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Items: 1 to 50 of 377

1.

Dissecting primate early post-implantation development using long-term in vitro embryo culture.

Niu Y, Sun N, Li C, Lei Y, Huang Z, Wu J, Si C, Dai X, Liu C, Wei J, Liu L, Feng S, Kang Y, Si W, Wang H, Zhang E, Zhao L, Li Z, Luo X, Cui G, Peng G, Izpisúa Belmonte JC, Ji W, Tan T.

Science. 2019 Oct 31. pii: eaaw5754. doi: 10.1126/science.aaw5754. [Epub ahead of print]

PMID:
31672917
2.

Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures.

Li R, Zhong C, Yu Y, Liu H, Sakurai M, Yu L, Min Z, Shi L, Wei Y, Takahashi Y, Liao HK, Qiao J, Deng H, Nuñez-Delicado E, Rodriguez Esteban C, Wu J, Izpisua Belmonte JC.

Cell. 2019 Oct 17;179(3):687-702.e18. doi: 10.1016/j.cell.2019.09.029.

PMID:
31626770
3.

Design Approaches for Generating Organ Constructs.

Xia Y, Izpisua Belmonte JC.

Cell Stem Cell. 2019 Sep 5;25(3):447. doi: 10.1016/j.stem.2019.08.001. No abstract available.

PMID:
31491397
4.

Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction.

Suzuki K, Yamamoto M, Hernandez-Benitez R, Li Z, Wei C, Soligalla RD, Aizawa E, Hatanaka F, Kurita M, Reddy P, Ocampo A, Hishida T, Sakurai M, Nemeth AN, Nuñez Delicado E, Campistol JM, Magistretti P, Guillen P, Rodriguez Esteban C, Gong J, Yuan Y, Gu Y, Liu GH, López-Otín C, Wu J, Zhang K, Izpisua Belmonte JC.

Cell Res. 2019 Oct;29(10):804-819. doi: 10.1038/s41422-019-0213-0. Epub 2019 Aug 23.

PMID:
31444470
5.

Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells.

Zhang Y, Li T, Preissl S, Amaral ML, Grinstein JD, Farah EN, Destici E, Qiu Y, Hu R, Lee AY, Chee S, Ma K, Ye Z, Zhu Q, Huang H, Fang R, Yu L, Izpisua Belmonte JC, Wu J, Evans SM, Chi NC, Ren B.

Nat Genet. 2019 Sep;51(9):1380-1388. doi: 10.1038/s41588-019-0479-7. Epub 2019 Aug 19.

PMID:
31427791
6.

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis.

Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Izpisua Belmonte JC, Chan P, Qu J, Liu GH.

Nat Commun. 2019 Jul 26;10(1):3329. doi: 10.1038/s41467-019-10831-8.

7.

Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network.

Low JH, Li P, Chew EGY, Zhou B, Suzuki K, Zhang T, Lian MM, Liu M, Aizawa E, Rodriguez Esteban C, Yong KSM, Chen Q, Campistol JM, Fang M, Khor CC, Foo JN, Izpisua Belmonte JC, Xia Y.

Cell Stem Cell. 2019 Sep 5;25(3):373-387.e9. doi: 10.1016/j.stem.2019.06.009. Epub 2019 Jul 11.

PMID:
31303547
8.

Development of de novo epithelialization method for treatment of cutaneous ulcers.

Kurita M, Izpisua Belmonte JC, Suzuki K, Okazaki M.

J Dermatol Sci. 2019 Jul;95(1):8-12. doi: 10.1016/j.jdermsci.2019.06.006. Epub 2019 Jun 22. Review.

PMID:
31255469
9.

Towards precise, safe genome editing.

Memczak S, Shao Y, Izpisua Belmonte JC.

Cell Res. 2019 Sep;29(9):687-689. doi: 10.1038/s41422-019-0188-x. No abstract available.

PMID:
31201381
10.

Pig Chimeric Model with Human Pluripotent Stem Cells.

Zhong C, Wu J, Izpisua Belmonte JC.

Methods Mol Biol. 2019;2005:101-124. doi: 10.1007/978-1-4939-9524-0_8.

PMID:
31175649
11.

Design Approaches for Generating Organ Constructs.

