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Items: 1 to 50 of 62


Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat.

Mediouni S, Chinthalapudi K, Ekka MK, Usui I, Jablonski JA, Clementz MA, Mousseau G, Nowak J, Macherla VR, Beverage JN, Esquenazi E, Baran P, de Vera IMS, Kojetin D, Loret EP, Nettles K, Maiti S, Izard T, Valente ST.

MBio. 2019 Feb 5;10(1). pii: e02662-18. doi: 10.1128/mBio.02662-18.


Shigella IpaA Binding to Talin Stimulates Filopodial Capture and Cell Adhesion.

Valencia-Gallardo C, Bou-Nader C, Aguilar-Salvador DI, Carayol N, Quenech'Du N, Pecqueur L, Park H, Fontecave M, Izard T, Tran Van Nhieu G.

Cell Rep. 2019 Jan 22;26(4):921-932.e6. doi: 10.1016/j.celrep.2018.12.091.


Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex.

Patil DN, Rangarajan ES, Novick SJ, Pascal BD, Kojetin DJ, Griffin PR, Izard T, Martemyanov KA.

Elife. 2018 Dec 12;7. pii: e42150. doi: 10.7554/eLife.42150.


The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation.

Chinthalapudi K, Rangarajan ES, Izard T.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10339-10344. doi: 10.1073/pnas.1806275115. Epub 2018 Sep 25.


Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.

Chinthalapudi K, Mandati V, Zheng J, Sharff AJ, Bricogne G, Griffin PR, Kissil J, Izard T.

Nat Commun. 2018 Apr 6;9(1):1338. doi: 10.1038/s41467-018-03648-4.


The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.

Cao W, Kayama H, Chen ML, Delmas A, Sun A, Kim SY, Rangarajan ES, McKevitt K, Beck AP, Jackson CB, Crynen G, Oikonomopoulos A, Lacey PN, Martinez GJ, Izard T, Lorenz RG, Rodriguez-Palacios A, Cominelli F, Abreu MT, Hommes DW, Koralov SB, Takeda K, Sundrud MS.

Immunity. 2017 Dec 19;47(6):1182-1196.e10. doi: 10.1016/j.immuni.2017.11.012.


Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.

Stender JD, Nwachukwu JC, Kastrati I, Kim Y, Strid T, Yakir M, Srinivasan S, Nowak J, Izard T, Rangarajan ES, Carlson KE, Katzenellenbogen JA, Yao XQ, Grant BJ, Leong HS, Lin CY, Frasor J, Nettles KW, Glass CK.

Mol Cell. 2017 Mar 16;65(6):1122-1135.e5. doi: 10.1016/j.molcel.2017.02.008.


Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.

Nwachukwu JC, Srinivasan S, Bruno NE, Nowak J, Wright NJ, Minutolo F, Rangarajan ES, Izard T, Yao XQ, Grant BJ, Kojetin DJ, Elemento O, Katzenellenbogen JA, Nettles KW.

Cell Chem Biol. 2017 Jan 19;24(1):35-45. doi: 10.1016/j.chembiol.2016.11.014. Epub 2016 Dec 29.


Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.

Chinthalapudi K, Rangarajan ES, Brown DT, Izard T.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9539-44. doi: 10.1073/pnas.1600702113. Epub 2016 Aug 8.


Mechanisms and Functions of Vinculin Interactions with Phospholipids at Cell Adhesion Sites.

Izard T, Brown DT.

J Biol Chem. 2016 Feb 5;291(6):2548-55. doi: 10.1074/jbc.R115.686493. Epub 2016 Jan 4. Review.


Vinculin-cell membrane interactions.

Brown DT, Izard T.

Oncotarget. 2015 Oct 27;6(33):34043-4. doi: 10.18632/oncotarget.5868. No abstract available.


Lipid-directed vinculin dimerization.

Chinthalapudi K, Patil DN, Rangarajan ES, Rader C, Izard T.

Biochemistry. 2015 May 5;54(17):2758-68. doi: 10.1021/acs.biochem.5b00015. Epub 2015 Apr 24.


Lipid binding promotes oligomerization and focal adhesion activity of vinculin.

