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Items: 1 to 50 of 137

1.

A multiple Piccolino-RIBEYE interaction supports plate-shaped synaptic ribbons in retinal neurons.

Müller TM, Gierke K, Joachimsthaler A, Sticht H, Izsvák Z, Hamra FK, Fejtová A, Ackermann F, Garner CC, Kremers J, Brandstätter JH, Regus-Leidig H.

J Neurosci. 2019 Jan 29. pii: 2038-18. doi: 10.1523/JNEUROSCI.2038-18.2019. [Epub ahead of print]

PMID:
30696732
2.

Author Correction: Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.

Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, Garcia-Cañadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Löwer J, Wolvetang EJ, Martin U, Ivics Z, Izsvák Z, Garcia-Perez JL, Faulkner GJ, Schumann GG.

Nat Commun. 2018 Dec 19;9(1):5398. doi: 10.1038/s41467-018-07917-0.

3.

Ten things you should know about transposable elements.

Bourque G, Burns KH, Gehring M, Gorbunova V, Seluanov A, Hammell M, Imbeault M, Izsvák Z, Levin HL, Macfarlan TS, Mager DL, Feschotte C.

Genome Biol. 2018 Nov 19;19(1):199. doi: 10.1186/s13059-018-1577-z. Review.

4.

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.

Wang H, Georgakopoulou A, Psatha N, Li C, Capsali C, Samal HB, Anagnostopoulos A, Ehrhardt A, Izsvák Z, Papayannopoulou T, Yannaki E, Lieber A.

J Clin Invest. 2019 Feb 1;129(2):598-615. doi: 10.1172/JCI122836. Epub 2018 Dec 18.

5.

Author Correction: Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.

Wang J, Singh M, Sun C, Besser D, Prigione A, Ivics Z, Hurst LD, Izsvák Z.

Nat Protoc. 2018 Oct 29. doi: 10.1038/s41596-018-0086-6. [Epub ahead of print]

PMID:
30374153
6.

A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.

Fink S, Zugelder L, Roth B, Brandt E, Meloche S, Izsvák Z, Bargou RC, Stühmer T.

PLoS One. 2018 Oct 19;13(10):e0205585. doi: 10.1371/journal.pone.0205585. eCollection 2018.

7.

The Antibiotic-free pFAR4 Vector Paired with the Sleeping Beauty Transposon System Mediates Efficient Transgene Delivery in Human Cells.

Pastor M, Johnen S, Harmening N, Quiviger M, Pailloux J, Kropp M, Walter P, Ivics Z, Izsvák Z, Thumann G, Scherman D, Marie C.

Mol Ther Nucleic Acids. 2018 Jun 1;11:57-67. doi: 10.1016/j.omtn.2017.12.017. Epub 2017 Dec 30.

8.

Integrating HDAd5/35++ Vectors as a New Platform for HSC Gene Therapy of Hemoglobinopathies.

Li C, Psatha N, Wang H, Singh M, Samal HB, Zhang W, Ehrhardt A, Izsvák Z, Papayannopoulou T, Lieber A.

Mol Ther Methods Clin Dev. 2018 Feb 15;9:142-152. doi: 10.1016/j.omtm.2018.02.004. eCollection 2018 Jun 15.

9.

Improved molecular platform for the gene therapy of rare diseases by liver protein secretion.

Quiviger M, Giannakopoulos A, Verhenne S, Marie C, Stavrou EF, Vanhoorelbeke K, Izsvák Z, De Meyer SF, Athanassiadou A, Scherman D.

Eur J Med Genet. 2018 Nov;61(11):723-728. doi: 10.1016/j.ejmg.2018.04.010. Epub 2018 Apr 26. Review.

PMID:
29704684
10.

Efficient Non-Viral T-Cell Engineering by Sleeping Beauty Minicircles Diminishing DNA Toxicity and miRNAs Silencing the Endogenous T-Cell Receptors.

Clauss J, Obenaus M, Miskey C, Ivics Z, Izsvák Z, Uckert W, Bunse M.

Hum Gene Ther. 2018 May;29(5):569-584. doi: 10.1089/hum.2017.136.

PMID:
29562762
11.

Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors.