Xia Y, Izpisua Belmonte JC.

Cell Stem Cell. 2019 Jun 6;24(6):877-894. doi: 10.1016/j.stem.2019.05.016. Review. Erratum in: Cell Stem Cell. 2019 Sep 5;25(3):447.

PMID:
31173717
12.

Organoids - Preclinical Models of Human Disease. Reply.

Li M, Izpisua Belmonte JC.

N Engl J Med. 2019 May 16;380(20):1982. doi: 10.1056/NEJMc1903253. No abstract available.

PMID:
31091397
13.

Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway.

Hishida T, Vazquez-Ferrer E, Hishida-Nozaki Y, Sancho-Martinez I, Takahashi Y, Hatanaka F, Wu J, Ocampo A, Reddy P, Wu MZ, Gerken L, Shaw RJ, Rodriguez Esteban C, Benner C, Nakagawa H, Guillen Garcia P, Nuñez Delicado E, Castells A, Campistol JM, Liu GH, Izpisua Belmonte JC.

Protein Cell. 2019 Jul;10(7):485-495. doi: 10.1007/s13238-019-0630-3. Epub 2019 Apr 30.

14.

Tailored chromatin modulation to promote tissue regeneration.

Martinez-Redondo P, Izpisua Belmonte JC.

Semin Cell Dev Biol. 2019 May 2. pii: S1084-9521(18)30322-7. doi: 10.1016/j.semcdb.2019.04.015. [Epub ahead of print] Review.

PMID:
31028854
15.

Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis.

Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Izpisua Belmonte JC, Chan P, Qu J, Tang F, Liu GH.

PLoS Biol. 2019 Apr 1;17(4):e3000201. doi: 10.1371/journal.pbio.3000201. eCollection 2019 Apr.

16.

Perspectives on Directions and Priorities for Future Preclinical Studies in Regenerative Medicine.

Grigorian Shamagian L, Madonna R, Taylor D, Climent AM, Prosper F, Bras-Rosario L, Bayes-Genis A, Ferdinandy P, Fernández-Avilés F, Izpisua Belmonte JC, Fuster V, Bolli R.

Circ Res. 2019 Mar 15;124(6):938-951. doi: 10.1161/CIRCRESAHA.118.313795.

PMID:
30870121
17.

Single-dose CRISPR-Cas9 therapy extends lifespan of mice with Hutchinson-Gilford progeria syndrome.

Beyret E, Liao HK, Yamamoto M, Hernandez-Benitez R, Fu Y, Erikson G, Reddy P, Izpisua Belmonte JC.

Nat Med. 2019 Mar;25(3):419-422. doi: 10.1038/s41591-019-0343-4. Epub 2019 Feb 18.

18.

Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells.

Garreta E, Prado P, Tarantino C, Oria R, Fanlo L, Martí E, Zalvidea D, Trepat X, Roca-Cusachs P, Gavaldà-Navarro A, Cozzuto L, Campistol JM, Izpisúa Belmonte JC, Hurtado Del Pozo C, Montserrat N.

Nat Mater. 2019 Apr;18(4):397-405. doi: 10.1038/s41563-019-0287-6. Epub 2019 Feb 18.

PMID:
30778227
19.

Organoids - Preclinical Models of Human Disease.

Li M, Izpisua Belmonte JC.

N Engl J Med. 2019 Feb 7;380(6):569-579. doi: 10.1056/NEJMra1806175. Review. No abstract available.

PMID:
30726695
20.

Corrigendum to: "Generation of two induced pluripotent stem cell (iPSC) lines from p.F508del Cystic Fibrosis patients" Stem Cell Res. 2018 May; 29:1-5.

Fleischer A, Lorenzo IM, Palomino E, Aasen T, Gómez F, Servera M, Asensio VJ, Gálvez V, Izpisúa-Belmonte JC, Bachiller D.

Stem Cell Res. 2019 Jan;34:101384. doi: 10.1016/j.scr.2019.101384. Epub 2019 Jan 22. No abstract available.

21.

FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration.

Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Izpisua Belmonte JC, Qu J, Tang F, Liu GH.

Cell Stem Cell. 2019 Mar 7;24(3):447-461.e8. doi: 10.1016/j.stem.2018.12.002. Epub 2019 Jan 17.