Chinthalapudi K, Rangarajan ES, Patil DN, George EM, Brown DT, Izard T.

J Cell Biol. 2014 Dec 8;207(5):643-56. doi: 10.1083/jcb.201404128.


Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma.

Poussin K, Pilati C, Couchy G, Calderaro J, Bioulac-Sage P, Bacq Y, Paradis V, Leteurtre E, Sturm N, Ramos J, Guettier C, Bardier-Dupas A, Boulai A, Wendum D, Selves J, Izard T, Nault JC, Zucman-Rossi J.

Oncoimmunology. 2013 Dec 1;2(12):e27090. Epub 2014 Jan 3.


Crystal structure of the N-terminal domains of the surface cell antigen 4 of Rickettsia.

Lee JH, Vonrhein C, Bricogne G, Izard T.

Protein Sci. 2013 Oct;22(10):1425-31. doi: 10.1002/pro.2322. Epub 2013 Aug 28.


Dimer asymmetry defines α-catenin interactions.

Rangarajan ES, Izard T.

Nat Struct Mol Biol. 2013 Feb;20(2):188-93. doi: 10.1038/nsmb.2479. Epub 2013 Jan 6.


The metavinculin tail domain directs constitutive interactions with raver1 and vinculin RNA.

Lee JH, Rangarajan ES, Vonrhein C, Bricogne G, Izard T.

J Mol Biol. 2012 Oct 5;422(5):697-704. doi: 10.1016/j.jmb.2012.06.015. Epub 2012 Jun 15.


The cytoskeletal protein α-catenin unfurls upon binding to vinculin.

Rangarajan ES, Izard T.

J Biol Chem. 2012 May 25;287(22):18492-9. doi: 10.1074/jbc.M112.351023. Epub 2012 Apr 6.


Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin.

Yogesha SD, Rangarajan ES, Vonrhein C, Bricogne G, Izard T.

Protein Sci. 2012 Apr;21(4):583-8. doi: 10.1002/pro.2041. Epub 2012 Feb 28.


Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor.

Yogesha SD, Sharff AJ, Giovannini M, Bricogne G, Izard T.

Protein Sci. 2011 Dec;20(12):2113-20. doi: 10.1002/pro.751. Epub 2011 Nov 9.


The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin.

Park H, Lee JH, Gouin E, Cossart P, Izard T.

J Biol Chem. 2011 Oct 7;286(40):35096-103. doi: 10.1074/jbc.M111.263855. Epub 2011 Aug 13.


Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas.

Pilati C, Amessou M, Bihl MP, Balabaud C, Nhieu JT, Paradis V, Nault JC, Izard T, Bioulac-Sage P, Couchy G, Poussin K, Zucman-Rossi J.

J Exp Med. 2011 Jul 4;208(7):1359-66. doi: 10.1084/jem.20110283. Epub 2011 Jun 20.


Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin.

Yogesha SD, Sharff A, Bricogne G, Izard T.

Protein Sci. 2011 Aug;20(8):1471-6. doi: 10.1002/pro.671.


Apo raver1 structure reveals distinct RRM domain orientations.

Rangarajan ES, Lee JH, Izard T.

Protein Sci. 2011 Aug;20(8):1464-70. doi: 10.1002/pro.664. Epub 2011 Jun 17.


Novel vinculin binding site of the IpaA invasin of Shigella.

Park H, Valencia-Gallardo C, Sharff A, Tran Van Nhieu G, Izard T.

J Biol Chem. 2011 Jul 1;286(26):23214-21. doi: 10.1074/jbc.M110.184283. Epub 2011 Apr 27.


Improving the diffraction of full-length human selenomethionyl metavinculin crystals by streak-seeding.

Rangarajan ES, Izard T.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1617-20. doi: 10.1107/S1744309110041059. Epub 2010 Nov 25.


A helix replacement mechanism directs metavinculin functions.

Rangarajan ES, Lee JH, Yogesha SD, Izard T.

PLoS One. 2010 May 19;5(5):e10679. doi: 10.1371/journal.pone.0010679.


Dramatic improvement of crystal quality for low-temperature-grown rabbit muscle aldolase.