Holstein M, Mesa-Nuñez C, Miskey C, Almarza E, Poletti V, Schmeer M, Grueso E, Ordóñez Flores JC, Kobelt D, Walther W, Aneja MK, Geiger J, Bonig HB, Izsvák Z, Schleef M, Rudolph C, Mavilio F, Bueren JA, Guenechea G, Ivics Z.

Mol Ther. 2018 Apr 4;26(4):1137-1153. doi: 10.1016/j.ymthe.2018.01.012. Epub 2018 Jan 31.

12.

High and long-term von Willebrand factor expression after Sleeping Beauty transposon-mediated gene therapy in a mouse model of severe von Willebrand disease.

Portier I, Vanhoorelbeke K, Verhenne S, Pareyn I, Vandeputte N, Deckmyn H, Goldenberg DS, Samal HB, Singh M, Ivics Z, Izsvák Z, De Meyer SF.

J Thromb Haemost. 2018 Mar;16(3):592-604. doi: 10.1111/jth.13938. Epub 2018 Jan 31.

PMID:
29288565
13.

A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice.

Wang H, Richter M, Psatha N, Li C, Kim J, Liu J, Ehrhardt A, Nilsson SK, Cao B, Palmer D, Ng P, Izsvák Z, Haworth KG, Kiem HP, Papayannopoulou T, Lieber A.

Mol Ther Methods Clin Dev. 2017 Nov 10;8:52-64. doi: 10.1016/j.omtm.2017.11.004. eCollection 2018 Mar 16.

14.

Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery.

Garcia-Garcia L, Recalde S, Hernandez M, Bezunartea J, Rodriguez-Madoz JR, Johnen S, Diarra S, Marie C, Izsvák Z, Ivics Z, Scherman D, Kropp M, Thumann G, Prosper F, Fernandez-Robredo P, Garcia-Layana A.

Mol Ther Nucleic Acids. 2017 Dec 15;9:1-11. doi: 10.1016/j.omtn.2017.08.001. Epub 2017 Aug 12.

15.

Gene Therapy with the Sleeping Beauty Transposon System.

Kebriaei P, Izsvák Z, Narayanavari SA, Singh H, Ivics Z.

Trends Genet. 2017 Nov;33(11):852-870. doi: 10.1016/j.tig.2017.08.008. Epub 2017 Sep 27. Review.

PMID:
28964527
16.

Generation of an immortalized mesenchymal stem cell line producing a secreted biosensor protein for glucose monitoring.

Siska EK, Weisman I, Romano J, Ivics Z, Izsvák Z, Barkai U, Petrakis S, Koliakos G.

PLoS One. 2017 Sep 26;12(9):e0185498. doi: 10.1371/journal.pone.0185498. eCollection 2017.

17.

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker.

Zadora J, Singh M, Herse F, Przybyl L, Haase N, Golic M, Yung HW, Huppertz B, Cartwright JE, Whitley G, Johnsen GM, Levi G, Isbruch A, Schulz H, Luft FC, Müller DN, Staff AC, Hurst LD, Dechend R, Izsvák Z.

Circulation. 2017 Nov 7;136(19):1824-1839. doi: 10.1161/CIRCULATIONAHA.117.028110. Epub 2017 Sep 13. Erratum in: Circulation. 2018 Oct 9;138(15):e423.

18.

Wide Awake and Ready to Move: 20 Years of Non-Viral Therapeutic Genome Engineering with the Sleeping Beauty Transposon System.

Hodge R, Narayanavari SA, Izsvák Z, Ivics Z.

Hum Gene Ther. 2017 Oct;28(10):842-855. doi: 10.1089/hum.2017.130. Review.

PMID:
28870121
19.

How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency.

Römer C, Singh M, Hurst LD, Izsvák Z.

Curr Opin Virol. 2017 Aug;25:49-58. doi: 10.1016/j.coviro.2017.07.001. Epub 2017 Jul 24. Review.

PMID:
28750248
20.

Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side.

Hudecek M, Izsvák Z, Johnen S, Renner M, Thumann G, Ivics Z.

Crit Rev Biochem Mol Biol. 2017 Aug;52(4):355-380. doi: 10.1080/10409238.2017.1304354. Epub 2017 Apr 12. Review. Erratum in: Crit Rev Biochem Mol Biol. 2017 Aug;52(4):i.

PMID:
28402189
21.

Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat.

