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Items: 1 to 50 of 166

1.

A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex.

Keskeny C, Raisch T, Sgromo A, Igreja C, Bhandari D, Weichenrieder O, Izaurralde E.

Genes Dev. 2019 Feb 1;33(3-4):236-252. doi: 10.1101/gad.320952.118. Epub 2019 Jan 28.

2.

Structural and biochemical analysis of a NOT1 MIF4G-like domain of the CCR4-NOT complex.

Raisch T, Sandmeir F, Weichenrieder O, Valkov E, Izaurralde E.

J Struct Biol. 2018 Dec;204(3):388-395. doi: 10.1016/j.jsb.2018.10.009. Epub 2018 Oct 24.

3.

Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast.

Grüner S, Weber R, Peter D, Chung MY, Igreja C, Valkov E, Izaurralde E.

Nucleic Acids Res. 2018 Jul 27;46(13):6893-6908. doi: 10.1093/nar/gky542.

4.

Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets.

Sgromo A, Raisch T, Backhaus C, Keskeny C, Alva V, Weichenrieder O, Izaurralde E.

RNA. 2018 Mar;24(3):381-395. doi: 10.1261/rna.064584.117. Epub 2017 Dec 18.

5.

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.

Peter D, Weber R, Sandmeir F, Wohlbold L, Helms S, Bawankar P, Valkov E, Igreja C, Izaurralde E.

Genes Dev. 2017 Jun 1;31(11):1147-1161. doi: 10.1101/gad.299420.117. Epub 2017 Jul 11.

6.

A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin.

Sgromo A, Raisch T, Bawankar P, Bhandari D, Chen Y, Kuzuoğlu-Öztürk D, Weichenrieder O, Izaurralde E.

Nat Commun. 2017 Feb 6;8:14307. doi: 10.1038/ncomms14307.

7.

The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.

Grüner S, Peter D, Weber R, Wohlbold L, Chung MY, Weichenrieder O, Valkov E, Igreja C, Izaurralde E.

Mol Cell. 2016 Nov 3;64(3):467-479. doi: 10.1016/j.molcel.2016.09.020. Epub 2016 Oct 20.

8.

Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.

Valkov E, Muthukumar S, Chang CT, Jonas S, Weichenrieder O, Izaurralde E.

Nat Struct Mol Biol. 2016 Jun;23(6):574-9. doi: 10.1038/nsmb.3232. Epub 2016 May 16.

PMID:
27183195
9.

miRISC and the CCR4-NOT complex silence mRNA targets independently of 43S ribosomal scanning.

Kuzuoğlu-Öztürk D, Bhandari D, Huntzinger E, Fauser M, Helms S, Izaurralde E.

EMBO J. 2016 Jun 1;35(11):1186-203. doi: 10.15252/embj.201592901. Epub 2016 Mar 23.

10.

Distinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate Nanos.

Raisch T, Bhandari D, Sabath K, Helms S, Valkov E, Weichenrieder O, Izaurralde E.

EMBO J. 2016 May 2;35(9):974-90. doi: 10.15252/embj.201593634. Epub 2016 Mar 11.

11.

Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation.

Peter D, Weber R, Köne C, Chung MY, Ebertsch L, Truffault V, Weichenrieder O, Igreja C, Izaurralde E.

Genes Dev. 2015 Sep 1;29(17):1835-49. doi: 10.1101/gad.269068.115. Epub 2015 Aug 20.

12.

GENE REGULATION. Breakers and blockers—miRNAs at work.

Izaurralde E.

Science. 2015 Jul 24;349(6246):380-2. doi: 10.1126/science.1260969. Epub 2015 Jul 23. No abstract available.

PMID:
26206919
13.

Towards a molecular understanding of microRNA-mediated gene silencing.

Jonas S, Izaurralde E.

Nat Rev Genet. 2015 Jul;16(7):421-33. doi: 10.1038/nrg3965. Epub 2015 Jun 16. Review.

PMID:
26077373
14.

Molecular architecture of 4E-BP translational inhibitors bound to eIF4E.

Peter D, Igreja C, Weber R, Wohlbold L, Weiler C, Ebertsch L, Weichenrieder O, Izaurralde E.

Mol Cell. 2015 Mar 19;57(6):1074-1087. doi: 10.1016/j.molcel.2015.01.017. Epub 2015 Feb 19.