PMID:
30661960
22.

Coordinated histone modifications and chromatin reorganization in a single cell revealed by FRET biosensors.

Peng Q, Lu S, Shi Y, Pan Y, Limsakul P, Chernov AV, Qiu J, Chai X, Shi Y, Wang P, Ji Y, Li YJ, Strongin AY, Verkhusha VV, Izpisua Belmonte JC, Ren B, Wang Y, Chien S, Wang Y.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11681-E11690. doi: 10.1073/pnas.1811818115. Epub 2018 Nov 26.

23.

Modeling epigenetic modifications in renal development and disease with organoids and genome editing.

Hurtado Del Pozo C, Garreta E, Izpisúa Belmonte JC, Montserrat N.

Dis Model Mech. 2018 Nov 20;11(11). pii: dmm035048. doi: 10.1242/dmm.035048. Review.

24.

Introduction to Cardiovascular Aging Compendium.

Marian AJ, Bhatnagar A, Bolli R, Izpisua Belmonte JC.

Circ Res. 2018 Sep 14;123(7):737-739. doi: 10.1161/CIRCRESAHA.118.313940. No abstract available.

PMID:
30355084
25.

Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.

Hong SH, Fang S, Lu BC, Nofsinger R, Kawakami Y, Castro GL, Yin Y, Lin C, Yu RT, Downes M, Izpisúa Belmonte JC, Shilatifard A, Evans RM.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10381-10386. doi: 10.1073/pnas.1809480115. Epub 2018 Sep 25.

26.

In vivo reprogramming of wound-resident cells generates skin epithelial tissue.

Kurita M, Araoka T, Hishida T, O'Keefe DD, Takahashi Y, Sakamoto A, Sakurai M, Suzuki K, Wu J, Yamamoto M, Hernandez-Benitez R, Ocampo A, Reddy P, Shokhirev MN, Magistretti P, Núñez Delicado E, Eto H, Harii K, Izpisua Belmonte JC.

Nature. 2018 Sep;561(7722):243-247. doi: 10.1038/s41586-018-0477-4. Epub 2018 Sep 5.

PMID:
30185909
27.

Forty years of IVF.

Niederberger C, Pellicer A, Cohen J, Gardner DK, Palermo GD, O'Neill CL, Chow S, Rosenwaks Z, Cobo A, Swain JE, Schoolcraft WB, Frydman R, Bishop LA, Aharon D, Gordon C, New E, Decherney A, Tan SL, Paulson RJ, Goldfarb JM, Brännström M, Donnez J, Silber S, Dolmans MM, Simpson JL, Handyside AH, Munné S, Eguizabal C, Montserrat N, Izpisua Belmonte JC, Trounson A, Simon C, Tulandi T, Giudice LC, Norman RJ, Hsueh AJ, Sun Y, Laufer N, Kochman R, Eldar-Geva T, Lunenfeld B, Ezcurra D, D'Hooghe T, Fauser BCJM, Tarlatzis BC, Meldrum DR, Casper RF, Fatemi HM, Devroey P, Galliano D, Wikland M, Sigman M, Schoor RA, Goldstein M, Lipshultz LI, Schlegel PN, Hussein A, Oates RD, Brannigan RE, Ross HE, Pennings G, Klock SC, Brown S, Van Steirteghem A, Rebar RW, LaBarbera AR.

Fertil Steril. 2018 Jul 15;110(2):185-324.e5. doi: 10.1016/j.fertnstert.2018.06.005. Review.

PMID:
30053940
28.

At the Heart of Genome Editing and Cardiovascular Diseases.

Hernandez-Benitez R, Martinez-Martinez ML, Lajara J, Magistretti P, Montserrat N, Izpisua Belmonte JC.

Circ Res. 2018 Jul 6;123(2):221-223. doi: 10.1161/CIRCRESAHA.118.312676. Review. No abstract available.

PMID:
29976689
29.

Deconstructing the pluripotency gene regulatory network.

Li M, Izpisua Belmonte JC.

Nat Cell Biol. 2018 Apr;20(4):382-392. doi: 10.1038/s41556-018-0067-6. Epub 2018 Mar 28. Review.