Liška F, Landa V, Zídek V, Mlejnek P, Šilhavý J, Šimáková M, Strnad H, Trnovská J, Škop V, Kazdová L, Starker CG, Voytas DF, Izsvák Z, Mancini M, Šeda O, Křen V, Pravenec M.

Hypertension. 2017 Jun;69(6):1084-1091. doi: 10.1161/HYPERTENSIONAHA.116.08798. Epub 2017 Apr 10.

PMID:
28396530
22.

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids.

Thumann G, Harmening N, Prat-Souteyrand C, Marie C, Pastor M, Sebe A, Miskey C, Hurst LD, Diarra S, Kropp M, Walter P, Scherman D, Ivics Z, Izsvák Z, Johnen S.

Mol Ther Nucleic Acids. 2017 Mar 17;6:302-314. doi: 10.1016/j.omtn.2017.02.002. Epub 2017 Feb 10.

23.

Long-Term Prevention of Congenital Thrombotic Thrombocytopenic Purpura in ADAMTS13 Knockout Mice by Sleeping Beauty Transposon-Mediated Gene Therapy.

Verhenne S, Vandeputte N, Pareyn I, Izsvák Z, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):836-844. doi: 10.1161/ATVBAHA.116.308680. Epub 2017 Mar 2.

PMID:
28254814
24.

Transposition of the bamboo Mariner-like element Ppmar1 in yeast.

Zhou MB, Hu H, Miskey C, Lazarow K, Ivics Z, Kunze R, Yang G, Izsvák Z, Tang DQ.

Mol Phylogenet Evol. 2017 Apr;109:367-374. doi: 10.1016/j.ympev.2017.02.005. Epub 2017 Feb 9.

PMID:
28189615
25.

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.

Lorenz C, Lesimple P, Bukowiecki R, Zink A, Inak G, Mlody B, Singh M, Semtner M, Mah N, Auré K, Leong M, Zabiegalov O, Lyras EM, Pfiffer V, Fauler B, Eichhorst J, Wiesner B, Huebner N, Priller J, Mielke T, Meierhofer D, Izsvák Z, Meier JC, Bouillaud F, Adjaye J, Schuelke M, Wanker EE, Lombès A, Prigione A.

Cell Stem Cell. 2017 May 4;20(5):659-674.e9. doi: 10.1016/j.stem.2016.12.013. Epub 2017 Jan 26.

26.

Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition.

Wang Y, Pryputniewicz-Dobrinska D, Nagy EÉ, Kaufman CD, Singh M, Yant S, Wang J, Dalda A, Kay MA, Ivics Z, Izsvák Z.

Nucleic Acids Res. 2017 Jan 9;45(1):311-326. doi: 10.1093/nar/gkw1164. Epub 2016 Dec 1.

27.

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.

Richter M, Saydaminova K, Yumul R, Krishnan R, Liu J, Nagy EE, Singh M, Izsvák Z, Cattaneo R, Uckert W, Palmer D, Ng P, Haworth KG, Kiem HP, Ehrhardt A, Papayannopoulou T, Lieber A.

Blood. 2016 Nov 3;128(18):2206-2217. Epub 2016 Aug 23.

28.

Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats.

Liška F, Peterková R, Peterka M, Landa V, Zídek V, Mlejnek P, Šilhavý J, Šimáková M, Křen V, Starker CG, Voytas DF, Izsvák Z, Pravenec M.

PLoS One. 2016 Oct 11;11(10):e0164206. doi: 10.1371/journal.pone.0164206. eCollection 2016.

29.

Sleeping Beauty transposition: from biology to applications.

Narayanavari SA, Chilkunda SS, Ivics Z, Izsvák Z.

Crit Rev Biochem Mol Biol. 2017 Feb;52(1):18-44. doi: 10.1080/10409238.2016.1237935. Epub 2016 Oct 4. Review.

PMID:
27696897
30.

Structural Determinants of Sleeping Beauty Transposase Activity.

Abrusán G, Yant SR, Szilágyi A, Marsh JA, Mátés L, Izsvák Z, Barabás O, Ivics Z.

Mol Ther. 2016 Aug;24(8):1369-77. doi: 10.1038/mt.2016.110. Epub 2016 Jun 6.

31.

Generation of human induced pluripotent stem cell line from a patient with a long QT syndrome type 2.

Fatima A, Ivanyuk D, Herms S, Heilmann-Heimbach S, O'Shea O, Chapman C, Izsvák Z, Farr M, Hescheler J, Šarić T.

