, Shales M, Portnoy DA, Hernandez R, Coscoy L, Cox JS, Krogan NJ.

Mol Cell. 2018 Aug 16;71(4):637-648.e5. doi: 10.1016/j.molcel.2018.07.010.


Mapping the electric field distribution of tightly focused cylindrical vector beams with gold nanorings.

Fulmes J, Gollmer DA, Jäger S, Schäfer C, Horrer A, Zhang D, Adam PM, Meixner AJ, Kern DP, Fleischer M.

Opt Express. 2018 Jun 11;26(12):14982-14998. doi: 10.1364/OE.26.014982.


Outcomes of outpatient ureteral stenting without fluoroscopy at Groote Schuur Hospital, Cape Town, South Africa.

Sinha S, Jaumdally SZ, Cassim F, Wicht J, Kaestner L, Panackal A, Jehle CH, Govender P, De Jager S, De Wet E, Dewar M, Kolia ME, Salukazana S, Moolman C, Van den Heever AP, Kowlessur B, Pinto G, Lazarus J.

S Afr Med J. 2018 May 25;108(6):506-510. doi: 10.7196/SAMJ.2018.v108i6.12983.


StreaMD: Advanced analysis of molecular dynamics using R.

Dombrowsky MJ, Jager S, Schiller B, Mayer BE, Stammler S, Hamacher K.

J Comput Chem. 2018 Aug 5;39(21):1666-1674. doi: 10.1002/jcc.25197. Epub 2018 Apr 17.


GADD45A and CDKN1A are involved in apoptosis and cell cycle modulatory effects of viscumTT with further inactivation of the STAT3 pathway.

Kleinsimon S, Longmuss E, Rolff J, Jäger S, Eggert A, Delebinski C, Seifert G.

Sci Rep. 2018 Apr 10;8(1):5750. doi: 10.1038/s41598-018-24075-x.


Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H, Taliun D, Rayner NW, Guo X, Lu Y, Li M, Jensen RA, Hu Y, Huo S, Lohman KK, Zhang W, Cook JP, Prins BP, Flannick J, Grarup N, Trubetskoy VV, Kravic J, Kim YJ, Rybin DV, Yaghootkar H, Müller-Nurasyid M, Meidtner K, Li-Gao R, Varga TV, Marten J, Li J, Smith AV, An P, Ligthart S, Gustafsson S, Malerba G, Demirkan A, Tajes JF, Steinthorsdottir V, Wuttke M, Lecoeur C, Preuss M, Bielak LF, Graff M, Highland HM, Justice AE, Liu DJ, Marouli E, Peloso GM, Warren HR; ExomeBP Consortium; MAGIC Consortium; GIANT Consortium, Afaq S, Afzal S, Ahlqvist E, Almgren P, Amin N, Bang LB, Bertoni AG, Bombieri C, Bork-Jensen J, Brandslund I, Brody JA, Burtt NP, Canouil M, Chen YI, Cho YS, Christensen C, Eastwood SV, Eckardt KU, Fischer K, Gambaro G, Giedraitis V, Grove ML, de Haan HG, Hackinger S, Hai Y, Han S, Tybjærg-Hansen A, Hivert MF, Isomaa B, Jäger S, Jørgensen ME, Jørgensen T, Käräjämäki A, Kim BJ, Kim SS, Koistinen HA, Kovacs P, Kriebel J, Kronenberg F, Läll K, Lange LA, Lee JJ, Lehne B, Li H, Lin KH, Linneberg A, Liu CT, Liu J, Loh M, Mägi R, Mamakou V, McKean-Cowdin R, Nadkarni G, Neville M, Nielsen SF, Ntalla I, Peyser PA, Rathmann W, Rice K, Rich SS, Rode L, Rolandsson O, Schönherr S, Selvin E, Small KS, Stančáková A, Surendran P, Taylor KD, Teslovich TM, Thorand B, Thorleifsson G, Tin A, Tönjes A, Varbo A, Witte DR, Wood AR, Yajnik P, Yao J, Yengo L, Young R, Amouyel P, Boeing H, Boerwinkle E, Bottinger EP, Chowdhury R, Collins FS, Dedoussis G, Dehghan A, Deloukas P, Ferrario MM, Ferrières J, Florez JC, Frossard P, Gudnason V, Harris TB, Heckbert SR, Howson JMM, Ingelsson M, Kathiresan S, Kee F, Kuusisto J, Langenberg C, Launer LJ, Lindgren CM, Männistö S, Meitinger T, Melander O, Mohlke KL, Moitry M, Morris AD, Murray AD, de Mutsert R, Orho-Melander M, Owen KR, Perola M, Peters A, Province MA, Rasheed A, Ridker PM, Rivadineira F, Rosendaal FR, Rosengren AH, Salomaa V, Sheu WH, Sladek R, Smith BH, Strauch K, Uitterlinden AG, Varma R, Willer CJ, Blüher M, Butterworth AS, Chambers JC, Chasman DI, Danesh J, van Duijn C, Dupuis J, Franco OH, Franks PW, Froguel P, Grallert H, Groop L, Han BG, Hansen T, Hattersley AT, Hayward C, Ingelsson E, Kardia SLR, Karpe F, Kooner JS, Köttgen A, Kuulasmaa K, Laakso M, Lin X, Lind L, Liu Y, Loos RJF, Marchini J, Metspalu A, Mook-Kanamori D, Nordestgaard BG, Palmer CNA, Pankow JS, Pedersen O, Psaty BM, Rauramaa R, Sattar N, Schulze MB, Soranzo N, Spector TD, Stefansson K, Stumvoll M, Thorsteinsdottir U, Tuomi T, Tuomilehto J, Wareham NJ, Wilson JG, Zeggini E, Scott RA, Barroso I, Frayling TM, Goodarzi MO, Meigs JB, Boehnke M, Saleheen D, Morris AP, Rotter JI, McCarthy MI.