30.

Generation of two induced pluripotent stem cell (iPSC) lines from p.F508del Cystic Fibrosis patients.

Fleischer A, Lorenzo IM, Palomino E, Aasen T, Gómez F, Servera M, Asensio VJ, Gálvez V, Izpisúa-Belmonte JC, Bachiller D.

Stem Cell Res. 2018 May;29:1-5. doi: 10.1016/j.scr.2018.03.004. Epub 2018 Mar 11. Erratum in: Stem Cell Res. 2019 Jan;34:101384.

31.

Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts.

Bogliotti YS, Wu J, Vilarino M, Okamura D, Soto DA, Zhong C, Sakurai M, Sampaio RV, Suzuki K, Izpisua Belmonte JC, Ross PJ.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2090-2095. doi: 10.1073/pnas.1716161115. Epub 2018 Feb 9.

32.

Elixir of Life: Thwarting Aging With Regenerative Reprogramming.

Beyret E, Martinez Redondo P, Platero Luengo A, Izpisua Belmonte JC.

Circ Res. 2018 Jan 5;122(1):128-141. doi: 10.1161/CIRCRESAHA.117.311866. Review.

33.

In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation.

Liao HK, Hatanaka F, Araoka T, Reddy P, Wu MZ, Sui Y, Yamauchi T, Sakurai M, O'Keefe DD, Núñez-Delicado E, Guillen P, Campistol JM, Wu CJ, Lu LF, Esteban CR, Izpisua Belmonte JC.

Cell. 2017 Dec 14;171(7):1495-1507.e15. doi: 10.1016/j.cell.2017.10.025. Epub 2017 Dec 7.

34.

In vivo genome editing via the HITI method as a tool for gene therapy.

Suzuki K, Izpisua Belmonte JC.

J Hum Genet. 2018 Feb;63(2):157-164. doi: 10.1038/s10038-017-0352-4. Epub 2017 Nov 13. Review.

PMID:
29215090
35.

Human Embryo Editing: Opportunities and Importance of Transnational Cooperation.

Pei D, Beier DW, Levy-Lahad E, Marchant G, Rossant J, Izpisua Belmonte JC, Lovell-Badge R, Jaenisch R, Charo A, Baltimore D.

Cell Stem Cell. 2017 Oct 5;21(4):423-426. doi: 10.1016/j.stem.2017.09.010.

36.

miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS.

Wu MZ, Cheng WC, Chen SF, Nieh S, O'Connor C, Liu CL, Tsai WW, Wu CJ, Martin L, Lin YS, Wu KJ, Lu LF, Izpisua Belmonte JC.

Nat Cell Biol. 2017 Oct;19(10):1286-1296. doi: 10.1038/ncb3615. Epub 2017 Sep 18.

37.

Regulation of Stem Cell Aging by Metabolism and Epigenetics.

Ren R, Ocampo A, Liu GH, Izpisua Belmonte JC.

Cell Metab. 2017 Sep 5;26(3):460-474. doi: 10.1016/j.cmet.2017.07.019. Epub 2017 Aug 17. Review.

38.

Keeping the Rhythm while Changing the Lyrics: Circadian Biology in Aging.

Hatanaka F, Ocampo A, Izpisua Belmonte JC.

Cell. 2017 Aug 10;170(4):599-600. doi: 10.1016/j.cell.2017.07.039.

39.

Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding.

Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Izpisua Belmonte JC, Qu J, Tang F, Liu GH.

Cell Res. 2017 Sep;27(9):1178-1181. doi: 10.1038/cr.2017.86. Epub 2017 Jul 7. No abstract available.

40.

Gathering by the Red Sea highlights links between environment and epigenetics.

Li M, Borrelli E, Magistretti PJ, Izpisua Belmonte JC, Sassone-Corsi P, Orlando V.

Nat Struct Mol Biol. 2017 Jun 6;24(6):491-493. doi: 10.1038/nsmb.3422. No abstract available.

PMID:
28586330
41.

Non-coding microRNAs for cardiac regeneration: Exploring novel alternatives to induce heart healing.

Garreta E, Prado P, Izpisua Belmonte JC, Montserrat N.