Stem Cell Res. 2016 Mar;16(2):304-7. doi: 10.1016/j.scr.2015.12.039. Epub 2016 Jan 6.

32.

Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.

Voigt F, Wiedemann L, Zuliani C, Querques I, Sebe A, Mátés L, Izsvák Z, Ivics Z, Barabas O.

Nat Commun. 2016 Mar 30;7:11126. doi: 10.1038/ncomms11126.

33.

A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes.

Grabundzija I, Messing SA, Thomas J, Cosby RL, Bilic I, Miskey C, Gogol-Döring A, Kapitonov V, Diem T, Dalda A, Jurka J, Pritham EJ, Dyda F, Izsvák Z, Ivics Z.

Nat Commun. 2016 Mar 2;7:10716. doi: 10.1038/ncomms10716.

34.

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.

Wang J, Singh M, Sun C, Besser D, Prigione A, Ivics Z, Hurst LD, Izsvák Z.

Nat Protoc. 2016 Feb;11(2):327-46. doi: 10.1038/nprot.2016.016. Epub 2016 Jan 21. Erratum in: Nat Protoc. 2018 Oct 29;:.

PMID:
26797457
35.

Full-length Dysferlin Transfer by the Hyperactive Sleeping Beauty Transposase Restores Dysferlin-deficient Muscle.

Escobar H, Schöwel V, Spuler S, Marg A, Izsvák Z.

Mol Ther Nucleic Acids. 2016 Jan 19;5:e277. doi: 10.1038/mtna.2015.52.

36.

Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4(+) T Cells.

Gogol-Döring A, Ammar I, Gupta S, Bunse M, Miskey C, Chen W, Uckert W, Schulz TF, Izsvák Z, Ivics Z.

Mol Ther. 2016 Mar;24(3):592-606. doi: 10.1038/mt.2016.11. Epub 2016 Jan 12.

37.

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.

Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, Garcia-Cañadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Löwer J, Wolvetang EJ, Martin U, Ivics Z, Izsvák Z, Garcia-Perez JL, Faulkner GJ, Schumann GG.

Nat Commun. 2016 Jan 8;7:10286. doi: 10.1038/ncomms10286. Erratum in: Nat Commun. 2018 Dec 19;9(1):5398.

38.

Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity?

Izsvák Z, Wang J, Singh M, Mager DL, Hurst LD.

Bioessays. 2016 Jan;38(1):109-17. doi: 10.1002/bies.201500096. Review.

PMID:
26735931
39.

Antiangiogenic and Neurogenic Activities of Sleeping Beauty-Mediated PEDF-Transfected RPE Cells In Vitro and In Vivo.

Johnen S, Djalali-Talab Y, Kazanskaya O, Möller T, Harmening N, Kropp M, Izsvák Z, Walter P, Thumann G.

Biomed Res Int. 2015;2015:863845. doi: 10.1155/2015/863845. Epub 2015 Dec 1.

40.

Sleeping Beauty Transposon Vectors in Liver-directed Gene Delivery of LDLR and VLDLR for Gene Therapy of Familial Hypercholesterolemia.

Turunen TA, Kurkipuro J, Heikura T, Vuorio T, Hytönen E, Izsvák Z, Ylä-Herttuala S.

Mol Ther. 2016 Mar;24(3):620-35. doi: 10.1038/mt.2015.221. Epub 2015 Dec 16.

41.

Identification and re-addressing of a transcriptionally permissive locus in the porcine genome.

Garrels W, Mukherjee A, Holler S, Cleve N, Talluri TR, Barg-Kues B, Diederich M, Köhler P, Petersen B, Lucas-Hahn A, Niemann H, Izsvák Z, Ivics Z, Kues WA.

Transgenic Res. 2016 Feb;25(1):63-70. doi: 10.1007/s11248-015-9914-4. Epub 2015 Oct 29.

PMID:
26515985
42.

Sleeping Beauty Transposition.

Ivics Z, Izsvák Z.

Microbiol Spectr. 2015 Apr;3(2):MDNA3-0042-2014. doi: 10.1128/microbiolspec.MDNA3-0042-2014. Review.

PMID:
26104705
43.

Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites.