Nat Genet. 2018 Apr;50(4):559-571. doi: 10.1038/s41588-018-0084-1. Epub 2018 Apr 9.


Janus revisited: The intricate role of the immune system in neovascularization.

Hoefer IE, de Jager SCA.

Int J Cardiol. 2018 Jun 1;260:193-194. doi: 10.1016/j.ijcard.2018.03.014. No abstract available.


The morphological and molecular mechanisms of epithelial/endothelial-to-mesenchymal transition and its involvement in atherosclerosis.

Wesseling M, Sakkers TR, de Jager SCA, Pasterkamp G, Goumans MJ.

Vascul Pharmacol. 2018 Jul;106:1-8. doi: 10.1016/j.vph.2018.02.006. Epub 2018 Feb 20. Review.


Noncanonical NF-κB signaling in microvessels of atherosclerotic lesions is associated with inflammation, atheromatous plaque morphology and myocardial infarction.

Maracle CX, Agca R, Helder B, Meeuwsen JAL, Niessen HWM, Biessen EAL, de Winther MPJ, de Jager SCA, Nurmohamed MT, Tas SW.

Atherosclerosis. 2018 Mar;270:33-41. doi: 10.1016/j.atherosclerosis.2018.01.032. Epub 2018 Jan 31.


Riboswitching with ciprofloxacin-development and characterization of a novel RNA regulator.

Groher F, Bofill-Bosch C, Schneider C, Braun J, Jager S, Geißler K, Hamacher K, Suess B.

Nucleic Acids Res. 2018 Feb 28;46(4):2121-2132. doi: 10.1093/nar/gkx1319.


CD1d deficiency inhibits the development of abdominal aortic aneurysms in LDL receptor deficient mice.

van Puijvelde GHM, Foks AC, van Bochove RE, Bot I, Habets KLL, de Jager SC, Ter Borg MND, van Osch P, Boon L, Vos M, de Waard V, Kuiper J.

PLoS One. 2018 Jan 18;13(1):e0190962. doi: 10.1371/journal.pone.0190962. eCollection 2018.