Noncoding RNA Res. 2017 May 17;2(2):93-99. doi: 10.1016/j.ncrna.2017.05.001. eCollection 2017 Jun. Review.

42.

iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types.

Panopoulos AD, D'Antonio M, Benaglio P, Williams R, Hashem SI, Schuldt BM, DeBoever C, Arias AD, Garcia M, Nelson BC, Harismendy O, Jakubosky DA, Donovan MKR, Greenwald WW, Farnam K, Cook M, Borja V, Miller CA, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Aguirre A, McGarry TJ, Matsui H, Li H, Reyna J, Rao F, O'Connor DT, Yeo GW, Evans SM, Chi NC, Jepsen K, Nariai N, Müller FJ, Goldstein LSB, Izpisua Belmonte JC, Adler E, Loring JF, Berggren WT, D'Antonio-Chronowska A, Smith EN, Frazer KA.

Stem Cell Reports. 2017 Apr 11;8(4):1086-1100. doi: 10.1016/j.stemcr.2017.03.012.

43.

Aberrant DNA Methylation in Human iPSCs Associates with MYC-Binding Motifs in a Clone-Specific Manner Independent of Genetics.

Panopoulos AD, Smith EN, Arias AD, Shepard PJ, Hishida Y, Modesto V, Diffenderfer KE, Conner C, Biggs W, Sandoval E, D'Antonio-Chronowska A, Berggren WT, Izpisua Belmonte JC, Frazer KA.

Cell Stem Cell. 2017 Apr 6;20(4):505-517.e6. doi: 10.1016/j.stem.2017.03.010.

44.

Interspecies Chimerism with Mammalian Pluripotent Stem Cells.

Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilariño M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sánchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nuñez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC.

Cell. 2017 Jan 26;168(3):473-486.e15. doi: 10.1016/j.cell.2016.12.036.

45.

Genome editing in human pluripotent stem cells: a systematic approach unrevealing pancreas development and disease.

Garreta E, Marco A, Izpisua Belmonte JC, Montserrat N.

Stem Cell Investig. 2016 Nov 14;3:76. doi: 10.21037/sci.2016.10.11. eCollection 2016. No abstract available.

46.

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.

Ocampo A, Reddy P, Martinez-Redondo P, Platero-Luengo A, Hatanaka F, Hishida T, Li M, Lam D, Kurita M, Beyret E, Araoka T, Vazquez-Ferrer E, Donoso D, Roman JL, Xu J, Rodriguez Esteban C, Nuñez G, Nuñez Delicado E, Campistol JM, Guillen I, Guillen P, Izpisua Belmonte JC.

Cell. 2016 Dec 15;167(7):1719-1733.e12. doi: 10.1016/j.cell.2016.11.052.

47.

Human Organs from Animal Bodies.

Izpisúa Belmonte JC.

Sci Am. 2016 Oct 18;315(5):32-37. doi: 10.1038/scientificamerican1116-32. No abstract available.

PMID:
27918510
48.

Generation of human organs in pigs via interspecies blastocyst complementation.

Wu J, Platero Luengo A, Gil MA, Suzuki K, Cuello C, Morales Valencia M, Parrilla I, Martinez CA, Nohalez A, Roca J, Martinez EA, Izpisua Belmonte JC.

Reprod Domest Anim. 2016 Oct;51 Suppl 2:18-24. doi: 10.1111/rda.12796.

PMID:
27762052
49.

3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors.

Li Z, Araoka T, Wu J, Liao HK, Li M, Lazo M, Zhou B, Sui Y, Wu MZ, Tamura I, Xia Y, Beyret E, Matsusaka T, Pastan I, Rodriguez Esteban C, Guillen I, Guillen P, Campistol JM, Izpisua Belmonte JC.

Cell Stem Cell. 2016 Oct 6;19(4):516-529. doi: 10.1016/j.stem.2016.07.016. Epub 2016 Aug 25.

50.

Looking to the future following 10 years of induced pluripotent stem cell technologies.

Li M, Izpisua Belmonte JC.

Nat Protoc. 2016 Sep;11(9):1579-85. doi: 10.1038/nprot.2016.108. Epub 2016 Aug 4. Review.

PMID:
27490631

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