Park H, Rangarajan ES, Sygusch J, Izard T.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt 5):595-600. doi: 10.1107/S1744309110011875. Epub 2010 Apr 30.


Nucleosome interaction surface of linker histone H1c is distinct from that of H1(0).

George EM, Izard T, Anderson SD, Brown DT.

J Biol Chem. 2010 Jul 2;285(27):20891-6. doi: 10.1074/jbc.M110.108639. Epub 2010 May 5.


Mechanism of aldolase control of sorting nexin 9 function in endocytosis.

Rangarajan ES, Park H, Fortin E, Sygusch J, Izard T.

J Biol Chem. 2010 Apr 16;285(16):11983-90. doi: 10.1074/jbc.M109.092049. Epub 2010 Feb 2.


Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions.

Lee JH, Rangarajan ES, Yogesha SD, Izard T.

Structure. 2009 Jun 10;17(6):833-42. doi: 10.1016/j.str.2009.04.010.


Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours.

Rebouissou S, Amessou M, Couchy G, Poussin K, Imbeaud S, Pilati C, Izard T, Balabaud C, Bioulac-Sage P, Zucman-Rossi J.

Nature. 2009 Jan 8;457(7226):200-4. doi: 10.1038/nature07475. Epub 2008 Nov 19.


Vinculin binding in its closed conformation by a helix addition mechanism.

Nhieu GT, Izard T.

EMBO J. 2007 Oct 31;26(21):4588-96. Epub 2007 Oct 11. Erratum in: EMBO J. 2008 Mar 19;27(6):922.


A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein.

St-Jean M, Izard T, Sygusch J.

J Biol Chem. 2007 May 11;282(19):14309-15. Epub 2007 Feb 27.


Capping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domain.

Ramarao N, Le Clainche C, Izard T, Bourdet-Sicard R, Ageron E, Sansonetti PJ, Carlier MF, Tran Van Nhieu G.

FEBS Lett. 2007 Mar 6;581(5):853-7. Epub 2007 Feb 2.


Shigella applies molecular mimicry to subvert vinculin and invade host cells.

Izard T, Tran Van Nhieu G, Bois PR.

J Cell Biol. 2006 Nov 6;175(3):465-75.


Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo.

Brown DT, Izard T, Misteli T.

Nat Struct Mol Biol. 2006 Mar;13(3):250-5. Epub 2006 Feb 5. Erratum in: Nat Struct Mol Biol. 2006 May;13(5):465.


The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin.

Bois PR, O'Hara BP, Nietlispach D, Kirkpatrick J, Izard T.

J Biol Chem. 2006 Mar 17;281(11):7228-36. Epub 2006 Jan 9.


Structural dynamics of alpha-actinin-vinculin interactions.

Bois PR, Borgon RA, Vonrhein C, Izard T.

Mol Cell Biol. 2005 Jul;25(14):6112-22. Erratum in: Mol Cell Biol. 2007 Aug;27(15):5606.


Managing the habitual no-show patient.

Izard T.

Fam Pract Manag. 2005 Feb;12(2):65-6. No abstract available.


Crystal structure of human vinculin.

Borgon RA, Vonrhein C, Bricogne G, Bois PR, Izard T.

Structure. 2004 Jul;12(7):1189-97. Epub 2004 Jun 3.


Rhombohedral crystals of the human vinculin head domain in complex with a vinculin-binding site of talin.

Rush CL, Izard T.

Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):945-7. Epub 2004 Apr 21.


Structural basis for amplifying vinculin activation by talin.

Izard T, Vonrhein C.

J Biol Chem. 2004 Jun 25;279(26):27667-78. Epub 2004 Apr 7.


Vinculin activation by talin through helical bundle conversion.

Izard T, Evans G, Borgon RA, Rush CL, Bricogne G, Bois PR.

Nature. 2004 Jan 8;427(6970):171-5. Epub 2003 Dec 31.


Rhombohedral crystals of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase.

Brown KL, Morris VK, Izard T.

Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):195-6. Epub 2003 Dec 18.


Crystallization of HLA-DR4 fused to an immunodominant collagen II peptide implicated in rheumatoid arthritis.

Hurlbert JC, Izard T.

Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 1):1749-51. Epub 2002 Sep 26.


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