15.

4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.

Igreja C, Peter D, Weiler C, Izaurralde E.

Nat Commun. 2014 Sep 2;5:4790. doi: 10.1038/ncomms5790.

16.

An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay.

Jonas S, Christie M, Peter D, Bhandari D, Loh B, Huntzinger E, Weichenrieder O, Izaurralde E.

Nat Struct Mol Biol. 2014 Jul;21(7):599-608. doi: 10.1038/nsmb.2837. Epub 2014 Jun 1.

PMID:
24880343
17.

A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.

Chen Y, Boland A, Kuzuoğlu-Öztürk D, Bawankar P, Loh B, Chang CT, Weichenrieder O, Izaurralde E.

Mol Cell. 2014 Jun 5;54(5):737-50. doi: 10.1016/j.molcel.2014.03.034. Epub 2014 Apr 24.

18.

Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression.

Bhandari D, Raisch T, Weichenrieder O, Jonas S, Izaurralde E.

Genes Dev. 2014 Apr 15;28(8):888-901. doi: 10.1101/gad.237289.113.

19.

The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.

Chang CT, Bercovich N, Loh B, Jonas S, Izaurralde E.

Nucleic Acids Res. 2014 Apr;42(8):5217-33. doi: 10.1093/nar/gku129. Epub 2014 Feb 8.

20.

The role of disordered protein regions in the assembly of decapping complexes and RNP granules.

Jonas S, Izaurralde E.

Genes Dev. 2013 Dec 15;27(24):2628-41. doi: 10.1101/gad.227843.113. Review.

21.

Structure and assembly of the NOT module of the human CCR4-NOT complex.

Boland A, Chen Y, Raisch T, Jonas S, Kuzuoğlu-Öztürk D, Wohlbold L, Weichenrieder O, Izaurralde E.

Nat Struct Mol Biol. 2013 Nov;20(11):1289-97. doi: 10.1038/nsmb.2681. Epub 2013 Oct 13.

PMID:
24121232
22.
23.

Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins.

Christie M, Boland A, Huntzinger E, Weichenrieder O, Izaurralde E.

Mol Cell. 2013 Aug 8;51(3):360-73. doi: 10.1016/j.molcel.2013.07.011.

24.

miRISC recruits decapping factors to miRNA targets to enhance their degradation.

Nishihara T, Zekri L, Braun JE, Izaurralde E.

Nucleic Acids Res. 2013 Oct;41(18):8692-705. doi: 10.1093/nar/gkt619. Epub 2013 Jul 17.

25.

Making sense of nonsense.

Hentze MW, Izaurralde E.

Nat Struct Mol Biol. 2013 Jun;20(6):651-3. doi: 10.1038/nsmb.2601. No abstract available.

PMID:
23739166
26.

A role for eIF4AII in microRNA-mediated mRNA silencing.

Izaurralde E.

Nat Struct Mol Biol. 2013 May;20(5):543-5. doi: 10.1038/nsmb.2582. No abstract available.

PMID:
23649363
27.

GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation.

Zekri L, Kuzuoğlu-Öztürk D, Izaurralde E.

EMBO J. 2013 Apr 3;32(7):1052-65. doi: 10.1038/emboj.2013.44. Epub 2013 Mar 5.

28.

An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay.

Jonas S, Weichenrieder O, Izaurralde E.

Genes Dev. 2013 Jan 15;27(2):211-25. doi: 10.1101/gad.206672.112.

29.

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain.

Bawankar P, Loh B, Wohlbold L, Schmidt S, Izaurralde E.

RNA Biol. 2013 Feb;10(2):228-44. doi: 10.4161/rna.23018. Epub 2013 Jan 9.

30.

The role of GW182 proteins in miRNA-mediated gene silencing.

Braun JE, Huntzinger E, Izaurralde E.

Adv Exp Med Biol. 2013;768:147-63. doi: 10.1007/978-1-4614-5107-5_9. Review.

PMID:
23224969
31.

A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs.

Braun JE, Huntzinger E, Izaurralde E.

Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12). pii: a012328. doi: 10.1101/cshperspect.a012328. Review.

32.

The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets.

Huntzinger E, Kuzuoglu-Öztürk D, Braun JE, Eulalio A, Wohlbold L, Izaurralde E.