Isolation of satellite glial cells for high-quality RNA purification.

Jager SB, Pallesen LT, Vaegter CB.

J Neurosci Methods. 2018 Mar 1;297:1-8. doi: 10.1016/j.jneumeth.2018.01.001. Epub 2018 Jan 2.


Leukocyte-Associated Immunoglobulin-like Receptor-1 is regulated in human myocardial infarction but its absence does not affect infarct size in mice.

Ellenbroek GHJM, de Haan JJ, van Klarenbosch BR, Brans MAD, van de Weg SM, Smeets MB, de Jong S, Arslan F, Timmers L, Goumans MTH, Hoefer IE, Doevendans PA, Pasterkamp G, Meyaard L, de Jager SCA.

Sci Rep. 2017 Dec 21;7(1):18039. doi: 10.1038/s41598-017-13678-5.


Complement 5a Receptor deficiency does not influence adverse cardiac remodeling after pressure-overload in mice.

de Haan JJ, Bosch L, Borgman A, Bastemeijer M, Brans MAD, van de Weg SM, de Kleijn DPV, Sluijter JPG, El Azzouzi H, de Jager SCA.

Sci Rep. 2017 Dec 6;7(1):17045. doi: 10.1038/s41598-017-16957-3.


Sex differences in peripheral not central immune responses to pain-inducing injury.

Lopes DM, Malek N, Edye M, Jager SB, McMurray S, McMahon SB, Denk F.

Sci Rep. 2017 Nov 28;7(1):16460. doi: 10.1038/s41598-017-16664-z.


Porosity of flowable resin composites is not influenced by applicator tip diameter.

Balthazard R, Jager S, Ferry O, Dahoun A, Mortier E.

Am J Dent. 2017 Jun;30(3):125-130.


Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects.

Rujano MA, Cannata Serio M, Panasyuk G, Péanne R, Reunert J, Rymen D, Hauser V, Park JH, Freisinger P, Souche E, Guida MC, Maier EM, Wada Y, Jäger S, Krogan NJ, Kretz O, Nobre S, Garcia P, Quelhas D, Bird TD, Raskind WH, Schwake M, Duvet S, Foulquier F, Matthijs G, Marquardt T, Simons M.

J Exp Med. 2017 Dec 4;214(12):3707-3729. doi: 10.1084/jem.20170453. Epub 2017 Nov 10.


Improvement in the Thermostability of a β-Amino Acid Converting ω-Transaminase by Using FoldX.

Buß O, Muller D, Jager S, Rudat J, Rabe KS.

Chembiochem. 2018 Feb 16;19(4):379-387. doi: 10.1002/cbic.201700467. Epub 2017 Dec 18. Erratum in: Chembiochem. 2018 Oct 18;19(20):2241.


Beyond the matrix: MMP2 as critical regulator of inflammation-mediated vascular dysfunction.

de Jager SCA, Hoefer IE.

Cardiovasc Res. 2017 Dec 1;113(14):1705-1707. doi: 10.1093/cvr/cvx202. No abstract available.


Clinical knowledge of community pharmacists in Croatia for detecting drug-related problems.

Zekan L, Mestrovic A, Seselja Perisin A, Portolan M, Jambrek N, Jager S, Sepetavc M, Modun D.

Int J Clin Pharm. 2017 Dec;39(6):1171-1174. doi: 10.1007/s11096-017-0546-z. Epub 2017 Oct 16.


Impaired kidney function is associated with intraplaque hemorrhage in patients undergoing carotid endarterectomy.

Wesseling M, van Koeverden ID, van Lammeren GW, van der Laan SW, Haitjema S, de Vries JPM, den Ruijter HM, de Jager SCA, Hoefer I, Blankestijn P, Verhaar M, de Kleijn DPV, de Borst GJ, Pasterkamp G.

Atherosclerosis. 2017 Nov;266:128-135. doi: 10.1016/j.atherosclerosis.2017.09.025. Epub 2017 Sep 22.


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