Grandi FC, Rosser JM, Newkirk SJ, Yin J, Jiang X, Xing Z, Whitmore L, Bashir S, Ivics Z, Izsvák Z, Ye P, Yu YE, An W.

Genome Res. 2015 Aug;25(8):1135-46. doi: 10.1101/gr.185132.114. Epub 2015 May 20.

44.

Genomic analysis of Sleeping Beauty transposon integration in human somatic cells.

Turchiano G, Latella MC, Gogol-Döring A, Cattoglio C, Mavilio F, Izsvák Z, Ivics Z, Recchia A.

PLoS One. 2014 Nov 12;9(11):e112712. doi: 10.1371/journal.pone.0112712. eCollection 2014.

45.

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.

Wang J, Xie G, Singh M, Ghanbarian AT, Raskó T, Szvetnik A, Cai H, Besser D, Prigione A, Fuchs NV, Schumann GG, Chen W, Lorincz MC, Ivics Z, Hurst LD, Izsvák Z.

Nature. 2014 Dec 18;516(7531):405-9. doi: 10.1038/nature13804. Epub 2014 Oct 15.

PMID:
25317556
46.

Gibbon genome and the fast karyotype evolution of small apes.

Carbone L, Harris RA, Gnerre S, Veeramah KR, Lorente-Galdos B, Huddleston J, Meyer TJ, Herrero J, Roos C, Aken B, Anaclerio F, Archidiacono N, Baker C, Barrell D, Batzer MA, Beal K, Blancher A, Bohrson CL, Brameier M, Campbell MS, Capozzi O, Casola C, Chiatante G, Cree A, Damert A, de Jong PJ, Dumas L, Fernandez-Callejo M, Flicek P, Fuchs NV, Gut I, Gut M, Hahn MW, Hernandez-Rodriguez J, Hillier LW, Hubley R, Ianc B, Izsvák Z, Jablonski NG, Johnstone LM, Karimpour-Fard A, Konkel MK, Kostka D, Lazar NH, Lee SL, Lewis LR, Liu Y, Locke DP, Mallick S, Mendez FL, Muffato M, Nazareth LV, Nevonen KA, O'Bleness M, Ochis C, Odom DT, Pollard KS, Quilez J, Reich D, Rocchi M, Schumann GG, Searle S, Sikela JM, Skollar G, Smit A, Sonmez K, ten Hallers B, Terhune E, Thomas GW, Ullmer B, Ventura M, Walker JA, Wall JD, Walter L, Ward MC, Wheelan SJ, Whelan CW, White S, Wilhelm LJ, Woerner AE, Yandell M, Zhu B, Hammer MF, Marques-Bonet T, Eichler EE, Fulton L, Fronick C, Muzny DM, Warren WC, Worley KC, Rogers J, Wilson RK, Gibbs RA.

Nature. 2014 Sep 11;513(7517):195-201. doi: 10.1038/nature13679.

47.

Human satellite cells have regenerative capacity and are genetically manipulable.

Marg A, Escobar H, Gloy S, Kufeld M, Zacher J, Spuler A, Birchmeier C, Izsvák Z, Spuler S.

J Clin Invest. 2014 Oct;124(10):4257-65. doi: 10.1172/JCI63992. Epub 2014 Aug 26.

48.

Human somatic cell mutagenesis creates genetically tractable sarcomas.

Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Izsvák Z, Lupien M, Mak TW, Khokha R.

Nat Genet. 2014 Sep;46(9):964-72. doi: 10.1038/ng.3065. Epub 2014 Aug 17. Erratum in: Nat Genet. 2014 Dec;46(12):1372. Iszvak, Zsuzsanna [corrected to Izsvák, Zsuzsanna.

PMID:
25129143
49.

Excision efficiency is not strongly coupled to transgenic rate: cell type-dependent transposition efficiency of sleeping beauty and piggyBac DNA transposons.

Kolacsek O, Erdei Z, Apáti A, Sándor S, Izsvák Z, Ivics Z, Sarkadi B, Orbán TI.

Hum Gene Ther Methods. 2014 Aug;25(4):241-52. doi: 10.1089/hgtb.2013.149.

50.

Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons.

Ivics Z, Garrels W, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Kues WA, Izsvák Z.

Nat Protoc. 2014 Apr;9(4):810-27. doi: 10.1038/nprot.2014.010. Epub 2014 Mar 13.

PMID:
24625780

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