Nucleic Acids Res. 2013 Jan;41(2):978-94. doi: 10.1093/nar/gks1078. Epub 2012 Nov 21.

33.

A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation.

Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M, Izaurralde E.

Nat Struct Mol Biol. 2012 Dec;19(12):1324-31. doi: 10.1038/nsmb.2413. Epub 2012 Nov 11.

PMID:
23142987
34.

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.

Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O.

Nucleic Acids Res. 2012 Nov;40(21):11058-72. doi: 10.1093/nar/gks883. Epub 2012 Sep 12.

35.

Elucidating the temporal order of silencing.

Izaurralde E.

EMBO Rep. 2012 Aug;13(8):662-3. doi: 10.1038/embor.2012.91. Epub 2012 Jun 22. No abstract available.

36.

The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes.

Kuzuoglu-Öztürk D, Huntzinger E, Schmidt S, Izaurralde E.

Nucleic Acids Res. 2012 Jul;40(12):5651-65. doi: 10.1093/nar/gks218. Epub 2012 Mar 7.

37.

The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex.

Fromm SA, Truffault V, Kamenz J, Braun JE, Hoffmann NA, Izaurralde E, Sprangers R.

EMBO J. 2012 Jan 18;31(2):279-90. doi: 10.1038/emboj.2011.408. Epub 2011 Nov 15.

38.

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.

Braun JE, Huntzinger E, Fauser M, Izaurralde E.

Mol Cell. 2011 Oct 7;44(1):120-33. doi: 10.1016/j.molcel.2011.09.007.

39.

CUP promotes deadenylation and inhibits decapping of mRNA targets.

Igreja C, Izaurralde E.

Genes Dev. 2011 Sep 15;25(18):1955-67. doi: 10.1101/gad.17136311.

40.

Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP.

Teplova M, Wohlbold L, Khin NW, Izaurralde E, Patel DJ.

Nat Struct Mol Biol. 2011 Aug 7;18(9):990-8. doi: 10.1038/nsmb.2094.

41.

Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein.

Boland A, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10466-71. doi: 10.1073/pnas.1103946108. Epub 2011 Jun 6.

42.

Gene silencing by microRNAs: contributions of translational repression and mRNA decay.

Huntzinger E, Izaurralde E.

Nat Rev Genet. 2011 Feb;12(2):99-110. doi: 10.1038/nrg2936. Review.

PMID:
21245828
43.

Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.

Huntzinger E, Braun JE, Heimstädt S, Zekri L, Izaurralde E.

EMBO J. 2010 Dec 15;29(24):4146-60. doi: 10.1038/emboj.2010.274. Epub 2010 Nov 9.

44.

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay.

Kashima I, Jonas S, Jayachandran U, Buchwald G, Conti E, Lupas AN, Izaurralde E.

Genes Dev. 2010 Nov 1;24(21):2440-50. doi: 10.1101/gad.604610. Epub 2010 Oct 7.

45.

The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa.

Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O, Izaurralde E.

EMBO J. 2010 Jul 21;29(14):2368-80. doi: 10.1038/emboj.2010.124. Epub 2010 Jun 11.

46.

Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein.

Boland A, Tritschler F, Heimstädt S, Izaurralde E, Weichenrieder O.

EMBO Rep. 2010 Jul;11(7):522-7. doi: 10.1038/embor.2010.81. Epub 2010 Jun 11.

47.

HPat provides a link between deadenylation and decapping in metazoa.

Haas G, Braun JE, Igreja C, Tritschler F, Nishihara T, Izaurralde E.

J Cell Biol. 2010 Apr 19;189(2):289-302. doi: 10.1083/jcb.200910141.

48.

Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu.

Tritschler F, Huntzinger E, Izaurralde E.

Nat Rev Mol Cell Biol. 2010 May;11(5):379-84. doi: 10.1038/nrm2885. Epub 2010 Apr 9. Review.

PMID:
20379206
49.

DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa.

Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, Izaurralde E, Weichenrieder O.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21591-6. doi: 10.1073/pnas.0909871106. Epub 2009 Dec 4.

50.

The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release.

Zekri L, Huntzinger E, Heimstädt S, Izaurralde E.

Mol Cell Biol. 2009 Dec;29(23):6220-31. doi: 10.1128/MCB.01081-09. Epub 2009 Sep 21.

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